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11. 发明授权

US5475032A 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals 失效
标题翻译： 2,4-二磺酰基苯基丁基硝酮，其盐，及其作为药物的用途
公开(公告)号：US5475032A
公开(公告)日：1995-12-12
申请号：US426961
申请日：1995-04-24
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A61K31/15 , A61K31/185 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P39/06 , A61P43/00 , C07C309/46
CPC分类号： C07C309/46 , A61K31/185
摘要： 2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.
摘要翻译：公开了2,4-二磺酰基α-苯基 - 叔丁基硝酮及其药学上可接受的盐。这些物质可用作口服或肠胃外的药物，例如静脉内给予患有急性中枢神经系统氧化的患者，发生在中风或逐渐中枢神经系统氧化，可能表现为进行性中枢神经系统功能损失。该材料也用于改善引起抗肿瘤疾病治疗的氧化损伤的副作用。

12. 发明授权

US5036097A Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration 失效
标题翻译：苯丁基硝酮组合物和预防胃溃疡的方法
公开(公告)号：US5036097A
公开(公告)日：1991-07-30
申请号：US491452
申请日：1990-03-09
申请人： Robert A. Floyd , John M. Carney
发明人： Robert A. Floyd , John M. Carney
IPC分类号： A61K31/16 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/22 , A61K31/265 , A61K31/40 , A61K31/44 , A61K31/54 , A61K31/60 , A61K45/06 , A61P1/04 , A61P43/00
CPC分类号： A61K31/135 , A61K31/15 , A61K31/40 , A61K31/44
摘要： Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compound(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. ItThe United States Government has certain rights in this invention by virtue of grants from the National Institutes of Health.
摘要翻译：公开了用于治疗或预防摄取非甾体抗炎药引起的胃溃疡的含有PBN或其活性衍生物的组合物在用于给予患者的合适的药物载体中。基于动物研究，剂量在3至300mg / kg的范围内，并且在摄取NSAID化合物之前，同时或不久之后施用。在优选的实施方案中，取决于保护粘膜所需的剂量单位，范围在10至30mg / kg之间。优选的给药方法是口服，单独使用或与非甾体抗炎剂组合。据信PBN还可用于治疗或预防溃疡，腹泻，胃炎，食管炎，回肠炎和止痛剂的方面。

13. 发明授权

US10549171B2 Eyes on golf training aid and method 有权
公开(公告)号：US10549171B2
公开(公告)日：2020-02-04
申请号：US16501816
申请日：2019-06-12
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A63B69/36
摘要： A device and method for aiding an improvement of a golfer's swing with the goal of teaching the golfer to keep the golfer's head down until a fraction of a second after making contact with the golf ball. The golfer loads a customizable app into a smartphone placed on the ground a short distance from the golf ball which app flashes a symbol or color on the touch screen of the smartphone a preset time after detecting the sound of the club impacting the ball. The eyes of the golfer are trained on the smartphone forcing the head to remain looking down until observing the flashing symbol or color upon which the head is then turned upward to observe the path of the struck golf ball.

14. 发明申请

US20190262688A1 Telescoping football holder 审中-公开
公开(公告)号：US20190262688A1
公开(公告)日：2019-08-29
申请号：US16501424
申请日：2019-04-12
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A63B69/00
摘要： A compact device for assisting place kicking a football is disclosed, including a module connecting telescoping legs and football tip telescoping holding arm, with the legs connecting the module for pivoting the legs from a ground engaging position to a transport position beneath and parallel to the arm.

15. 发明授权

US06403627B1 Spin trapping pharmaceutical compositions and methods for use thereof 失效
标题翻译：旋转捕获药物组合物及其使用方法
公开(公告)号：US06403627B1
公开(公告)日：2002-06-11
申请号：US09357297
申请日：1999-07-20
申请人： John M. Carney , Robert A. Floyd
发明人： John M. Carney , Robert A. Floyd
IPC分类号： A61K31415
CPC分类号： A61K31/135 , A61K31/15 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/445 , C07C291/02
摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide (DMPO), &agr;-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives thereof. Examples of derivatives of PBN include halogenated derivatives, bifunctional derivatives, conjugates with drugs or targeting molecules, dimers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.
摘要翻译：现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是外周器官疾病具有多种病因。在优选的实施方案中，用于治疗缺血组织损伤的组合物在用于静脉内，口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。其他优选的自旋捕获剂包括5,5-二甲基吡咯啉N-氧化物（DMPO），α-（4-吡啶基-1-氧化物）-N-叔丁基硝酮（POBN）和（TEMPO）和自旋捕获衍生物其中。 PBN衍生物的实例包括卤代衍生物，双官能衍生物，与药物或靶向分子的缀合物，二聚体和PBN的环糊精聚合物。可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程作为老化。

16. 发明授权

US06342523B1 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation 失效
标题翻译： 3,4,5-三取代芳基硝酮化合物，含有该化合物的药物组合物和治疗炎症的方法
公开(公告)号：US06342523B1
公开(公告)日：2002-01-29
申请号：US09452529
申请日：1999-12-01
申请人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
发明人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
IPC分类号： A61K3124
CPC分类号： C07C291/02
摘要： Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
摘要翻译：公开了3,4,5-三取代的芳基硝酮化合物和含有这些化合物的药物组合物。 3,4,5-三取代的芳基硝酮化合物具有下式：其中R 1 -R 4如说明书中所定义。所公开的组合物可用作哺乳动物例如关节炎中的炎症相关病症的治疗剂，以及用作检测自由基的分析试剂。

17. 发明授权

US5780510A 2,4-disulfo phenyl butyl nitrone, its salts and their use as pharmaceuticals 失效
标题翻译： 2,4-二磺基苯基丁基硝酮，其盐及其作为药物的用途
公开(公告)号：US5780510A
公开(公告)日：1998-07-14
申请号：US663316
申请日：1997-06-19
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A61K31/15 , A61K31/185 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P39/06 , A61P43/00 , C07C309/46
CPC分类号： C07C309/46 , A61K31/185
摘要： 2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.
摘要翻译： PCT No.PCT / US94 / 14545 Sec。 371日期：1997年6月19日 102（e）日期1996年6月19日PCT 1994年12月22日PCT PCT。第WO95 / 17876号公报日期：19952年7月6日公开了2,4-二磺酰基α-苯基 - 叔丁基硝酮及其药学上可接受的盐。这些物质可用作口服或肠胃外的药物，例如静脉内给予患有急性中枢神经系统氧化的患者，发生在中风或逐渐中枢神经系统氧化，可能表现为进行性中枢神经系统功能损失。该材料也用于改善引起抗肿瘤疾病治疗的氧化损伤的副作用。

18. 发明授权

US5681965A Spin trapping compounds 失效
标题翻译：旋转捕获化合物
公开(公告)号：US5681965A
公开(公告)日：1997-10-28
申请号：US468561
申请日：1995-06-06
申请人： John M. Carney , Robert A. Floyd
发明人： John M. Carney , Robert A. Floyd
IPC分类号： A61K31/13 , A61K31/00 , A61K31/135 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/167 , A61K31/215 , A61K31/22 , A61K31/222 , A61K31/265 , A61K31/325 , A61K31/40 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P25/30 , A61P29/00 , A61P31/12 , A61P39/06 , A61P43/00 , C07C251/32 , C07C291/02 , C07D207/46 , C07D213/89 , C07C69/00 , C07C233/00 , C07C249/00 , C07D211/70 , C07D211/72
CPC分类号： A61K31/44 , A61K31/135 , A61K31/15 , A61K31/40
摘要： Compositions containing as the active ingredient a spin-trapping reagent, preferably .alpha.-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or .alpha.-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, cardiovascular system, and lymphatic system. Studies in animals demonstrate that administration of compound for a two week period reduces the level of oxidized brain enzymes to normal and restores memory to the same level as tested in young control animals.
摘要翻译：公开了用于治疗或预防与老化或其他症状相关的症状的组合物，其包含作为活性成分的自旋捕获试剂，优选α-苯基丁基硝酮（PBN）或其自旋捕获衍生物在合适的药物载体中用于给予患者与氧化组织损伤相关的病症。还可以使用其它的自旋捕获剂，例如5,5-二甲基吡咯啉N-氧化物（DMPO）或α-（4-吡啶基1-氧化物）-N-叔丁基硝酮（POBN）和其它自旋捕获衍生物。这些组合物和方法可用于治疗年龄相关疾病，手术前和/或麻醉前制剂或化疗剂的施用，以及治疗脑，心血管系统和淋巴系统的病症或创伤。动物研究表明，给予化合物两周时间将氧化的脑酶水平降低至正常水平，并将记忆恢复至与年轻对照动物试验相同的水平。

19. 发明授权

US5622994A Spin trapping pharmaceutical compositions and methods for use thereof 失效
标题翻译：旋转捕获药物组合物及其使用方法
公开(公告)号：US5622994A
公开(公告)日：1997-04-22
申请号：US212800
申请日：1994-03-15
申请人： John M. Carney , Robert A. Floyd
发明人： John M. Carney , Robert A. Floyd
IPC分类号： A61K31/15 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/255
CPC分类号： A61K31/44 , A61K31/15 , A61K31/167 , A61K31/40
摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.
摘要翻译：现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是外周器官疾病具有多种病因。在优选的实施方案中，用于治疗缺血组织损伤的组合物在用于静脉内，口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程作为老化。

20. 再颁专利

USRE35213E Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration 失效
标题翻译：苯丁基硝酮组合物和预防胃溃疡的方法
公开(公告)号：USRE35213E
公开(公告)日：1996-04-16
申请号：US97998
申请日：1993-07-29
申请人： Robert A. Floyd , John M. Carney
发明人： Robert A. Floyd , John M. Carney
IPC分类号： A61K31/135 , A61K31/15 , A61K31/40 , A61K31/44 , A61K31/415
CPC分类号： A61K31/44 , A61K31/135 , A61K31/15 , A61K31/40
摘要： Compositions containing PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient, are disclosed for treating or preventing gastric ulceration caused by ingestion of non-steroidal anti-inflammatories. Based on animal studies, the dosage is in the range of 3 to 300 mg/kg and is administered prior to, simultaneously, or shortly after ingestion of the NSAID compounds(s). In the preferred embodiment, the range is between 10 and 30 mg/kg, depending on the dosage unit required to protect the mucosa. The preferred method of administration is orally, alone or in combination with the non-steroidal anti-inflammatory. It is believed that the PBN is also useful alone for treatment or prevention of ulcers, aspects of diarrhea, gastritis, esophagitis, ileitis, and as an analgesic.
摘要翻译：公开了用于治疗或预防摄取非甾体抗炎药引起的胃溃疡的含有PBN或其活性衍生物的组合物在用于给予患者的合适的药物载体中。基于动物研究，剂量在3至300mg / kg的范围内，并且在摄入NSAID化合物之前，同时或不久之后施用。在优选的实施方案中，取决于保护粘膜所需的剂量单位，范围在10至30mg / kg之间。优选的给药方法是口服，单独使用或与非甾体抗炎剂组合。据信PBN还可用于治疗或预防溃疡，腹泻，胃炎，食管炎，回肠炎和止痛剂的方面。

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