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131. 发明申请

US20050196853A1 Alpha-amylase variants 有权
标题翻译： α-淀粉酶变体
公开(公告)号：US20050196853A1
公开(公告)日：2005-09-08
申请号：US11039565
申请日：2005-01-19
申请人： Allan Svendsen , Soeren Kjaerulff , Henrik Bisgaard-Frantzen , Carsten Andersen
发明人： Allan Svendsen , Soeren Kjaerulff , Henrik Bisgaard-Frantzen , Carsten Andersen
IPC分类号： C07H21/04 , C12N9/28 , C12N9/32
CPC分类号： C12N9/2414 , C07H21/04 , C11D3/38609 , C11D3/38618 , C12N9/2417
摘要： The invention relates to a variant of a parent Termamyl-like α-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an α-amylase variant of the invention, a recombinant expression vector which carries a DNA construct of the invention, a cell which is transformed with a DNA construct of the invention, the use of an α-amylase variant of the invention for washing and/or dishwashing, textile desizing, starch liquefaction, a detergent additive comprising an α-amylase variant of the invention, a manual or automatic dishwashing detergent composition comprising an α-amylase variant of the invention, a method for generating a variant of a parent Termamyl-like α-amylase, which variant exhibits increased.
摘要翻译：本发明涉及亲本的类戊酰样α-淀粉酶的变体，其包含2,3,4,5或6个/位置的突变。这些变体在高温下（相对于亲本）具有增加的稳定性。本发明还涉及包含编码本发明的α-淀粉酶变体的DNA序列的DNA构建体，携带本发明的DNA构建体的重组表达载体，用本发明的DNA构建体转化的细胞，使用本发明的α-淀粉酶变体用于洗涤和/或餐具洗涤，纺织品退浆，淀粉液化，包含本发明的α-淀粉酶变体的洗涤剂添加剂，手动或自动洗碗洗涤剂组合物，其包含α-淀粉酶变体本发明提供一种产生母体类戊酰样α-淀粉酶的变体的方法，该变体表现出增加。

132. 发明申请

US20050084937A1 Alpha-amylase mutants 审中-公开
标题翻译： α-淀粉酶突变体
公开(公告)号：US20050084937A1
公开(公告)日：2005-04-21
申请号：US10980923
申请日：2004-11-04
申请人： Torben Borchert , Allan Svendsen , Carsten Andersen , Bjarne Nielsen , Torben Nissen , Soren Kjaerulff
发明人： Torben Borchert , Allan Svendsen , Carsten Andersen , Bjarne Nielsen , Torben Nissen , Soren Kjaerulff
IPC分类号： C12N15/09 , C07K14/32 , C11D3/386 , C12N1/21 , C12N9/28 , C12R1/10 , C07H21/04 , C12N9/32
摘要： The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibits an alteration in at least one of the following properties relative to said parent α-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or iii) increased specific activity at temperatures from 10 to 60° C.
摘要翻译：本发明涉及亲本的类戊酰样α-淀粉酶的变体，其相对于所述亲本α-淀粉酶表现出至少一种以下特性的改变：i）在8至10.5的pH下改善的pH稳定性; 和/或ii）在pH 8至10.5下改善的Ca 2+稳定性，和/或iii）在10至60℃的温度下提高比活性。

133. 发明授权

US06410295B1 Alpha-amylase variants 有权
标题翻译： α-淀粉酶变体
公开(公告)号：US06410295B1
公开(公告)日：2002-06-25
申请号：US09537168
申请日：2000-03-29
申请人： Carsten Andersen , Christel Thea Jørgensen , Henrik Bisgård-Frantzen , Allan Svendsen , Søren Kjaerulff
发明人： Carsten Andersen , Christel Thea Jørgensen , Henrik Bisgård-Frantzen , Allan Svendsen , Søren Kjaerulff
IPC分类号： C12N900
CPC分类号： C12N9/2417 , C07K2319/00 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/17 , Y02P20/52
摘要： The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.
摘要翻译：本发明涉及母体类戊酰样α-淀粉酶的变体，该变体表现出改变的性质，特别是降低了切割接近分支点的底物的能力，以及相对于母体改善的底物特异性和/或改善的比活性 α-淀粉酶。

134. 发明授权

US06271010B1 Cyclomaltodextrin glucanotransferase variants 失效
标题翻译：环糊精葡聚糖转化酶变体
公开(公告)号：US06271010B1
公开(公告)日：2001-08-07
申请号：US09158216
申请日：1998-09-22
申请人： Carsten Andersen , Bjarne Rønfeldt Nielsen , Lubbert Dijkhuizen , Bauke Dijkstra
发明人： Carsten Andersen , Bjarne Rønfeldt Nielsen , Lubbert Dijkhuizen , Bauke Dijkstra
IPC分类号： C12N900
CPC分类号： C12N9/1074 , C12P19/18 , C12Y204/01019
摘要： The present invention relates to variants of cyclomaltodextrin glucanotransferase of increased product specificity.
摘要翻译：本发明涉及增加产品特异性的环糊精葡聚糖转移酶的变体。

135. 发明授权

US06204232B1 &agr;-amlase mutants 有权
标题翻译： α-淀粉酶突变体
公开(公告)号：US06204232B1
公开(公告)日：2001-03-20
申请号：US09183412
申请日：1998-10-30
申请人： Torben Vedel Borchert , Allan Svendsen , Carsten Andersen , Bjarne Nielsen , Torben Lauesgaard Nissen , Søren Kjærulff
发明人： Torben Vedel Borchert , Allan Svendsen , Carsten Andersen , Bjarne Nielsen , Torben Lauesgaard Nissen , Søren Kjærulff
IPC分类号： C12N928
CPC分类号： C12N9/2417 , C07K14/32 , C11D3/386 , C11D3/38609 , C11D3/38636 , C12Y302/01001
摘要： The invention relates to a variant of a parent Termamyl-like &agr;-amylase, which exhibits an alteration in at least one of the following properties relative to said parent &agr;-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or iii) increased specific activity at temperatures from 10 to 60° C.
摘要翻译：本发明涉及亲本的类戊酰样α-淀粉酶的变体，其相对于所述亲本α-淀粉酶表现出至少一种以下特性的改变：i）在8至10.5的pH下改善的pH稳定性; 和/或ii）在pH8至10.5时提高的Ca 2+稳定性，和/或iii）在10至60℃的温度下提高比活性。

136. 发明授权

US6004790A Cyclomaltodextrin glucanotransferase variants 失效
标题翻译：环糊精葡聚糖转化酶变体
公开(公告)号：US6004790A
公开(公告)日：1999-12-21
申请号：US947965
申请日：1997-10-09
申请人： Lubbert Dijkhuizen , Bauke W. Dijkstra , Carsten Andersen , Claus von der Osten
发明人： Lubbert Dijkhuizen , Bauke W. Dijkstra , Carsten Andersen , Claus von der Osten
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12N9/26 , C12P19/18 , C12R1/19 , C07H21/04 , C12N15/00
CPC分类号： C12N9/1074 , C12P19/18 , C12Y204/01019
摘要： The present invention relates to variants of cyclomaltodextrin glucanotransferase. More specifically the invention relates to a method of modifying the substrate binding and/or product selectivity of a precursor CGTase enzyme, and CGTase variants derived from a precursor CGTase enzyme by substitution, insertion and/or deletion of one or more amino acid residue(s), which amino acid residue(s) holds a position close to the substrate. Moreover, the invention relates to DNA constructs encoding the CGTase variants, expression vectors, host cells and methods of producing the CGTase variants of the invention.
摘要翻译：本发明涉及环糊精葡聚糖转移酶的变体。更具体地，本发明涉及一种通过取代，插入和/或缺失一个或多个氨基酸残基来修饰前体CGT酶的底物结合和/或产物选择性的方法和衍生自前体CGT酶的CGTase变体（s ），其中氨基酸残基保持靠近底物的位置。此外，本发明涉及编码CGTase变体，表达载体，宿主细胞的DNA构建体和产生本发明的CGTase变体的方法。

137. 发明授权

US09420806B2 Buffered gum base for high pH release 有权
标题翻译：缓冲胶基，用于高pH释放
公开(公告)号：US09420806B2
公开(公告)日：2016-08-23
申请号：US13330452
申请日：2011-12-19
申请人： Carsten Andersen , Gitte Lorenzen , Nicolai Arent , Bitten Thorengaard , Helle Wittorff
发明人： Carsten Andersen , Gitte Lorenzen , Nicolai Arent , Bitten Thorengaard , Helle Wittorff
IPC分类号： A61K9/68 , A61K9/00 , A61K9/22 , A61K31/465 , A61P25/34 , A23G4/06 , A23G4/08 , A23G4/12 , A23G4/20
CPC分类号： A23G4/064 , A23G4/06 , A23G4/08 , A23G4/126 , A23G4/20 , A61K9/0058
摘要： A chewing gum composition with high pH-release includes an insoluble gum base matrix and a soluble bulk portion, wherein the gum base matrix and the bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion. Furthermore, a method of producing a chewing gum core, wherein a gum base matrix and a bulk portion is mixed and extruded to form a final chewing gum core, and wherein the gum base matrix is buffered before mixing with the bulk portion, and the gum base matrix includes a first amount of buffer from 2 to 20 percent by weight of the gum base matrix before mixing with the bulk portion.
摘要翻译：具有高pH释放的口香糖组合物包括不溶性胶基基质和可溶性本体部分，其中将胶基基质和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质被缓冲在与本体部分混合之前。此外，制备口香糖芯的方法，其中将胶基基体和本体部分混合并挤出以形成最终的口香糖芯，并且其中胶基基质在与本体部分混合之前被缓冲，而胶基基础基质包括在与本体部分混合之前的胶基基质的2至20重量％的第一量缓冲剂。

138. 发明授权

US08863756B2 Tobacco chewing gum formulation 有权
标题翻译：烟草口香糖配方
公开(公告)号：US08863756B2
公开(公告)日：2014-10-21
申请号：US13446776
申请日：2012-04-13
申请人： Carsten Andersen
发明人： Carsten Andersen
IPC分类号： A24B15/00 , A61K9/68 , A24B15/16 , A61K31/465 , A23G4/06
CPC分类号： A24B15/16 , A23G4/068 , A24B13/00 , A61K9/0058 , A61K31/465
摘要： A chewing gum formulation including tobacco particles and a gum base, where the gum base includes one or more hydrophobic gum base polymers, and where the tobacco particles are made from tobacco leaves. The amount of tobacco particles is between 0.5 and 30% by weight of the chewing gum formulation, and nicotine is released from the tobacco particles when chewing the chewing gum formulation.
摘要翻译：一种口香糖制剂，包括烟草颗粒和胶基，其中胶基包括一种或多种疏水性胶基聚合物，并且其中烟草颗粒由烟叶制成。烟草颗粒的量为口香糖配方的0.5至30重量％，并且当咀嚼口香糖制剂时尼古丁从烟草颗粒中释放。

139. 发明授权

US08623331B2 Compressed chewing gum tablet 有权
标题翻译：压缩口香糖片
公开(公告)号：US08623331B2
公开(公告)日：2014-01-07
申请号：US12819932
申请日：2010-06-21
申请人： Carsten Andersen , Gitte Lorenzen , Nicolai Arent , Bitten Thorengaard , Helle Wittorff
发明人： Carsten Andersen , Gitte Lorenzen , Nicolai Arent , Bitten Thorengaard , Helle Wittorff
IPC分类号： A61K9/68 , A01N43/40 , A61K31/44
CPC分类号： A61K9/2072 , A23G4/043 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/146 , A61K9/2077 , A61K9/2086 , A61K31/465 , A61K38/00
摘要： A compressed chewing gum tablet includes at least a first and a second chewing gum module, the first chewing gum module including a first chewing gum composition including at least a first active ingredient and chewing gum granules containing gum base, the second chewing gum module including a second chewing gum composition including at least a second active ingredient and chewing gum granules containing gum base, wherein the first active ingredient is a pharmaceutically active ingredient, and the second active ingredient is selected from the group consisting of pharmaceutically active ingredients and enhancers, wherein the gum base content of the first and second chewing gum modules is different.
摘要翻译：压缩口香糖片包括至少第一和第二口香糖组件，所述第一口香糖模块包括包含至少第一活性成分的第一口香糖组合物和含有胶基糖的口香糖颗粒，所述第二口香糖模块包括第二口香糖组合物，其包含至少第二活性成分和含有胶基的口香糖颗粒，其中所述第一活性成分是药物活性成分，所述第二活性成分选自药物活性成分和增强剂，其中第一和第二口香糖模块的胶基含量不同。

140. 发明授权

US08435577B2 Alpha-amylases 有权
公开(公告)号：US08435577B2
公开(公告)日：2013-05-07
申请号：US13514727
申请日：2011-01-04
申请人： Carsten Andersen , Thomas Agersten Poulsen
发明人： Carsten Andersen , Thomas Agersten Poulsen
IPC分类号： A21D2/00 , A21D2/20 , C12P7/06 , C11D3/386
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38681 , C12N9/2414 , C12N15/8257 , C12P7/06 , C12P7/14 , C12P19/02 , C12P19/04 , C12P19/14 , C12P2203/00 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.

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