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11. 发明授权

US5469435A Bus deadlock avoidance during master split-transactions 失效
标题翻译：主分拆交易期间总线避免避免
公开(公告)号：US5469435A
公开(公告)日：1995-11-21
申请号：US187396
申请日：1994-01-25
申请人： William T. Krein , Ronald R. Hochsprung , James D. Kelly
发明人： William T. Krein , Ronald R. Hochsprung , James D. Kelly
IPC分类号： G06F13/364 , G06F13/00
CPC分类号： G06F13/364
摘要： Signal transactions are conducted between nodes coupled to a bus, without causing bus deadlock during split transactions. Deadlock avoidance is achieved by rendering a node effectively unavailable at such times to serve as a bus slave for a new bus master. When the "locking" node serves as a transaction source, deadlock is avoided by deasserting, during a split transaction, a buffer-available signal, which is used normally to indicate receiver buffer availability. Additionally, when the "locking" node serves as a transaction destination, deadlock is avoided by deasserting a bus-ownership request signal, which is used normally for requesting bus ownership. After completion of the split transactions, such signals may be unmasked.
摘要翻译：信号事务在耦合到总线的节点之间进行，而不会在分离事务期间导致总线死锁。通过使节点在这样的时间有效地不可用来作为新总线主机的总线从设备来实现死锁避免。当“锁定”节点用作事务源时，通过在分离事务期间解除缓冲器可用信号来解除死锁，通常用于指示接收器缓冲区可用性。另外，当“锁定”节点用作事务目的地时，通过解除总线所有权请求信号（通常用于请求总线所有权）来避免死锁。拆分事务完成后，这些信号可能被屏蔽。

12. 发明授权

US4427647A Method and reagent for making a radiopharmaceutical composition based on pertechnetate 失效
标题翻译：制备基于高锝酸盐的放射性药物组合物的方法和试剂
公开(公告)号：US4427647A
公开(公告)日：1984-01-24
申请号：US286752
申请日：1981-07-27
申请人： Anthony Brockas , Roy Abrahams , James D. Kelly
发明人： Anthony Brockas , Roy Abrahams , James D. Kelly
IPC分类号： A61K51/04 , A61K43/00 , A61K49/00
CPC分类号： A61K51/0478 , A61K2123/00
摘要： A method of making a radiopharmaceutical composition by mixing an aqueous solution of pertechnetate with a reducing agent comprising tin metal or stannous ion to reduce the pertechnetate and a complexing agent to form a complex with the reduced technetium, is characterized by incorporating nitrate and/or nitrite in an amount to diminish oxidation of Sn.sup.2+ to Sn.sup.4+, and hence to prevent re-oxidation of technetium to pertechnetate, during preparation and storage of the complex. Nitrate and nitrite are superior to organic antioxidants previously proposed.A reagent for the purpose comprises the reducing agent, the complexing agent and the nitrate and/or nitrite usually in a sterile freeze-dried state.
摘要翻译：通过将高锝酸盐水溶液与包含锡金属或亚锡离子的还原剂混合以制备放射性药物组合物以减少高锝酸盐和络合剂与还原锝形成络合物的方法，其特征在于将硝酸盐和/或亚硝酸盐以减少Sn2 +的氧化为Sn4 +的量，从而防止在络合物的制备和储存过程中锝到高锝酸盐的再氧化。硝酸盐和亚硝酸盐优于以前提出的有机抗氧化剂。用于该目的的试剂包括通常处于无菌冷冻干燥状态的还原剂，络合剂和硝酸盐和/或亚硝酸盐。

13. 再颁专利

USRE44688E1 Bus transaction reordering in a computer system having unordered slaves 有权
标题翻译：在具有无序奴隶的计算机系统中的总线事务重新排序
公开(公告)号：USRE44688E1
公开(公告)日：2013-12-31
申请号：US10669119
申请日：2003-09-22
申请人： James D. Kelly , Michael L. Regal
发明人： James D. Kelly , Michael L. Regal
IPC分类号： G06F9/46 , G06F13/36 , G11C7/00
CPC分类号： G06F13/362 , G06F13/16 , G06F13/1626 , G06F13/364 , G06F13/368 , G06F13/4013
摘要： A mechanism is provided for reordering Reordering bus transactions to increase increases bus utilization in a computer system in which where a split-transaction bus is bridged to a single-envelope bus. In one embodiment, both masters and slaves are ordered, simplifying implementation. In; in another embodiment, the system is more loosely coupled with only masters being are ordered. Greater bus utilization is thereby achieved. To avoid deadlock, transactions begun on the split-transaction bus are monitored. When a combination of transactions would, result in deadlock if a predetermined further transaction were to begin, result in deadlock, this condition is detected. In the more tightly coupled system, the predetermined further transaction, if it is refused if requested, is refused, thereby avoiding deadlock. In the more loosely-coupled system, the flexibility afforded by unordered slaves is taken advantage of to, in the typical case, reorder the transactions and avoid deadlock without killing any transaction. Where a data dependency exists that would prevent such reordering, the further transactions transaction is killed as in the more tightly-coupled embodiment. Data dependencies are detected in accordance with address-coincidence signals generated by slave devices on a cache-line basis. In accordance with a further optimization, at least one slave device (e.g., DRAM) generates page-coincidence bits. When two transactions to the slave device are to the same address page, the transactions are reordered if necessary to ensure that they are executed one after another without any intervening transaction. Latency of the slave is thereby reduced.
摘要翻译：提供了一种机制来重新排序重新排序总线事务以增加在分组事务总线桥接到单信封总线的计算机系统中增加总线利用率。在一个实施例中，主机和从机都被排序，从而简化了实现。在; 在另一个实施例中，系统更松散地耦合，只有主人被命令。从而实现更大的总线利用率。为了避免死锁，在分割事务总线上开始的事务被监视。当交易的组合会导致死锁，如果预定的进一步交易开始，则导致死锁，则检测到该条件。在更紧密耦合的系统中，预定的进一步交易（如果被请求被拒绝）被拒绝，从而避免死锁。在更松散耦合的系统中，无序奴隶所提供的灵活性被利用于在典型情况下重新排序事务，并避免死锁而不杀死任何事务。在存在将阻止这种重新排序的数据依赖性的情况下，如更紧密耦合的实施例那样，进一步的事务处理被杀死。根据从设备在高速缓存行基础上产生的地址一致信号来检测数据依赖性。根据进一步的优化，至少一个从设备（例如，DRAM）产生寻呼重合位。当到从设备的两个事务处于相同的地址页面时，如果需要，则事务被重新排序以确保它们被一个接一个执行，而没有任何中间事务。从而减少从机的延迟。

14. 发明授权

US07387780B2 Soluble interleukin-20 receptor 有权
标题翻译：可溶性白介素20受体
公开(公告)号：US07387780B2
公开(公告)日：2008-06-17
申请号：US11458360
申请日：2006-07-18
申请人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
发明人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
IPC分类号： C07K14/705 , C12P21/02
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译：具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。两个亚基优选连接在一起。在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。轻链和重链通过二硫键连接。

15. 再颁专利

USRE38428E1 Bus transaction reordering in a computer system having unordered slaves 有权
标题翻译：在具有无序奴隶的计算机系统中的总线事务重新排序
公开(公告)号：USRE38428E1
公开(公告)日：2004-02-10
申请号：US10006939
申请日：2001-11-30
申请人： James D. Kelly , Michael L. Regal
发明人： James D. Kelly , Michael L. Regal
IPC分类号： G06F946
CPC分类号： G06F13/362 , G06F13/16 , G06F13/1626 , G06F13/364 , G06F13/368 , G06F13/4013
摘要： A mechanism is provided for reordering bus transactions to increase bus utilization in a computer system in which a split-transaction bus is bridged to a single-envelope bus. In one embodiment, both masters and slaves are ordered, simplifying implementation. In another embodiment, the system is more loosely coupled with only masters being ordered. Greater bus utilization is thereby achieved. To avoid deadlock, transactions begun on the split-transaction bus are monitored. When a combination of transactions would, if a predetermined further transaction were to begin, result in deadlock, this condition is detected. In the more tightly coupled system, the predetermined further transaction, if it is requested, is refused, thereby avoiding deadlock. In the more loosely-coupled system, the flexibility afforded by unordered slaves is taken advantage of to, in the typical case, reorder the transactions and avoid deadlock without killing any transaction. Where a data dependency exists that would prevent such reordering, the further transactions is killed as in the more tightly-coupled embodiment. Data dependencies are detected in accordance with address-coincidence signals generated by slave devices on a cache-line basis. In accordance with a further optimization, at least one slave device (e.g., DRAM) generates page-coincidence bits. When two transactions to the slave device are to the same address page, the transactions are reordered if necessary to ensure that they are executed one after another without any intervening transaction. Latency of the slave is thereby reduced.

16. 发明授权

US06646183B2 DNA encoding for a disease resistance gene from common bean and methods of use 失效
公开(公告)号：US06646183B2
公开(公告)日：2003-11-11
申请号：US09838955
申请日：2001-04-20
申请人： James D. Kelly , Maeli Melotto
发明人： James D. Kelly , Maeli Melotto
IPC分类号： C12N1509
CPC分类号： C07K14/415 , C12N15/8282
摘要： The present invention provides novel purified and isolated nucleic acid sequences associated with disease resistance and tolerance in plants. Methods of using the nucleic acid sequences to confer disease resistance and tolerance to plants are also provided.

17. 发明授权

US06610286B2 Method for treating inflammation using soluble receptors to interleukin-20 失效
标题翻译：用可溶性受体将白细胞介素20治疗炎症的方法
公开(公告)号：US06610286B2
公开(公告)日：2003-08-26
申请号：US09746359
申请日：2000-12-22
申请人： Penny Thompson , Donald C. Foster , Wenfeng Xu , James D. Kelly , Hal Blumberg , Yasmin A. Chandrasekher
发明人： Penny Thompson , Donald C. Foster , Wenfeng Xu , James D. Kelly , Hal Blumberg , Yasmin A. Chandrasekher
IPC分类号： A61K4500
CPC分类号： C07K16/244 , A61K31/07 , A61K31/20 , A61K31/203 , A61K31/366 , A61K31/519 , A61K31/525 , A61K31/573 , A61K31/59 , A61K38/13 , A61K39/395 , A61K39/3955 , A61K45/06 , C07K14/7155 , C07K16/2887 , C07K2319/00 , C07K2319/30 , Y10S514/886 , A61K2300/00
摘要： A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
摘要翻译：一种治疗IL-20诱导炎症的方法。施用IL-20拮抗剂以治疗炎症和相关疾病。拮抗剂可以是结合IL-20或其受体或与IL-20结合的可溶性受体的抗体。这些疾病的例子包括成人呼吸系统疾病，牛皮癣，湿疹，接触性皮炎，特应性皮炎，脓毒性休克，多器官衰竭，炎性肺损伤，细菌性肺炎，炎性肠病，类风湿性关节炎，哮喘，溃疡性结肠炎和克罗恩病。

18. 发明授权

US6004929A Biologically active PDGF A-chain homodimers 失效
标题翻译：生物活性PDGF A链同源二聚体
公开(公告)号：US6004929A
公开(公告)日：1999-12-21
申请号：US412551
申请日：1995-03-29
申请人： Mark J. Murray , James D. Kelly
发明人： Mark J. Murray , James D. Kelly
IPC分类号： A61K38/00 , C07K14/15 , C07K14/49 , C12N15/81 , A61K38/18
CPC分类号： C07K14/005 , C07K14/49 , C12N15/81 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N2740/11022
摘要： Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the protein may have two substantially identical polypeptide chains, each of the chains being substantially homologous to the A-chain of PDGF. Alternatively, the protein may have two polypeptide chains that are substantially identical to the A-chain of PDGF. In addition, proteins comprising polypeptides that are variants or derivatives of the A-chain of PDGF are also disclosed. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.
摘要翻译：公开了具有与PDGF基本相同的生物活性的二聚体蛋白质。更具体地，蛋白质可以具有两个基本相同的多肽链，每条链与PDGF的A链基本上同源。或者，蛋白质可以具有与PDGF的A链基本相同的两条多肽链。此外，还公开了包含作为PDGF的A链的变体或衍生物的多肽的蛋白质。还公开了含有这些蛋白质的治疗组合物和用于增强温血动物中伤口愈合过程的方法。

19. 发明授权

US5951669A Method and apparatus for serialized interrupt transmission 失效
标题翻译：串行中断传输的方法和装置
公开(公告)号：US5951669A
公开(公告)日：1999-09-14
申请号：US773686
申请日：1996-12-27
申请人： Robert L. Bailey , Lesley A. Bird , James D. Kelly
发明人： Robert L. Bailey , Lesley A. Bird , James D. Kelly
IPC分类号： G06F13/24 , G06F9/46
CPC分类号： G06F13/24
摘要： A computer system in which interrupt signals are serially transmitted from an input/output (I/O) controller is disclosed. The I/O controller initially receives the interrupt signals and then serially transmits them to an interrupt controller where the received interrupt signals are managed. According to the invention, the sequencing by which the interrupt signals are serially transmitted is controlled such that it largely conforms to the sequencing by which the received interrupt signals are processed at the interrupt controller, thereby controlling and reducing latency. The interrupt controller can be a separate integrated circuit chip or integral to another integrated circuit chip of the computer system.
摘要翻译：公开了一种从输入/输出（I / O）控制器串行发送中断信号的计算机系统。 I / O控制器最初接收中断信号，然后将它们串行发送到中断控制器，在该中断控制器处理接收到的中断信号。根据本发明，控制中断信号串行发送的顺序，使其大体上符合中断控制器处理接收到的中断信号的顺序，从而控制和减少等待时间。中断控制器可以是单独的集成电路芯片或与计算机系统的另一个集成电路芯片集成。

20. 发明授权

US5933612A Deadlock avoidance in a split-bus computer system 失效
标题翻译：分流总线计算机系统中的死锁避免
公开(公告)号：US5933612A
公开(公告)日：1999-08-03
申请号：US903412
申请日：1997-07-30
申请人： James D. Kelly , Michael L. Regal
发明人： James D. Kelly , Michael L. Regal
IPC分类号： G06F13/16 , G06F13/00
CPC分类号： G06F13/1626
摘要： A mechanism is provided for avoiding deadlock in a computer system in which a split-transaction bus is bridged to a single-envelope bus. In one embodiment, transactions begun on said split-transaction bus are monitored. When a combination of transactions would, if a predetermined further transaction were to begin, result in deadlock, this condition is detected. The predetermined further transaction, if it is requested, is refused, thereby avoiding deadlock. In accordance with another embodiment of the invention, the bus bridge detects when a state of the split-transaction bus would, if a protocol of said split-transaction bus were adhered to, result in deadlock. The bus bridge then drives one or more signals on the split-transaction bus in disregard of the protocol of the split-transaction bus, thereby avoiding deadlock. In accordance with still a further embodiment of the invention, transactions accepted within the bus bridge are monitored. When a combination of said transactions would, if a predetermined further transaction were to begin, result in deadlock, this condition is detected. The predetermined further transaction, if it is requested, is refused, thereby avoiding deadlock.
摘要翻译：提供了一种用于避免分组事务总线桥接到单信封总线的计算机系统中的死锁的机制。在一个实施例中，监视在所述分组交易总线上开始的事务。当交易的组合将如果预定的进一步交易开始时会导致死锁，则检测到该状况。如果被请求，预定的另外的事务被拒绝，从而避免死锁。根据本发明的另一个实施例，如果所述分组交易总线的协议被遵守，则总线桥检测分组交易总线的状态何时会导致死锁。然后，总线桥驱动分拆事务总线上的一个或多个信号，而不考虑拆分事务总线的协议，从而避免死锁。根据本发明的又一实施例，监视在总线桥内接受的事务。当所述交易的组合将如果预定的另外的交易开始时会导致死锁，则检测到该条件。如果被请求，预定的另外的事务被拒绝，从而避免死锁。

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