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11. 发明公开

US20230281808A1 SYSTEM FOR DETERMING MECHANICAL TISSUE CHARACTERISTICS FROM IMAGING DATA 审中-公开
公开(公告)号：US20230281808A1
公开(公告)日：2023-09-07
申请号：US18116997
申请日：2023-03-03
申请人： Helmholtz-Zentrum hereon GmbH , Technische Universität Hamburg (TUHH) , Heinrich Heine Universität Düsseldorf
发明人： Christian Cyron , Kevin Linka , Sven Nebelung
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T2207/30004 , G06T2207/20081
摘要： A system and methods for determining a mechanical tissue characteristic (Ψ) are provided. The system comprises a providing unit for providing a set of images of a tissue region of interest, wherein the provided set of images comprises image features indicative of one or more structural properties (α, a0, CO, PG) of the tissue region of interest and has been acquired using an imaging modality suitable for in-vivo imaging of the tissue region of interest. The system further comprises a determining unit for determining, based on the provided set of images, a mechanical tissue characteristic (Ψ) indicative of a mechanical responsiveness of the tissue region of interest. The determining unit comprises a machine learning architecture adapted to receive the provided set of images as an input and to provide the mechanical tissue characteristic as an output.

12. 发明申请

US20210163574A1 SYNTHETIC SIGNALING CONSTRUCTS AND ITS USE 有权
公开(公告)号：US20210163574A1
公开(公告)日：2021-06-03
申请号：US17045363
申请日：2019-04-08
申请人： HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF
发明人： Artur SCHNEIDER , Jürgen SCHELLER , Philipp LANG , Doreen FLOSS , Erika ENGELOWSKI , Haifeng XU , Manuel FRANKE
IPC分类号： C07K14/715 , C07K16/18
摘要： In a first aspect, the present invention relates to new recombinant artificial polypeptides allowing cytoplasmic signaling in cells containing the same. In particular, the present invention relates to a system for transmitting signals containing a recombinant polypeptide containing a domain with a first binding partner selected from an artificial ligand and a receptor binding an artificial ligand, a transmembrane domain and a cytoplasmic signaling domain whereby the domain with the binding partner and the cytoplasmic signaling domain are a combination of domains not naturally occurring in an organism and the second binding partner for specific forming of the binding pair. In a further aspect, a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide according to the present invention as well as a vector, cell, cell line or host cell containing said vector are provided. In addition, the present invention relates to the use of the recombinant polypeptide according to the present invention in treating cancer or autoimmune disease or allowing immune modulation of a subject as well as for use to change the status of cells when applying the specific second binding partner of the first binding partner present in the recombinant polypeptide according to the present invention.

13. 发明申请

US20160138066A1 METHODS FOR THE EXPRESSION OF PEPTIDES AND PROTEINS 审中-公开
标题翻译：表达肽和蛋白质的方法
公开(公告)号：US20160138066A1
公开(公告)日：2016-05-19
申请号：US14785216
申请日：2014-04-17
申请人： HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF
发明人： Lutz Schmitt , Christian Schwarz , Sander Hendrikus Joannes Smits
IPC分类号： C12P21/02 , C07K14/195 , C07K14/00 , C07K14/575 , C07K14/47 , C07K14/56 , C12N9/88 , C12N9/10
CPC分类号： C12P21/02 , C07K14/00 , C07K14/195 , C07K14/245 , C07K14/47 , C07K14/4711 , C07K14/4713 , C07K14/475 , C07K14/56 , C07K14/57509 , C07K2319/00 , C07K2319/036 , C07K2319/35 , C12N9/13 , C12N9/88 , C12Y208/01008 , C12Y406/01001
摘要： The present invention lies in the field of molecular biology, recombinant peptide and protein expression and relates to methods comprising nucleic acid sequences comprising allocrites of T1SSs or fragments thereof for the efficient production of recombinant Pe OIs and Pr OI. The allocrites or fragments thereof improve the expression of PeOI and Pr OI as IB and function as IB-tags.
摘要翻译：本发明在于分子生物学，重组肽和蛋白质表达领域，涉及含有包含T1SS或其片段分配的核酸序列以有效生产重组PeOI和PrOI的方法。其分配或片段改善了作为IB的PeOI和Pr OI的表达，并且作为IB标签起作用。

14. 发明申请

US20150366206A1 SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES 审中-公开
标题翻译： C4-PEP羧酸的选择性抑制
公开(公告)号：US20150366206A1
公开(公告)日：2015-12-24
申请号：US14761088
申请日：2014-01-16
申请人： HEINRICH HEINE UNIVERSITÄT DÜSSELDORF
发明人： Georg GROTH , Judith PAULUS , Daniel SCHLIEPER , Peter WESTHOFF
IPC分类号： A01N43/90 , A01N43/26 , A01N35/04 , A01N43/32 , A01N43/30 , A01N37/40 , A01N43/60 , A01N43/16
CPC分类号： A01N43/90 , A01N31/16 , A01N35/04 , A01N37/40 , A01N43/16 , A01N43/26 , A01N43/30 , A01N43/32 , A01N43/60
摘要： The present invention relates to the use of a compound, a salt or solvate thereof as C4 plant selective herbicide wherein said compound has a structure according to formula (I) wherein A is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and B is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and wherein R1, R2, R3, R4 and R5 are, independently of each other H or an alkyl group, and wherein integer i is 0 or 1, preferably 1, and the bond (a) is a single or double bond, and wherein in case (a) is a double bond, n is 0 and X is O or S, and wherein in case (a) is a single bond n is 1, and X is H or an alkyl group, and wherein the bond (b) is a single or double bond, and wherein in case (b) is a double bond, m and p are 0, and wherein in case (b) is a single bond m and p are both 1, and/or according to formula (II) including tautomeric structures thereof, wherein R01 and R02 are independently of each other selected from the group consisting of H, OH, carboxylic acid, ester, alkyl, alkoxy and halogen, wherein Y1 is selected from the group consisting of (S(=0)2), S(=0)) and (C(═O)), and wherein Y2 is O, and wherein r is 0 or 1 and wherein in case r is 0, q and s are 1, and wherein in case r is 1, q and s are 0, and wherein R01, R02, R04, R05, R06, R07, R04#, R05#, R06#, R07#, R09, R010, R011 and R012 are independently of each other selected from the group consisting of H, OH, —SO3H, carboxylic acid, ester, alkyl, alkoxy and halogen, said compound being capable of binding to the malate binding site comprised by a phosphoenolpyruvate carboxylase from a C4 plant, thereby inhibiting said phosphoenolpyruvate carboxylase.
摘要翻译：本发明涉及化合物，其盐或溶剂合物作为C4植物选择性除草剂的用途，其中所述化合物具有式（I）结构，其中A为环烷基，芳基，杂环烷基或杂芳基，B 是环烷基，芳基，杂环烷基或杂芳基，其中R1，R2，R3，R4和R5彼此独立地为H或烷基，其中整数i为0或1，优选1，键（a）是单键或双键，其中（a）为双键的情况下，n为0，X为O或S，其中（a）为单键，n为1，X 是（H）或烷基，并且其中键（b）是单键或双键，并且其中（b）是双键的情况下，m和p为0，并且其中（b）为单键 m和p分别为1和/或根据式（II）包括其互变异构结构，其中R01和R02彼此独立地选自H，OH，羧酸 C 1 -C 6烷基，烷氧基和卤素，其中Y 1选自（S（= O）2），S（= O））和（C（= O）），并且其中Y2是O，其中r为0或1，并且其中在r为0的情况下，q和s为1，并且其中在r为1的情况下，q和s为0，并且其中R01，R02，R04，R05，R06，R07，R04＃，R05＃，R06＃，R07＃，R09，R010，R011和R012彼此独立地选自H，OH，-SO 3 H，羧酸，酯，烷基，烷氧基和卤素，所述化合物能够与来自C4植物的磷酸烯醇丙酮酸羧化酶包含的苹果酸结合位点结合，从而抑制所述磷酸烯醇丙酮酸羧化酶。

15. 发明申请

US20140288019A1 Phosphorylated A2A Receptor Agonists 有权
标题翻译：磷酸化A2A受体激动剂
公开(公告)号：US20140288019A1
公开(公告)日：2014-09-25
申请号：US14108010
申请日：2013-12-16
申请人： Rheinische Friedrich-Wilhelms-Universitat Bonn , Heinrich-Heine- Universität Düsseldorf
发明人： Jurgen SCHRADER , Christa Muller , Ali El-Tayeb , Jamshed Iqbal
IPC分类号： C07H19/20
CPC分类号： C07H19/20
摘要： A phosphorylated A2A receptor agonist providing agonist properties on the A2A receptor after dephosphorylation the phosphorylated A2A receptor agonist comprises a ribosyl moiety and a purine moiety and being phosphorylated at the 5′-position of the ribose moiety except adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), a medicament containing the compound of the invention including ADP and the use of the compound of the invention including ATP and ADP for several medical indications e.g. inflammatory events. In particular, compounds of formula (I) are also disclosed.
摘要翻译：在磷酸化A2A受体激动剂脱磷酸化后，在A2A受体上提供激动剂性质的磷酸化A2A受体激动剂包含核糖基部分和嘌呤部分，并且在核糖部分的5'-位被磷酸化，除了腺苷一磷酸（AMP），二磷酸腺苷 ADP）或三磷酸腺苷（ATP），一种含有本发明化合物的药物，包括ADP和包括ATP和ADP在内的多种医学适应症的本发明化合物的用途，例如炎性事件。特别地，还公开了式（I）的化合物。

16. 发明公开

US20240050939A1 DEVICE FOR EFFICIENT MEDIUM EXCHANGE IN MICROTITER PLATES 审中-公开
公开(公告)号：US20240050939A1
公开(公告)日：2024-02-15
申请号：US18283908
申请日：2022-03-25
申请人： HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF
发明人： Knud ESSER , Andrea KULIK
IPC分类号： B01L3/00
CPC分类号： B01L3/5025 , B01L2200/0642 , B01L2400/0409 , B01L2300/0829 , B01L2200/025
摘要： A device for the simultaneous filling of microtiter plate wells via centrifugal forces. In an implementation, the device includes a planar attachment for a microtiter plate having one or more liquid reservoirs for filling one well each of the microtiter plate per liquid reservoir. Each liquid reservoir has an upper filling opening for receiving a filling liquid, one or more lower filling nozzles for dispensing the filling liquid into the well of the microtiter plate, and a reservoir wall which connects the filling opening and the filling nozzle to one another. The filling nozzle is arranged off-center to the axis of symmetry of the microtiter plate well and off-center to the axis of symmetry of the filling opening of the filling device in a subregion of the reservoir wall.

17. 发明申请

US20220315942A1 A METHOD FOR THE PRODUCTION OF PLANTS WITH ALTERED PHOTORESPIRATION AND IMPROVED CO2 FIXATION 有权
公开(公告)号：US20220315942A1
公开(公告)日：2022-10-06
申请号：US17632867
申请日：2020-08-05
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Heinrich-Heine-Universität Düsseldorf
发明人： Lennart Schada Von Borzyskowski , Tobias Jürgen Erb , Andreas Paul Michael Weber , Marc-Sven Roll
IPC分类号： C12N15/82 , C12N9/88
摘要： The present invention relates to transgenic plants with altered photorespiration and improved CO2 fixation as well as a method of producing said transgenic plants. Particularly, the transgenic plants show an improved growth rate, productivity and energy conversion efficiency. This method can be successfully applied to many agricultural crop plants with nutritional and medicinal uses.

18. 发明申请

US20190388388A1 PARTHENOLIDE AND ITS DERIVATIVE FOR USE IN THE TREATMENT OF AXONAL DAMAGE 审中-公开
公开(公告)号：US20190388388A1
公开(公告)日：2019-12-26
申请号：US16555461
申请日：2019-08-29
申请人： HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF
发明人： Phillip Ludwig Alexander GOBRECHT , Dietmar FISCHER
IPC分类号： A61K31/365
摘要： The present invention relates to a compound reducing microtubule detyrosination in axonal tips selected from the group consisting of tubulin carboxypeptidase inhibitors and tubulin tyrosine ligase activators and combinations thereof for use in the treatment of axonal damage.

19. 发明授权

US10464904B2 Dextrorphan-derivatives with suppressed central nervous activity 有权
公开(公告)号：US10464904B2
公开(公告)日：2019-11-05
申请号：US15780850
申请日：2016-12-02
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Eckhard Lammert , Alena Welters , Silke Otter , Jan Marquard , Thomas Meissner , Diran Herebian , Ertan Mayatepek
IPC分类号： C07D221/18 , A61K31/439 , C07D221/28 , C07D401/04 , A61P3/10
摘要： The invention relates to dextrorphan-derivatives, pharmaceutical compositions and pharmaceutical dosage forms containing such dextrorphan-derivatives as well as the use of those dextrorphan-derivatives and/or compositions for treating and preventing diseases and conditions in man and mammals.

20. 发明授权

US09921175B2 Sensor and method for manufacturing a sensor 有权
公开(公告)号：US09921175B2
公开(公告)日：2018-03-20
申请号：US14351097
申请日：2012-10-10
申请人： HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF
发明人： Klaus Schierbaum , Mhamed El Achhab , Christiane Schüle
IPC分类号： G01N27/26 , C25D7/00 , G01N27/12
CPC分类号： G01N27/127 , C25D7/00 , G01N27/125 , G01N27/26
摘要： The present invention refers to a sensor (10) having a layer arrangement (12), wherein the layer arrangement (12) comprises at least a base layer (14), a middle layer (16) and an outer layer (18), wherein the middle layer (16) is arranged at least partly upon and in contact with the base layer (14) and wherein the outer layer (18) is arranged at least partly upon and in contact with the middle layer (16), wherein the base layer (14) comprises a metal, wherein the middle layer (16) comprises a metal oxide, and wherein the outer layer (18) is porous and comprises a material selected from the group comprising electrically conductive carbon compounds such as, more particularly, graphite or carbon nanotubes (CNTs), organic electrical conductors and base metals, and wherein electrical contacts can be formed with the base layer (14) and outer layer (18) for a conductivity measurement and/or a resistance measurement. Such a sensor (10) provides a high sensitivity with a high selectivity already at ambient temperature and is furthermore producible especially cost-saving. The present invention further refers to a method for producing a sensor (10). The present invention further refers to the use of a sensor (10) according to the invention as gas sensor and/or as liquid sensor.

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