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121. 发明申请

US20090017051A1 Allergy vaccines and their preparation 审中-公开
标题翻译：过敏疫苗及其制剂
公开(公告)号：US20090017051A1
公开(公告)日：2009-01-15
申请号：US11711741
申请日：2007-02-28
申请人： Margarete Focke , Vera Mahler , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Rudolf Valenta
发明人： Margarete Focke , Vera Mahler , Wolfgang R. Sperr , Peter Valent , Dietrich Kraft , Rudolf Valenta
IPC分类号： A61K39/35 , G01N33/566 , A61K39/36 , A61P37/08
CPC分类号： A61K39/35 , A61K39/36 , C07K14/415 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein the peptide has a length of 8 to 50 amino acids, at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein, and said at least three amino acids are solvent-exposed amino acids in the allergenic protein. The invention also concerns a method for the preparation of the pharmaceutical composition.
摘要翻译：本发明涉及含有肽和药学上可接受的载体或稀释剂的药物组合物，其中该肽具有8至50个氨基酸的长度，该肽的至少3个优选连续的氨基酸与至少3个氨基酸相同，出现在过敏原蛋白的分子表面附近，并且所述至少三个氨基酸是过敏原蛋白质中的溶剂暴露的氨基酸。本发明还涉及制备药物组合物的方法。

122. 发明申请

US20080299108A1 Peptides for Diagnostic and Therapeutic Methods for Celiac Sprue 审中-公开
标题翻译：用于乳糜泻的诊断和治疗方法的肽
公开(公告)号：US20080299108A1
公开(公告)日：2008-12-04
申请号：US11997135
申请日：2006-08-03
申请人： Chaitan Khosla , Jiang Xia , Matthew John Siegel
发明人： Chaitan Khosla , Jiang Xia , Matthew John Siegel
IPC分类号： A61K38/10 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/16 , G01N33/53 , A61K38/48 , A61P1/00
CPC分类号： A61K39/35 , A61K38/08 , A61K38/10 , A61K38/482 , A61K47/60 , C07K14/415 , C07K2299/00 , G01N33/6854 , G01N2800/02 , G01N2800/202 , A61K2300/00
摘要： Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue. Analogs of such oligopeptides are useful in the inhibition of immune responses.
摘要翻译：检测难以消化的毒性麸质寡肽和对其产生的抗体和T细胞可用于诊断腹腔注射。这种寡肽的类似物可用于抑制免疫应答。

123. 发明申请

US20080293660A1 CHEMICALLY-DEFINED NON-POLYMERIC VALENCY PLATFORM MOLECULES AND CONJUGATES THEREOF 审中-公开
标题翻译：化学定义非聚合物平台分子及其结合体
公开(公告)号：US20080293660A1
公开(公告)日：2008-11-27
申请号：US12100356
申请日：2008-04-09
申请人： Stephen M. COUTTS , David S. Jones , Douglas Alan Livingston , Lin Yu
发明人： Stephen M. COUTTS , David S. Jones , Douglas Alan Livingston , Lin Yu
IPC分类号： A61K31/7088 , C07K14/435 , A61P37/00 , C07H21/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K47/59 , A61K47/595 , A61K47/60 , A61K47/645 , A61K2039/6093 , C07H21/00 , C07K14/003 , Y10S514/885
摘要： Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
摘要翻译：化学定义的非聚合物价态平台分子和缀合物，其包含化学定义的价态平台分子和生物或化学分子，包括对人类狼疮抗dsDNA自身抗体具有显着结合活性的至少20个碱基对的多核苷酸双链体。

124. 发明申请

US20080274131A1 Molecular antigen arrary 审中-公开
标题翻译：分子抗原可以是arrary
公开(公告)号：US20080274131A1
公开(公告)日：2008-11-06
申请号：US12010107
申请日：2008-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek , Rainer Ortmann , Rainer Luond , Matthias Staufenbiel , Peter Frey
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。

125. 发明申请

US20080050406A1 Modified Mite Allergen and Pharmaceutical Uses Thereof 有权
标题翻译：改良螨过敏原及其制药用途
公开(公告)号：US20080050406A1
公开(公告)日：2008-02-28
申请号：US11778946
申请日：2007-07-17
申请人： Ching-Hsiang Hsu , Wei-Chih Su
发明人： Ching-Hsiang Hsu , Wei-Chih Su
IPC分类号： A61K39/35 , A61P37/00
CPC分类号： A61K39/35 , C07H21/04 , C07K14/43531 , Y10S530/868
摘要： The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modified D. pteronyssinus allergen Der p 5 protein to a subject suffering from allergy Der p 5 is also provided.
摘要翻译：本发明提供了当暴露于抗原时具有抑制IgE结合的能力的修饰的Dermatophagoides pteronyssinus变应原Der p 5蛋白。还提供了治疗过敏的方法，其包括将治疗有效剂量的经修饰的D.tteronyssinus变应原Der p 5蛋白施用于患有过敏Der p 5的受试者。

126. 发明申请

US20070231402A1 Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof 审中-公开
标题翻译：治疗性干细胞组合物和兴奋剂，促进剂，促进剂及其增效剂，生长因子，抗炎组合物及其用途
公开(公告)号：US20070231402A1
公开(公告)日：2007-10-04
申请号：US11592530
申请日：2006-11-02
申请人： Leonard Girsh
发明人： Leonard Girsh
IPC分类号： A61K35/20
CPC分类号： A61K39/35 , A61K31/198 , A61K31/20 , A61K31/737 , A61K35/20 , A61K38/39 , A61K39/39 , A61K2039/55511 , A61K2039/55566
摘要： The present invention relates to a non-invasive medical therapy and a composition for avoiding organ transplantation, or controlling biological rejection of transplanted organs, or treating organs under consideration for replacement by transplant, and otherwise treating aged, diseased and/or abnormal tissues and/or organs. More specifically, the non-invasive medical therapy involves administering to a patient an elemental nutritional feeding comprising a free amino acid profile simulating and/or replicating a targeted diseased or transplanted tissue and/or organ. The subject invention provides methods of inactivating reactive component epitopes of moieties pathogenic substances or producing immunogenic compositions containing pathogenic substances comprising contacting pathogenic substances, or compositions containing pathogenic substances, with super critical carbon dioxide or liquid nitrogen. Similar benefits are produced using high HLB surfactants also reducing carcinogenic factors. In various embodiments, the pathogenic reactive components, epitopes, moieties or substances are inactivated and processed into immunogenic compositions. The subject invention also provides oral mucosal delivery systems for the subject therapeutic compositions and/or medications, and/or vaccines that avert the need for parenteral administration in the medical and veterinary fields.
摘要翻译：本发明涉及非侵入性药物治疗和组织，用于避免器官移植，或控制移植器官的生物排斥反应，或治疗被考虑移植的器官，以及否则治疗老年，患病和/或异常组织和/ 或器官。更具体地，非侵入性药物治疗涉及向患者施用包含模拟和/或复制靶向患病或移植的组织和/或器官的游离氨基酸谱的元素营养饲料。本发明提供灭活部分致病物质的反应性组分表位的方法或产生含有致病物质的免疫原性组合物的方法，其包括将含致病物质的病原物质或含有致病物质的组合物与超临界二氧化碳或液氮接触。使用高HLB表面活性剂也可减少致癌因素产生类似的益处。在各种实施方案中，致病反应性组分，表位，部分或物质被灭活并加工成免疫原性组合物。本发明还提供用于本发明治疗组合物和/或药物的口腔粘膜递送系统和/或避免在医疗和兽医领域中肠胃外给药的需要的疫苗。

127. 发明申请

US20070166335A1 Allergy inhibitor compositions and kits and methods of using the same 有权
标题翻译：过敏抑制剂组合物及其使用方法
公开(公告)号：US20070166335A1
公开(公告)日：2007-07-19
申请号：US11644435
申请日：2006-12-22
申请人： Bin Wang , Huali Jin , Youmin Kang , Hsien-Jue Chu , Terry Kaleung Ng
发明人： Bin Wang , Huali Jin , Youmin Kang , Hsien-Jue Chu , Terry Kaleung Ng
IPC分类号： A61K39/35 , A61K48/00
CPC分类号： A61K39/35 , A61K39/0003 , A61K39/0005 , A61K39/0008 , A61K2039/53 , A61K2039/57
摘要： Compositions and kits for inhibiting an allergic response against an allergenic protein are disclosed. The compositions comprise a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein; and an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein. The kits comprise a first container which comprises a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein and a second container which comprises an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein. Compositions and kits for inhibiting an allergic response against an flea allergenic protein; a feline allergenic protein; a canine allergenic protein; a dust mite allergenic protein; a peanut allergenic protein; a Japanese cedar allergenic protein; and a blomia tropicalis allergenic protein are disclosed. Methods if using such compositions and kits are also disclosed.
摘要翻译：公开了抑制对变应原性蛋白质的过敏反应的组合物和试剂盒。所述组合物包含含有编码过敏原蛋白或包含所述变应原蛋白的抗原表位的多肽的核苷酸序列的真核细胞表达载体; 以及包含过敏原蛋白的抗原表位的变应原蛋白或多肽。所述试剂盒包括第一容器，其包含含有编码过敏原蛋白的核苷酸序列的真核细胞表达载体或包含过敏原蛋白的抗原表位的多肽，以及第二容器，其包含过敏原蛋白或包含抗原表位的多肽说过敏性蛋白质。用于抑制针对跳蚤过敏原蛋白质的过敏反应的组合物和试剂盒; 猫过敏原蛋白; 犬过敏蛋白; 尘螨过敏原蛋白; 花生过敏蛋白; 日本雪松过敏蛋白; 并且公开了热带炎热带炎性过敏蛋白。还公开了使用这些组合物和试剂盒的方法。

128. 发明申请

US20070128219A1 Molecular antigen arrays 失效
标题翻译：分子抗原阵列
公开(公告)号：US20070128219A1
公开(公告)日：2007-06-07
申请号：US11601687
申请日：2006-11-20
申请人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
发明人： Martin Bachmann , Alain Tissot , Paul Pumpens , Indulis Cielens , Regina Renhofa
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C12N7/00 , A61K39/00 , A61K39/0005 , A61K39/35 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K14/5409 , C07K16/24 , C07K16/40 , C07K2317/34 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C12N2795/18122 , C12N2795/18123 , Y02A50/412
摘要： The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性免疫应答，特别是抗体应答。

129. 发明申请

US20070117129A1 Antigen arrays for treatment of bone disease 失效
标题翻译：用于治疗骨病的抗原阵列
公开(公告)号：US20070117129A1
公开(公告)日：2007-05-24
申请号：US11589321
申请日：2006-10-30
申请人： Martin Bachmann , Patrik Maurer , Gunther Spohn
发明人： Martin Bachmann , Patrik Maurer , Gunther Spohn
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K14/70575 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

130. 发明授权

US07208156B2 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule 失效
标题翻译：用于诱导对包含与非免疫原性价态平台分子缀合的免疫原的T细胞表位缺陷型类似物的免疫原的体液无反应的组合物
公开(公告)号：US07208156B2
公开(公告)日：2007-04-24
申请号：US10081076
申请日：2002-02-20
申请人： Paul A. Barstad , G. Michael Iverson
发明人： Paul A. Barstad , G. Michael Iverson
IPC分类号： A61K39/00 , A61K39/385
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K2039/6093 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
摘要翻译：公开了非免疫原价态平台分子和免疫原类似物的缀合物，其具有免疫原的特异性B细胞结合能力但缺乏T细胞表位，并且当被引入个体时，诱导免疫原的体液无反应性。因此，这些缀合物可用于治疗由外源或自身免疫原引起的抗体介导的病理学。

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