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121. 发明授权

US5373085A Memory enhancing thermal proteins 失效
标题翻译：记忆增强热蛋白
公开(公告)号：US5373085A
公开(公告)日：1994-12-13
申请号：US951788
申请日：1992-09-28
申请人： Sidney W. Fox , James F. Flood
发明人： Sidney W. Fox , James F. Flood
IPC分类号： C07K14/00 , C08G69/10
CPC分类号： C07K14/001 , C08G69/10
摘要： Memory enhancing thermal proteins were synthesized from heating aspartic acid, glutamic acid, proline and tryptophan above 100.degree. C. Two hydrophobic and one non-hydrophobic polymer were injected intracerebroventricularly into the brains of mice after the mice had undergone partial training in footshock avoidance conducted in a T-maze. When retention of footshock avoidance was tested one week later, the hydrophobic polymers enhanced retention while the non-hydrophobic polymer did not.
摘要翻译：通过加热天冬氨酸，谷氨酸，脯氨酸和色氨酸超过100℃合成记忆增强热蛋白。将小鼠经过部分训练后的脚踏回避进行了两只疏水性和一种非疏水性聚合物脑内注射到小鼠脑中一个迷宫。一个星期后测试了脚踏回避的保留时，疏水性聚合物增强了保持性，而非疏水性聚合物则没有。

122. 发明授权

US5329044A Glucaric acid monoamides and their use to prepare poly(glucaramides) 失效
标题翻译：葡萄糖酸单酰胺及其制备聚（葡糖酰胺）的用途
公开(公告)号：US5329044A
公开(公告)日：1994-07-12
申请号：US928007
申请日：1992-08-12
申请人： Donald E. Kiely , Liang Chen
发明人： Donald E. Kiely , Liang Chen
IPC分类号： C07C235/10 , C08G69/10 , C07C229/00
CPC分类号： C07C235/10 , C08G69/10
摘要： Novel monomers are described which contain a glucaric acid unit linked through an amide bond formed between a carbonyl carbon of a D-glucaric acid and one of the amino nitrogens of a primary diamine as well as their alkali metal salts. These N-aminohydrocarbylene (or N-aminoheterohydrocarbylene)-D-glucaramidates may then be polymerized to form polyhydroxypolyamides and in particular stereoregular polyhydroxypolyamides.
摘要翻译：描述了含有通过D-葡糖二酸的羰基碳与一级胺的一种氨基氮之间形成的酰胺键连接的葡糖二酸单元及其碱金属盐的新型单体。然后可以将这些N-氨基亚烃基（或N-氨基杂烃基）-D-葡糖酰氨基聚合物聚合形成多羟基聚酰胺，特别是立体规则的聚羟基聚酰胺。

123. 发明授权

US5135754A Method of preparing a copolymer of two .alpha.-amino acids and a copolymer thus obtained 失效
标题翻译：制备两种α-氨基酸的共聚物和由此获得的共聚物的方法
公开(公告)号：US5135754A
公开(公告)日：1992-08-04
申请号：US657249
申请日：1991-02-15
申请人： Andre E. Brack
发明人： Andre E. Brack
IPC分类号： A61L26/00 , C08G69/10
CPC分类号： C08G69/10 , A61L26/0019 , A61L26/008
摘要： The invention provides a method of synthesizing a copolymer of two .alpha.-amino acids which comprises the preparation of an N-carboxyanhydride of a first .alpha.-amino acid and the N-carboxyanhydride of a second .alpha.-amino acid, followed by the copolymerization of this mixture. The mixture is obtained by the reaction of phosgene with a mixture of a first and the second .alpha.-amino acids, the amino acids having similar reaction rates with phosgene. It also relates to the copolymer obtained by implementation of this method and an agent for covering skin wounds comprising this copolymer.
摘要翻译：本发明提供了一种合成两种α-氨基酸的共聚物的方法，包括制备第一种α-氨基酸的N-羧酸酐和第二种α-氨基酸的N-羧酸酐，然后将该共聚合混合物。通过光气与第一和第二α-氨基酸的混合物的反应获得混合物，氨基酸与光气具有相似的反应速率。它还涉及通过实施该方法获得的共聚物和用于覆盖包含该共聚物的皮肤伤口的试剂。

124. 发明授权

US5095090A Polypeptide thin film from amphiphilic compounds 失效
标题翻译：来自两亲化合物的多肽薄膜
公开(公告)号：US5095090A
公开(公告)日：1992-03-10
申请号：US507540
申请日：1992-04-11
申请人： Mitsunori Ono , Tsutomu Miyasaka , Naoyuki Nishikawa
发明人： Mitsunori Ono , Tsutomu Miyasaka , Naoyuki Nishikawa
IPC分类号： C07K14/00 , C08G69/10
CPC分类号： B82Y30/00 , B82Y40/00 , B82Y5/00 , C07K14/001 , C08G69/10
摘要： A polypeptide thin film obtained by polymerizing a monomolecular film comprising a monomer mixture of(a) an amphiphilic compound having a hydrophobic moiety and a hydrophilic moiety having an amino acid ester structure per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 14, and(b) an amphiphilic compound having two amino groups per molecule or an amphiphilic compound having two ester structures per molecule, the conjugated acid of the elimination group of the ester having a pKa of not higher than 16,or a built-up film of the monomolecular film; and a process for preparing a material carrying the polypeptide thin film.
摘要翻译：通过使包含单体混合物（a）具有疏水部分的两亲性化合物和每分子具有氨基酸酯结构的亲水部分的单体混合物聚合获得的多肽薄膜，所述酯的消除基团的共轭酸具有 pKa不高于14，和（b）每分子具有两个氨基的两亲化合物或每分子具有两个酯结构的两亲化合物，所述酯的消除基团的共轭酸的pKa不高于16，或单分子膜的叠层膜; 以及制备携带多肽薄膜的材料的方法。

125. 发明授权

US4996292A Self-sealing artificial skin comprising copoly-alpha-amino acid 失效
标题翻译：包含共聚α-氨基酸的自密封人造皮肤
公开(公告)号：US4996292A
公开(公告)日：1991-02-26
申请号：US373503
申请日：1989-06-30
申请人： Sidney W. Fox , Peter R. Bahn
发明人： Sidney W. Fox , Peter R. Bahn
IPC分类号： A61L27/18 , C08G69/10
CPC分类号： C08G69/10 , A61L27/18
摘要： Thermally polymerized copolyamino acids are used to make a biologically compatible self-sealing skin.
摘要翻译：热聚合的共聚氨基酸用于制备生物相容的自密封皮肤。

126. 发明授权

US4916204A Pure polyanhydride from dicarboxylic acid and coupling agent 失效
标题翻译：来自二羧酸和偶联剂的纯聚酐
公开(公告)号：US4916204A
公开(公告)日：1990-04-10
申请号：US80332
申请日：1987-07-31
申请人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
发明人： Abraham J. Domb , Robert S. Langer , Eyal Ron , Steven Giannos , Rohit Kothari , Edith Mathiowitz
IPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10
CPC分类号： A61K31/335 , A61K31/365 , A61K31/39 , C08G67/04 , C08G69/08 , C08G69/10 , Y10S514/863
摘要： A method for synthesizing polyanhydrides in solution using coupling agents and a removable acid acceptor to effect a one-step polymerization of dicarboxylic acids. As used in the method, these coupling agents include phosgene, diphosgene, and acid chlorides. Insoluble acid acceptors include insoluble polyamines and crosslinked polyamines such as polyethyleneimine and polyvinylpyridine and inorganic bases such as K.sub.2 CO.sub.3, Na.sub.2 CO.sub.3, NaHCO.sub.3, and CaCO.sub.3. The only byproduct formed is a removable hydrochloric acid-acid acceptor.Examples are provided of the polymerization of highly pure polyanhydrides using phosgene, diphosgene or an acid chloride as the coupling agent, in combination with either an insoluble acid acceptor or a soluble acid acceptor in a solvent wherein the polymerization byproduct or polymer is insoluble.A particularly important application of these polyanhydrides is in the formation of drug delivery devices containing bioactive compounds. The method is also useful in the polymerization of dicarboxylic acids including heat liable dipeptides of glutamic or aspartic acid.
摘要翻译：使用偶联剂和可除去的酸受体在溶液中合成聚酐以进行二羧酸的一步聚合的方法。如该方法所用，这些偶联剂包括光气，双光气和酰氯。不溶性酸受体包括不溶性多胺和交联聚胺如聚乙烯亚胺和聚乙烯吡啶以及无机碱如K 2 CO 3，Na 2 CO 3，NaHCO 3和CaCO 3。形成的唯一副产物是可除去的盐酸酸受体。提供了使用光气，双极光或酰氯作为偶联剂的高纯度聚酐与在溶剂中的不溶性酸受体或可溶性酸受体组合的聚合反应，其中聚合副产物或聚合物是不溶的。这些多酸酐的特别重要的应用是形成含有生物活性化合物的药物递送装置。该方法也可用于二羧酸的聚合，包括谷氨酸或天冬氨酸的热应答二肽。

127. 发明授权

US4857427A Recording medium 失效
标题翻译：录音媒体
公开(公告)号：US4857427A
公开(公告)日：1989-08-15
申请号：US236338
申请日：1988-08-19
申请人： Hiroyuki Itoh , Takafumi Ishii , Tetsuo Satoh
发明人： Hiroyuki Itoh , Takafumi Ishii , Tetsuo Satoh
IPC分类号： B41M5/26 , C08G69/10 , C09K19/38 , G02F1/13 , G11B7/244 , G11B7/245 , G11B7/25
CPC分类号： G11B7/25 , C08G69/10 , C09K19/389 , G11B7/245 , Y10S430/146
摘要： A recording medium having a base and a recording layer provided on said base, said recording layer consisting essentially of a thermotropic cholesteric liquid crystalline glutamate copolymer represented by the following general formula: ##STR1## wherein R.sub.1 is an alkyl, cycloalkyl, aryl or arylalkyl group having not more than 10 carbon atoms, R.sub.2 is an alkyl, cycloalkyl, aryl or arylalkyl group having 6 to 30 carbon atoms, provided R.sub.1 and R.sub.2 are not the same, and m and n are in the relation of 50.ltoreq.m+n.ltoreq.2,000, m/n=80.about.10/20.about.90.
摘要翻译：一种记录介质，其具有设置在所述基底上的基底和记录层，所述记录层基本上由以下通式表示的热致变性胆固醇液晶谷氨酸共聚物组成：其中R1是烷基，环烷基，芳基或芳基烷基具有不超过10个碳原子，R 2是具有6至30个碳原子的烷基，环烷基，芳基或芳烷基，其中R1和R2不相同，并且m和n的关系为50 + n

128. 发明授权

US3833684A Stable,homogeneous solutions of polyalkyl glutamates containing dissolved elastomers 失效
标题翻译：稳定的含有溶解弹性体的聚谷氨酸盐的均质溶液
公开(公告)号：US3833684A
公开(公告)日：1974-09-03
申请号：US29798272
申请日：1972-10-16
申请人： AJINOMOTO KK
发明人： AKAMATSU A , TOGO K , IWATSUKI M
IPC分类号： C08G69/10 , C08L21/00 , C08L77/00
CPC分类号： B32B27/12 , B32B27/304 , B32B27/34 , B32B27/40 , B32B2255/02 , B32B2255/26 , B32B2327/06 , B32B2375/00 , B32B2379/08 , B32B2451/00 , C08G69/10 , C08L9/02 , C08L11/00 , C08L21/00 , C08L75/04 , C08L2666/14 , C08L77/00
摘要： A STABLE, CLEAR HOMOGENEOUS SOLUTION OF A POLYALKYL GLUTAMATE AND OF AN ELASTOMER IS PRODUCED BY POLYMERIZING AN OPTICALLY ACTIVE Y-LOWER-ALKYL GLYTAMATE N-CARBOXY ANHYDRIDE IN A SOLUTION OF THE ELASTOMER, IF THE ELASTOMER IS INERT TO THE ANHYDRIDE AND TO THE POLYALKYL GLYTAMATE PRODUCED UNDER THE POLYMERIZATION CONDITIONS, AND THE PPOLYALKYL GLUTAMATE IS SOLUBLE IN THE SOLUTION. SHAPED OBJECTS AND COATINGS COMBINING THE DESIRED PROPERTIES OF BOTH POLYMERS MAY BE PREPARED FROM THE SOLUTIONS.

129. 发明授权

US3635909A Method for polymerizing alpha-amino acid n - carboxyanhydrides using alkali metal salts of 2-pyrrolidone 失效
标题翻译：使用2-吡咯烷酮的碱金属盐聚合α-氨基酸N-羧酸的方法
公开(公告)号：US3635909A
公开(公告)日：1972-01-18
申请号：US3635909D
申请日：1970-06-02
申请人： KYOWA HAKKO KOGYO KK
发明人： FUJIMOTO YASUO , TATSUKAWA KEIZO , DOIUCHI TORU
IPC分类号： C08G69/10 , C08G20/08
CPC分类号： C08G69/10
摘要： THE POLYMERIZATION OF A-AMINO ACID N-CARBOXYAHYDRIDES IS CARRIED OUT IN THE PRESENCE OF AN ALKALI METAL SALT OF 2-PYRROLIDONE OR DERRIVATES THEREOF TO PRODUCE AMINO ACID POLYMERS.

130. 发明授权

US3563767A Margarine containing polyamide 失效
标题翻译：包含聚酰胺的玛格丽珠
公开(公告)号：US3563767A
公开(公告)日：1971-02-16
申请号：US3563767D
申请日：1968-03-08
申请人： MERCK & CO INC
发明人： WASSERMAN DAVID , GARBER JOHN D , MEIGS FREDERICK M
IPC分类号： A23D7/005 , C08G69/10 , A23D3/00
CPC分类号： A23D7/0056 , C08G69/10
摘要： NOVEL HOMO- AND CO-POLYPEPTIDES USEFUL IN A WIDE VARIETY OF DIFFERENT AND UNRELATED ARTS. METHODS FOR PRODUCING SAID POLYPEPTIDES VIA A NOVEL N-CARBOXY ANHYDRIDE CONSISTING OF CONDENSING SAID N-CARBOXY ANHYDRIDE WITH ONE OR A MIXTURE OF TWO OR MORE N-CARBOXY ANHYDRIDES TO PRODUCE NOVEL HOMO-POLYMERS AND CO-POLYMERS. NOVEL COMPOSTITIONS OF MATTER IN WHICH ONE OR MORE OF SAID NOVEL POLYPEPTIDES IS PRESENT AS A COMPONENT.

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