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11. 发明授权

US08361807B2 Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other 有权
公开(公告)号：US08361807B2
公开(公告)日：2013-01-29
申请号：US13069213
申请日：2011-03-22
申请人： Willy Wiyatno , Linda Lee , David Cox , Richard Reel , Mark Oldham , Jim Nurse , Douglas Greiner , Dennis Lehto , Janusz Wojtowicz , Sam Woo
发明人： Willy Wiyatno , Linda Lee , David Cox , Richard Reel , Mark Oldham , Jim Nurse , Douglas Greiner , Dennis Lehto , Janusz Wojtowicz , Sam Woo
IPC分类号： G01N1/14 , G01N1/28
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.

12. 发明申请

US20090305426A1 AXIAL ILLUMINATION FOR CAPILLARY ELECTROPHORESIS 审中-公开
标题翻译：用于毛细管电泳的轴向照明
公开(公告)号：US20090305426A1
公开(公告)日：2009-12-10
申请号：US12543470
申请日：2009-08-18
申请人： Richard REEL , Eric S. Nordman
发明人： Richard REEL , Eric S. Nordman
IPC分类号： G01N33/00 , G01J3/30
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

13. 发明申请

US20060187450A1 Axial illumination for capillary electrophoresis 有权
公开(公告)号：US20060187450A1
公开(公告)日：2006-08-24
申请号：US11356497
申请日：2006-02-16
申请人： Richard Reel , Eric Nordman
发明人： Richard Reel , Eric Nordman
IPC分类号： G01N21/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.

14. 发明授权

US08446588B2 Axial illumination for capillary electrophoresis 有权
标题翻译：毛细管电泳的轴向照明
公开(公告)号：US08446588B2
公开(公告)日：2013-05-21
申请号：US13465999
申请日：2012-05-07
申请人： Richard Reel , Eric Nordman
发明人： Richard Reel , Eric Nordman
IPC分类号： G01N21/00 , G01N21/55
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

15. 发明授权

US08384899B2 DNA sequencing system 有权
公开(公告)号：US08384899B2
公开(公告)日：2013-02-26
申请号：US13442143
申请日：2012-04-09
申请人： Mark Oldham , Eric Nordman , Richard Reel , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

16. 发明申请

US20070097390A1 Method for correcting cartridge color shifts for performing imaging with an imaging apparatus using a cartridge 审中-公开
标题翻译：用于通过使用盒的成像装置进行成像的校正盒颜色偏移的方法
公开(公告)号：US20070097390A1
公开(公告)日：2007-05-03
申请号：US11263387
申请日：2005-10-31
申请人： Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： H04N1/60
CPC分类号： H04N1/603
摘要： A method for correcting cartridge color shifts for imaging with an imaging apparatus includes determining a spectral signature band for each colorant to yield a plurality of spectral signature bands; determining a minimum number of the spectral signature bands from the plurality of spectral signature bands to form a group of spectral signature bands that are applicable to all colorants of the plurality of colorants; determining a primary colorant profile for each colorant of the plurality of colorants of the cartridge based on the minimum number of the spectral signature bands; determining primary colorant shift data based on the primary colorant profile for each colorant and based on a standard cartridge primary colorant profile; estimating combined colorant shift data using the primary colorant shift data; and generating color correction data based on the combined colorant shift data for use in imaging with an imaging apparatus using the cartridge.
摘要翻译：用于校正用成像装置成像的盒颜色偏移的方法包括确定每个着色剂的光谱签名带以产生多个光谱签名带; 确定来自所述多个频谱签名频带的频谱签名频带的最小数量，以形成可应用于所述多个着色剂中的所有着色剂的一组频谱签名带; 基于所述光谱签名带的最小数量确定所述多个着色剂中的每个着色剂的主要着色剂轮廓; 基于每个着色剂的主要着色剂轮廓和基于标准盒初级着色剂轮廓确定主要着色剂转移数据; 使用主要着色剂移位数据估计组合的着色剂位移数据; 以及基于与使用所述盒的成像装置成像的组合的着色剂移位数据产生颜色校正数据。

17. 发明申请

US20070068573A1 Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible 审中-公开
标题翻译：用于与第二流体接触的第一流体的微流控制的装置和方法，其中第一和第二流体是不混溶的
公开(公告)号：US20070068573A1
公开(公告)日：2007-03-29
申请号：US11508756
申请日：2006-08-22
申请人： David Cox , Sam Woo , Steven Boege , Mark Oldham , Richard Reel , Eric Nordman , Linda Lee , Willy Wiyatno , Dmitry Sagatelyan
发明人： David Cox , Sam Woo , Steven Boege , Mark Oldham , Richard Reel , Eric Nordman , Linda Lee , Willy Wiyatno , Dmitry Sagatelyan
IPC分类号： F17D1/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , C12Q2535/101 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575
摘要： Various embodiments described in the application relate to an apparatus, system, and method for fluidically controlling, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise combinations of detectors, controllers, valves, and fluid supply units to control the spatial size, location and/or fluidic composition of discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.
摘要翻译：在本申请中描述的各种实施例涉及用于在管道内流体控制与第二流体不混溶的一种或多种流体的离散体积的装置，系统和方法。离散体积可用于涉及小体积的生物化学或分子生物学过程，例如微升体积，纳升级体积或更小体积。该系统可以包括检测器，控制器，阀和流体供应单元的组合，以控制通过与离散的流体不混溶的流体彼此分离的离散体积的空间尺寸，位置和/或流体组成体积，例如由油分离的含水不混溶流体离散体积。

18. 发明申请

US20060072133A1 Method for converting a source gamut of an image to a destination gamut 有权
标题翻译：将图像的源色域转换为目标色域的方法
公开(公告)号：US20060072133A1
公开(公告)日：2006-04-06
申请号：US10957032
申请日：2004-09-30
申请人： Yao Han , Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Yao Han , Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： H04N1/60
CPC分类号： H04N1/6058
摘要： A method for converting a source gamut of an image to a destination gamut includes providing an imaging apparatus having a plurality of destination gamuts, determining a source gamut boundary for the source gamut of the image; selecting an appropriate destination gamut from the plurality of destination gamuts based on a desired output; mapping to the appropriate destination gamut based at least in part on the source gamut boundary; and determining a color conversion lookup table based on the mapping to the appropriate destination gamut for use in replicating the image to provide the desired output using the imaging apparatus.
摘要翻译：一种用于将图像的源色域转换为目标色域的方法包括提供具有多个目标色域的成像装置，确定图像的源色域的源色域边界; 基于期望的输出从所述多个目的地色域中选择适当的目的地色域; 至少部分地基于源色域边界映射到适当的目的地色域; 以及基于对适当的目的地色域的映射来确定颜色转换查找表，以用于复制图像以使用成像装置提供期望的输出。

19. 发明申请

US20060066650A1 Method and apparatus for printing using a plurality of basic colorants and at least one high fidelity colorant 审中-公开
标题翻译：使用多种基础着色剂和至少一种高保真着色剂进行印刷的方法和装置
公开(公告)号：US20060066650A1
公开(公告)日：2006-03-30
申请号：US10955540
申请日：2004-09-29
申请人： Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： B41J2/195
CPC分类号： G06K15/02 , G06K2215/0094 , H04N1/54
摘要： A method of printing using a plurality of basic colorants and at least one high fidelity colorant includes obtaining system variables that impact high fidelity color printing; and printing with an optimized usage of the plurality of basic colorants and the at least one high fidelity colorant based on a colorant level, wherein a reduced output of the at least one high fidelity colorant will occur if an average colorant level of the at least one high fidelity colorant is lower than an average colorant level of the plurality of basic colorants.
摘要翻译：使用多种基础着色剂和至少一种高保真着色剂进行印刷的方法包括获得影响高保真彩色印刷的系统变量; 以及基于着色剂水平优化使用所述多种基础着色剂和所述至少一种高保真着色剂的印刷，其中，如果所述至少一种高保真着色剂的平均着色剂水平高保真着色剂低于多种碱性着色剂的平均着色剂含量。

20. 发明授权

US08169610B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US08169610B2
公开(公告)日：2012-05-01
申请号：US13153902
申请日：2011-06-06
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura, legal representative
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

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