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1. 发明授权

US07208156B2 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule 失效
标题翻译：用于诱导对包含与非免疫原性价态平台分子缀合的免疫原的T细胞表位缺陷型类似物的免疫原的体液无反应的组合物
公开(公告)号：US07208156B2
公开(公告)日：2007-04-24
申请号：US10081076
申请日：2002-02-20
申请人： Paul A. Barstad , G. Michael Iverson
发明人： Paul A. Barstad , G. Michael Iverson
IPC分类号： A61K39/00 , A61K39/385
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K2039/6093 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
摘要翻译：公开了非免疫原价态平台分子和免疫原类似物的缀合物，其具有免疫原的特异性B细胞结合能力但缺乏T细胞表位，并且当被引入个体时，诱导免疫原的体液无反应性。因此，这些缀合物可用于治疗由外源或自身免疫原引起的抗体介导的病理学。

2. 发明授权

US4425438A Assay method and device 失效
标题翻译：测定方法和装置
公开(公告)号：US4425438A
公开(公告)日：1984-01-10
申请号：US243547
申请日：1981-03-13
申请人： David S. Bauman , Paul A. Barstad
发明人： David S. Bauman , Paul A. Barstad
IPC分类号： G01N33/58 , C12Q1/00 , G01N23/06 , G01N30/00 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/558 , B65D71/00
CPC分类号： G01N33/558 , Y10S436/81 , Y10S436/824
摘要： A method and device for assaying a test substance utilizing a primary absorbent substance for selectively allowing only a quantity of an analytical reagent proportional to the quantity of test substance to pass therethrough when test substance and analytical reagent are contacted with the primary absorbent. An analytical absorbent is disposed in a series of zones for sequentially absorbing the analytical reagent which passes through the primary absorbent so that detection of the last zone of absorbed analytical reagent indicates the quantity of test substance. The method comprises passing test substance and analytical reagent through the primary absorbent and then the analytical absorbent followed by detection of the last zone in which analytical reagent is absorbed. The device comprises a funnel with the primary absorbent therein for directing the test substance and analytical reagent to a narrow tube holding the analytical absorbent.
摘要翻译：一种使用初级吸收物质测定试验物质的方法和装置，当测试物质和分析试剂与初级吸收剂接触时，选择性地仅允许与试验物质的量成比例的分析试剂通过。分析吸收剂设置在一系列区域中，用于顺序吸收通过初级吸收剂的分析试剂，使得吸收的分析试剂的最后一个区域的检测指示测试物质的量。该方法包括使检测物质和分析试剂通过初级吸收剂，然后通过分析吸收剂检测分析试剂吸收的最后一个区域。该装置包括其中具有主要吸收剂的漏斗，用于将测试物质和分析试剂引导至保持分析吸收剂的窄管。

3. 发明授权

US06060056A Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule 失效
公开(公告)号：US06060056A
公开(公告)日：2000-05-09
申请号：US118055
申请日：1993-09-08
申请人： Stephen M. Coutts , Paul A. Barstad , G. Michael Iverson , David S. Jones
发明人： Stephen M. Coutts , Paul A. Barstad , G. Michael Iverson , David S. Jones
IPC分类号： A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/385 , A61K47/48 , A61P37/04 , A61P37/06 , C07K7/06 , C07K14/76 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0008 , A61K39/35 , A61K47/48023 , A61K2039/6093 , A61K38/00 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.

4. 发明授权

US4962023A Single incubation immuno sorbent assay method using particle labels to detect test antigen specific antibodies in presence of other antibodies 失效
标题翻译：使用粒子标记物在其他抗体存在下检测测试抗原特异性抗体的单一孵育免疫吸附测定法
公开(公告)号：US4962023A
公开(公告)日：1990-10-09
申请号：US66763
申请日：1987-06-22
申请人： William J. Todd , Paul A. Barstad
发明人： William J. Todd , Paul A. Barstad
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , G01N33/54306 , Y10S436/80 , Y10S436/801 , Y10S436/804 , Y10S436/808 , Y10S436/828
摘要： An immunoassay method for one-step detection of specific antibodies which includes incubation of a solid phase support or matrix having a spot of the antigen bound thereto with a sample of the clinical fluid to be tested in the presence of a signal developing reagent, including a detector substance, which is preferably a colloidal metal sol, and a ligand, such as protein A or other antibody binding ligand. A diagnostic field kit containing the test antigens and signal developing reagent is also described.

5. 发明授权

US5268454A Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier 失效
标题翻译：用于诱导对包含与非免疫原性载体缀合的免疫原的t细胞表位缺陷型类似物的免疫原的体液无反应的组合物
公开(公告)号：US5268454A
公开(公告)日：1993-12-07
申请号：US652648
申请日：1991-02-08
申请人： Paul A. Barstad , Gilbert M. Iverson
发明人： Paul A. Barstad , Gilbert M. Iverson
IPC分类号： A61K38/00 , A61K38/11 , A61K39/00 , A61K39/35 , A61K39/385 , A61K47/48 , A61P37/04 , A61P37/06 , C07K7/06 , C07K14/76 , C07K16/00 , C07K17/00 , C07K17/08 , C07K17/14
CPC分类号： A61K39/0008 , A61K39/35 , A61K47/48023 , A61K2039/6093 , A61K38/00 , Y10S424/81 , Y10S530/868
摘要： Conjugates of stable nonimmunogenic polymers and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.

6. 发明授权

US07138244B2 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule 失效
公开(公告)号：US07138244B2
公开(公告)日：2006-11-21
申请号：US10957198
申请日：2004-10-01
申请人： Paul A. Barstad , Gilbert M. Iverson
发明人： Paul A. Barstad , Gilbert M. Iverson
IPC分类号： G01N33/53
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K2039/6093 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.

7. 发明授权

US07163683B2 Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule 失效
公开(公告)号：US07163683B2
公开(公告)日：2007-01-16
申请号：US10892956
申请日：2004-07-16
申请人： Paul A. Barstad , G. Michael Iverson
发明人： Paul A. Barstad , G. Michael Iverson
IPC分类号： A61K39/385
CPC分类号： A61K39/0008 , A61K38/00 , A61K39/35 , A61K47/54 , A61K2039/6093 , Y10S424/81 , Y10S530/868
摘要： Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.

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