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141. 发明授权

US4987209A Diethynyl monomers and polymers thereof 失效
标题翻译：二乙炔基单体及其聚合物
公开(公告)号：US4987209A
公开(公告)日：1991-01-22
申请号：US281911
申请日：1988-12-07
申请人： Thomas X. Neenan , George M. Whitesides
发明人： Thomas X. Neenan , George M. Whitesides
IPC分类号： C07C25/24 , C07C33/28 , C07C323/09 , C08F38/00
CPC分类号： C08F38/00 , C07C25/24 , C07C323/09 , C07C33/28
摘要： The compound 1,3-diethynyl tetrafluorobenzene, and compounds having the structure ##STR1## in which ##STR2## represents a perfluorinated benzene ring and X represents oxygen or sulfur, as well as homopolymers and copolymers thereof.
摘要翻译：化合物1,3-二乙炔基四氟苯以及具有“IMAGE”结构的化合物，其中“IMAGE”表示全氟化苯环，X表示氧或硫，以及其均聚物和共聚物。

142. 发明授权

US4701285A Acyl phosphate salts and their use 失效
标题翻译：酰基磷酸盐及其用途
公开(公告)号：US4701285A
公开(公告)日：1987-10-20
申请号：US793722
申请日：1985-10-31
申请人： George M. Whitesides , Debbie C. Crans , Romas J. Kazlaukas
发明人： George M. Whitesides , Debbie C. Crans , Romas J. Kazlaukas
IPC分类号： C07F9/09 , C07C153/00
CPC分类号： C07F9/096
摘要： This invention consists of the production of a salt of acyl phosphate in an aqueous solution by a process which involves (1) acylation of phosphoric acid (H.sub.3 PO.sub.4) with an acid anhydride of the general formula RCOX, where R can be hydrogen or a lower alkyl or aryl group having from 1 to 10 carbon atoms, and X can be a leaving group of the general formula OR, OCOR, X or NR.sub.2, followed by (2a) extraction of acyl phosphate to water by treatment of the reaction mixture with an aqueous bicarbonate or hydroxide solution or other basic aqueous solution, if the reaction is carried out in non-aqueous solvent or (2b) in the case where water has been used as reaction solvent acidification with acid or acid form of a carbon exchange resin. After (3) extraction of residual carboxylic acid from the resulting acidic aqueous mixture using a solvent in which the acid is soluble but with which water does not mix, the remaining aqueous solution of acyl phosphate is (4) neutralized by addition of a base such as sodium or potassium hydroxide.
摘要翻译：本发明包括在水溶液中制备酰基磷酸盐的方法，该方法包括：（1）用通式RCOX的酸酐使磷酸（H 3 PO 4）酰化，其中R可以是氢或低级烷基或具有1至10个碳原子的芳基，X可以是通式OR，OCOR，X或NR2的离去基团，然后（2a）通过用水溶液处理反应混合物（2a）将酰基磷酸酯提取到水中碳酸氢盐或氢氧化物溶液或其他碱性水溶液，如果反应在非水溶剂中进行，或（2b）在使用水作为与酸或酸形式的碳交换树脂反应溶剂酸化的情况下。（3）使用其中酸是可溶性但不与水混合的溶剂从所得酸性含水混合物中提取残余羧酸后，残留的酰基磷酸酯水溶液（4）通过加入碱中和作为氢氧化钠或氢氧化钾。

143. 发明授权

US09829488B2 Paper-based cellular arrays 有权
公开(公告)号：US09829488B2
公开(公告)日：2017-11-28
申请号：US12934192
申请日：2009-03-27
申请人： Ratmir Derda , Anna Laromaine Sague , George M. Whitesides
发明人： Ratmir Derda , Anna Laromaine Sague , George M. Whitesides
IPC分类号： G01N33/548 , B01L3/00 , B01J19/00 , G01N33/50
CPC分类号： G01N33/548 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00619 , B01J2219/00641 , B01J2219/00644 , B01J2219/00743 , B01L3/5085 , B01L2300/0819 , B01L2300/0829 , B01L2300/126 , B01L2300/161 , G01N33/502
摘要： Three-dimensional cellular arrays, methods of making three-dimensional cellular arrays, and methods of identifying agents using the arrays are disclosed.

144. 发明申请

US20160349417A1 SYSTEM AND METHOD FOR FABRICATION OF MINIATURE ENDOSCOPE USING NANOIMPRINT LITHOGRAPHY 审中-公开
标题翻译：使用NANOIMPRINT LITHOGRAPHY制造微小内窥镜的系统和方法
公开(公告)号：US20160349417A1
公开(公告)日：2016-12-01
申请号：US15115206
申请日：2015-01-30
申请人： Guillermo J. TEARNEY , Dongkyun KANG , Mitsuhiro IKUTA , George M. WHITESIDES , Ramses V. MARTINEZ , CANON U.S.A., INC. , THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Guillermo J Tearney , Dongkyun Kang , Mitsuhiro Ikuta , George M. Whitesides , Ramses V. Martinez
IPC分类号： G02B5/18 , G02B23/24 , B29D11/00 , G02B27/42
CPC分类号： G02B5/1852 , B29D11/00769 , B29K2105/0002 , B29K2995/0027 , G02B5/1814 , G02B5/1847 , G02B23/2423 , G02B23/2469 , G02B27/4244
摘要： Exemplary method and system for providing a diffractive configuration in an optical arrangement are provided. For example, a material can be provided with at least one patterned surface having a very high aspect ratio. The material can be connected with at least one portion of a waveguide arrangement using a pre-polymer adhesive composition. Further, the pre-polymer adhesive composition can be caused to polymerize so as to form the diffractive configuration which at least approximately replicates a structure or at least one feature of the patterned surface.
摘要翻译：提供了用于在光学装置中提供衍射构造的示例性方法和系统。例如，材料可以设置有具有非常高的纵横比的至少一个图案化表面。该材料可以使用预聚物粘合剂组合物与波导布置的至少一部分连接。此外，可以使预聚物粘合剂组合物聚合以形成至少近似复制图案化表面的结构或至少一个特征的衍射构型。

145. 发明授权

US09176105B2 Density-based separation of biological analytes using multiphase systems 有权
标题翻译：使用多相系统的生物分析物的密度分离
公开(公告)号：US09176105B2
公开(公告)日：2015-11-03
申请号：US13817985
申请日：2011-08-22
申请人： Charles R. Mace , Ashok A. Kumar , Dyann F. Wirth , George M. Whitesides
发明人： Charles R. Mace , Ashok A. Kumar , Dyann F. Wirth , George M. Whitesides
IPC分类号： A01N1/02 , G01N33/18 , B03B5/28 , B03B5/44 , B03D3/00 , G01N33/49 , G01N33/537 , G01N33/574
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
摘要翻译：所公开的方法使用多相系统根据感兴趣的分析物的密度分离样品。该方法使用包含两个或多个相分离溶液和相成分如表面活性剂或聚合物的多相体系。感兴趣的分析物的密度与样品其余部分的密度不同。感兴趣的分析物的密度基本上与一个或多个相位相同。因此，当将样品引入多相系统时，感兴趣的分析物迁移到具有与感兴趣的分析物相同的密度的相位，顺序地通过一个或多个相。

146. 发明授权

US09090868B2 Alginate hydrogel fibers and related materials 有权
标题翻译：藻酸盐水凝胶纤维及相关材料
公开(公告)号：US09090868B2
公开(公告)日：2015-07-28
申请号：US13808887
申请日：2011-07-12
申请人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
发明人： Charles R. Mace , Jabulani Barber , Anna Laromaine Sagué , George M. Whitesides , Rebecca Cademartiri
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N5/0068 , C12N2533/30 , C12N2533/56 , C12N2533/74 , D01D5/40 , D01F9/04
摘要： Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight of the fiber, wherein the cross-link is a cation. An alginate hydrogel paper includes one or more alginate hydrogel fibers, which form a non-woven matrix. Three-dimensional cellular arrays are also provided, wherein the alginate hydrogel making up the alginate paper is substantially index-matched with a predetermined culture medium. A method for making alginate hydrogel fiber and a method for index-matching alginate hydrogel paper with culture medium are provided. A kit for conducting biochemical, diagnostic, cellular, and/or non-cellular analysis comprises alginate hydrogel paper index-matched to culture medium.
摘要翻译：提供藻酸盐水凝胶纤维及相关材料以及制备这些材料的方法。藻酸盐水凝胶纤维包含水量大于纤维重量的约92％，交联藻酸盐的量为纤维重量的约0.1％至约8％，其中交联是阳离子。藻酸盐水凝胶纸包括形成非织造基质的一种或多种藻酸盐水凝胶纤维。还提供三维细胞阵列，其中构成藻酸盐纸的藻酸盐水凝胶与预定培养基基本上是指数匹配的。提供了藻酸盐水凝胶纤维的制备方法和藻酸盐水凝胶纸与培养基的折射率匹配方法。用于进行生化，诊断，细胞和/或非细胞分析的试剂盒包括与培养基指数匹配的藻酸盐水凝胶纸。

147. 发明授权

US08821810B2 Devices and methods for multiplexed assays 有权
标题翻译：多重测定的装置和方法
公开(公告)号：US08821810B2
公开(公告)日：2014-09-02
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascareñas , Xinyu Liu , Xiujun Li
IPC分类号： G01N33/52 , B01L3/00
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

148. 发明申请

US20140220500A1 MANIPULATION OF FLAMES AND RELATED METHODS AND APPARATUS 审中-公开
标题翻译：火焰的操作及相关方法和装置
公开(公告)号：US20140220500A1
公开(公告)日：2014-08-07
申请号：US14119560
申请日：2012-05-31
申请人： Ludovico Cademartiri , Charles R. Mace , Robert Shepherd , Aaron D. Mazzeo , Kyle J.M. Bishop , Ryan C. Chiechi , George M. Whitesides
发明人： Ludovico Cademartiri , Charles R. Mace , Robert Shepherd , Aaron D. Mazzeo , Kyle J.M. Bishop , Ryan C. Chiechi , George M. Whitesides
IPC分类号： F23N5/00
CPC分类号： F23N5/00 , F23C99/001
摘要： Manipulation of flames is described using electric fields. In those instances in which electric fields are used, the electric fields may be time-varying gradient electric fields, and in some instances may be oscillating electric fields. The manipulation may include extinction, suppression, control of mixing of the flame, concentration, and/or bending, among other types.
摘要翻译：使用电场描述火焰的操纵。在使用电场的情况下，电场可以是时变梯度电场，并且在一些情况下可以是振荡电场。操作可以包括消除，抑制，火焰混合的控制，浓度和/或弯曲等。

149. 发明申请

US20130314080A1 QUALITY CONTROL OF DIAMAGNETIC MATERIALS USING MAGNETIC LEVITATION 有权
标题翻译：使用磁性检测的钻孔材料的质量控制
公开(公告)号：US20130314080A1
公开(公告)日：2013-11-28
申请号：US13989725
申请日：2011-11-29
申请人： George M. Whitesides , Audrey Ellerbee , Simon Tricard
发明人： George M. Whitesides , Audrey Ellerbee , Simon Tricard
IPC分类号： G01N27/72
CPC分类号： G01N27/72 , G01R33/1269 , G01R33/1276
摘要： The ability to levitate and detect height and orientation of diamagnetic objects suspended in paramagnetic solutions using an inhomogeneous magnetic field is described. By comparing the measured height and orientation of a sample material with the measured height and orientation of a reference material, quality control of objects can be carried out. The major advantages of this quality control technique are: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection; iii) it is a cost-effective and simple method that can carry out quality control between sample and reference materials rapidly.
摘要翻译：描述了使用非均匀磁场悬浮和检测悬浮在顺磁性溶液中的抗磁性物体的高度和取向的能力。通过将样品材料的测量高度和取向与测量的参考材料的高度和取向相比较，可以进行物体的质量控制。这种质量控制技术的主要优点是：i）不需要电力的简单设备（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）与简单的光学检测兼容; iii）可以快速，高效地进行样品和参比物质的质量控制。

150. 发明申请

US20130210680A1 SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY 有权
标题翻译：放大和污染显示的系统和方法
公开(公告)号：US20130210680A1
公开(公告)日：2013-08-15
申请号：US13702603
申请日：2011-06-10
申请人： Ratmir Derda , Sindy K.Y. Tang , George M. Whitesides
发明人： Ratmir Derda , Sindy K.Y. Tang , George M. Whitesides
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C40B40/02 , C40B50/06
摘要： The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in separate compartments (e.g., in separate microfluidic droplets) and amplified. As a specific example, by putting members of a phage display library into microfluidic droplets such that no droplet contains more than one member of the library, the library can be amplified without any substantial changes in growth rates or population distributions, or other artifacts created due to differences in growth rates or amplification between different members of the library. In some cases, the volume of the compartments can be used to control the copy number of a biological entity during amplification. In certain cases, biological entities with different amplification rates can be amplified independently of each other. In some embodiments, the ratio of a rapidly amplifying biological entity to a slowly amplifying biological entity can be controlled. This can be advantageous, for example, in preserving diversity within a library by preventing rapidly amplifying biological entities from outcompeting slowly amplifying biological entities. For example, certain methods and systems of the invention can be useful in situations where preferential amplification of library members can present a problem.
摘要翻译：本发明通常涉及生物实体的扩增，例如用于噬菌体展示。在一个方面，生物实体文库的成员被包封在分离的隔室中（例如，在单独的微流体液滴中）并被扩增。作为具体实例，通过将噬菌体展示文库的成员置于微流体液滴中，使得没有液滴包含多于一个文库的成员，可以扩增文库，而不会在生长速率或群体分布或由其产生的其他伪影中产生任何实质性变化图书馆不同成员之间的增长速度差异或差异。在一些情况下，隔室的体积可以用于在放大期间控制生物实体的拷贝数。在某些情况下，具有不同扩增率的生物实体可以彼此独立地扩增。在一些实施方案中，可以控制快速扩增的生物实体与缓慢扩增的生物实体的比例。这可能是有利的，例如，通过防止快速扩增生物实体免于超过慢性扩增的生物实体来保存文库内的多样性。例如，本发明的某些方法和系统可用于库成员的优先扩增可能存在问题的情况。

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