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11. 发明申请

US20070044810A1 Method of enhanced drug application 审中-公开
标题翻译：增强药物应用的方法
公开(公告)号：US20070044810A1
公开(公告)日：2007-03-01
申请号：US11476954
申请日：2006-06-28
申请人： Jose Ramirez , Joseph Faryniarz
发明人： Jose Ramirez , Joseph Faryniarz
IPC分类号： A61B19/00
CPC分类号： A61K9/0014 , A61K9/7015
摘要： Methods of treating skin in need thereof are disclosed including applying a drug or active agent or formulation thereof to the skin of a user and applying a sealer thereto. The methods are useful in actively enhancing penetration of the actives immediately upon application to skin, sealing the skin surface to prevent removal of the drug or active agent, holding the drug or active agent in a reservoir film, and/or enhancing long term penetration of the drug or active agent.
摘要翻译：公开了治疗有需要的皮肤的方法，包括将药物或活性剂或其制剂施用于使用者的皮肤并向其施加密封剂。所述方法可用于在施用于皮肤时立即积极增强活性物质的渗透，密封皮肤表面以防止药物或活性剂的除去，将药物或活性剂保持在储存器膜中和/或增强长期渗透药物或活性剂。

12. 发明申请

US20060204530A1 Benzoyl peroxide compositions and methods of use 审中-公开
标题翻译：过氧化苯甲酰组合物及其使用方法
公开(公告)号：US20060204530A1
公开(公告)日：2006-09-14
申请号：US11373538
申请日：2006-03-10
申请人： Jose Ramirez , Joseph Faryniarz
发明人： Jose Ramirez , Joseph Faryniarz
IPC分类号： A61K8/35 , A61K8/36 , A61K31/192
CPC分类号： A61K8/38 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/368 , A61K8/37 , A61K31/192 , A61K2800/522 , A61Q19/00
摘要： Solutions of benzoyl peroxide, in one or more solvents are provided that are suitable for direct topical application to the skin of a user or can be formulated into a product that is suitable for topical application to the skin of a user. In embodiments, the solutions include benzoyl peroxide and optionally additional active or inactive ingredients, and a solvent or mixture of solvents in which the benzoyl peroxide is prepared as a clear solution at 25° C. Methods of using the solutions are also described. Product formulations such as emulsion are also described. The solutions and product formulations can increase the efficacy and percutaneous absorption of benzoyl peroxide.
摘要翻译：提供了在一种或多种溶剂中的过氧化苯甲酰溶液，其适于直接局部施用于使用者的皮肤，或者可以配制成适合于局部施用于使用者皮肤的产品。在实施方案中，溶液包括过氧化苯甲酰和任选的另外的活性或非活性成分，以及在25℃下制备澄清溶液中的过氧化苯甲酰的溶剂或溶剂混合物。还描述了使用溶液的方法。还描述了产品配方如乳液。溶液和产品制剂可以增加过氧化苯甲酰的功效和经皮吸收。

13. 发明授权

US09116112B2 UV protective skin treatment compositions and screening methods 有权
标题翻译：紫外线防护皮肤治疗组合物和筛选方法
公开(公告)号：US09116112B2
公开(公告)日：2015-08-25
申请号：US13544206
申请日：2012-07-09
申请人： Jose E. Ramirez
发明人： Jose E. Ramirez
IPC分类号： A61K8/34 , A61Q17/04 , A61Q19/00 , G01N27/26 , A61K8/49 , A61Q19/02 , A61K8/60 , A61K8/69
CPC分类号： A61K8/4913 , A61K8/347 , A61K8/4953 , A61K8/498 , A61K8/602 , A61K8/69 , A61K31/40 , A61K2800/522 , A61K2800/592 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/02 , G01N27/26
摘要： Methods of screening antioxidants for skin protective capacity and antioxidant formulations which protect the skin from UV radiation are disclosed, including using the Briggs-Rauscher Oxidant Method method to one or more antioxidants for predicting protection to the epidermal layer. One antioxidant formulation for use in sunscreens, lip-balms and other types of skincare products for protecting the skin from UV radiation includes a mixture of antioxidants in the skincare product including an effective amount of arbutin in combination with BHT, wherein the ratio of arbutin to BHT ranges from 1:4 to 4:1, and wherein the measured BROM value of the antioxidant mixture is greater than the sum of the BROM values of the individual antioxidants in the mixture at the same concentration. The measured BROM value of the resultant product is greater than or equal to 0.2 sec/μg. The antioxidant formulation may also optionally include hydroquinone, resveratrol, uric acid and/or atorvastatin.
摘要翻译：公开了用于保护皮肤保护能力的抗氧化剂和保护皮肤免受紫外线辐射的抗氧化剂制剂的方法，包括使用Briggs-Rauscher Oxidant Method方法将一种或多种抗氧化剂预防对表皮层的保护。一种用于防晒霜，唇膏和其它类型护肤产品的用于保护皮肤免受紫外线辐射的抗氧化剂配方包括护肤品中的抗氧化剂混合物，包括有效量的熊果苷与BHT的组合，其中熊果苷与 BHT范围为1:4至4:1，并且其中抗氧化剂混合物的测量BROM值大于混合物中相同浓度的各抗氧化剂的BROM值的总和。所得产物的测量BROM值大于或等于0.2秒/μg。抗氧化剂制剂还可以任选地包括氢醌，白藜芦醇，尿酸和/或阿托伐他汀。

14. 发明申请

US20130039869A1 ROSACEA TREATMENTS AND KITS FOR PERFORMING THEM 有权
标题翻译： ROSACEA治疗及其实施的工具
公开(公告)号：US20130039869A1
公开(公告)日：2013-02-14
申请号：US13368915
申请日：2012-02-08
申请人： Jose E. Ramirez , Hovig Ounanian
发明人： Jose E. Ramirez , Hovig Ounanian
IPC分类号： A61K8/67 , A61P17/00 , A61P17/10 , A61K31/7048 , A61K31/60 , A61P33/00 , A61K31/65 , A61K31/7056 , A61K31/315 , A61Q17/04
CPC分类号： A61K9/0014 , A61K8/18 , A61K8/27 , A61K8/362 , A61K8/368 , A61K8/38 , A61K8/4913 , A61K8/67 , A61K8/671 , A61K31/07 , A61K31/203 , A61K31/222 , A61K31/30 , A61K31/315 , A61K31/327 , A61K31/4164 , A61K31/4168 , A61K31/59 , A61K31/60 , A61K33/30 , A61K33/34 , A61K45/06 , A61K2800/88 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/10 , A61K2300/00
摘要： Regimen for the treatment of rosacea include the application of an anti-redness composition to at least a portion of the cleansed area of skin afflicted with rosacea. The regimen may include the application of one or more of a polymetal complex, a composition containing metronidazole, and/or a protective composition. Kits containing components useful in performing such regimens are also described.
摘要翻译：用于治疗红斑痤疮的方案包括将抗发红组合物应用于患有红斑痤疮的皮肤清洁区域的至少一部分。该方案可以包括施用一种或多种多金属络合物，含有甲硝唑的组合物和/或保护性组合物。还描述了含有用于实施这种方案的组分的试剂盒。

15. 发明授权

US08273791B2 Compositions, kits and regimens for the treatment of skin, especially décolletage 有权
标题翻译：用于治疗皮肤的组合物，成套工具和方案，特别是décolletage
公开(公告)号：US08273791B2
公开(公告)日：2012-09-25
申请号：US12331781
申请日：2008-12-10
申请人： José E. Ramirez , Joseph R. Faryniarz
发明人： José E. Ramirez , Joseph R. Faryniarz
IPC分类号： A01N55/02
CPC分类号： A61K8/19 , A61K8/27 , A61K8/362 , A61K8/602 , A61K8/671 , A61K2800/88 , A61Q19/02 , A61Q19/08
摘要： Compositions, kits and regimens for treatment of damaged skin, especially décolletage, include application of a retinoid, hydroquinone or hydroquinone derivatives, and a composition containing a multi-metal complex.
摘要翻译：用于治疗受损皮肤，特别是耐药性的组合物，试剂盒和方案包括应用类视色素，氢醌或氢醌衍生物，以及含有多金属络合物的组合物。

16. 发明授权

US07897800B2 Chemical compositions and methods of making them 有权
标题翻译：化学成分及其制备方法
公开(公告)号：US07897800B2
公开(公告)日：2011-03-01
申请号：US11668020
申请日：2007-01-29
申请人： José E. Ramirez , Joseph Faryniarz
发明人： José E. Ramirez , Joseph Faryniarz
IPC分类号： C07F1/08
CPC分类号： C07C55/02 , C07C55/07 , C07C55/08 , C07C55/10 , C07C55/14 , C07C55/18 , C07C55/20 , C07C55/21 , C07C57/13 , C07C57/145 , C07C57/15 , C07C57/155 , C07C61/09 , C07C63/15 , C07C63/20 , C07C63/24 , C07C63/28 , C07C229/76
摘要： Reaction products of polyfunctional compounds with two or more coordination elements are described.
摘要翻译：描述了具有两个或更多个配位元素的多官能化合物的反应产物。

17. 发明申请

US20110008271A1 ROSACEA TREATMENTS USING POLYMETAL COMPLEXES 审中-公开
标题翻译：使用聚合物复合物的ROSACEA处理
公开(公告)号：US20110008271A1
公开(公告)日：2011-01-13
申请号：US12831424
申请日：2010-07-07
申请人： Hovig Ounanian , José E. Ramirez , Joseph R. Faryniarz
发明人： Hovig Ounanian , José E. Ramirez , Joseph R. Faryniarz
IPC分类号： A61K8/18 , A61K33/30 , A61K31/59 , A61K31/415 , A61K31/315 , A61Q17/04
CPC分类号： A61K8/67 , A61K8/27 , A61K8/362 , A61K8/671 , A61K31/07 , A61K31/235 , A61K31/315 , A61K31/415 , A61K31/4164 , A61K31/59 , A61K31/60 , A61K33/30 , A61K45/06 , A61K2800/88 , A61K2800/884 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K2300/00
摘要： Described herein are novel methods for the treatment of rosacea which include the step of applying of a composition containing a polymetal complex to an area of the skin afflicted with rosacea and novel regimens using such compounds.
摘要翻译：本文描述了用于治疗红斑痤疮的新方法，其包括将含有多金属配合物的组合物施用于患有红斑痤疮的皮肤区域和使用这些化合物的新方案的步骤。

18. 发明授权

US07867522B2 Method of wound/burn healing using copper-zinc compositions 有权
标题翻译：使用铜锌组合物的伤口/烧伤愈合方法
公开(公告)号：US07867522B2
公开(公告)日：2011-01-11
申请号：US11648278
申请日：2006-12-29
申请人： Joseph R. Faryniarz , Jose E. Ramirez
发明人： Joseph R. Faryniarz , Jose E. Ramirez
IPC分类号： A01N59/00 , A01N59/20 , A01N59/16 , A61K33/00 , A61K33/34 , A61K33/32
CPC分类号： A61K31/315 , A61K31/30 , A61K33/30 , A61K33/34 , A61K45/06 , A61K2300/00
摘要： Composition and methods for alleviating or eliminating wounds and/burns by providing an effective amount of one or more copper, zinc and copper-zinc compositions are disclosed. Treatment is accomplished through the use of topical compositions containing one or more copper or zinc salts and/or copper-zinc compounds or complexes, particularly copper-zinc malonate active ingredient.
摘要翻译：公开了通过提供有效量的一种或多种铜，锌和铜 - 锌组合物来减轻或消除伤口和/或烧伤的组合物和方法。通过使用含有一种或多种铜或锌盐和/或铜 - 锌化合物或复合物，特别是丙酮酸铜 - 锌的活性成分的局部组合物来实现治疗。

19. 发明申请

US20060202160A1 Stable organic peroxide compositions 有权
标题翻译：稳定的有机过氧化物组合物
公开(公告)号：US20060202160A1
公开(公告)日：2006-09-14
申请号：US11372958
申请日：2006-03-10
申请人： Joseph Faryniarz , Jose Ramirez
发明人： Joseph Faryniarz , Jose Ramirez
IPC分类号： C11D3/39
CPC分类号： A61K8/38 , A61K8/22 , A61K8/347 , A61K8/37 , A61K8/676 , A61K8/678 , A61K9/0014 , A61K47/10 , A61K47/22 , A61K47/26 , A61K2800/522 , A61Q5/08 , A61Q19/00 , C11D3/0084 , C11D3/2034 , C11D3/2058 , C11D3/2068 , C11D3/2096 , C11D3/3945 , Y10S514/846 , Y10S514/859 , Y10S514/937 , Y10S514/938
摘要： Organic peroxide compositions are stabilized against decomposition by the use of antioxidants, resulting in increased shelf life of products made using the compositions.
摘要翻译：有机过氧化物组合物通过使用抗氧化剂而稳定化以防分解，导致使用该组合物制备的产品的保质期延长。

20. 发明授权

US09737468B2 UV protective skin treatment compositions and screening methods 有权
公开(公告)号：US09737468B2
公开(公告)日：2017-08-22
申请号：US14818791
申请日：2015-08-05
申请人： JR Chem LLC
发明人： Jose E. Ramirez
IPC分类号： A61K31/40 , A61K8/34 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61K8/60 , A61K8/69 , G01N27/26
CPC分类号： A61K8/4913 , A61K8/347 , A61K8/4953 , A61K8/498 , A61K8/602 , A61K8/69 , A61K31/40 , A61K2800/522 , A61K2800/592 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/02 , G01N27/26
摘要： Provided are methods of screening antioxidants for skin protective capacity and antioxidant formulations which protect the skin from UV radiation. The method of screening antioxidants for protecting the skin from UV radiation includes using the Briggs-Rauscher Oxidant Method (BROM) method to one or more antioxidants for predicting protection to the epidermal layer. One advantageous antioxidant formulation for use in sun screens, lip balms and other types of topically applied skin care products for protecting the skin from UV radiation includes a mixture of antioxidants in the skin care product including an effective amount of arbutin in combination with BHT, wherein the ratio of arbutin to BHT in the skin care product ranges from 1:4 to 4:1, and wherein the measured BROM value of the antioxidant mixture is greater than the sum of the BROM values of the individual antioxidants in the mixture at the same concentration. The measured BROM value of the resultant product is greater than or equal to 0.2 sec/μg. The antioxidant formulation may also optionally include hydroquinone, resveratrol, uric acid and/or atorvastatin.

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