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1. 发明授权

US10532262B2 Telescoping football holder 有权
公开(公告)号：US10532262B2
公开(公告)日：2020-01-14
申请号：US16501424
申请日：2019-04-12
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A63B71/00 , A63B69/00
摘要： A compact device for assisting place kicking a football is disclosed, including a module connecting telescoping legs and football tip telescoping holding arm, with the legs connecting the module for pivoting the legs from a ground engaging position to a transport position beneath and parallel to the arm.

2. 发明申请

US20180111031A1 Telescoping Football Holder 审中-公开
公开(公告)号：US20180111031A1
公开(公告)日：2018-04-26
申请号：US15732219
申请日：2017-10-06
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A63B69/00
CPC分类号： A63B69/0075 , A63B2210/50 , A63B2243/007
摘要： A compact device for assisting place kicking a football is disclosed, including a module connecting telescoping legs and football tip telescoping holding arm, with the legs connecting the module for pivoting the legs from a ground engaging position to a transport position beneath and parallel to the arm.

3. 发明授权

US07244220B2 Exercise log 失效
标题翻译：锻炼日志
公开(公告)号：US07244220B2
公开(公告)日：2007-07-17
申请号：US10999035
申请日：2004-11-29
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A63B21/075
CPC分类号： A63B21/0724 , A63B21/072 , A63B21/0728
摘要： An exercise device providing an exterior sheath for a standard Olympic weight bearing bar that secures the bar and weight while providing access to the bar for gripping and also providing secure handles which are perpendicular to the bar and parallel to the torso, providing alternate gripping posture for alternate exercise paradigms.
摘要翻译：提供用于标准奥林匹克承重杆的外护套的运动装置，其确保杆和重量，同时提供进入用于抓握的杆的接合，并且还提供垂直于杆并平行于躯干的安全手柄，为替代锻炼范例

4. 发明授权

US6002001A Spin trapping pharmaceutical compositions and methods for use thereof 失效
标题翻译：旋转捕获药物组合物及其使用方法
公开(公告)号：US6002001A
公开(公告)日：1999-12-14
申请号：US969344
申请日：1997-11-28
申请人： John M. Carney , Robert A. Floyd
发明人： John M. Carney , Robert A. Floyd
IPC分类号： A61K31/135 , A61K31/15 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/445 , C07C291/02 , C07D279/10
CPC分类号： A61K31/135 , A61K31/15 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/445 , C07C291/02
摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide, (DMPO), .alpha.-(4-pyridyl-1-oxide)-N-tert-butylnitrone, (POBN), and (TEMPO) spin-trapping derivatives thereof. Examples of derivatives of PBN include halogenated derivatives, bifunctional derivatives, conjugates with drugs or targeting molecules, dimers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.
摘要翻译：现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是外周器官疾病具有多种病因。在优选的实施方案中，用于治疗缺血组织损伤的组合物在用于静脉内，口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。其他优选的自旋捕获剂包括5,5-二甲基吡咯啉N-氧化物（DMPO），α-（4-吡啶基-1-氧化物）-N-叔丁基硝酮，（POBN）和（TEMPO）自旋捕获衍生物。 PBN衍生物的实例包括卤代衍生物，双官能衍生物，与药物或靶向分子的缀合物，二聚体和PBN的环糊精聚合物。可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程作为老化。

5. 发明授权

US06998419B2 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same 失效
标题翻译： 3,4,5-三取代的芳基硝酮化合物和含有它们的药物组合物
公开(公告)号：US06998419B2
公开(公告)日：2006-02-14
申请号：US10754624
申请日：2004-01-12
申请人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
发明人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
IPC分类号： A01N47/10
CPC分类号： C07C291/02
摘要： Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1–R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
摘要翻译：公开了3,4,5-三取代的芳基硝酮化合物d和含有这些化合物的药物组合物。 3,4,5-三取代的芳基硝酮化合物具有式（I）; 其中R 1〜R 4如说明书中所定义。所公开的组合物可用作哺乳动物例如关节炎中的炎症相关病症的治疗剂，以及用作检测自由基的分析试剂。

6. 发明授权

US06730700B2 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same 失效
标题翻译： 3,4,5-三取代芳基硝酮化合物和含有它们的药物组合物
公开(公告)号：US06730700B2
公开(公告)日：2004-05-04
申请号：US10196800
申请日：2002-07-15
申请人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
发明人： L. David Waterbury , Allan L. Wilcox , John M. Carney , Farah Mavandadi , Albert Danielzadeh
IPC分类号： A01N4710
CPC分类号： C07C291/02
摘要： Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
摘要翻译：公开了3,4,5-三取代的芳基硝酮化合物和含有这些化合物的药物组合物。 3,4,5-三取代的芳基硝酮化合物具有式（I）; 其中R 1 -R 4如说明书中所定义。所公开的组合物可用作哺乳动物例如关节炎中的炎症相关病症的治疗剂，以及用作检测自由基的分析试剂。

7. 发明授权

US5840838A Process for enhancing the activity of amyloid .beta. peptides 失效
标题翻译：增强β淀粉样蛋白活性的方法
公开(公告)号：US5840838A
公开(公告)日：1998-11-24
申请号：US609090
申请日：1996-02-29
申请人： Kenneth Hensley , D. Allan Butterfield , John M. Carney , Michael Aksenov
发明人： Kenneth Hensley , D. Allan Butterfield , John M. Carney , Michael Aksenov
IPC分类号： C07K14/47 , C07K7/00 , C07K14/00
CPC分类号： C07K14/4711
摘要： A novel process for enhancing activity of an oligopeptide or polypeptide comprising the steps of: providing an oligopeptide or polypeptide, dissolving the oligopeptide or polypeptide in an organic solvent, heating, removing the solvent, and recovering an oligopeptide or polypeptide with enhanced activity is disclosed. Also disclosed are novel oligopeptides and polypeptides enhanced by the process according the invention.
摘要翻译：一种用于增强寡肽或多肽的活性的新方法，包括以下步骤：提供寡肽或多肽，将寡肽或多肽溶解在有机溶剂中，加热，除去溶剂，以及回收具有增强活性的寡肽或多肽。还公开了通过本发明的方法增强的新型寡肽和多肽。

8. 发明授权

US5578617A Method and compositions for treating age related disorders 失效
标题翻译：治疗年龄相关疾病的方法和组合物
公开(公告)号：US5578617A
公开(公告)日：1996-11-26
申请号：US365548
申请日：1994-12-28
申请人： John M. Carney , Robert A. Floyd
发明人： John M. Carney , Robert A. Floyd
IPC分类号： A61K31/13 , A61K31/00 , A61K31/135 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/167 , A61K31/215 , A61K31/22 , A61K31/222 , A61K31/265 , A61K31/325 , A61K31/40 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4425 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P25/30 , A61P29/00 , A61P31/12 , A61P39/06 , A61P43/00 , C07C251/32 , C07C291/02 , C07D207/46 , C07D213/89
CPC分类号： A61K31/44 , A61K31/135 , A61K31/15 , A61K31/40
摘要： Compositions containing as the active ingredient a spin-trapping reagent, preferably .alpha.-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or .alpha.-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, cardiovascular system, and lymphatic system. Studies in animals demonstrate that administration of compound for a two week period reduces the level of oxidized brain enzymes to normal and restores memory to the same level as tested in young control animals.
摘要翻译：公开了用于治疗或预防与老化或其他症状相关的症状的组合物，其包含作为活性成分的自旋捕获试剂，优选α-苯基丁基硝酮（PBN）或其自旋捕获衍生物在合适的药物载体中用于给予患者与氧化组织损伤相关的病症。还可以使用其它的自旋捕获剂，例如5,5-二甲基吡咯啉N-氧化物（DMPO）或α-（4-吡啶基1-氧化物）-N-叔丁基硝酮（POBN）和其它自旋捕获衍生物。这些组合物和方法可用于治疗年龄相关疾病，手术前和/或麻醉前制剂或化疗剂的施用，以及治疗脑，心血管系统和淋巴系统的病症或创伤。动物研究表明，给予化合物两周时间将氧化的脑酶水平降低至正常水平，并将记忆恢复至与年轻对照动物试验相同的水平。

9. 发明授权

US5488145A 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps 失效
标题翻译： 2,4-二磺酰基苯基丁基硝酮，其盐，以及它们作为药物自由基捕获剂的用途
公开(公告)号：US5488145A
公开(公告)日：1996-01-30
申请号：US173579
申请日：1993-12-23
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A61K31/15 , A61K31/185 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P39/06 , A61P43/00 , C07C309/46
CPC分类号： C07C309/46 , A61K31/185
摘要： 2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss.
摘要翻译：公开了2,4-二磺酰基α-苯基 - 叔丁基硝酮及其药学上可接受的盐。这些材料可用作用于口服或静脉内施用于患有急性中枢神经系统氧化的患者的药剂，如中风发作或逐渐中枢神经系统氧化，其可表现为进展性中枢神经系统功能损失。

10. 发明授权

US5508305A 2, 4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals 失效
标题翻译： 2,4-二磺酰基苯基丁基硝酮及其盐，以及它们作为药物的用途
公开(公告)号：US5508305A
公开(公告)日：1996-04-16
申请号：US468564
申请日：1995-06-06
申请人： John M. Carney
发明人： John M. Carney
IPC分类号： A61K31/15 , A61K31/185 , A61P9/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P39/06 , A61P43/00 , C07C309/46 , A61K31/255
CPC分类号： C07C309/46 , A61K31/185
摘要： 2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.
摘要翻译：公开了2,4-二磺酰基α-苯基 - 叔丁基硝酮及其药学上可接受的盐。这些物质可用作口服或肠胃外的药物，例如静脉内给予患有急性中枢神经系统氧化的患者，发生在中风或逐渐中枢神经系统氧化，可能表现为进行性中枢神经系统功能损失。该材料也用于改善引起抗肿瘤疾病治疗的氧化损伤的副作用。

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