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151. 发明申请

US20120184520A1 GLYCINE COMPOUND 有权
标题翻译：甘氨酸化合物
公开(公告)号：US20120184520A1
公开(公告)日：2012-07-19
申请号：US13394505
申请日：2010-09-15
申请人： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
发明人： Kousei Yoshihara , Daisuke Suzuki , Susumu Yamaki , Yuji Koga , Norio Seki , Jiro Fujiyasu , Masahiro Neya
IPC分类号： A61K31/506 , C07D401/14 , A61K31/4545 , C07D403/14 , C07C237/06 , A61K31/167 , C07C275/40 , A61K31/17 , C07D309/06 , A61K31/351 , A61K31/24 , C07D213/82 , A61K31/455 , C07D413/12 , A61K31/5377 , C07D413/14 , C07D401/12 , C07D413/04 , A61K31/551 , C07D295/215 , A61K31/495 , C07D417/04 , A61K31/541 , C07D223/04 , A61K31/55 , C07D223/12 , C07D267/10 , A61K31/553 , A61P3/10 , A61P9/12 , A61P29/00 , A61P19/06 , A61P19/02 , A61P17/02 , A61P25/28 , A61P9/10 , A61P11/06 , A61P11/00 , A61P1/00 , A61P17/00 , A61P17/06 , A61P9/00 , A61P1/16 , C07D403/04
CPC分类号： C07D401/06 , C07C237/06 , C07C237/08 , C07C237/10 , C07C237/12 , C07C237/42 , C07C255/60 , C07C271/28 , C07C275/40 , C07C311/05 , C07C311/21 , C07C311/46 , C07C317/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
摘要： [Problem]The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases.[Means for Solution]The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that a compound of the present invention or a salt thereof exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. The present invention further relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound of the present invention or a salt thereof, and an excipient.
摘要翻译： [问题]本发明提供了作为药物组合物的活性成分，特别是用于预防和/或治疗VAP-1相关疾病的药物组合物有用的化合物。 [解决方案]本发明人对具有VAP-1抑制活性的化合物进行了深入研究，结果发现本发明的化合物或其盐表现出优异的VAP-1抑制活性并且可用于预防和/或治疗VAP-1相关疾病，特别是糖尿病性肾病或糖尿病性黄斑水肿，从而完成本发明。本发明还涉及包含本发明化合物或其盐和赋形剂的药物组合物，特别是用于预防和/或治疗VAP-1相关疾病的药物组合物。

152. 发明授权

US08133882B2 Quinolone derivative or pharmaceutically acceptable salt thereof 失效
标题翻译：喹诺酮衍生物或其药学上可接受的盐
公开(公告)号：US08133882B2
公开(公告)日：2012-03-13
申请号：US12293055
申请日：2007-03-14
申请人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
发明人： Yuji Koga , Takao Okuda , Susumu Watanuki , Takashi Kamikubo , Fukushi Hirayama , Hiroyuki Moritomo , Jiro Fujiyasu , Michihito Kageyama , Toshio Uemura , Jun Takasaki
IPC分类号： A61K31/675 , A61K31/47 , C07D215/22 , C07F9/60
CPC分类号： C07D513/04 , C07D215/22 , C07D215/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07F7/1804 , C07F9/60
摘要： Provided are quinolone derivatives having a lower alkyl or cycloalkyl at the 1-position; —N(R0)C(O)-lower alkylene-CO2R0, lower alkylene-CO2R0, lower alkenylene-CO2R0, —O-lower alkylene-CO2R0, —O-(lower alkylene which may be substituted with —CO2R0)-aryl or —O-lower alkenylene-CO2R0 (wherein R0 is H or lower alkyl) at the 3-position; halogen at the 6-position; and amino group substituted with a substituent group having a ring structure at the 7-position, respectively, or pharmaceutically acceptable salts thereof. Pharmaceutical composition containing the quinolone derivatives and methods of using the compositions are provided.
摘要翻译：提供在1-位具有低级烷基或环烷基的喹诺酮衍生物; -N（R 0）C（O） - 低级亚烷基-CO 2 R 0，低级亚烷基-CO 2 R 0，低级亚烯基-CO 2 R O，-O-低级亚烷基-CO 2 R O，-O-（可被-CO 2 R 0取代的低级亚烷基） - 芳基或 O-低级亚烯基-CO 2 R 0（其中R 0是H或低级烷基）在3-位; 6位卤素; 分别被具有7-位上的环结构的取代基取代的氨基或其药学上可接受的盐。提供了含有喹诺酮衍生物的药物组合物和使用该组合物的方法。

153. 发明申请

US20100245449A1 IMAGE RECORDING APPARATUS 有权
标题翻译：图像记录装置
公开(公告)号：US20100245449A1
公开(公告)日：2010-09-30
申请号：US12726859
申请日：2010-03-18
申请人： Yuji Koga , Naohisa Kinoshita , Shingo Ito
发明人： Yuji Koga , Naohisa Kinoshita , Shingo Ito
IPC分类号： B41J29/38 , B65H5/06 , B65H9/00 , B65H7/02
CPC分类号： H04N1/00567 , H04N1/00588 , H04N1/00591 , H04N1/00602 , H04N1/00615 , H04N1/00623 , H04N1/0473 , H04N1/121 , H04N1/1911 , H04N2201/0471 , H04N2201/04725 , H04N2201/04731 , H04N2201/04732 , H04N2201/04734 , H04N2201/04739 , H04N2201/04756 , H04N2201/04791 , H04N2201/04793
摘要： An image recording apparatus includes a conveyance roller which conveys the recording medium, a drive source for rotating the conveyance roller, a print head and a carriage mounted with the print head. The carriage includes an abutment portion. The image recording apparatus further includes a carriage position detector which detects a position of the carriage in a movement direction of the carriage and still further includes a rotating body which rotates in synchronization with the conveyance roller. The rotating body includes a reference portion which protrudes or depresses in the movement direction at a predetermined rotation phase of the rotating body and abut with the reference portion. Moreover, the image recording apparatus includes an origin determination section which, based on a result of the detection by the carriage position detector, determines an origin position of a rotation phase of the conveyance roller.
摘要翻译：图像记录装置包括传送记录介质的传送辊，用于旋转传送辊的驱动源，打印头和安装有打印头的滑架。托架包括邻接部分。图像记录装置还包括滑架位置检测器，其检测托架在托架运动方向上的位置，并且还包括与输送辊同步旋转的旋转体。旋转体包括基准部，该参考部在旋转体的规定的旋转相位沿移动方向突出或按压，并与基准部抵接。此外，图像记录装置包括原点确定部分，其基于滑架位置检测器的检测结果确定输送辊的旋转相位的原点位置。

154. 发明授权

US07786106B2 Substituted benzene derivatives or salts thereof 失效
标题翻译：取代的苯衍生物或其盐
公开(公告)号：US07786106B2
公开(公告)日：2010-08-31
申请号：US12356376
申请日：2009-01-20
申请人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
发明人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
IPC分类号： A61K31/551 , C07D243/08
CPC分类号： C07D401/12 , C07D211/26 , C07D401/14 , C07H15/203 , C07H15/26
摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl) carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.
摘要翻译：提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6' - （b-）-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （ -2'-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。

155. 发明授权

US07690645B2 Sheet supplying apparatus 有权
标题翻译：供纸装置
公开(公告)号：US07690645B2
公开(公告)日：2010-04-06
申请号：US11339663
申请日：2006-01-26
申请人： Yuji Koga
发明人： Yuji Koga
IPC分类号： B65H3/34
CPC分类号： B41J13/103 , B65H1/266 , B65H3/56 , B65H2404/54 , B65H2405/1136 , B65H2405/141
摘要： A sheet supplying apparatus, including a sheet holder which accommodates recording sheets stacked on each other; a feeding device which feeds an uppermost one of the stacked sheets in a sheet-feed direction; an inclined guide plate which is provided downstream of the sheet holder in the sheet-feed direction, wherein the inclined guide plate has a sheet-guide surface which guides a movement of each sheet while changing a direction of the movement thereof; a sheet-separate body with which the sheet feeding device cooperates to separate and feed the sheets, one by one, wherein the sheet-separate body is supported by the inclined guide plate, and includes sheet-separate portions which are arranged in the sheet-feed direction and which project from respective portions of the sheet-guide surface; and a projecting portion which is supported by the inclined guide plate, at a position distant from the sheet-separate body in a widthwise direction of the sheet holder, and which has a curved surface projecting from the sheet-guide surface.
摘要翻译：一种片材供应装置，包括容纳彼此堆叠的记录片材的片材保持器; 馈送装置，其在片材进给方向上馈送最上面的堆叠片材; 倾斜导向板，其设置在纸张保持器的纸张供给方向的下游，其中，倾斜导向板具有引导每个纸张的移动同时改变其移动方向的纸张引导表面; 片材分离体，其中片材进给装置与之一体地分离和供给片材，其中片材分离体由倾斜导向板支撑，并且包括布置在片材分离体中的片材分离部分，进给方向，并且从片材引导表面的各个部分突出; 以及突出部，其在所述片保持器的宽度方向上离开所述片分离体的位置处被所述倾斜导板支撑，并且具有从所述片材引导面突出的弯曲表面。

156. 发明授权

US07654515B2 Image forming device with two attached cassettes and one transportation device 有权
标题翻译：图像形成装置，带有两个连接盒和一个运输装置
公开(公告)号：US07654515B2
公开(公告)日：2010-02-02
申请号：US11564317
申请日：2006-11-29
申请人： Yuji Koga
发明人： Yuji Koga
IPC分类号： B65H3/44
CPC分类号： B65H3/44 , B65H1/266 , B65H3/0684 , B65H2301/423245 , B65H2402/31 , B65H2402/46 , B65H2405/115 , B65H2405/31 , B65H2405/324 , B65H2405/332
摘要： An image forming device is provided with a device main body, a first cassette, a second cassette that is capable of moving between a first position and a second position with respect to the device main body, a transportation device, and a printing device. The transportation device is capable of transporting a print medium housed in the first cassette in a case where the first cassette is positioned at a predetermined position wit respect to the device main body and the second cassette is positioned at the first position. The transportation device is capable of transporting a print medium housed in the second cassette in a case where the second cassette is positioned at the second position. The printing device prints an image on the print medium transported by the transportation device. A part of the second cassette positioned at the first position and/or the second position is positioned outside the device main body.
摘要翻译：图像形成装置设置有装置主体，第一盒，能够相对于装置主体在第一位置和第二位置之间移动的第二盒，输送装置和打印装置。在第一盒位于相对于装置主体的预定位置并且第二盒位于第一位置的情况下，运送装置能够运送容纳在第一盒中的打印介质。在第二盒位于第二位置的情况下，运送装置能够运送容纳在第二盒中的打印介质。打印装置在由运送装置输送的打印介质上打印图像。位于第一位置和/或第二位置的第二盒的一部分位于装置主体的外部。

157. 发明授权

US07618035B2 Image recording apparatus 有权
标题翻译：图像记录装置
公开(公告)号：US07618035B2
公开(公告)日：2009-11-17
申请号：US11964477
申请日：2007-12-26
申请人： Yuji Koga , Keisuke Wakakusa
发明人： Yuji Koga , Keisuke Wakakusa
IPC分类号： B65H3/44
CPC分类号： B65H3/44 , B65H1/266 , B65H2405/31 , B65H2405/3322
摘要： One aspect of the invention provides an image recording apparatus including: an image recording unit; a first sheet feeding cassette; a second sheet feeding cassette including a second placing portion and a discharged sheet placing portion disposed an upstream side of a second placing portion with respect to the first direction; a sheet feed unit configured to feed the recording medium; an auxiliary cover member disposed above the second placing portion; and an auxiliary sheet discharging tray disposed below the discharged sheet placing portion. A sheet insertion opening is formed between an upstream end of the cover member and the discharged sheet placing portion and communicates with the second sheet placing portion. The auxiliary sheet discharging tray is movable in a forward direction and a rearward direction opposite to the forward direction, with respect to the sheet insertion opening.
摘要翻译：本发明的一个方面提供一种图像记录装置，包括：图像记录单元; 第一供纸盒; 第二片材进给盒，包括第二放置部分和排出片材放置部分，其相对于第一方向设置在第二放置部分的上游侧; 配置成供给记录介质的送纸单元; 设置在所述第二放置部分上方的辅助盖部件; 以及设置在排出纸张放置部分下方的辅助纸张排出托盘。在盖构件的上游端和排出片材放置部之间形成有片材插入口，与第二片材放置部连通。辅助片材排出托盘可相对于片材插入口在向前方向和与向前方向相反的向后方向上移动。

158. 发明申请

US20090137498A1 SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF 失效
标题翻译：取代的苯甲酸衍生物或其盐
公开(公告)号：US20090137498A1
公开(公告)日：2009-05-28
申请号：US12356376
申请日：2009-01-20
申请人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
发明人： Tsukasa Ishihara , Fukushi Hirayama , Keizo Sugasawa , Yuji Koga , Takeshi Kadokura , Takeshi Shigenaga
IPC分类号： A61K31/704 , C07D211/26
CPC分类号： C07D401/12 , C07D211/26 , C07D401/14 , C07H15/203 , C07H15/26
摘要： There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4′-bromo-2′-[(5-chloro-2-pyridyl)carbamoyl]-6′-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2′-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4′-bromo-6′-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.
摘要翻译：提供了基于活化凝血因子X的抑制具有抗凝血作用的化合物，并且可用作血栓形成或栓塞引起的疾病的抗凝剂或预防/治疗剂。有效成分是诸如4'-溴-2' - [（5-氯-2-吡啶基）氨基甲酰基] -6'-β-D-吡喃半乳糖氧基-1-异丙基哌啶-4-甲酰苯胺，2' - （2 - 乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基氧基）-4'-溴-6' - [（5-氯-2-吡啶基）氨基甲酰基] -1-异丙基哌啶-4-甲酰苯胺等或其盐。

159. 发明授权

US07488739B2 Quinolone derivative or salt thereof 失效
标题翻译：喹诺酮衍生物或其盐
公开(公告)号：US07488739B2
公开(公告)日：2009-02-10
申请号：US10562128
申请日：2004-07-22
申请人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
发明人： Susumu Watanuki , Yuji Koga , Hiroyuki Moritomo , Issei Tsukamoto , Daisuke Kaga , Takao Okuda , Fukushi Hirayama , Yumiko Moritani , Jun Takasaki
IPC分类号： A61K31/47 , C07D215/233 , C07D237/28 , C07D407/02
CPC分类号： C07D237/28 , A61K31/4709 , A61K31/4725 , C07D215/56 , C07D405/04 , C07F9/5765 , C07F9/60 , C07F9/650947
摘要： A platelet aggregation inhibitor comprising a quinolone derivative or a pharmaceutically acceptable salt thereof as an active ingredient, and a novel quinolone derivative or a pharmaceutically acceptable salt thereof useful as a platelet aggregation inhibitor.
摘要翻译：包含喹诺酮衍生物或其药学上可接受的盐作为活性成分的血小板聚集抑制剂和用作血小板聚集抑制剂的新型喹诺酮衍生物或其药学上可接受的盐。

160. 发明申请

US20080200551A1 Flourene Derivative 审中-公开
标题翻译： Flourene衍生物
公开(公告)号：US20080200551A1
公开(公告)日：2008-08-21
申请号：US10568684
申请日：2005-02-17
申请人： Hiroyoshi Yamada , Hirotsune Itahana , Ayako Moritomo , Takaho Matsuzawa , Koichiro Harada , Jiro Fujiyasu , Yuji Koga , Makoto Oku , Toshio Okazaki , Shinobu Akuzawa , Toshihiro Watanabe
发明人： Hiroyoshi Yamada , Hirotsune Itahana , Ayako Moritomo , Takaho Matsuzawa , Koichiro Harada , Jiro Fujiyasu , Yuji Koga , Makoto Oku , Toshio Okazaki , Shinobu Akuzawa , Toshihiro Watanabe
IPC分类号： A61K31/166 , C07C233/78 , A61P25/06
CPC分类号： C07D311/96 , A61K31/166 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/385 , A61K31/41 , A61K31/4168 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/438 , C07C279/22 , C07D207/20 , C07D209/54 , C07D209/96 , C07D211/70 , C07D221/20 , C07D233/50 , C07D249/14 , C07D257/06 , C07D263/28 , C07D277/18 , C07D303/06 , C07D305/14 , C07D307/94 , C07D309/06 , C07D309/20 , C07D317/12 , C07D319/14 , C07D327/04 , C07D335/04 , C07D339/06
摘要： This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof.The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT2B receptor and 5-HT7 receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT2B receptor and 5-HT7 receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.
摘要翻译：本发明涉及具有胍基等官能团通过羰基与芴结构连接的特征结构的新型芴衍生物或其盐。本发明的化合物具有的优点在于其对5-羟色胺受体亚型具有高亲和力，特别是对于5-HT 2B受体和5-HT 7受体，并且显示出优异的与仅具有5-HT 2B受体和5-HT 7受体的拮抗活性的常规化合物相比，药理作用可用作预防性抗偏头痛药剂安全性高，效果好。

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