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151. 发明申请

US20070054403A1 Method of preventing white blood cell interferences to red blood cell measurements of a blood sample 有权
标题翻译：防止白细胞干扰血液样本红细胞测量的方法
公开(公告)号：US20070054403A1
公开(公告)日：2007-03-08
申请号：US11210346
申请日：2005-08-24
申请人： Min Zheng , Jing Li , Yi Li , Michael Switzer
发明人： Min Zheng , Jing Li , Yi Li , Michael Switzer
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/107497 , Y10T436/25 , Y10T436/25125
摘要： Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are disclosed. The interference to MCV can be prevented by identifying a valley between the red blood cell and white blood cell modes on the red blood cell distribution histogram, defining a red blood cell region using the valley and calculating MCV within the defined region. Alternatively, a curve fit of the white blood cell population on the red blood cell distribution histogram can be used to exclude the white blood cells. RBC can be corrected by subtracting the white blood cell concentration obtained from the analysis of a second aliquot sample, when the white blood cell concentration (WBC) exceeds a predetermined criterion. Hct of the blood sample can be calculated using the obtained MCV and RBC.
摘要翻译：公开了对血液样本的平均细胞体积（MCV），红细胞浓度（RBC）和血细胞比容（Hct）的测量的白细胞干扰的预防和校正方法。通过在红细胞分布直方图上识别红细胞和白细胞模式之间的谷，可以防止对MCV的干扰，使用谷定义红细胞区域并计算定义区域内的MCV。或者，可以使用白细胞群体对红细胞分布直方图的曲线拟合来排除白细胞。当白细胞浓度（WBC）超过预定标准时，可通过减去从第二等份样品的分析获得的白细胞浓度来校正RBC。可以使用获得的MCV和RBC计算血液样品的Hct。

152. 发明申请

US20060194553A1 Systems, methods and apparatus for determining a radiated performance of a wireless device 有权
公开(公告)号：US20060194553A1
公开(公告)日：2006-08-31
申请号：US11258334
申请日：2005-10-24
申请人： Ernest Ozaki , Kenny Fok , Paul Seckendorf , Tia Cassett , Patrick Tierney , Gregory Breit , Jing Li
发明人： Ernest Ozaki , Kenny Fok , Paul Seckendorf , Tia Cassett , Patrick Tierney , Gregory Breit , Jing Li
IPC分类号： H04B17/00
CPC分类号： H04W24/00 , G01R29/10 , H04B17/102 , H04B17/15 , H04B17/29 , H04B17/327
摘要： Systems, methods, apparatus, processors and computer-readable media include a radiated testing module that executes a predetermined radiated performance test on a wireless device. The test dictates various performance-related parameters to measure and log at each of a plurality of predetermined positions. Further, the wireless device receives synchronization information operable to enable synchronization between the logged measurements and each of the positions. The synchronized log allows the wireless device, or another apparatus, to determine a radiated performance characteristic based on a predetermined analysis protocol. Further, the described embodiments allow for the determination of several radiated performance characteristics in a single test, using a single, unaltered wireless device.

153. 发明授权

US07091330B2 Cloning and characterization of a CD2 binding protein (CD2BP2) 失效
公开(公告)号：US07091330B2
公开(公告)日：2006-08-15
申请号：US09873106
申请日：2001-06-01
申请人： Ellis L. Reinherz , Christian Freund , Jing Li , Kazuhisa Nishizawa , Gerhard Wagner
发明人： Ellis L. Reinherz , Christian Freund , Jing Li , Kazuhisa Nishizawa , Gerhard Wagner
IPC分类号： C12P21/02 , C12N15/12
CPC分类号： C07K14/4702 , A61K38/00
摘要： A human CD2 cytoplasmic tail binding protein, CD2BP2, is described, as well as the nucleic acids encoding the protein. Also described are expression vectors and recombinant host cells comprising nucleic acids encoding the CD2BP2 protein, and methods of use for the CD2BP2 protein and nucleic acids encoding the CD2BP2 protein.

154. 发明申请

US20050261262A1 Rifamycin derivatives effective against drug-resistant microbes 有权
标题翻译：对抗耐药性微生物有效的利福霉素衍生物
公开(公告)号：US20050261262A1
公开(公告)日：2005-11-24
申请号：US11034195
申请日：2005-01-12
申请人： Zhenkun Ma , Yafei Jin , Jing Li , Charles Ding , Keith Minor , Jamie Longgood , In Kim , Susan Harran , Keith Combrink , Timothy Morris
发明人： Zhenkun Ma , Yafei Jin , Jing Li , Charles Ding , Keith Minor , Jamie Longgood , In Kim , Susan Harran , Keith Combrink , Timothy Morris
IPC分类号： A61K31/33 , A61K31/395 , C07D491/14 , C07D498/08
CPC分类号： C07D498/00
摘要： Rifamycin derivatives having antimicrobial activities, including activities against drug-resistant microorganisms are claimed in this invention. The inventive rifamycin derivatives are uniquely designed in that they have a rifamycin moiety covalently linked to a linker group through the C-3 carbon of the rifamycin moiety and the linker is, in turn covalently linked to a therapeutic moiety or antibacterial agent/pharmacophore. The therapeutic moiety can be a quinolone, an oxazolidinone, a macrolide, an aminoglycoside, a tetracycline core or a structure/pharmacophore associated with an antibacterial agent.
摘要翻译：本发明要求具有抗微生物活性的利福霉素衍生物，包括抗药性微生物的活性。本发明的利福霉素衍生物是唯一设计的，因为它们具有通过利福霉素部分的C-3碳与连接基共价连接的利福霉素部分，接头又与治疗部分或抗菌剂/药效基团共价连接。治疗部分可以是喹诺酮，恶唑烷酮，大环内酯，氨基糖苷，四环素核心或与抗菌剂相关的结构/药效团。

155. 发明授权

US06916658B2 Method for measurement of immature granulocytes 有权
标题翻译：未成熟粒细胞的测定方法
公开(公告)号：US06916658B2
公开(公告)日：2005-07-12
申请号：US10770193
申请日：2004-02-02
申请人： Jing Li , Yi Li
发明人： Jing Li , Yi Li
IPC分类号： A01N1/02 , C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/06 , G01N15/00 , G01N15/10 , G01N15/12 , G01N15/14 , G01N25/08 , G01N25/18 , G01N27/00 , G01N27/02 , G01N27/06 , G01N27/12 , G01N31/00 , G01N33/00 , G01N33/48 , G01N33/50 , G01N33/80
CPC分类号： G01N33/5094 , G01N15/1031 , G01N15/12 , G01N15/14 , G01N15/1459 , G01N33/80 , G01N2015/0065 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/1037 , G01N2015/1062 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： A method for measuring immature granulocytes in a blood sample is described. The method includes the steps of lysing red blood cells of a blood sample with a lytic reagent, analyzing the sample mixture by DC impedance measurement, determining immature granulocytes from obtained DC histogram, and reporting immature granulocytes in the blood sample. The method further includes measuring nucleated red blood cells in the blood sample.
摘要翻译：描述了用于测量血液样品中未成熟粒细胞的方法。该方法包括用裂解试剂裂解血液样品的红细胞，通过直流阻抗测定分析样品混合物，从获得的直方图直方图测定未成熟粒细胞，以及报告血液样品中的未成熟粒细胞的步骤。该方法还包括测量血液样品中的有核红细胞。

156. 发明授权

US06895338B2 Measuring and analyzing multi-dimensional sensory information for identification purposes 失效
标题翻译：测量和分析多维感官信息进行识别
公开(公告)号：US06895338B2
公开(公告)日：2005-05-17
申请号：US09802513
申请日：2001-03-09
申请人： Chang-Meng B. Hsiung , Jing Li , Beth Munoz , Ajoy K. Roy , Michael G. Steinthal , Steven A. Sunshine , Michael A. Vicic , Shou-Hua Zhang
发明人： Chang-Meng B. Hsiung , Jing Li , Beth Munoz , Ajoy K. Roy , Michael G. Steinthal , Steven A. Sunshine , Michael A. Vicic , Shou-Hua Zhang
IPC分类号： G01N33/00 , G06K9/00 , G06K9/62 , G01N31/00 , G06F19/00
CPC分类号： G06K9/6253 , G01N33/0031 , G06K9/00
摘要： Methods and systems are provides for measuring multi-dimensional sensing information for identification purposes. The identity of one or more substances is determined through analysis of multidimensional data that can include, among others, intrinsic information as well as extrinsic information. The method for identification of a substance comprises utilizing pattern recognition to form descriptors to identify characteristics of the substance. A system and computer program for performing analysis of the multidimensional data are also described.
摘要翻译：方法和系统提供用于测量用于识别目的的多维感测信息。通过分析多维数据来确定一种或多种物质的身份，多维数据可以包括固有信息以及外在信息。用于物质鉴定的方法包括利用模式识别形成描述符以识别物质的特征。还描述了用于执行多维数据分析的系统和计算机程序。

157. 发明申请

US20050042220A1 Antibodies against interleukin-22 and uses therefor 失效
标题翻译：抗白细胞介素-22抗体的用途
公开(公告)号：US20050042220A1
公开(公告)日：2005-02-24
申请号：US10873972
申请日：2004-06-22
申请人： Jing Li , Xiang-Yang Tan , Kathleen Tomkinson , Debra Pittman , Geertruida Veldman , Lynette Fouser
发明人： Jing Li , Xiang-Yang Tan , Kathleen Tomkinson , Debra Pittman , Geertruida Veldman , Lynette Fouser
IPC分类号： A61K38/20 , C07K14/54 , C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K14/54 , C07K14/5428 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N2799/022 , A61K2300/00
摘要： Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).
摘要翻译：公开了结合白介素22（IL-22），特别是人IL-22的抗体及其抗原结合片段及其在调节IL-22相关免疫应答中的用途。本文公开的抗体可用于诊断，预防或治疗IL-22相关免疫病症，例如自身免疫性疾病（例如关节炎）。

158. 发明申请

US20050036992A1 Novel use of liver X receptor agonists 审中-公开
标题翻译：新型使用肝脏X受体激动剂
公开(公告)号：US20050036992A1
公开(公告)日：2005-02-17
申请号：US10745334
申请日：2003-12-22
申请人： Enrique Saez , Peter Tontonoz , Bryan Laffitte , Jing Li
发明人： Enrique Saez , Peter Tontonoz , Bryan Laffitte , Jing Li
IPC分类号： A01N41/06 , A61K20060101 , A61K48/00 , C12N5/08 , C12N15/85 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6897 , G01N33/566
摘要： This invention provides novel methods for modulating expression of glut4 and other genes involved in glucose metabolism, and methods for treating or ameliorating diabetes and related diseases. The methods comprise administering to cells in a subject an effective amount of an LXR agonist and thereby modulating expression of those genes that are important for glucose uptake or gluconeogenesis. The modulation will lead to increased uptake of glucose by cells in the subject and/or reduced glucose output in the liver, and accordingly ameliorate symptoms associated with, e.g., type II diabetes.
摘要翻译：本发明提供调节葡萄糖代谢过程中glut4等基因表达的新方法，以及治疗或改善糖尿病及相关疾病的方法。所述方法包括向受试者的细胞施用有效量的LXR激动剂，从而调节对葡萄糖摄取或糖异生重要的那些基因的表达。调节将导致受试者中细胞对葡萄糖的摄取增加和/或肝脏中葡萄糖产量降低，从而改善与例如II型糖尿病相关的症状。

159. 发明授权

US06673618B1 Method for measurement of nucleated red blood cells 有权
标题翻译：有核红细胞测定方法
公开(公告)号：US06673618B1
公开(公告)日：2004-01-06
申请号：US10226800
申请日：2002-08-23
申请人： Yi Li , Jing Li , Ted W. Britton
发明人： Yi Li , Jing Li , Ted W. Britton
IPC分类号： G01N3100
CPC分类号： G01N15/12 , G01N15/14 , G01N33/80 , G01N2015/0069 , G01N2015/0073 , G01N2015/008 , G01N2015/1062 , Y10T436/10 , Y10T436/101666 , Y10T436/107497
摘要： A method for differentiating and enumerating nucleated red blood cells in a blood sample is described. The method includes the steps of lysing red blood cells of a blood sample with a lytic reagent, measuring nucleated blood cells by DC impedance measurement in a non-focused flow aperture, differentiating nucleated red blood cells from other cell types, and reporting nucleated red blood cells in the blood sample. The method further includes subtracting nucleated red blood cells and other interference materials from the count of remaining blood cells, and reporting a corrected white blood cell count of the blood sample. Additionally, the method further includes measuring spectrophotometric absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed upon lysing the blood sample, and reporting hemoglobin concentration of the blood sample.
摘要翻译：描述了一种用于分离和计数血液样品中有核红细胞的方法。该方法包括用溶解试剂裂解血液样品的红细胞的步骤，通过非聚焦流动孔中的直流阻抗测量测量有核血细胞，将有核红细胞与其他细胞类型区分开，并报告有核红血血样中的细胞。该方法还包括从剩余血细胞计数中减去有核红细胞和其他干扰物质，并报告血样的校正白细胞计数。此外，该方法还包括在裂解血液样品时形成的血红蛋白色原体的预定波长测量样品混合物的分光光度吸光度，并报告血液样品的血红蛋白浓度。

160. 发明授权

US06614851B1 Efficient algorithm for blind detection of signal constellation 有权
标题翻译：用于信号星座盲检测的高效算法
公开(公告)号：US06614851B1
公开(公告)日：2003-09-02
申请号：US09615890
申请日：2000-07-14
申请人： Hossein Dehghan , Ramon A. Cruz , Jing Li
发明人： Hossein Dehghan , Ramon A. Cruz , Jing Li
IPC分类号： H04L512
CPC分类号： H04L27/0012
摘要： A method for determining the signal constellation of a received signal establishes a moment based on each waveform, squares the moment, fourth powers the moment, divides the fourth power by the square to obtain a ratio, and compares the ratio to a threshold. If the ratio is less than threshold, the signal constellation corresponds to a first type, and if greater than the threshold, the signal constellation corresponds to a second type. The method can be generalized to a magnitude mean in place of a second moment.
摘要翻译：用于确定接收信号的信号星座的方法基于每个波形建立一个时刻，平方的时刻，第四个功率的瞬间，将第四个功率除以平方以获得一个比率，并将该比率与阈值进行比较。如果比率小于阈值，信号星座对应于第一类型，并且如果大于阈值，则信号星座对应于第二类型。该方法可以被推广到大小平均值代替第二时刻。

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