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121. 发明申请

US20120213777A1 VASCULAR ENDOTHELIAL GROWTH FACTOR 2 审中-公开
标题翻译：血管内皮生长因子2
公开(公告)号：US20120213777A1
公开(公告)日：2012-08-23
申请号：US13460217
申请日：2012-04-30
申请人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
发明人： Craig A. Rosen , Vivian R. Albert , Steven M. Ruben , Ruth E. Wager
IPC分类号： A61K39/395 , A61P37/00 , A61P41/00 , A61P29/00 , A61P3/02 , A61P31/00 , A61P17/02
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
摘要翻译：公开了人VEGF-2抗体，抗体片段或其变体。还提供了产生这种抗体的方法。本发明涉及用于预防，治疗或改善疾病或病症的方法和组合物，包括向动物（优选人）施用有效量的一种或多种VEGF-2抗体或其片段或变体。

122. 发明申请

US20120208772A1 CYTOKINE ZALPHA11 LIGAND 有权
公开(公告)号：US20120208772A1
公开(公告)日：2012-08-16
申请号：US13339639
申请日：2011-12-29
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： A61K38/17 , A61P37/02 , A61P7/00 , C07K14/435 , C07K17/08
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

123. 发明授权

US08236527B2 Recombinant production of authentic human proteins using human cell expression systems 有权
标题翻译：使用人类细胞表达系统重组生产真实的人类蛋白质
公开(公告)号：US08236527B2
公开(公告)日：2012-08-07
申请号：US12922293
申请日：2009-03-12
申请人： Ridong Chen , Soon Seog Jeong , Hui Feng
发明人： Ridong Chen , Soon Seog Jeong , Hui Feng
IPC分类号： C12P1/00 , C12N15/64 , C12N15/00 , C12N15/74 , C12N5/02 , C12N5/10 , C12N5/071 , C12N5/00
CPC分类号： C12N15/85 , A61K38/18 , A61K38/1816 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/193 , A61K38/20 , A61K38/2026 , A61K45/06 , C07K14/4716 , C07K14/495 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/75 , C07K14/765 , C12N2800/107 , C12N2840/60
摘要： The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against those authentic recombinant proteins.
摘要翻译：本发明涉及用于从新型人类细胞系的稳定培养物，由其产生的真实重组蛋白质以及针对这些真实的重组蛋白产生的抗体有效地产生真正的重组人蛋白质的新型表达盒和载体。

124. 发明授权

US08232252B2 P-selectin ligand protein 失效
标题翻译： P-选择蛋白配体蛋白
公开(公告)号：US08232252B2
公开(公告)日：2012-07-31
申请号：US12167705
申请日：2008-07-03
申请人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
发明人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw
IPC分类号： A61K38/10 , A61K38/16 , C07K7/08 , C07K14/435 , C12N15/09
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/4703 , C07K14/51 , C07K14/52 , C07K14/5431 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C07K2319/00 , C07K2319/24 , C12N9/10 , C12N9/1051 , C12N9/6454 , C12N2770/36222
摘要： A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
摘要翻译：公开了一种新型P-选择蛋白配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

125. 发明申请

US20120190830A1 Antibody to Human Zcyto-10 Polypeptide 有权
标题翻译：人类Zcyto-10多肽的抗体
公开(公告)号：US20120190830A1
公开(公告)日：2012-07-26
申请号：US13361638
申请日：2012-01-30
申请人： Darrell C. Conklin , Betty A. Haldeman , Angelika Grossman
发明人： Darrell C. Conklin , Betty A. Haldeman , Angelika Grossman
IPC分类号： C07K16/18
CPC分类号： A61K39/3955 , C07K14/52
摘要： Antibodies that which specifically bind to mammalian cytokine-like polypeptide, called Zcyto10, are described. The antibodies include monoclonal antibodies and those that where the antibody is an antigen-binding fragment. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
摘要翻译：描述了特异性结合哺乳动物细胞因子样多肽的称为Zcyto10的抗体。抗体包括单克隆抗体和抗体是抗原结合片段的抗体。 Zcyto10可用于促进伤口愈合和刺激血小板增殖。

126. 发明授权

US08227410B2 Methods of stimulating wound healing by administration of vascular endothelial growth factor D (VEGF-D) 失效
标题翻译：通过给予血管内皮生长因子D（VEGF-D）刺激伤口愈合的方法
公开(公告)号：US08227410B2
公开(公告)日：2012-07-24
申请号：US13049308
申请日：2011-03-16
申请人： Marc G. Achen , Andrew F. Wilks , Steven A. Stacker , Kari Alitalo
发明人： Marc G. Achen , Andrew F. Wilks , Steven A. Stacker , Kari Alitalo
IPC分类号： A61K38/18 , C07K14/475 , C07K14/49
CPC分类号： C07K14/475 , A61K38/00 , C07K14/52
摘要： VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.
摘要翻译： VEGF-D是生长因子PDGF家族的新成员，其中刺激内皮细胞增殖和血管生成并增加血管通透性，以及编码其的核苷酸序列，其生产方法，抗体及其它拮抗剂，转染或转化的宿主细胞进行表达，含有它的药物组合物及其在医学和诊断应用中的用途。

127. 发明授权

US08148500B2 Method of preparing cysteine mutants of human recombinant GM-CSF 有权
标题翻译：制备人重组GM-CSF的半胱氨酸突变体的方法
公开(公告)号：US08148500B2
公开(公告)日：2012-04-03
申请号：US12886876
申请日：2010-09-21
申请人： George N. Cox, III , Daniel H. Doherty
发明人： George N. Cox, III , Daniel H. Doherty
IPC分类号： A61K38/19 , A61K45/00 , C07K14/00 , C12P21/02
CPC分类号： A61K38/193 , A61K47/60 , C07K14/475 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/5431 , C07K14/61
摘要： The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
摘要翻译：生长激素超基因家族包含大于20个结构相关的细胞因子和生长因子。提供了一种用于产生这些蛋白质的位点特异性，生物活性缀合物的通用方法。该方法包括将半胱氨酸残基添加到蛋白质的非必需区域中，或者使用定点突变将蛋白质中的非必需氨基酸取代半胱氨酸残基，然后将半胱氨酸反应性聚合物或其它类型的半胱氨酸反应性部分共价偶联到通过添加的半胱氨酸残基的蛋白质。本文公开了用于添加半胱氨酸残基或将半胱氨酸取代引入蛋白质的优选位点，以及由此产生的蛋白质和蛋白质衍生物。还公开了使用本发明的半胱氨酸变体的治疗方法。

128. 发明申请

US20120065129A1 METHOD OF MASS PRODUCING GROWTH FACTOR USING ADIPOSE DERIVED ADULT STEM CELLS 审中-公开
标题翻译：使用ADIPOSE衍生成熟干细胞生产生长因子的方法
公开(公告)号：US20120065129A1
公开(公告)日：2012-03-15
申请号：US13227113
申请日：2011-09-07
申请人： ByungSoon Park , BongGeun Choi , ChulHong Park
发明人： ByungSoon Park , BongGeun Choi , ChulHong Park
IPC分类号： A61K8/64 , A61Q19/08 , A61Q19/00
CPC分类号： C07K14/503 , C07K14/495 , C07K14/52 , C12N5/0667 , C12N2500/02 , C12N2500/38 , C12N2500/60 , C12N2500/90 , C12N2500/99 , C12N2502/1382 , C12N2510/02
摘要： The present invention relates to a method for producing large amounts of human growth factors from human adipose-derived stem cells. More specifically, the invention provides a method capable of synthesizing human growth factors in significantly large amounts by culturing adipose-derived stem cells extracted from human adipose cells in suitable media and conditions. Also, stem cell culture media produced according to the method of the invention, and human growth factors isolated from the culture media, can be advantageously used as raw materials for drugs and cosmetics.
摘要翻译：本发明涉及从人脂肪干细胞产生大量人生长因子的方法。更具体地，本发明提供了一种能够通过在合适的培养基和条件下培养从人脂肪细胞提取的脂肪来源的干细胞来大量合成人生长因子的方法。此外，根据本发明的方法制备的干细胞培养基和从培养基中分离的人生长因子可以有利地用作药物和化妆品的原料。

129. 发明授权

US08110347B2 Diagnostic method for detecting cancer by measuring amount of cytokine like IL-6 有权
标题翻译：通过测量细胞因子如IL-6的量来检测癌症的诊断方法
公开(公告)号：US08110347B2
公开(公告)日：2012-02-07
申请号：US11918488
申请日：2006-04-12
申请人： Leif Håkansson , Birgitta Clinchy , Rune Sjödahl
发明人： Leif Håkansson , Birgitta Clinchy , Rune Sjödahl
IPC分类号： C12Q1/00
CPC分类号： G01N33/6863 , C07K14/52 , C07K14/5412 , G01N33/5047 , G01N33/5091 , G01N33/57488 , G01N2333/5412 , G01N2400/50
摘要： The present invention relates to a diagnostic method for predicting the possible recurrence of tumors in cancer patients. The method comprises culturing blood cells from a patient suffering from cancer in the presence of a cytokine stimulating factor, where after the amount of induced cytokine thereby produced is determined giving an indication of the risk of recurrence of the cancer.
摘要翻译：本发明涉及用于预测癌症患者肿瘤可能复发的诊断方法。该方法包括在细胞因子刺激因子存在下培养来自患有癌症的患者的血细胞，其中确定了由此产生的诱导的细胞因子的量，其给出了癌症复发风险的指征。

130. 发明授权

US08110180B2 Method of use of cytokine ZALPHA11 ligand 有权
标题翻译：细胞因子ZALPHA11配体的使用方法
公开(公告)号：US08110180B2
公开(公告)日：2012-02-07
申请号：US11551356
申请日：2006-10-20
申请人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
发明人： Julia E. Novak , Scott R. Presnell , Cindy A. Sprecher , Donald C. Foster , Richard D. Holly , Jane A. Gross , Janet V. Johnston , Andrew J. Nelson , Stacey R. Dillon , Angela K. Hammond
IPC分类号： A61K45/00 , A61K35/12 , A61K38/00 , A61K38/16
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译：描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。还描述了产生抗体的方法。

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