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11. 发明申请

US20090228426A1 PLATFORM FOR CAPTURING KNOWLEDGE 审中-公开
标题翻译：掌握知识的平台
公开(公告)号：US20090228426A1
公开(公告)日：2009-09-10
申请号：US12042451
申请日：2008-03-05
申请人： Jeffrey J. Bonasso , Sara Giordano , Rahul Gupta , Kathryn Marietta-Tondin , Janis A. Morariu , Devang D. Patel , Amy S. Purdy , Michael Reed , Amy B. Sander Thrasher , Antonella Vaccina
发明人： Jeffrey J. Bonasso , Sara Giordano , Rahul Gupta , Kathryn Marietta-Tondin , Janis A. Morariu , Devang D. Patel , Amy S. Purdy , Michael Reed , Amy B. Sander Thrasher , Antonella Vaccina
IPC分类号： G06N5/02
CPC分类号： G06N20/00
摘要： A platform used for capturing knowledge. More specifically, a framework configured to capture expert knowledge (e.g., of trained and/or skilled workers) for future instructional purposes (e.g., training of a younger, or less experienced, workforce). The platform comprises a knowledge recorder, instructional design tool, standardized XML, and gaming engine. The knowledge recorder is configured to capture knowledge of a user, which is transferable using a standardized XML format. The instructional design tool is configured to visually model a gaming scenario in order to expose and define logical situations based on the captured knowledge.
摘要翻译：用于捕获知识的平台。更具体地，被配置为捕获专家知识（例如，经过训练和/或熟练的工人）以用于将来的教学目的（例如，训练较年轻或较少经验的劳动力）的框架。该平台包括知识记录器，教学设计工具，标准化XML和游戏引擎。知识记录器被配置为捕获可以使用标准化XML格式传送的用户的知识。教学设计工具被配置为可视地模拟游戏场景，以便基于所捕获的知识来公开和定义逻辑情境。

12. 发明申请

US20080133562A1 CODING COMPRESSIBLE VARIABLE LENGTH DATABASE FIELDS 审中-公开
标题翻译：编码可压缩长度数据库字段
公开(公告)号：US20080133562A1
公开(公告)日：2008-06-05
申请号：US11566768
申请日：2006-12-05
申请人： Chi Ping Bess Cheong , Michael Reed , May Pederson
发明人： Chi Ping Bess Cheong , Michael Reed , May Pederson
IPC分类号： G06F7/00
CPC分类号： G06F16/2455 , G06F16/22
摘要： A method, computer program, database system and data structure for coding a compressible variable length field in a row to be added to a database table are disclosed. The row has a value to be stored in the compressible variable length field. The value is searched for in a list of values for the compressible variable length field stored in the table. IF the value is found in the list of values, the row is created in the table with a first code associated with the value, a second code associated with a location in the row, but without the compressible variable length field. Otherwise, the row is created in the table with the value stored in the compressible variable length field, a first code indicating that the value is stored in the row, and a second code associated with the location of the value in the row.
摘要翻译：公开了一种方法，计算机程序，数据库系统和用于编码要添加到数据库表的行中的可压缩可变长度字段的数据结构。该行具有要存储在可压缩可变长度字段中的值。在表中存储的可压缩可变长度字段的值列表中搜索该值。如果值在值列表中找到，则在表中创建具有与该值相关联的第一代码的行，该行与该行中的位置相关联但不具有可压缩可变长度字段的第二代码。否则，该行在表中创建，其值存储在可压缩可变长度字段中，第一个代码指示该值存储在该行中，第二个代码与该行中值的位置相关联。

13. 发明申请

US20080114042A1 Compound 失效
标题翻译：复合
公开(公告)号：US20080114042A1
公开(公告)日：2008-05-15
申请号：US11979160
申请日：2007-10-31
申请人： Nigel Vicker , Su Xiangdong , Dharshini Ganeshapillai , Atul Purohit , Michael Reed , Barry Potter
发明人： Nigel Vicker , Su Xiangdong , Dharshini Ganeshapillai , Atul Purohit , Michael Reed , Barry Potter
IPC分类号： A61K31/428 , A61P3/00 , A61P37/00 , A61P19/00 , A61K31/404 , A61P3/10 , A61P3/04 , A61K31/4184 , A61P9/00 , A61P35/00
CPC分类号： C07D277/64 , C07D209/08 , C07D235/08 , C07D263/56 , C07D277/14 , C07D417/12
摘要： A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
摘要翻译：具有式I的化合物，其中R 1和R 2中的一个是下式的基团其中R 4选自H和烃基， R 5是烃基，L是任选的连接基团，或者R 1和R 2一起形成被下列基团取代的环，其中， R 3是H或取代基，其中X选自S，O，NR 6和C（R 7）（R 7）其中R 6选自H和烃基，其中R 7和R 8中的每一个是独立地选自H和烃基。

14. 发明申请

US20070251337A1 Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices 有权
标题翻译：用于检测无菌存储设备中的化学扰动的荧光检测器系统
公开(公告)号：US20070251337A1
公开(公告)日：2007-11-01
申请号：US11789431
申请日：2007-04-23
申请人： Michael Reed , Steven Geelhood , Paul Harris , Lynn Barker , Perry Hargrave , Oliver Nanassy
发明人： Michael Reed , Steven Geelhood , Paul Harris , Lynn Barker , Perry Hargrave , Oliver Nanassy
IPC分类号： G01N33/00
CPC分类号： G01N33/84 , C12Q1/04 , C12Q1/22 , C12Q1/54 , G01N21/6428 , G01N21/77 , G01N21/80 , G01N33/492 , G01N33/542 , G01N33/582 , G01N33/66 , G01N2021/6421 , G01N2021/6434 , G01N2021/6484 , G01N2021/7786 , G01N2201/062 , G01N2201/068 , G01N2201/0826 , G01N2201/084 , G01N2400/00
摘要： System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.
摘要翻译：用于检测和测量样品中化学扰动的系统和方法。该系统和方法可用于密封在储存袋中的血液或血液制品的非侵入性pH监测。

15. 发明申请

US20070225256A1 COMPOUND 审中-公开
标题翻译：复合
公开(公告)号：US20070225256A1
公开(公告)日：2007-09-27
申请号：US11689936
申请日：2007-03-22
申请人： Matthew Leese , Atul Purohit , Michael Reed , Fabrice Jourdan , Barry Victor Potter , Christian Bubert
发明人： Matthew Leese , Atul Purohit , Michael Reed , Fabrice Jourdan , Barry Victor Potter , Christian Bubert
IPC分类号： A61K31/675 , A61K31/58 , C07J43/00 , C07J41/00
CPC分类号： C07J43/003 , C07J3/00 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0072
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the A ring of the steroidal ring system is optionally substituted at position 2 or 4 with a group R4 which may be a suitable subtituent, wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of (i) —SO2R5, wherein R5 is H, a hydrocarbyl group or a bond or group attached to the D ring; (ii) —NO2; (iii) —SOR6, wherein R6 is H or a hydrocarbyl group; (iv) —R7, wherein R7 is a halogen; (v) -alkyl; (vi) —C(═O)R3, wherein R3 is H or hydrocarbyl; (vii) —C≡CR9, wherein R9 is H or hydrocarbyl; (viii) —OC(═O)NR10R11 wherein R10 and R11 are independently selected from H and hydrocarbyl; (ix), (x), (xi), (xii) and (xiii) are formulae wherein when R3 is -alkyl, R4 is present as a hydrocarbon group, when R3 is —NO2R4 is present and/or R1 is present as a sulphamate group, and when R3 is —C(═O)R3R4 is present and R1 is present as a sulphamate group.
摘要翻译：本发明提供了包含甾族环系统和选自-OH，氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的任选基团R1的化合物; 其中所述甾族环系统的A环任选在位置2或4处被基团R 4取代，所述基团R 4可以是合适的取代基，其中所述甾族环系统的D环被基团 R L 3，其中L是任选的连接基团，R 3选自以下基团，或其中包含一个的（i）-SO 2 R 5，其中R 5是H，连接到D环上的烃基或键或基团 ; （ii）-NO 2 2; （iii）-SOR 6，其中R 6是H或烃基; （iv）-R 7，其中R 7为卤素; （v） - 烷基; （vi）-C（-O）R 3，其中R 3是H或烃基; （vii）-C≡CR9，其中R 9是H或烃基; （viii）-OC（-O）NR 10 R 11，其中R 10和R 11独立地选自由H和烃基组成; （ix），（x），（xi），（xii）和（xiii）是其中当R 3为 - 烷基时，R 4为烃，当R 3为-NO 2 R 4存在时，和/或R 1存在作为并且当R 3为-C（-O）R 3 3 R 4时，存在R 1和R 2 >以氨基磺酸盐基团存在。

16. 发明申请

US20070196534A1 NON-CRYSTALLIZING SYRUPS CONTAINING SORBITOL AND THEIR USE IN CHEWING GUM 有权
标题翻译：含有SORBITOL的非结晶学习及其在CHEWING GUM中的应用
公开(公告)号：US20070196534A1
公开(公告)日：2007-08-23
申请号：US11673890
申请日：2007-02-12
申请人： David Barkalow , Miguel Soto , Michael Reed
发明人： David Barkalow , Miguel Soto , Michael Reed
IPC分类号： A23G4/18
CPC分类号： A23G4/10 , A23G4/062 , A23L27/34
摘要： An aqueous syrup for use in chewing gum, particularly pellet gum, comprises, on a dry basis, greater than about 98% polyols, of which i) about 50% to about 90% is sorbitol, ii) about 3% to about 30% is maltitol, iii) about 2% to about 20% are polyols, other than sorbitol and maltitol, with a degree of polymerization (DP) of 1 or 2, and iv) less than about 20% (and perhaps less than about 12%) are polyols with a DP of 3 or greater. The syrup is made with less than about 1.0% plasticizing agent, such as glycerin or propylene glycol. The syrup contains less than 5% water. The syrup can be made by evaporating a mixture of a sorbitol solution, a maltitol syrup and one or more polyols selected from the group consisting of mannitol, xylitol, lactitol, erythritol, hydrogenated isomaltulose, and combinations thereof. Methods of using the syrup to make chewing gum, and chewing gum products containing the syrup are also provided.
摘要翻译：用于口香糖，特别是颗粒胶的含水糖浆包含大于约98％的多元醇，其中i）约50％至约90％为山梨糖醇，ii）约3％至约30％是麦芽糖醇，iii）约2％至约20％是除了山梨糖醇和麦芽糖醇之外的多元醇，聚合度（DP）为1或2，以及iv）小于约20％（可能小于约12％）是DP为3或更大的多元醇。糖浆由少于约1.0％的增塑剂（如甘油或丙二醇）制成。糖浆含有少于5％的水。可以通过蒸发山梨醇溶液，麦芽糖醇糖浆和选自甘露醇，木糖醇，乳糖醇，赤藓糖醇，氢化异麦芽酮糖和其组合的一种或多种多元醇的混合物来制备糖浆。还提供了使用糖浆制备口香糖的方法和含有糖浆的口香糖产品。

17. 发明申请

US20070117855A1 Phenyl-sulfamates as aromatase inhibitors 失效
标题翻译：苯基磺酸盐作为芳香酶抑制剂
公开(公告)号：US20070117855A1
公开(公告)日：2007-05-24
申请号：US11633572
申请日：2006-12-04
申请人： Lok Lawrence Woo , Toby Jackson , Christian Bubert , Atul Purohit , Michael Reed , Barry Victory Potter
发明人： Lok Lawrence Woo , Toby Jackson , Christian Bubert , Atul Purohit , Michael Reed , Barry Victory Potter
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08
摘要： There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; R1 is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.
摘要翻译：提供式I的化合物，其中X，Y和Z各自独立地为任选的连接基团; R 1是环系; R 2选自烃基，羟基烃基，氰基（-CN），硝基（-NO 2 N 2）和卤素; R 3和R 4独立地选自H和烃基，环A和B独立地任选被进一步取代。

18. 发明申请

US20070105886A1 Steroidal compounds for inhibiting steroid sulphatase 失效
标题翻译：用于抑制类固醇硫酸酶的甾体化合物
公开(公告)号：US20070105886A1
公开(公告)日：2007-05-10
申请号：US11329982
申请日：2006-01-11
申请人： Barry Victor Potter , Michael Reed , Lok Wai Woo
发明人： Barry Victor Potter , Michael Reed , Lok Wai Woo
IPC分类号： C07D221/18 , A61K31/473
CPC分类号： C07J1/0051 , C07J63/00 , C07J63/008
摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.
摘要翻译：提供具有式（I）的化合物，其中G是H或取代基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺胺类，能够抑制类固醇硫酸酯酶。

19. 发明申请

US20070021624A1 Steroid sulphatase inhibitors 审中-公开
标题翻译：类固醇硫酸酶抑制剂
公开(公告)号：US20070021624A1
公开(公告)日：2007-01-25
申请号：US11406079
申请日：2006-04-18
申请人： Michael Reed , Barry Lloyd Potter
发明人： Michael Reed , Barry Lloyd Potter
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , A61K31/56
摘要： A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to which is attached a sulphamate group of the formula wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain; and wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2); and if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37° C. it would provide a Km value of less than 50 μM.
摘要翻译：描述了在需要相同的受试者中抑制类固醇硫酸酯酶活性的方法。所述方法包括向所述受试者施用抑制甾族硫酸酯酶的量的环系化合物; 该环系化合物包含连接下式的氨基磺酸酯基团的环，其中R 1和R 2各自独立地选自H，烷基，烯基，环烷基或芳基，或一起表示亚烷基链中任选含有一个或多个杂原子或基团的亚烷基; 并且其中所述化合物是具有类固醇硫酸酯酶活性的酶的抑制剂（E.C.3.1.6.2）; 并且如果所述化合物的氨基磺酸酯基团被硫酸根基团取代以形成硫酸盐化合物，并在pH 7.4和37℃下与类固醇硫酸酶（EC3.1.6.2）一起孵育，则其将提供K 值小于50μM。

20. 发明申请

US20060241173A1 Compound 审中-公开
标题翻译：复合
公开(公告)号：US20060241173A1
公开(公告)日：2006-10-26
申请号：US11400791
申请日：2006-04-07
申请人： Michael Reed , Barry Potter
发明人： Michael Reed , Barry Potter
IPC分类号： A61K31/353
CPC分类号： C07D249/08 , C07D311/30 , C07D311/36 , C07D413/12 , C07D417/12
摘要： The present invention relates to sulphamate compounds that are an inhibitor of both oestrone sulphatase activity and aromatase activity.
摘要翻译：本发明涉及作为雌二醇硫酸酯酶活性和芳香酶活性的抑制剂的氨基磺酸酯化合物。

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