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    • 132. 发明授权
    • Lined infusion catheter
    • 内衬输液管
    • US5702372A
    • 1997-12-30
    • US385498
    • 1995-02-08
    • Timothy S. Nelson
    • Timothy S. Nelson
    • A61L29/04A61L29/06A61L29/08A61M25/00
    • A61M25/0045A61L29/041A61L29/06A61L29/085A61M2025/0047A61M2025/0048A61M25/0069
    • An infusion catheter for delivering drugs or other agents to selected sites in an organism, such as a human. In an alternate embodiment, a catheter system is disclosed having an infusion catheter and a pump that may be implanted or disposed outside the organism. In either embodiment, the free end of the catheter bears a rounded tip that has at least one elution hole for discharging an agent or drug to a selected site. The catheter has a tubular inner liner that is integral with the tip. The inner liner and tip are formed from a drug compatible polymeric material that is relatively nonporous and unreactive with the agent to be infused. A biocompatible flexible elastomeric tubular jacket surrounds the inner liner and a portion of the tip excluding that portion containing the elution hole or holes. Since the agent flowing in the catheter is isolated from the jacket while flowing through the catheter, and since the inner liner is relatively nonporous and unreactive with the agent to be infused, the agent is prevented from diffusing out of the catheter, adsorbing to the surface of the biocompatible jacket, reacting adversely with the jacket material or becoming exposed to substances diffusing through the jacket.
    • 用于将药物或其它试剂递送到生物体例如人的选定部位的输液导管。 在替代实施例中,公开了具有输注导管和可以植入或设置在生物体外部的泵的导管系统。 在任一实施例中,导管的自由端具有圆形尖端,其具有用于将药剂或药物排出到选定部位的至少一个洗脱孔。 导管具有与尖端成一体的管状内衬。 内衬和尖端由与药物相容的聚合物材料形成,其相对无孔并且与待注入的药剂不反应。 生物相容的柔性弹性体管状护套围绕内衬和除了包含洗脱孔或孔的部分之外的尖端的一部分。 由于在导管中流动的药剂在流过导管的同时与护套隔离,并且由于内衬相对无孔并且与待注射药物不反应,因此防止药剂扩散出导管,吸附到表面 的生物相容性护套,与护套材料不利地反应或暴露于通过护套扩散的物质。