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131. 发明授权

US09955971B2 Method for treating aortic arch diseases 有权
公开(公告)号：US09955971B2
公开(公告)日：2018-05-01
申请号：US14984084
申请日：2015-12-30
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Zhiyun Xu , Xiangman Zhang , Lin Han , Deyuan Zhang , Benhao Xiao
IPC分类号： A61F2/856 , A61B17/11 , A61F2/07 , A61B17/12 , A61F2/06
CPC分类号： A61B17/11 , A61B2017/1107 , A61B2017/1132 , A61B2017/12004 , A61F2/07 , A61F2/856 , A61F2002/061 , A61F2002/075
摘要： In a method for treating an aortic arch disease, after an intraoperative stent is expanded in an aorta and at least one arch branch vessel, and before the vessel is exactly anastomosed with an incision, by blocking a thoracic aorta between the incision and an arch branch vessel closest to the incision, the intraoperative stent in the thoracic aorta is also blocked, so that blood is prevented from flowing from the incision, and a proximal orifice of the intraoperative stent, and the low body perfusion may be recovered in advance, thereby reducing the circulatory arrest time of the low body perfusion and reducing the time of ischemia of visceral organs and lower limbs of a patient. Meanwhile, the flow of a cerebral perfusion through the right axillary artery may be recovered to a normal flow in advance, and the time of ischemia of the brain of the patient is reduced.

132. 发明授权

US09918707B2 Occlusion device having varying angle flat disk 有权
公开(公告)号：US09918707B2
公开(公告)日：2018-03-20
申请号：US14765102
申请日：2014-01-20
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Shaochun Zhuang
IPC分类号： A61B17/08 , A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12109 , A61B17/12172 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00615 , A61B2017/1205
摘要： Disclosed is an occlusion device having an angle variable flat disk, comprising a single-layer disk (4), a plug (6) and a waist (5) connecting the single-layer disk (4) and the plug (6). The single-layer disk (4) is braided from elastic strands and comprises a plurality of radially-arranged support rods (40). Grids braided from elastic strands are provided on the surface of the plug (6). The waist (5) comprises at least one connecting strand. An annular interlocking structure is provided in the center of the single-layer disk (4). The plurality of support rods (40) are connected into a flat integral body via the annular interlocking structure. The connecting strand of the waist (5) is connected to the annular interlocking structure and the grids of the plug (6). The occlusion device has the features of a flat single-layer disk and a flexible waist structure at the same time, and the single-layer disk has the function of adaptive regulation of morphology and is able to effectively adapt to different physiological structures while reducing complications.

133. 发明申请

US20180071076A1 Aneurysm Treatment Method 审中-公开
公开(公告)号：US20180071076A1
公开(公告)日：2018-03-15
申请号：US15241349
申请日：2016-09-13
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Wei Guo , Deyuan Zhang , Benhao Xiao , Wuyang Li , Caiping Liu
IPC分类号： A61F2/07 , A61F2/954
CPC分类号： A61F2/07 , A61F2/954 , A61F2002/061 , A61F2002/067
摘要： A method for treating an aneurysm with at least one branch blood vessel branched from a diseased aorta comprises implanting an aortic stent graft and an auxiliary stent into a diseased blood vessel to isolate the aneurysm, wherein the auxiliary stent comprises a bifurcated stent graft, one end of the aortic stent graft is attached to the wall of a healthy blood vessel upstream of the aneurysm, and the auxiliary stent comprises a body portion and a branch portion communicated with the body portion, one end of the body portion is communicated with a healthy blood vessel downstream of the aneurysm, the other end of the body portion is communicated with the aortic stent graft, and the branch portion is suspended within the diseased blood vessel. A straight stent graft is advanced towards the branch portion from the location downstream of the bifurcated stent graft and deployed to communicate the branch portion and the branch blood vessel.

134. 发明授权

US09863031B2 Method for preparing a coating of the surface of medical devices made of nickel-titanium alloy 有权
公开(公告)号：US09863031B2
公开(公告)日：2018-01-09
申请号：US12312769
申请日：2006-11-27
申请人： DeYuan Zhang , YueHui Xie
发明人： DeYuan Zhang , YueHui Xie
IPC分类号： C23C14/00 , C23C14/32 , C23C14/02 , A61L27/06 , A61L27/30 , C23C14/06 , A61L31/08
CPC分类号： C23C14/024 , A61L27/06 , A61L27/306 , A61L31/082 , A61L2300/608 , A61L2400/16 , C23C14/0641 , Y10T428/12493
摘要： Provided is a method for plating a biocompatible coating with nano structure on the surface of a nickel-titanium shape memory alloy, particularly a method suitable for plating a coating on the surface of medical devices made of nickel-titanium alloy. The method includes the following steps: heat treating, surface pretreating, ion sputter cleaning, depositing a pseudodiffusion layer, plating a sub-layer film, plating a pure TiN layer, and so on. The coating has the following advantages: 1) it could deform in response to the deformation of substrate without delaminating and cracking; 2) it has less resistance to the deformation of substrate; 3) it has less penetrable holes so as to reduce the dissolution of nickel into bio-body through these holes; 4) the coating has better biocompatibility compared to the substrate material.

135. 发明申请

US20170340780A1 Degradable Iron-Base Alloy Support 审中-公开
公开(公告)号：US20170340780A1
公开(公告)日：2017-11-30
申请号：US15534406
申请日：2015-12-02
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Liping CHEN , Hongtao SUN , Deyuan ZHANG
IPC分类号： A61L31/02 , A61L31/04 , A61L31/06 , A61L31/10
CPC分类号： A61L31/022 , A61L31/02 , A61L31/041 , A61L31/043 , A61L31/06 , A61L31/10 , A61L31/16
摘要： A degradable iron-based alloy stem comprises an iron-based alloy substrate and a degradable polymer in contact with the surface of the substrate. The weight-average molecular weight of the degradable polymer is in the range of [1, 100]*104, and the polydispersity index of the degradable polymer is in the range of (1.0. 50]. The degradable polymer is selected from a degradable polyamino acid that can generate an acidic amino acid after degradation; or a mixture of the degradable polyamino acid and a degradable polyester, or a copolymer of monomers of the two; or a mixture of the degradable polyamino acid and a degradable polymer that does not generate acidic products after degradation, or a copolymer of the monomers of the two; or a mixture of the degradable polyamino acid, the degradable polyester and the degradable polymer that does not generate acidic products after degradation, or a copolymer of monomers of the three, or a mixture of a copolymer of monomers of any two of the three with the remaining one.

136. 发明申请

US20170325824A1 Left Atrial Appendage Occluder 审中-公开
公开(公告)号：US20170325824A1
公开(公告)日：2017-11-16
申请号：US15525907
申请日：2015-12-31
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Anning LI , Zhuo CHEN
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12122 , A61B17/00 , A61B17/0057 , A61B17/12168 , A61B2017/00597 , A61B2017/00632
摘要： A left atrial appendage occluder (200) comprises a sealing part (220), a fixing part (210) disposed at one side of the sealing part (220), and a connection part (230) for connecting the sealing part (220) and the fixing part (210). The radial deformation capacity of the sealing part (220) is greater than the radial deformation capacity of the fixing part (210), and/or, the axial deformation capacity of the sealing part (220) is greater than the axial deformation capacity of the fixing part (210). In the left atrial appendage occluder (200), the radial or axial deformation capacity of the sealing part (220) is configured to be greater than the radial or axial deformation capacity of the fixing part (210), thereby avoiding the situation in which the sealing part (220) is not optimally fitted with the opening of the left atrial appendage (10) when the fixing part (210) is placed inside of the left atrial appendage (10), which in turn enhances the occlusion effect. Additionally, the sealing part (220) has great deformation capacity which reduces the risks of the sealing part (220) causing abrasion to the opening of the left atrial appendage, or even damaging the opening of the left atrial appendage. The fixing part (210) not only avoids the risks but also fixes the occluder in the left atrial appendage (10) more effectively, and prevents the occluder (200) from being disengaged from the left atrial appendage.

137. 发明申请

US20170156904A1 Occluder and Occlusion Device 审中-公开
公开(公告)号：US20170156904A1
公开(公告)日：2017-06-08
申请号：US15322669
申请日：2015-07-03
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Xiangdong LIU , Xianmiao CHEN , Xiang FU , Jie CHEN
IPC分类号： A61F2/94 , A61F2/966 , A61F2/86
CPC分类号： A61F2/94 , A61B17/00 , A61B17/0057 , A61B17/12168 , A61B17/12172 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/12095 , A61F2/02 , A61F2/86 , A61F2/966 , A61F2002/9505
摘要： The present invention relates to an occluder (100), comprising a meshed occlusion body (I) provided with a cavity (103), and a proximal hub (2), as well as a locking member (10) and a stopping member (13) both of which are located in the cavity (103). The distal end of the locking member (10) is connected to the distal end of the occlusion body (1). The stopping member (13) is disposed at the proximal end of the locking member (10). The proximal occluder head (2) is provided with a locking hole (15) in communication with the cavity (103). The radial size of the stopping member (13) is slightly larger than the diameter of the locking hole (15). The radial size of the locking member (10) is smaller than the diameter of the locking hole (15), and at least one of the proximal occluder head (2) and the stopping member (13) is an elastic member. An occlusion device comprises the occluder (100), a hollow delivery mechanism (200) and a traction member (4). The distal end of the traction member (4) is detachably connected to the proximal end of the locking member (10) of the occluder (100) after extending through the distal end of the delivery mechanism (200). The occlusion device has a simple locking structure, and simplifies the manufacturing process and the locking operation.

138. 发明申请

US20170113017A1 Adjustable curved medical catheter and assembling method thereof 审中-公开
公开(公告)号：US20170113017A1
公开(公告)日：2017-04-27
申请号：US15317889
申请日：2015-06-09
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Tingchao ZHANG , Yang LI , Quanjie JIANG , Mingyang CAI
IPC分类号： A61M25/00 , A61M25/01
摘要： Disclosed is an adjustable curved medical catheter, including a catheter (110), a handle (140), and a traction wine (122) provided in the catheter (110). The distal end of the traction wire (122) is connected to the elastic distal end of the catheter (110). The adjustable curved medical catheter further includes a retainer device (130) provided in the handle (140) and connected to the handle (140). The retainer device (130) includes a rotating member (132) and a body (131) having a receiving groove (131a) for receiving the rotating member (132) and a guiding hole (133) extending through the outer wall of the body (131) to the receiving groove (131a). A slot (134) formed between the rotating member (132) and the inner wall of the body (131) is smaller than the diameter of the traction wire (122). The proximal end of the traction wire (122) extends through the guiding hole (133) and engages in the slot (134). The traction wire (122) of the adjustable curved medical catheter has the advantages of a solid and reliable connection, a high reliability of curve adjustment and high flexibility, and can be live-adjusted to fit individual circumstances.

139. 发明申请

US20170079630A1 Steerable Sheath Tube and Method for Occluding Atrial Septal Defect 审中-公开
公开(公告)号：US20170079630A1
公开(公告)日：2017-03-23
申请号：US14940398
申请日：2015-11-13
申请人： Lifetech Scientific (Shenzhen) Co., Ltd.
发明人： Shaobo Xie , Gang Wang , Mingyang Cai , Kui Liu
IPC分类号： A61B17/00
摘要： A steerable sheath tube has a tubular body having a distal end, a traction wire; and a handle connected to the tubular body. The handle has a lateral branch tube that is coupled to the tubular body at an angle thereof, a slider positioned inside the lateral branch tube for translating movement therein, and a positioning member provided within the lateral branch tube and positioned further from the tubular body than from the slider. One end of the traction wire is fixed on the slider while the other end thereof is fixed at the distal end of the tubular body, and when the slider is moved to come into contact with the positioning member, the distal end of the tubular body is bent to a predetermined angle. A method for occluding an atrial septal defect includes the steps of delivering an occluder from a right internal jugular vein to an atrial septal defect by using the steerable sheath tube, and releasing the occluder to occlude the atrial septal defect,

140. 发明申请

US20160331870A1 Drug Coated Balloon Catheter 审中-公开
标题翻译：药物涂层气球导管
公开(公告)号：US20160331870A1
公开(公告)日：2016-11-17
申请号：US15107806
申请日：2014-12-08
申请人： LIFETECH SCIENTIFIC (SHENZHEN ) CO., LTD
发明人： Qizong XIE , Yongmu ZHANG , Jinhua LU , Jingzhong SONG
IPC分类号： A61L29/16 , A61M25/10 , A61L29/06
CPC分类号： A61L29/16 , A61L29/06 , A61L29/14 , A61L2300/416 , A61M25/10 , A61M2025/105 , C08L67/02 , C08L77/00 , C08L23/06
摘要： The present invention relates to a drug coated balloon catheter, comprising a balloon and a drug coating covering the surface of the balloon; the drug coating comprises an active drug and a carrier; the active drug is paclitaxel, rapamycin, a paclitaxel derivative or rapamycin derivative; the carrier comprises an organic acid salt and polyalcohol; a mass ratio of the active drug to the carrier in the drug coating is 0.2 to 100, and a mass ratio of the organic acid salt to the polyalcohol is (0.2 to 5):1, The organic acid salt and the polyalcohol in the drug coating jointly take effect to prevent the premature release of drugs before the balloon catheter is positioned at a target site, and to promote the drugs being quickly released from the surface of the balloon and absorbed by the target tissue, thus reducing drug loss during transmission, and also having a better drug transfer effect.
摘要翻译：本发明涉及药物包衣球囊导管，其包括覆盖气囊表面的气囊和药物涂层; 药物包衣包含活性药物和载体; 活性药物是紫杉醇，雷帕霉素，紫杉醇衍生物或雷帕霉素衍生物; 载体包含有机酸盐和多元醇; 药物包衣中活性药物与载体的质量比为0.2〜100，有机酸盐与多元醇的质量比为（0.2〜5）：1，药物中的有机酸盐和多元醇联合起效，以防止气囊导管位于目标位置之前药物过早释放，并促使药物从球囊表面快速释放并被靶组织吸收，从而减少传播过程中的药物流失，并具有更好的药物转移效果。

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