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181. 发明授权

US08377924B2 Protein kinase C inhibitors and uses thereof 有权
公开(公告)号：US08377924B2
公开(公告)日：2013-02-19
申请号：US12691607
申请日：2010-01-21
申请人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
发明人： Rajinder Singh , Huí Li , Haoran Zhao , Rao Kolluri , Kin Tso , John Ramphal , Shihai Gu , Carlos Valdez , Jing Zhang , Emily Stauffer , Matthew Duncton , Salvador Alvarez
IPC分类号： A61K31/55 , A61K31/497 , A61K31/535 , A61K31/505 , C07D403/10 , C07D413/12 , C07D401/12
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

182. 发明授权

US08323635B2 Methods of using interleukin-1 receptor antagonist as a myeloprotective agent 有权
标题翻译：使用白细胞介素-1受体拮抗剂作为骨髓保护剂的方法
公开(公告)号：US08323635B2
公开(公告)日：2012-12-04
申请号：US12740264
申请日：2007-11-14
申请人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
发明人： Wei Han , Jing Zhang , Di Xiang , Shunying Zhu
IPC分类号： A61K45/00 , A61K38/18 , A61K38/16 , C07K14/475
CPC分类号： A61K45/06 , A61K31/255 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/20 , A61K2300/00
摘要： The present invention relates to uses of interleukin-1 receptor antagonist (IL-1Ra) in promoting bone marrow regeneration, increasing peripheral white blood cells, and increasing platelet levels in subjects if administered prior to treatment with chemotherapeutic agents. Thus, particular embodiments of the invention are directed to uses of IL-1Ra as an adjuvant or ancillary therapy to alleviate the hematopoietic toxicities associated with chemotherapy.
摘要翻译：本发明涉及白介素-1受体拮抗剂（IL-1Ra）在促进骨髓再生中的用途，增加外周白细胞，以及在用化学治疗剂治疗前给予受试者血小板水平增加。因此，本发明的具体实施方案涉及IL-1Ra用作佐剂或辅助治疗以减轻与化学疗法相关的造血毒性。

183. 发明申请

US20120294505A1 METHOD FOR DETECTING ANATOMICAL STRUCTURES 有权
标题翻译：检测解剖结构的方法
公开(公告)号：US20120294505A1
公开(公告)日：2012-11-22
申请号：US13487394
申请日：2012-06-04
申请人： Zhimin Huo , Jing Zhang
发明人： Zhimin Huo , Jing Zhang
IPC分类号： G06K9/46
CPC分类号： G06K9/4609 , G06K2209/051 , G06T7/74 , G06T2207/10116 , G06T2207/30061
摘要： A method for estimating the location of an anatomical structure in an x-ray image of a patient obtains the x-ray data in digital format. The method estimates the location of at least a first benchmark feature within the x-ray image according to the obtained digital x-ray data and defines a region of interest within the image according to the estimated location of at least the first benchmark feature. A region of interest for the anatomical structure is searched using a template. The location of the anatomical structure on a display according to the template searching results is highlighted.
摘要翻译：用于估计患者的x射线图像中的解剖结构的位置的方法获得数字格式的X射线数据。该方法根据获得的数字X射线数据估计X射线图像内的至少第一基准特征的位置，并且根据至少第一基准特征的估计位置来定义图像内的感兴趣区域。使用模板搜索解剖结构的感兴趣区域。根据模板搜索结果，解剖结构在显示器上的位置被突出显示。

184. 发明授权

US08288431B2 Substituted spiroindolinones 失效
标题翻译：取代的螺吲哚啉酮
公开(公告)号：US08288431B2
公开(公告)日：2012-10-16
申请号：US13009225
申请日：2011-01-19
申请人： Jin-Jun Liu , Jing Zhang , Zhuming Zhang
发明人： Jin-Jun Liu , Jing Zhang , Zhuming Zhang
IPC分类号： A61K31/4015 , C07D487/10
CPC分类号： C07D487/10
摘要： There is provided a compound of the formula wherein X, Y, W, R1, R2 and R3 are as described herein. The compounds have activity as anticancer agents.
摘要翻译：提供下式的化合物其中X，Y，W，R 1，R 2和R 3如本文所述。该化合物具有作为抗癌剂的活性。

185. 发明申请

US20120256213A1 LED STRUCTURE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译： LED结构及其制造方法
公开(公告)号：US20120256213A1
公开(公告)日：2012-10-11
申请号：US13128102
申请日：2011-04-14
申请人： Kuangyao Chang , Chechang Hu , Jing Zhang
发明人： Kuangyao Chang , Chechang Hu , Jing Zhang
IPC分类号： H01L33/50 , H01L33/48
CPC分类号： H01L33/54 , H01L2224/48091 , H01L2224/48247 , H01L2933/005 , H01L2924/00014
摘要： The present invention discloses an LED structure and a manufacturing method thereof. The LED structure has a housing, an LED chip and a transparent encapsulant. The housing has a recess and at least one protruded wall. The LED chip is received in the recess. The transparent encapsulant is formed by dispensing a molding compound into the recess by an adhesive dispenser. The transparent encapsulant has an edge matched with an edge of the recess to encapsulate the LED chip in the recess, and has a height smaller than that of the protruded wall. The LED chip of the LED structure of the present invention can emit light through the spherical surface of the transparent encapsulant based on a greater visual angle, and thus enhance the light extraction efficiency.
摘要翻译：本发明公开了一种LED结构及其制造方法。 LED结构具有壳体，LED芯片和透明密封剂。壳体具有凹部和至少一个突出的壁。 LED芯片被容纳在凹槽中。透明密封剂通过用粘合剂分配器将模塑料分配到凹槽中而形成。透明密封剂具有与凹部的边缘匹配的边缘，以将LED芯片封装在凹部中，并且具有比突出壁的高度更小的高度。本发明的LED结构的LED芯片可以基于更大的视角通过透明密封剂的球面发光，从而提高光提取效率。

186. 发明授权

US08267159B2 Thermal module 有权
标题翻译：散热模块
公开(公告)号：US08267159B2
公开(公告)日：2012-09-18
申请号：US12758740
申请日：2010-04-12
申请人： Jian Yang , Jing Zhang
发明人： Jian Yang , Jing Zhang
IPC分类号： F28F7/00 , H05K7/20
CPC分类号： F28D15/04 , G06F1/20
摘要： An exemplary thermal module includes a heat absorbing member, a heat sink, a heat conducting member connecting the heat absorbing member with the heat sink, and centrifugal fan. The heat absorbing member has four fixing portions for fixing the thermal module. The heat sink includes a base and a fin assembly disposed on the base. The centrifugal fan includes a housing defining a lateral air outlet therein and an impeller rotatably received in the housing. The housing engages with the engaging portion and is detachably mounted to the heat absorbing member, with the air outlet facing the fin assembly. One of the fixing portions of heat absorbing member is shaded by the housing. The housing and the engaging portion cooperatively provide a sliding mechanism therebetween to allow the centrifugal blower to be slidable relative to the base after the lateral side of the housing detached from the heat absorbing member.
摘要翻译：示例性的热模块包括吸热构件，散热器，将吸热构件与散热器连接的导热构件和离心式风扇。吸热构件具有用于固定热模块的四个固定部分。散热器包括设置在基座上的底座和翅片组件。离心风扇包括限定其中的侧向空气出口的壳体和可旋转地容纳在壳体中的叶轮。壳体与接合部分接合并且可拆卸地安装到吸热构件，空气出口面向翅片组件。吸热构件的一个固定部分被壳体遮蔽。壳体和接合部分协同地在其之间提供滑动机构，以允许离心鼓风机在壳体的侧面从吸热构件分离之后相对于基座滑动。

187. 发明授权

US08168636B2 Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors 有权
标题翻译：可用作Axl抑制剂的多环杂芳基取代的三唑
公开(公告)号：US08168636B2
公开(公告)日：2012-05-01
申请号：US12986951
申请日：2011-01-07
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Thilo J. Heckrodt , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/502 , C07D237/26
CPC分类号： C07D401/14 , A61K31/502 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D491/20 , C07D495/04 , C07D519/00
摘要： Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译：公开了多环杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。

188. 发明授权

US08119278B2 Flexible thin printed battery and device and method of manufacturing same 有权
标题翻译：柔性薄型印刷电池及其制造方法
公开(公告)号：US08119278B2
公开(公告)日：2012-02-21
申请号：US13185048
申请日：2011-07-18
申请人： John C. Bailey , Abdelkader Hilmi , Mark A. Schubert , Jing Zhang , Guanghong Zheng
发明人： John C. Bailey , Abdelkader Hilmi , Mark A. Schubert , Jing Zhang , Guanghong Zheng
IPC分类号： H01M6/40 , H01M6/46 , H01M6/12 , H01M4/42
CPC分类号： H01M6/12 , H01M2/0257 , H01M2/0275 , H01M2/0277 , H01M2/1653 , H01M2/18 , H01M4/0404 , H01M4/0414 , H01M4/06 , H01M4/08 , H01M4/244 , H01M4/26 , H01M4/50 , H01M4/62 , H01M4/623 , H01M4/625 , H01M4/663 , H01M4/667 , H01M6/045 , H01M6/22 , H01M6/40 , H01M2004/021 , H01M2004/027 , H01M2004/028 , H01M2300/0002 , H01M2300/0014 , H01M2300/0085 , Y10T29/49108 , Y10T29/4911 , Y10T29/49114 , Y10T29/49115
摘要： A flat, flexible electrochemical cell is provided. The within invention describes various aspects of the flat, flexible electrochemical cell. A printed anode is provided that obviates the need for a discrete anode current collector, thereby reducing the size of the battery. An advantageous electrolyte is provided that enables the use of a metallic cathode current collector, thereby improving the performance of the battery. Printable gelled electrolytes and separators are provided, enabling the construction of both co-facial and co-planar batteries. Cell contacts are provided that reduce the potential for electrolyte creepage in the flat, flexible electrochemical cells of the within invention.
摘要翻译：提供一种扁平，柔性的电化学电池。本发明描述了扁平的柔性电化学电池的各个方面。提供了一种印刷阳极，其不需要离散的阳极集电器，从而减小了电池的尺寸。提供了一种有利的电解质，其能够使用金属阴极集电器，从而提高电池的性能。提供可印刷胶凝电解质和分离器，能够构建共面和共面电池。提供了电池触点，其减少了在本发明的平坦，柔性的电化学电池中的电解质蠕变的潜力。

189. 发明授权

US08073229B2 Image analysis of tube tip positioning 有权
标题翻译：管尖定位图像分析
公开(公告)号：US08073229B2
公开(公告)日：2011-12-06
申请号：US11942021
申请日：2007-11-19
申请人： Zhimin Huo , Jing Zhang , Minjie Chen
发明人： Zhimin Huo , Jing Zhang , Minjie Chen
IPC分类号： G06K9/00
CPC分类号： G06T7/77 , A61B6/12 , G06T7/74 , G06T2207/10116 , G06T2207/30061
摘要： A method for processing a radiographic image of a patient obtains radiographic image data and detects the position of inserted tubing or other foreign object in the obtained image and determines the tubing tip or object location. A region of interest in the neighborhood of the tubing tip or object location is defined and at least one anatomy structure within the region of interest is detected. The probability for mal-positioning of the tip or object is calculated by determining the position of the tip or object relative to the at least one anatomy structure.
摘要翻译：用于处理患者的放射线照相图像的方法获得放射线照相图像数据并且检测所获得的图像中插入的管道或其他异物的位置并确定管道尖端或物体位置。定义管尖或物体位置附近的感兴趣区域，并且检测感兴趣区域内的至少一个解剖结构。通过确定尖端或物体相对于至少一个解剖结构的位置来计算尖端或物体的错误定位的概率。

190. 发明申请

US20110281846A1 BRIDGED BICYCLIC ARYL AND BRIDGED BICYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS 有权
标题翻译：桥双环芳基和桥双环杂芳基取代三唑有用AS AXL抑制剂
公开(公告)号：US20110281846A1
公开(公告)日：2011-11-17
申请号：US13191252
申请日：2011-07-26
申请人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Joane Litvak
发明人： Dane Goff , Jing Zhang , Rajinder Singh , Sacha Holland , Jiaxin Yu , Pingyu Ding , Joane Litvak
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/502 , A61K31/497 , A61K31/496 , A61K31/519 , A61K31/439 , A61P35/02 , A61P19/02 , A61P17/06 , A61P27/02 , A61P3/10 , A61P13/12 , A61P19/10 , A61P9/00 , A61P27/12 , A61P35/00 , A61K31/5513
CPC分类号： C07D495/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D409/14 , C07D453/06 , C07D471/18
摘要： Bridged bicyclic aryl or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
摘要翻译：公开了桥连双环芳基或杂芳基取代的三唑和含有这些化合物的药物组合物可用于抑制受体蛋白酪氨酸激酶Ax1的活性。还公开了使用该化合物治疗与Axl活性相关的疾病或病症的方法。

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