专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US4923438A Blood recovery system and method 失效
标题翻译：血液回收系统及方法
公开(公告)号：US4923438A
公开(公告)日：1990-05-08
申请号：US220193
申请日：1988-07-18
申请人： Alfred V. Vasconcellos , Preston J. Keeler, III
发明人： Alfred V. Vasconcellos , Preston J. Keeler, III
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/3627 , A61M1/0007
摘要： An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve an uninterrupted flow of blood into and delivery of blood out of the reservoir.

12. 发明授权

US4730615A Sternum closure device 失效
标题翻译：胸骨闭合装置
公开(公告)号：US4730615A
公开(公告)日：1988-03-15
申请号：US835394
申请日：1986-03-03
申请人： Lloyd A. Sutherland , Alfred V. Vasconcellos
发明人： Lloyd A. Sutherland , Alfred V. Vasconcellos
IPC分类号： A61B17/58 , A61B17/82 , A61B17/08 , B65D63/00 , B65D77/10
CPC分类号： A61B17/823 , A61B17/82 , Y10T24/1498 , Y10T24/153
摘要： A sternum closure device for closing the sternum of a patient comprising a head portion, tail portion and flexible spine portion. The head portion includes a locking tang to prevent backward movement of the spine portion once it is received and engaged in the head portion. The spine is made of a biocompatible metal coated with a biocompatible polymer along part of its length. One end of the spine is sharpened to serve as a needle. The tang pierces the polymer and locks against a serration of the spine. A method of using the sternum closure device is also disclosed.
摘要翻译：一种用于封闭患者胸骨的胸骨闭合装置，包括头部，尾部和柔性脊部。头部包括锁定柄，以防止一旦其被接收并接合在头部中，脊部的向后运动。脊柱由生物相容性金属制成，其生物相容性聚合物沿其长度的一部分涂覆。脊柱的一端被削尖以作为针。脚刺穿聚合物并锁定脊柱的锯齿。还公开了使用胸骨闭合装置的方法。

13. 外观设计

USD309350S Surgical sternotomy band tightening instrument 失效
标题翻译：手术胸腰带收紧器械
公开(公告)号：USD309350S
公开(公告)日：1990-07-17
申请号：US56565
申请日：1987-06-01
申请人： Lloyd A. Sutherland , Alfred V. Vasconcellos
设计人： Lloyd A. Sutherland , Alfred V. Vasconcellos

14. 发明授权

US06960351B2 Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products 失效
标题翻译：用于递送选定治疗产品的植入式生物相容性免疫佐剂
公开(公告)号：US06960351B2
公开(公告)日：2005-11-01
申请号：US10624081
申请日：2003-07-21
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61F13/00 , A61F2/00 , A61F9/14 , A61F9/16 , A61F9/22
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.
摘要翻译：用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送，个人该载体特别适合于从朗格汉斯的免疫隔离胰岛递送胰岛素，并且还可有利地用于递送高分子量产物，例如大于IgG的产物。在共挤出方法的第一实施方案中和在逐步方法的第二实施方案中制备生物相容的免疫隔离可植入载体的方法。一种用于分离生物相容的免疫隔离可植入载体中的细胞的方法，其保护分离的细胞免受被植入其中的个体的免疫系统的攻击。向个体提供所需的生物制品或代谢功能的方法，包括向个体植入包含产生产物或提供代谢功能的分离细胞的免疫隔离载体。

15. 发明授权

US06322804B1 Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products 失效
标题翻译：用于递送选定治疗产品的植入式生物相容性免疫佐剂
公开(公告)号：US06322804B1
公开(公告)日：2001-11-27
申请号：US09563248
申请日：2000-05-02
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Scharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61K950
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/4816 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K2035/126 , A61K2035/128 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual.
摘要翻译：用于植入到产生所需产品或提供所需代谢功能的细胞个体中的免疫分析载体。载体由含有分离的细胞和足以维持细胞的材料的核心区域组成，以及不含分离细胞的选择性选择性生物相容的外周区域，所述细胞免疫分离核心，但提供分泌产物或代谢功能的递送，个人

16. 发明授权

US06179826B2 Implantable therapy systems and methods 失效
标题翻译：植入式治疗系统和方法
公开(公告)号：US06179826B2
公开(公告)日：2001-01-30
申请号：US08741228
申请日：1996-10-29
申请人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
发明人： Patrick Aebischer , Moses Goddard , John G. Moldauer , Paul J. Mulhauser , Anne M. Rathbun , Paul R. Sanberg , Alfred V. Vasconcellos , Nicholas F. Warner
IPC分类号： A61M3100
CPC分类号： A61K9/0092 , A61F2/022 , A61K9/0024 , A61K9/0085 , A61K35/55 , A61K2035/126 , A61M31/002 , A61M37/0069 , A61M39/0208 , A61M2210/0687 , A61M2210/0693 , B01J13/02 , C12N5/0012 , C12N5/0614 , C12N5/0619 , C12N5/0676 , C12N11/04 , C12N2533/30 , A61M2230/005
摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) or dilator (104) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. In some instances, the cannula can be inserted along the path of a guidewire (102) previously positioned at the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30) or dilator (104), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A pusher can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the proximal tip of the cannula (20b). Once the vehicle (40) is positioned near the proximal end of the cannula (20), the cannula is removed from the passageway, followed by the pusher, leaving the vehicle (40) positioned at the treatment site (12).
摘要翻译：公开了植入式治疗系统，用于将局部和受控制的生物活性因子递送至患有二体化病症的受试者的脑，脊髓和其他靶区域。本发明的方法涉及通常在患者体内暴露通常位于预定治疗部位（12）上方的插入部位。具有定位在其中的闭塞器（30）或扩张器（104）的插管（20）插入插入位置，从而限定到治疗部位的通路。在一些情况下，套管可以沿着预先位于治疗部位的导丝（102）的路径插入。插管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。插管（20）通常具有用于接收封闭器（30）或扩张器（104）的开放近端，以及用于将神经活性因子递送至治疗部位（12）的开口远端，优选地为锥形末端。然后将塞子（30）从插管（20）中取出，并且将包含生物活性物质的生物相容性系留载体（40）沿通道插入插管中。推动器可以插入插管内，在车辆（40）后面，以将车辆的近端定位在套管（20b）的近端处。一旦车辆（40）定位在套管（20）的近端附近，则套管从通道中移开，随后是推动器，使车辆（40）位于治疗部位（12）处。

17. 发明授权

US5834001A Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core 失效
标题翻译：制备具有生物相容性护套和生物相容性基质芯的免疫隔离植入式车辆的方法
公开(公告)号：US5834001A
公开(公告)日：1998-11-10
申请号：US449214
申请日：1995-05-24
申请人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Sharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
发明人： Keith E. Dionne , Dwaine F. Emerich , Diane Hoffman , Paul R. Sanberg , Lisa Christenson , Orion D. Hegre , David W. Sharp , Paul E. Lacy , Patrick Aebischer , Alfred V. Vasconcellos , Michael J. Lysaght , Frank T. Gentile
IPC分类号： A61F2/02 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/18 , A61K39/395 , A61K47/36 , A61K48/00 , A61L27/00 , C12N5/00 , C12N5/071 , C12N5/077 , A61K9/14
CPC分类号： A61K9/0092 , A61K35/12 , A61K35/30 , A61K35/39 , A61K38/185 , A61K48/00 , A61K9/0024 , A61K9/4816 , C12N5/0012 , C12N5/0062 , C12N5/0614 , C12N5/0656 , C12N5/0677 , A61K2035/126 , A61K2035/128 , C12N2510/02 , Y10S514/814 , Y10S514/866
摘要： A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 .mu.l and at least 10.sup.4 cells capable of secreting a biocompatible matrix comprising a hydrogel or extracellular matrix, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product or said function.
摘要翻译：公开了一种形成可植入和可回收的免疫隔离载体的方法，所述方法包括以下步骤：首先形成生物相容性热塑性或水凝胶的护套，然后用包含至少1μl体积和至少104 能够分泌包含水凝胶或细胞外基质的生物相容性基质的细胞，所述护套具有分子量截留允许分子跨越其通过以提供所述生物活性产物或所述功能。

18. 发明授权

US5024613A Blood recovery system and method 失效
标题翻译：血液回收系统及方法
公开(公告)号：US5024613A
公开(公告)日：1991-06-18
申请号：US515397
申请日：1990-04-27
申请人： Alfred V. Vasconcellos , Preston J. Keeler, III
发明人： Alfred V. Vasconcellos , Preston J. Keeler, III
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/3627 , A61M1/0005
摘要： An intraoperative blood recovery system and method for salvaging operative blood while simultaneously delivering previously collected blood to a reinfusion system. A blood collection and transfer reservoir, having multiple compartments which can be separated by vacuum or pressure barriers, is designed to maintain a continuous suction for blood inflow while blood previously collected can be simultaneously transported through the reservoir to achieve the uninterrupted flow of blood into and delivery of blood out of the reservoir.
摘要翻译：一种术中血液回收系统和方法，用于回收手术血液，同时将以前收集的血液输送到再灌注系统。设有具有可被真空或压力屏障隔开的多个隔间的血液采集和转运储存器被设计成保持血液流入的连续抽吸，同时先前收集的血液可以同时传送通过储存器，以实现血液不间断流入和将血液送出水库。

19. 发明授权

US4907591A Surgical instrument for establishing compression anastomosis 失效
标题翻译：手术器械用于建立压缩吻合
公开(公告)号：US4907591A
公开(公告)日：1990-03-13
申请号：US174570
申请日：1988-03-29
申请人： Alfred V. Vasconcellos , Ionel E. Teodorescu , Joel W. Cummings , Dean E. McBeth
发明人： Alfred V. Vasconcellos , Ionel E. Teodorescu , Joel W. Cummings , Dean E. McBeth
IPC分类号： A61B17/11 , A61B17/115
CPC分类号： A61B17/115 , A61B17/1155
摘要： A surgical instrument for installing a plurality of interlocking coupling members forming a compression anastomosis assembly, particularly suitable for use in achieving anastomosis of a resected tubular organ, with the instrument having a cutting portion designed and configured for rotational movement as the cutter advances to perform its intended functions of severing tissue and at least a portion of one of the members of the assembly. Also disclosed is a dual locking feature for alternately locking a driving component and an aligning component against movement where, in a first mode, the aligning component is operative when the driving component is locked and, in a second mode, the driving component is operative when the aligning component is locked. Additionally disclosed is a unique aligning component for aligning and exerting a compressive force on members of an associated coupling assembly. Lastly, there is disclosed a surgical instrument capable of assuming a variety of configurations to accommodate a number of anatomical orientations and operating situations.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式