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121. 发明授权

US6036697A Balloon catheter with balloon inflation at distal end of balloon 失效
标题翻译：球囊导管，球囊远端气球膨胀
公开(公告)号：US6036697A
公开(公告)日：2000-03-14
申请号：US112387
申请日：1998-07-09
申请人： Fernando DiCaprio
发明人： Fernando DiCaprio
IPC分类号： A61M25/00 , A61F2/06 , A61F2/82 , A61F2/84 , A61L29/00 , A61L29/04 , A61L29/06 , A61M25/10 , A61F11/00
CPC分类号： A61F2/958 , A61L29/041 , A61L29/06 , A61M25/10 , A61M2025/1059 , C08L23/06 , C08L23/10 , C08L67/00 , C08L77/00
摘要： A balloon catheter is provided having an expandable distal portion, said expandable portion having a proximal end, a distal end and distal expansion means, said expandable portion being adapted for expansion at its distal end, from its distal end to its proximal end. A stent delivery system is provided to facilitate introduction and placement of a stent, and includes a catheter having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state, said distal portion further comprising a balloon, and a stent positioned around the distal portion of the catheter around the balloon, said stent having a proximal end and a distal end and further having a contracted condition, said stent being sized in the contracted condition to closely surround the balloon in the contracted state, and being adapted to expand to an expanded condition from its distal end to its proximal end in response to expansion of the balloon member from its distal end.
摘要翻译：提供了具有可扩展远端部分的气囊导管，所述可扩张部分具有近端，远端和远侧扩张装置，所述可扩张部分适于在其远端处从其远端到其近端膨胀。提供支架输送系统以便于引入和放置支架，并且包括导管，其具有被构造和布置成用于将导管的外径从收缩状态扩大到扩张状态的可扩展远端部分，所述远端部分还包括气囊和围绕球囊定位在导管的远端部分周围的支架，所述支架具有近端和远端并且还具有收缩状态，所述支架的尺寸在收缩状态下以在收缩状态下紧密围绕气囊状态，并且响应于球囊构件从其远端的膨胀而适于从其远端扩展到扩展状态到其近端。

122. 发明授权

US6024693A Intra-aortic balloon catheter 有权
标题翻译：主动脉内气囊导管
公开(公告)号：US6024693A
公开(公告)日：2000-02-15
申请号：US174279
申请日：1998-10-16
申请人： Robert Schock , Olga Laksin , Manuel Marques
发明人： Robert Schock , Olga Laksin , Manuel Marques
IPC分类号： A61F2/958 , A61L29/06 , A61L29/08 , A61L33/00 , A61M1/10 , A61N1/362
CPC分类号： A61M25/10 , A61L29/06 , A61L29/085 , A61L33/0011 , A61M1/1072
摘要： An improved intra-aortic balloon catheter with a balloon membrane, a tip, and a co-lumen extruded tube having an outer lumen and an inner lumen between the inner and outer surfaces of the co-lumen extruded tube. The portion of the co-lumen extruded tube that defines the inner lumen and which is disposed within the balloon membrane is made from polyimide, a lubricous material, to facilitate guide wire tracking. The polyimide inner tube portion demonstrates good kink resistance and flexural stiffness. In a first alternative embodiment of the invention the co-lumen tube comprises an outer tube with an inner tube embedded in the wall of said outer tube. In a second alternative embodiment of the invention a longitudinal signal pathway is provided.
摘要翻译：一种改进的主动脉内气囊导管，其具有球囊膜，尖端和共管腔挤压管，其在共管腔挤压管的内表面和外表面之间具有外腔和内腔。限定内腔并且设置在球囊膜内的共管腔挤出管的部分由聚酰亚胺（润滑材料）制成，以便于导丝跟踪。聚酰亚胺内管部分具有良好的耐扭结和弯曲刚度。在本发明的第一替代实施例中，共管腔管包括外管，内管嵌在所述外管的壁中。在本发明的第二替代实施例中，提供了纵向信号路径。

123. 发明授权

US5998551A Crosslinked nylon block copolymers 失效
标题翻译：交联尼龙嵌段共聚物
公开(公告)号：US5998551A
公开(公告)日：1999-12-07
申请号：US867362
申请日：1997-06-02
申请人： Charles J. O'Neil , Lawrence A. Acquarulo, Jr.
发明人： Charles J. O'Neil , Lawrence A. Acquarulo, Jr.
IPC分类号： A61M25/00 , A61F2/958 , A61L29/00 , A61L29/06 , A61M25/16 , C08G69/40 , C08G69/42 , C08G69/44 , C08G69/48
CPC分类号： A61M25/1036 , A61L29/06 , C08G69/40 , C08G69/42 , C08G69/44 , C08G69/48
摘要： A crosslinked nylon block copolymer comprising a copolymer containing a polyamide block and an elastomeric block, irradiation crosslinked, including a compound which promotes crosslinking therein. In process form, the present invention comprises supplying a nylon block copolymer, containing a polyamide block and an elastomeric block, along with crosslinking promotor and exposing the block copolymer to irradiation, sufficient to crosslink the copolymer and improve mechanical properties therein. The crosslinked nylon block copolymers here have particular utility in both the medical and wire and cable industries.
摘要翻译：一种交联的尼龙嵌段共聚物，其包含含有聚酰胺嵌段和弹性体嵌段的共聚物，辐照交联，包括促进其中交联的化合物。在工艺形式中，本发明包括与交联促进剂一起提供含有聚酰胺嵌段和弹性体嵌段的尼龙嵌段共聚物，并将嵌段共聚物暴露于照射下，足以使共聚物交联并改善其中的机械性能。交联的尼龙嵌段共聚物在医疗和电线电缆行业都具有特殊的用途。

124. 发明授权

US5993972A Hydrophilic and hydrophobic polyether polyurethanes and uses therefor 失效
标题翻译：亲水和疏水聚醚聚氨酯及其用途
公开(公告)号：US5993972A
公开(公告)日：1999-11-30
申请号：US40692
申请日：1998-03-18
申请人： Murray H. Reich , John Teffenhart , Jirina Kuzma
发明人： Murray H. Reich , John Teffenhart , Jirina Kuzma
IPC分类号： A61K8/87 , A61K9/22 , A61K47/34 , A61L27/18 , A61L29/06 , A61L31/06 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q19/00 , B32B27/40 , C08G18/40 , C08G18/44 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/66 , C08G18/75
CPC分类号： C08G18/758 , A61K47/34 , A61K8/87 , A61L27/18 , A61L29/06 , A61L31/06 , A61Q19/00 , B32B27/40 , C08G18/4018 , C08G18/44 , C08G18/4808 , C08G18/4858 , C08G18/5096 , C08G18/61 , C08G18/6607 , C08G18/667 , C08G18/6674 , C08G18/6681 , A61Q17/04 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q9/02 , Y10T428/2933 , Y10T428/31551 , Y10T428/31565 , Y10T428/31587
摘要： An improved amphiphilic diol is prepared with a controlled type and amount of alkylene glycol, catalyst, hydrophobic and hydrophilic diol with diisocyanate and water. Critical selection of the type, molecular weight and ratios of hydrophilic to hydrophobic diol, isocyanate to hydroxyl groups, average molecular weight of the diol component, the amount of water in the reaction mixture produces a polyuretheane having high slip, Shore A Hardness values, wet tensile strength and tear strength. This invention also includes uses of the polyurethane in catheters, shaving products, synthetic valves, veins and arteries, stents, ports, shunts and coatings. Preferably, the polyurethane is used in combination with a filler for application to rubber gloves. In addition, dispersions, lotions, gels and solutions can be formed of the polyurethane.
摘要翻译：用受控类型和量的亚烷基二醇，催化剂，疏水和亲水二醇与二异氰酸酯和水制备改进的两亲二醇。关键选择亲水至疏水二醇，异氰酸酯与羟基的类型，分子量和比例，二醇组分的平均分子量，反应混合物中的水量产生具有高滑移，肖氏A硬度值，湿润拉伸强度和撕裂强度。本发明还包括聚氨酯在导管，剃须产品，合成瓣膜，静脉和动脉，支架，端口，分流器和涂层中的用途。优选地，聚氨酯与用于橡胶手套的填料结合使用。此外，分散体，洗剂，凝胶和溶液可以由聚氨酯形成。

125. 发明授权

US5908406A Dilatation catheter balloons with improved puncture resistance 失效
公开(公告)号：US5908406A
公开(公告)日：1999-06-01
申请号：US791799
申请日：1997-01-29
申请人： George Joseph Ostapchenko , Donna Lynn Visioli
发明人： George Joseph Ostapchenko , Donna Lynn Visioli
IPC分类号： A61L29/00 , A61L29/04 , A61L29/06 , A61L29/08 , A61M25/00 , A61M29/02 , B29C55/00 , B32B1/08 , B32B27/08 , A61M29/00 , A61M5/32 , B29D22/00
CPC分类号： A61M25/1029 , A61L29/041 , A61L29/049 , A61L29/06 , A61L29/085 , B32B1/08 , B32B27/08 , A61M25/104 , B29C55/00 , Y10T428/1352
摘要： Multi-layer puncture-resistant biaxially oriented coextruded films or tubings are disclosed for use in dilatation balloon catheters. The catheter balloons so formed comprise a first, inner layer of an orientable thermoplastic resin; a second layer of a thermoplastic inomeric olefin copolymer secured to the outside surface of the first layer; and an optional third layer of an orientable thermoplastic resin secured to the outside surface of the second layer. Processes for forming the dilatation catheter balloons herein are also disclosed.

126. 发明授权

US5859150A Prepolymers of absorbable polyoxaesters 失效
标题翻译：可吸收聚氧乙烯酯的预聚物
公开(公告)号：US5859150A
公开(公告)日：1999-01-12
申请号：US964733
申请日：1997-11-05
申请人： Dennis D. Jamiolkowski , Rao S. Bezwada
发明人： Dennis D. Jamiolkowski , Rao S. Bezwada
IPC分类号： A61L15/22 , A61L15/26 , A61L15/60 , A61L27/18 , A61L27/52 , A61L29/04 , A61L29/06 , A61L29/14 , A61L31/04 , A61L31/06 , C08G63/664 , C08G63/672 , C08G63/676 , C08G69/40 , C08G69/44 , C08F20/00 , C08F2/46
CPC分类号： C08G69/44 , A61L15/225 , A61L15/26 , A61L15/60 , A61L27/18 , A61L27/52 , A61L29/049 , A61L29/06 , A61L29/145 , A61L31/041 , A61L31/06 , C08G63/664 , C08G63/672 , C08G63/676 , C08G69/40
摘要： The present invention describes a prepolymer of an aliphatic polyoxaester having a polymerizable end group that may be used to produce hydrogels, surgical devices such as sutures, sutures with attached needles, molded devices, and the like.
摘要翻译：本发明描述了具有可用于制备水凝胶的可聚合端基的脂族聚氧乙烯酯的预聚物，诸如缝合线的外科装置，带有针的缝合线，模制装置等。

127. 发明授权

US5830182A Block copolymer elastomer catheter balloons 失效
公开(公告)号：US5830182A
公开(公告)日：1998-11-03
申请号：US805899
申请日：1997-02-25
申请人： Lixiao Wang , Jianhua Chen
发明人： Lixiao Wang , Jianhua Chen
IPC分类号： A61L29/06 , A61L29/14 , A61M29/00
CPC分类号： A61L29/14 , A61L29/06 , B29L2031/7542
摘要： Balloons for medical devices, particularly balloon angioplasty catheters, are made from particular block copolymer thermoplastic elastomers in which the block copolymer is made up of hard segments of a polyester or polyamide and soft segments of polyether; the polyester hard segments are polyesters of an aromatic dicarboxylic acid and a C.sub.2 -C.sub.4 diol; the polyamide hard segments are polyamides of C.sub.6 or higher carboxylic acids and C.sub.6 or higher organic diamines or of C.sub.6 or higher aliphatic .omega.-amino-.alpha.-acids, and the polyether soft segments are polyethers of C.sub.2 -C.sub.10, diols; the block copolymer has a low flexural modulus, namely less than 150,000 psi; the block copolymer has a hardness, Shore D scale, of greater than 60; and the percentage by weight of the block polymer attributable to the hard segments is between about 50% and about 95%. The polymers provide high strength, thin wall, compliant and semi-compliant balloons, which leads to a low profile catheter. The low profile catheters have very good initial crossing, good trackability, good recrossing after first inflation.

128. 发明授权

US5820607A Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections 失效
标题翻译：多用途抗微生物硅橡胶护套系统，用于预防器械相关感染
公开(公告)号：US5820607A
公开(公告)日：1998-10-13
申请号：US465587
申请日：1995-06-05
申请人： Robert Tcholakian , Issam Raad
发明人： Robert Tcholakian , Issam Raad
IPC分类号： A61L29/06 , A61L29/08 , A61L29/16 , A61M25/00 , A61M37/00 , A61M5/32
CPC分类号： A61M25/0017 , A61L29/06 , A61L29/085 , A61L29/16 , A61L2300/406 , A61L2300/41 , A61L2300/42 , A61L2300/45 , A61L2300/63
摘要： The present invention relates generally to indwelling medical devices. In particular, there is provided a device constructed from permeable or nonpermeable material having a pharmacologically active ingredient layer surrounding the device, and an outer sheath which is permeable to the pharmacologically active ingredient. This construction provides a device that allows the pharmacologically active ingredient located between the catheter tube and the outer sheath to slowly diffuse through the outer sheath and/or inner tube, thus inhibiting microbial infection on the outer surface and lumen of the catheter.
摘要翻译：本发明一般涉及留置医疗器械。特别地，提供了由可渗透或不可渗透的材料构成的装置，其具有围绕该装置的药理活性成分层和可渗透药理活性成分的外护套。这种结构提供了允许位于导管管和外护套之间的药理活性成分缓慢地扩散通过外鞘和/或内管的装置，从而抑制导管的外表面和内腔上的微生物感染。

129. 发明授权

US5554121B1 Intraluminal catheter with high strength proximal shaft 无效
标题翻译：具有高强度近端轴的管腔内导管
公开(公告)号：US5554121B1
公开(公告)日：1998-07-14
申请号：US28021094
申请日：1994-07-25
申请人： ADVANCED CARDIOVASCULAR SYSTEM
发明人： AINSWORTH ROBERT D , CHENG TAI C , WASICEK LAWRENCE D
IPC分类号： A61L29/00 , A61L29/06 , A61L29/14 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61L29/06 , A61L29/14 , A61M25/0045 , A61M25/0054 , C08L71/12 , C08L81/06 , C08L71/00

130. 发明授权

US5762996A Silicone balloon catheter 失效
标题翻译：硅胶球导管
公开(公告)号：US5762996A
公开(公告)日：1998-06-09
申请号：US631946
申请日：1996-04-15
申请人： Daniel R. Lucas , Celia L. Lucas
发明人： Daniel R. Lucas , Celia L. Lucas
IPC分类号： A61L29/06 , A61M25/00 , B05D3/12 , B05D1/32 , B05D7/02
CPC分类号： A61M25/1029 , A61L29/06 , A61M25/1034
摘要： The present invention includes an improved configuration and method of forming an inflatable silicone balloon on a cured silicone catheter that does not require a release agent to free the balloon from the catheter. The method includes a catheter having an inflation lumen therein and an inflation port on the distal end thereof communicating the inflation lumen with the outer surface of the catheter within the interior of the balloon, comprising the following steps: Providing a substantially cured silicone compound sleeve having an inner diameter corresponding to the outer diameter of the catheter and having a length corresponding to the desired length of the inflatable balloon. Positioning the sleeve onto the distal end of the catheter and centered on the inflation port. Overdipping the distal end of the catheter and the sleeve into an uncured silicone dispersion compound to a depth of about 0.25 inches beyond the sleeve, forming an uncured silicone compound layer over the catheter and the sleeve. Drying the silicone compound layer on the sleeve and catheter. Next, Curing the silicone compound layer and the sleeve on the catheter, whereby the compound layer is securely bonded to the outer surface of the catheter and is bonded to the outer surface and ends of the sleeve, and the inner surface of the sleeve does not bond to the surface of the catheter. Finally, releasing the inflatable balloon portion from the catheter, by applying a slight lateral force to the surface thereof, whereby the inner surface of the sleeve is translated a slight distance relative to the surface of the catheter to thereby separate any residual adhesion of the surfaces.
摘要翻译：本发明包括在固化的硅氧烷导管上形成可膨胀硅酮球囊的改进的构造和方法，其不需要脱模剂来从导管释放气球。该方法包括其中具有充气腔的导管，并且其远端上的充气端口将充气腔与气囊内部的导管外表面连通，包括以下步骤：提供基本上固化的硅氧烷化合物套筒，其具有内径对应于导管的外径，其长度对应于可充气球囊的期望长度。将套管定位在导管的远端并以充气口为中心。将导管和套管的远端覆盖未固化的硅氧烷分散体化合物至套筒外约0.25英寸的深度，在导管和套管上形成未固化的硅氧烷化合物层。干燥套管和导管上的硅氧烷化合物层。接下来，将硅酮化合物层和套管固化在导管上，由此化合物层牢固地结合到导管的外表面并结合到套筒的外表面和端部，并且套筒的内表面不结合到导管的表面。最后，通过对其表面施加轻微的横向力，从导管释放可充气球囊部分，由此套筒的内表面相对于导管表面平移一点距离，从而分离表面的任何残留粘附。

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