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1. 发明申请

US20230133761A1 INHIBITION OF FKBP1A FOR THE TREATMENT OF TRIPLE-NEGATIVE MAMMARY CARCINOMA 有权
公开(公告)号：US20230133761A1
公开(公告)日：2023-05-04
申请号：US17801547
申请日：2021-03-11
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Knud Esser , Andrea Kulik , Tanja Fehm , Judith Steimel
IPC分类号： G01N33/50 , G01N33/574
摘要： The invention relates to a method for finding inhibitors of the peptidyl-prolyl cis-trans isomerase FKBP1A or antibodies, proteins or molecules having a specific affinity to FKBP1A. The invention also relates to FKBP1A-specific siRNA, inhibitors of the expression of FKBP1A, inhibitors of the enzymatic activity of FKBP1A, and inhibitors of the interaction(s) of FKBP1A with interaction partner(s), in each case for the treatment of diseases, in particular cancers or neurodegenerative diseases. The invention further relates to the use of FKBP1A as a prognostic or diagnostic marker for cancers. The cancers are preferably mammary carcinoma, in particular triple-negative mammary carcinoma, in this case very particularly the mesenchymal stem-like sub-type.

2. 发明申请

US20190161807A1 RAD51C as a Human Cancer Susceptibility Gene 审中-公开
公开(公告)号：US20190161807A1
公开(公告)日：2019-05-30
申请号：US16216307
申请日：2018-12-11
申请人： Helmut Hanenberg , Heinrich-Heine-Universität Düsseldorf , Universität zu Köln
发明人： Helmut Hanenberg , Dieter Niederacher , Kathrin Irmgard Maria Scheckenbach , Rita Schmutzler , Alfons Meindl , Constanze Wiek , Verena Friemann , Marcel Freund
IPC分类号： C12Q1/6886
摘要： The invention discloses in vitro methods and a system for determining a predisposition of a subject for developing a cancer on the basis of analyzing a sample of the subject for an alteration of at least one allele of the RAD51C gene. Further disclosed are in vitro methods for assessing clinical features or a pathological progression of a cancer and for assessing at least one RAD51C gene alteration in a cell. In addition a kit for determining a predisposition of a subject for developing a cancer, and certain uses of oligonucleotides for determining the presence of at least one mono-allelic germ-line mutation of the RAD51C gene.

3. 发明授权

US10188107B2 Selective inhibition of C4-PEP carboxylases 有权
公开(公告)号：US10188107B2
公开(公告)日：2019-01-29
申请号：US14761088
申请日：2014-01-16
申请人： Heinrich Heine Universität Düsseldorf
发明人： Georg Groth , Judith Katharina Paulus , Daniel Schlieper , Peter Westhoff
IPC分类号： A01N43/90 , A01N31/16 , A01N35/04 , A01N37/40 , A01N43/26 , A01N43/30 , A01N43/32 , A01N43/16 , A01N43/60
摘要： The present invention relates to the use of a compound, a salt or solvate thereof as C4 plant selective herbicide wherein said compound has a structure according to formula (I) wherein A is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and B is a cyclic alkyl, aryl, heterocycloalkyl, or heteroaryl group, and wherein R1, R2, R3, R4 and R5 are, independently of each other H or an alkyl group, and wherein integer i is 0 or 1, preferably 1, and the bond (a) is a single or double bond, and wherein in case (a) is a double bond, n is 0 and X is O or S, and wherein in case (a) is a single bond n is 1, and X is H or an alkyl group, and wherein the bond (b) is a single or double bond, and wherein in case (b) is a double bond, m and p are 0, and wherein in case (b) is a single bond m and p are both 1, and/or according to formula (II) including tautomeric structures thereof, wherein R01 and R02 are independently of each other selected from the group consisting of H, OH, carboxylic acid, ester, alkyl, alkoxy and halogen, wherein Y1 is selected from the group consisting of (S(═O)2), S(═O)) and (C(═O)), and wherein Y2 is O, and wherein r is 0 or 1 and wherein in case r is 0, q and s are 1, and wherein in case r is 1, q and s are 0, and wherein R01, R02, R04, R05, R06, R07, R04#, R05#, R06#, R07#, R09, R010, R011 and R012 are independently of each other selected from the group consisting of H, OH, —SO3H, carboxylic acid, ester, alkyl, alkoxy and halogen, said compound being capable of binding to the malate binding site comprised by a phosphoenolpyruvate carboxylase from a C4 plant, thereby inhibiting said phosphoenolpyruvate carboxylase.

4. 发明申请

US20220226339A1 INHIBITATION OF ACID LIPASE FOR CANCER THERAPY 有权
公开(公告)号：US20220226339A1
公开(公告)日：2022-07-21
申请号：US17617218
申请日：2020-07-02
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Knud Esser , Andrea Kulik , Tanja Fehm
IPC分类号： A61K31/5377 , G01N33/50 , C12Q1/44 , A61K31/175 , A61K31/337 , A61P35/00
摘要： The invention relates to new cancer treatment strategies based on the inhibition of acid lipase. In addition, the invention relates to methods for discovering new active substances suitable for cancer therapy.

5. 发明申请

US20210147415A1 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION 有权
公开(公告)号：US20210147415A1
公开(公告)日：2021-05-20
申请号：US17091247
申请日：2020-11-06
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Alexander Metz , Holger Gohlke , Julia Schanda , Christian Wichmann , Manuel Grez
IPC分类号： C07D471/04 , C07D317/60 , C07D235/28 , C07D493/04 , C07D207/337 , C07D209/42 , C07D307/68 , C07C59/70 , C07C59/68 , C07D239/22 , G01N27/447 , G01N33/50
摘要： The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.

6. 发明申请

US20180362469A1 DEXTRORPHAN-DERIVATIVES WITH SUPPRESSED CENTRAL NERVOUS ACTIVITY 审中-公开
公开(公告)号：US20180362469A1
公开(公告)日：2018-12-20
申请号：US15780850
申请日：2016-12-02
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Eckhard Lammert , Alena Welters , Silke Otter , Jan Marquard , Thomas Meissner , Diran Herebian , Ertan Mayatepek
IPC分类号： C07D221/28 , C07D401/04 , A61P3/10
CPC分类号： C07D221/28 , A61P3/10 , C07D401/04
摘要： The invention relates to dextrorphan-derivatives, pharmaceutical compositions and pharmaceutical dosage forms containing such dextrorphan-derivatives as well as the use of those dextrorphan-derivatives and/or compositions for treating and preventing diseases and conditions in man and mammals.

7. 发明申请

US20180230143A1 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION 审中-公开
公开(公告)号：US20180230143A1
公开(公告)日：2018-08-16
申请号：US15837235
申请日：2017-12-11
申请人： Heinrich-Heine-Universität Düsseldorf
发明人： Alexander Metz , Holger Gohlke , Julia Schanda , Christian Wichmann , Manuel Grez
IPC分类号： C07D471/04 , C07D209/42 , C07D317/60 , C07D239/22 , C07C59/68 , C07D493/04 , C07D207/337 , C07D307/68 , G01N27/447 , C07C59/70 , G01N33/50 , C07D235/28
CPC分类号： C07D471/04 , C07C59/68 , C07C59/70 , C07D207/337 , C07D209/42 , C07D235/28 , C07D239/22 , C07D307/68 , C07D317/60 , C07D493/04 , G01N27/447 , G01N33/5011 , G01N2333/47
摘要： The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.

8. 发明申请

US20180140574A1 PARTHENOLIDE AND ITS DERIVATIVE FOR USE IN THE TREATMENT OF AXONAL DAMAGE 审中-公开
公开(公告)号：US20180140574A1
公开(公告)日：2018-05-24
申请号：US15567823
申请日：2016-03-10
申请人： HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF
发明人： Phillip Ludwig Alexander GOBRECHT , Dietmar FISCHER
IPC分类号： A61K31/365
CPC分类号： A61K31/365 , A61K45/06
摘要： The present invention relates to a compound reducing microtubule detyrosination in axonal tips selected from the group consisting of tubulin carboxypeptidase inhibitors and tubulin tyrosine ligase activators and combinations thereof for use in the treatment of axonal damage.

9. 发明申请

US20160108031A1 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION 审中-公开
标题翻译： NHR2和/或RUNX1 / ETO-TETRAMERIZATION的抑制剂
公开(公告)号：US20160108031A1
公开(公告)日：2016-04-21
申请号：US14787151
申请日：2014-04-25
申请人： HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF
发明人： Alexander Metz , Holger Gohlke , Julia Schanda , Christian Wichmann , Manuel Grez
IPC分类号： C07D471/04 , C07D307/68 , C07D493/04 , G01N27/447 , C07C59/68 , C07D317/60 , C07D239/22 , G01N33/50 , C07D207/337 , C07D209/42
CPC分类号： C07D471/04 , C07C59/68 , C07C59/70 , C07D207/337 , C07D209/42 , C07D235/28 , C07D239/22 , C07D307/68 , C07D317/60 , C07D493/04 , G01N27/447 , G01N33/5011 , G01N2333/47
摘要： The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics, and diagnostic agents.
摘要翻译：本发明涉及NHR2四聚化的抑制剂及其作为肿瘤治疗剂（例如针对急性骨髓性白血病（AML）），细胞抑制剂和诊断剂的用途。

10. 发明申请

US20140291160A1 Sensor and method for manufacturing a sensor 有权
标题翻译：用于制造传感器的传感器和方法
公开(公告)号：US20140291160A1
公开(公告)日：2014-10-02
申请号：US14351097
申请日：2012-10-10
申请人： HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF
发明人： Klaus Schierbaum , Mhamed El Achhab , Christiane Schüle
IPC分类号： G01N27/26 , C25D7/00
CPC分类号： G01N27/127 , C25D7/00 , G01N27/125 , G01N27/26
摘要： The present invention refers to a sensor (10) having a layer arrangement (12), wherein the layer arrangement (12) comprises at least a base layer (14), a middle layer (16) and an outer layer (18), wherein the middle layer (16) is arranged at least partly upon and in contact with the base layer (14) and wherein the outer layer (18) is arranged at least partly upon and in contact with the middle layer (16), wherein the base layer (14) comprises a metal, wherein the middle layer (16) comprises a metal oxide, and wherein the outer layer (18) is porous and comprises a material selected from the group comprising electrically conductive carbon compounds such as, more particularly, graphite or carbon nanotubes (CNTs), organic electrical conductors and base metals, and wherein electrical contacts can be formed with the base layer (14) and outer layer (18) for a conductivity measurement and/or a resistance measurement. Such a sensor (10) provides a high sensitivity with a high selectivity already at ambient temperature and is furthermore producible especially cost-saving. The present invention further refers to a method for producing a sensor (10). The present invention further refers to the use of a sensor (10) according to the invention as gas sensor and/or as liquid sensor.
摘要翻译：本发明涉及具有层布置（12）的传感器（10），其中层布置（12）至少包括基层（14），中间层（16）和外层（18），其中所述中间层（16）至少部分地布置在所述基底层（14）上并与所述基底层（14）接触，并且其中所述外层（18）至少部分地布置在所述中间层（16）上并与所述中间层（16）接触，其中所述基底层（14）包括金属，其中中间层（16）包括金属氧化物，并且其中外层（18）是多孔的，并且包括选自包括导电碳化合物的材料，特别是石墨或碳纳米管（CNT），有机电导体和贱金属，并且其中可以与基底层（14）和外层（18）形成电接触以进行电导率测量和/或电阻测量。这种传感器（10）在环境温度下已经具有高选择性的高灵敏度，并且进一步可生产，特别是节省成本。本发明还涉及一种用于制造传感器（10）的方法。本发明还涉及使用根据本发明的传感器（10）作为气体传感器和/或液体传感器。

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