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11. 发明授权

US08758274B2 Automated adjustment of posture state definitions for a medical device 有权
标题翻译：自动调整医疗器械的姿势状态定义
公开(公告)号：US08758274B2
公开(公告)日：2014-06-24
申请号：US12769431
申请日：2010-04-28
申请人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
发明人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
IPC分类号： A61B5/00
CPC分类号： A61B5/4839 , A61B5/021 , A61B5/024 , A61B5/0476 , A61B5/0488 , A61B5/1116 , A61B5/1118 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2560/0475 , A61N1/36071 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/324 , G16H50/20
摘要： Techniques relate to operating a medical device by classifying a detected posture state of a patient. This classification may be performed by comparing the detected posture state of the patient to posture state definitions available within the system. Each definition may be described in terms of a parameter (e.g., vector) indicative of a direction in three-dimensional space. The posture state definitions may be calibrated by automatically estimating values for these parameters, thereby eliminating the need for the patient to assume each posture state during the calibration process to capture actual parameter values. According to another aspect, the estimated parameter values may be updated as the patient assumes various postures during a daily routine. For instance, estimated vectors initially used to calibrate the posture state definitions may be changed over time to more closely represent posture states the patient actually assumes, and to further adapt to changes in a patient's condition.
摘要翻译：技术涉及通过对检测到的患者的姿势状态进行分类来操作医疗装置。可以通过将检测到的患者的姿势状态与系统内可用的姿势状态定义进行比较来执行该分类。可以根据指示三维空间中的方向的参数（例如，矢量）来描述每个定义。可以通过自动估计这些参数的值来校准姿势状态定义，从而消除了在校准过程期间患者承担每个姿势状态以捕获实际参数值的需要。根据另一方面，当患者在日常例行程序中呈现各种姿势时，可以更新所估计的参数值。例如，最初用于校准姿势状态定义的估计矢量可以随着时间而改变以更加紧密地表示患者实际假定的姿势状态，并进一步适应患者状况的变化。

12. 发明授权

US08108038B2 System and method for segmenting a cardiac signal based on brain activity 有权
标题翻译：基于脑活动分割心脏信号的系统和方法
公开(公告)号：US08108038B2
公开(公告)日：2012-01-31
申请号：US11380462
申请日：2006-04-27
申请人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , Eric J. Panken , David L. Carlson
发明人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , Eric J. Panken , David L. Carlson
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3611 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a brain event time period by evaluation of the brain signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the brain event time period.
摘要翻译：一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。处理器还被配置为通过评估脑信号来确定大脑事件时间段的至少一个参考点。处理器还基于大脑事件时间段的至少一个参考点识别心脏信号的第一部分。

13. 发明申请

US20110172927A1 AUTOMATED ADJUSTMENT OF POSTURE STATE DEFINITIONS FOR A MEDICAL DEVICE 有权
标题翻译：自动调整医疗器械的姿态定义
公开(公告)号：US20110172927A1
公开(公告)日：2011-07-14
申请号：US12769431
申请日：2010-04-28
申请人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
发明人： Rajeev M. Sahasrabudhe , Lynn Davenport , Jon P. Davis , Wende L. Dewing , Elizabeth A. Fehrmann , Steven Goetz , Shyam Gokaldas , Eric J. Panken
IPC分类号： G06F19/00
CPC分类号： A61B5/4839 , A61B5/021 , A61B5/024 , A61B5/0476 , A61B5/0488 , A61B5/1116 , A61B5/1118 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2560/0475 , A61N1/36071 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/324 , G16H50/20
摘要： Techniques relate to operating a medical device by classifying a detected posture state of a patient. This classification may be performed by comparing the detected posture state of the patient to posture state definitions available within the system. Each definition may be described in terms of a parameter (e.g., vector) indicative of a direction in three-dimensional space. The posture state definitions may be calibrated by automatically estimating values for these parameters, thereby eliminating the need for the patient to assume each posture state during the calibration process to capture actual parameter values. According to another aspect, the estimated parameter values may be updated as the patient assumes various postures during a daily routine. For instance, estimated vectors initially used to calibrate the posture state definitions may be changed over time to more closely represent posture states the patient actually assumes, and to further adapt to changes in a patient's condition.
摘要翻译：技术涉及通过对检测到的患者的姿势状态进行分类来操作医疗装置。可以通过将检测到的患者的姿势状态与系统内可用的姿势状态定义进行比较来执行该分类。可以根据指示三维空间中的方向的参数（例如，矢量）来描述每个定义。可以通过自动估计这些参数的值来校准姿势状态定义，从而消除了在校准过程期间患者承担每个姿势状态以捕获实际参数值的需要。根据另一方面，当患者在日常例行程序中呈现各种姿势时，可以更新所估计的参数值。例如，最初用于校准姿势状态定义的估计矢量可以随着时间而改变以更加紧密地表示患者实际假定的姿势状态，并进一步适应患者状况的变化。

14. 发明授权

US07979130B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US07979130B2
公开(公告)日：2011-07-12
申请号：US11677360
申请日：2007-02-21
申请人： David L Carlson , Eric J Panken , Touby A Drew , Jonathan C Werder
发明人： David L Carlson , Eric J Panken , Touby A Drew , Jonathan C Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06F19/00 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delivery components prior to the expected delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。本发明的其它实施方案包括通过在治疗的预期递送之前预热治疗递送成分来准备递送治疗。

15. 发明申请

US20100121214A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于内分泌压力和患者运动的癫痫病症评估
公开(公告)号：US20100121214A1
公开(公告)日：2010-05-13
申请号：US12359055
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0476 , A61B5/03 , A61B5/11 , A61B5/053
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压，以评估癫痫发作障碍。在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间发生癫痫发作。除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

16. 发明申请

US20100010384A1 POSTURE STATE DETECTION USING SELECTABLE SYSTEM CONTROL PARAMETERS 有权
标题翻译：使用可选择的系统控制参数进行姿态检测
公开(公告)号：US20100010384A1
公开(公告)日：2010-01-14
申请号：US12433029
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61B5/103
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动相关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以以可选择的方式处理一个或多个感测信号。该可选择方式可以基于描述患者以前被分类的姿势状态的当前姿势状态数据。或者或另外，该当前姿势状态数据可以描述先前由患者进行的姿势状态转换。然后可以将如此处理的一个或多个信号用于对患者的姿势状态进行分类。

17. 发明申请

US20080081958A1 Implantable medical device with sensor self-test feature 审中-公开
标题翻译：具有传感器自检功能的植入式医疗设备
公开(公告)号：US20080081958A1
公开(公告)日：2008-04-03
申请号：US11789438
申请日：2007-04-24
申请人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
发明人： Timothy J. Denison , Brian B. Lee , Keith A. Miesel , Eric J. Panken
IPC分类号： A61B5/00
CPC分类号： A61N1/3706 , A61B2560/0276 , A61N1/36535 , A61N1/36542 , A61N1/3702
摘要： An implantable medical device (IMD) applies a sensor self-test when a sensing device generates a sensor signal indicating an event, or when the sensor is used to validate an event detected by another device. The event may be based on a sensed condition that triggers an operational adjustment, such as a therapy or diagnostic adjustment within the IMD. A sensor self-test verifies that an implantable sensing device is functional, and can be performed with or without activating the sensor. Activating the sensor may involve, application of an electrical input signal that causes the sensor to generate an output signal. Alternatively, the sensor self-test may be performed without activating the sensor by analyzing the continuity of a signal path between the sensor and sensor interface circuitry. In either case, a sensor self-test verifies proper operation so that operational adjustments can be made with greater confidence.
摘要翻译：当感测装置产生指示事件的传感器信号时，或者当传感器用于验证另一个设备检测到的事件时，可植入医疗设备（IMD）应用传感器自检。事件可以基于触发操作调整的感测条件，例如IMD内的治疗或诊断调整。传感器自检可以验证可植入的感测装置是否起作用，并且可以在启动或不启动传感器的情况下执行。激活传感器可能涉及施加导致传感器产生输出信号的电输入信号。或者，可以通过分析传感器和传感器接口电路之间的信号路径的连续性而不激活传感器来执行传感器自检。在任一种情况下，传感器自检将验证正确的操作，以便可以更有信心地进行操作调整。

18. 发明授权

US08688225B2 Posture state detection using selectable system control parameters 有权
标题翻译：姿态检测采用可选择的系统控制参数
公开(公告)号：US08688225B2
公开(公告)日：2014-04-01
申请号：US12433029
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61N1/00
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques for detecting and classifying a posture state of a patient are disclosed, wherein a posture state includes at least one of a posture and/or an activity state related to motion. In one embodiment, one or more signals indicative of at least one of posture and activity state of the patient may be sensed by a sensor. Control logic may be provided to process the one or more sensed signals in a selectable manner. This selectable manner may be based on current posture state data describing a posture state in which the patient has previously been classified. Alternatively or additionally, this current posture state data may describe a posture state transition previously undergone by the patient. The one or more signals that are so processed may then be used to classify a posture state of the patient.
摘要翻译：公开了用于检测和分类患者的姿势状态的技术，其中姿势状态包括与运动相关的姿势和/或活动状态中的至少一个。在一个实施例中，可以由传感器感测指示患者的姿势和活动状态中的至少一个的一个或多个信号。可以提供控制逻辑以以可选择的方式处理一个或多个感测信号。该可选择方式可以基于描述患者以前被分类的姿势状态的当前姿势状态数据。或者或另外，该当前姿势状态数据可以描述先前由患者进行的姿势状态转换。然后可以将如此处理的一个或多个信号用于对患者的姿势状态进行分类。

19. 发明授权

US08565864B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08565864B2
公开(公告)日：2013-10-22
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

20. 发明授权

US08515549B2 Associating therapy adjustments with intended patient posture states 有权
标题翻译：将治疗调整与预期的患者姿势状态相关联
公开(公告)号：US08515549B2
公开(公告)日：2013-08-20
申请号：US12433756
申请日：2009-04-30
申请人： Eric J. Panken , Dennis M. Skelton
发明人： Eric J. Panken , Dennis M. Skelton
IPC分类号： A61B5/00 , A61B5/02 , A61B5/103 , A61B5/11 , A61N1/00 , A61N1/05 , A61N1/372
CPC分类号： A61B5/1116 , A61B5/103 , A61B5/686 , A61B2560/0219 , A61B2562/0219 , A61N1/36071 , A61N1/36139 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： The disclosure described techniques for associating therapy adjustments with intended patient posture states. The techniques may include receiving a patient therapy adjustment to a parameter of a therapy program that defines electrical stimulation therapy delivered to the patient, identifying a posture state of the patient, and associating the patient therapy adjustment with the posture state when the patient therapy adjustment is within a range determined based on stored adjustment information for the identified posture state.
摘要翻译：本公开描述了将治疗调整与预期患者姿势状态相关联的技术。这些技术可以包括接收患者治疗调整，该治疗程序的参数限定递送给患者的电刺激治疗，识别患者的姿势状态，以及当患者治疗调整为在基于所识别的姿势状态的存储的调整信息确定的范围内。

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