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11. 发明授权

US08593155B2 MEMS in-plane resonators 有权
标题翻译： MEMS平面内谐振器
公开(公告)号：US08593155B2
公开(公告)日：2013-11-26
申请号：US12853619
申请日：2010-08-10
申请人： Andrew Sparks , Milind Bhagavat
发明人： Andrew Sparks , Milind Bhagavat
IPC分类号： G01R27/04
CPC分类号： G01N29/022 , G01N29/036 , G01N2291/014 , G01N2291/0256 , G01N2291/0422 , H03H9/1057 , H03H9/2463 , H03H2009/02511
摘要： MEMS in-plane resonators include a substrate wafer, at least one resonant mass supported by the substrate wafer and configured to resonate substantially in-plane, and at least one transducer coupled to the at least one resonant mass for at least one of driving and sensing in-plane movement of the at least one resonant mass, wherein at least part of one surface of the resonant mass is configured for exposure to an external environment and wherein the at least one transducer is isolated from the external environment. Such MEMS in-plane resonators may be fabricated using conventional surface micromachining techniques and high-volume wafer fabrication processes and may be configured for liquid applications (e.g., viscometry, densitometry, chemical/biological sensing), gas sensing (e.g., where a polymer film is added to the sensor surface, further degrading the damping performance), or other applications.
摘要翻译： MEMS平面内谐振器包括衬底晶片，由衬底晶片支撑并被配置为基本上共面谐振的至少一个谐振块，以及耦合到至少一个谐振块的至少一个谐振器，用于至少一个驱动和感测所述至少一个谐振质量块的平面内运动，其中所述谐振块的一个表面的至少一部分被配置为暴露于外部环境，并且其中所述至少一个换能器与所述外部环境隔离。这样的MEMS平面内谐振器可以使用传统的表面微加工技术和大容量晶片制造工艺来制造，并且可以被配置用于液体应用（例如，粘度测定，密度测定，化学/生物感测），气体感测（例如，其中聚合物膜被添加到传感器表面，进一步降低阻尼性能）或其他应用。

12. 发明申请

US20120122699A1 Methods and Oligonucleotide Designs for Insertion of Multiple Adaptors Employing Selective Methylation 审中-公开
标题翻译：用于插入选择性甲基化的多个适配器的方法和寡核苷酸设计
公开(公告)号：US20120122699A1
公开(公告)日：2012-05-17
申请号：US13021141
申请日：2011-02-04
申请人： Fredrik DAHL , Radoje Drmanac , Andrew Sparks
发明人： Fredrik DAHL , Radoje Drmanac , Andrew Sparks
IPC分类号： C40B20/00 , C12N15/66 , C40B50/06 , C12P19/34
CPC分类号： C12Q1/6855 , C12Q1/6874 , C12Q2531/125 , C12Q2521/313 , C12Q2521/125 , C12Q2537/163 , C12Q2525/191 , C12Q2521/531 , C12Q2521/501
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译：在此描述和要求保护的方面提供了将多个DNA适配器插入到相对于彼此的限定位置和取向的圆形靶DNA群中的方法。然后将所得多连接体构建体用于大规模并行核酸测序技术。

13. 发明授权

US07901890B2 Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation 有权
标题翻译：使用选择性甲基化插入多个适配器的方法和寡核苷酸设计
公开(公告)号：US07901890B2
公开(公告)日：2011-03-08
申请号：US12265593
申请日：2008-11-05
申请人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
发明人： Fredrik Dahl , Radoje Drmanac , Andrew Sparks
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6855 , C12Q1/6874 , C12Q2531/125 , C12Q2521/313 , C12Q2521/125 , C12Q2537/163 , C12Q2525/191 , C12Q2521/531 , C12Q2521/501
摘要： Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.
摘要翻译：在此描述和要求保护的方面提供了将多个DNA适配器插入到相对于彼此的限定位置和取向的圆形靶DNA群中的方法。然后将所得多连接体构建体用于大规模并行核酸测序技术。

14. 发明申请

US20100105052A1 Nucleic acid sequencing and process 有权
标题翻译：核酸测序和过程
公开(公告)号：US20100105052A1
公开(公告)日：2010-04-29
申请号：US12573697
申请日：2009-10-05
申请人： Radoje DRMANAC , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
发明人： Radoje DRMANAC , Andrew Sparks , Fredrik Dahl , Matthew J. Callow , Clifford Reid
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q2533/107 , C12Q2525/185 , C12Q2525/151
摘要： The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid templates to amplification methods to form nucleic acid nanoballs. The invention also includes methods of detecting and identifying sequences using various sequencing applications, including sequencing by ligation methods.
摘要翻译：本发明涉及用于核酸鉴定和检测的组合物和方法。本发明的组合物和方法包括从样品中提取和分离靶核酸，使用片段化的靶核酸产生靶核酸模板，并使这些靶核酸模板进行扩增方法以形成核酸纳米棒。本发明还包括使用各种测序应用检测和鉴定序列的方法，包括通过连接方法测序。

15. 发明申请

US20070159541A1 Single camera multi-spectral imager 有权
标题翻译：单相机多光谱成像仪
公开(公告)号：US20070159541A1
公开(公告)日：2007-07-12
申请号：US11327417
申请日：2006-01-09
申请人： Andrew Sparks , Michael DeWeert
发明人： Andrew Sparks , Michael DeWeert
IPC分类号： H04N9/04
CPC分类号： H04N9/045 , H04N5/332
摘要： An imaging system has a single focal plane array that does not require the precise alignment of multiple cameras relative to one another. It incorporates a multi-band, band pass filter that includes filter elements corresponding to pixel regions of a detector within a camera. The imaging system may further incorporate a detector that vertically discriminates among radiation in different spectral bands incident on an image plane of the detector. In this manner, spectral content may be determined in each spatial region without the need for beam splitting or multiple cameras. The filter itself may further comprise different filter elements, for example, filter elements A and B arranged in a checkerboard pattern, where filter element A passes different spectral bands than filter element B. In this manner, multi-spectral, high resolution images may be generated using a single camera that significantly improves upon image discrimination as compared to, for example, the Bayer color filter array pattern. The single camera implementation is well suited for incorporation into marine, land and air vehicles.
摘要翻译：成像系统具有单个焦平面阵列，其不需要相对于彼此的多个相机的精确对准。它包括一个多频带通滤波器，其包括对应于相机内的检测器的像素区域的滤波器元件。成像系统还可以并入检测器，其垂直地区分入射在检测器的图像平面上的不同光谱带中的辐射。以这种方式，可以在每个空间区域中确定频谱内容，而不需要分束或多个相机。滤波器本身还可以包括不同的滤波器元件，例如布置在棋盘图案中的滤波器元件A和B，其中滤波器元件A通过与滤波器元件B不同的频谱带。以这种方式，多光谱，高分辨率图像可以是使用单个相机生成，与例如拜耳滤色器阵列图案相比，显着地改善了图像鉴别。单个摄像机实现非常适合并入海洋，陆地和空中的车辆。

16. 发明申请

US20050100911A1 Methods for enriching populations of nucleic acid samples 审中-公开
标题翻译：富集核酸样品群体的方法
公开(公告)号：US20050100911A1
公开(公告)日：2005-05-12
申请号：US10635175
申请日：2003-08-06
申请人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
发明人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6855 , C12Q2531/113 , C12Q2565/501 , C12Q2521/313 , C12Q2525/191 , C12Q2525/313 , C12Q2533/101
摘要： The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired properly. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high decree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.
摘要翻译：本发明提供了在对核酸探针阵列上的核酸进行分析之前降低核酸群体的复杂性的几种方法。该方法导致富集所需性质的初始群体的子集，或缺少具有不理想的核酸。然后将该子集中得到的核酸应用于阵列进行各种类型的分析。该方法对于分析具有高复杂度的群体特别有用，例如染色体衍生的DNA或全基因组DNA或mRNA群体。此外，这种方法允许对合并的样品进行分析。

17. 发明授权

US06498013B1 Serial analysis of transcript expression using MmeI and long tags 有权
标题翻译：使用MmeI和长标签进行转录表达的连续分析
公开(公告)号：US06498013B1
公开(公告)日：2002-12-24
申请号：US09916228
申请日：2001-07-27
申请人： Victor E. Velculescu , Andrew Sparks , Kenneth W. Kinzler , Bert Vogelstein
发明人： Victor E. Velculescu , Andrew Sparks , Kenneth W. Kinzler , Bert Vogelstein
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q2525/191 , C12Q2521/501 , C12Q2521/313 , C12Q2521/301
摘要： Serial analysis of gene expression, SAGE, a method for the rapid quantitative and qualitative analysis of transcripts, has been improved to provide more genetic information about each analyzed transcript by use of MmeI restriction endonuclease. In SAGE, defined sequence tags corresponding to expressed genes are isolated and analyzed. Sequencing of over 1,000 defined tags in a short period of time (e.g., hours) reveals a gene expression pattern characteristic of the function of a cell or tissue. Moreover, SAGE is useful as a gene discovery tool for the identification and isolation of novel sequence tags corresponding to novel transcripts and genes.
摘要翻译：基因表达的序列分析，SAGE，用于快速定量和定性分析转录物的方法已被改进，以通过使用MmeI限制性内切核酸酶提供关于每个分析的转录物的更多遗传信息。在SAGE中，分离和分析与表达基因相对应的定义的序列标签。在短时间（例如，小时）内测定超过1,000个定义的标签显示了细胞或组织功能特征的基因表达模式。此外，SAGE可用作用于鉴定和分离对应于新转录物和基因的新序列标签的基因发现工具。

18. 发明授权

US10167508B2 Detection of genetic abnormalities 有权
公开(公告)号：US10167508B2
公开(公告)日：2019-01-01
申请号：US13407978
申请日：2012-02-29
申请人： Ken Song , Arnold Oliphant , John Stuelpnagel , Andrew Sparks
发明人： Ken Song , Arnold Oliphant , John Stuelpnagel , Andrew Sparks
IPC分类号： C12Q1/6883
摘要： The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.

19. 发明授权

US08756020B2 Enhanced risk probabilities using biomolecule estimations 有权
标题翻译：使用生物分子估计增强风险概率
公开(公告)号：US08756020B2
公开(公告)日：2014-06-17
申请号：US13274309
申请日：2011-10-15
申请人： Craig Struble , Eric Wang , Andrew Sparks , Arnold Oliphant
发明人： Craig Struble , Eric Wang , Andrew Sparks , Arnold Oliphant
IPC分类号： G01N33/50
CPC分类号： G06F19/18
摘要： The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample.
摘要翻译：本发明提供了用于确定医疗状况的更准确的风险概率的方法。使用来自所选生物分子的频率数据和混合样品中至少一种来源的生物分子来源贡献来计算存在或不存在医学状况的风险概率。

20. 发明申请

US20130004950A1 ASSAY SYSTEMS FOR GENETIC ANALYSIS 审中-公开
公开(公告)号：US20130004950A1
公开(公告)日：2013-01-03
申请号：US13293419
申请日：2011-11-10
申请人： Andrew Sparks , Arnold Oliphant , Jacob Zahn , Ken Song , John Stuelpnagel
发明人： Andrew Sparks , Arnold Oliphant , Jacob Zahn , Ken Song , John Stuelpnagel
IPC分类号： C12Q1/68 , C12M1/40
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6862 , C12Q2525/155 , C12Q2525/161 , C12Q2533/107 , C12Q2535/131 , C12Q2565/514 , C12Q2565/543
摘要： The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source.

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