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111. 发明申请

US20120094896A1 INHIBITORS OF VIRAL INTEGRASE AND METHODS OF USE 有权
标题翻译：病毒复合物的抑制剂及其使用方法
公开(公告)号：US20120094896A1
公开(公告)日：2012-04-19
申请号：US13257550
申请日：2010-03-18
申请人： Tanya Sandrock , Robert Craigie
发明人： Tanya Sandrock , Robert Craigie
IPC分类号： A61K38/10 , C12Q1/70 , A61P31/18 , C12N9/99 , C07K7/08 , C07H21/04
CPC分类号： C07K4/00 , A61K38/00 , A61K38/03 , A61K38/10 , A61K39/00 , C07K1/00 , C07K7/02 , C07K7/08 , C12Q1/68 , C12Q1/70 , C40B30/04 , G01N33/573 , G01N2333/15 , G01N2500/02
摘要： Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identifying agents that inhibit HIV viral mutants that are resistant to integrase inhibitors.
摘要翻译：本文描述了用于抑制HIV整合酶活性的组合物和方法。还描述了鉴定抑制HIV整合酶用于治疗或预防HIV的药剂的方法。还公开了鉴定抑制对整合酶抑制剂有抗性的HIV病毒突变体的药剂的方法。

112. 发明申请

US20120021404A1 Method for Diagnosis and Monitoring of Viral Infection by Analysis of Viral Transrenal Nucleic Acids in Urine 有权
标题翻译：通过尿液中病毒性肾上腺核酸分析病毒感染的诊断和监测方法
公开(公告)号：US20120021404A1
公开(公告)日：2012-01-26
申请号：US13114289
申请日：2011-05-24
申请人： Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
发明人： Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译：本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。

113. 发明授权

US08088907B2 Detection of mutations in a gene associated with resistance to viral infection, OAS1 有权
标题翻译：检测与病毒感染相关的基因中的突变，OAS1
公开(公告)号：US08088907B2
公开(公告)日：2012-01-03
申请号：US12061548
申请日：2008-04-02
申请人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
发明人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
IPC分类号： C07H21/04
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53 , Y02A50/54
摘要： A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
摘要翻译：用于检测与编码OAS1的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽或编码该蛋白质或多肽的多核苷酸组成的治疗剂。还提供人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OAS1特异性的组合物。

114. 发明授权

US08084443B2 Biological specimen collection and transport system and methods of use 有权
标题翻译：生物样本采集和运输系统及使用方法
公开(公告)号：US08084443B2
公开(公告)日：2011-12-27
申请号：US12243949
申请日：2008-10-01
申请人： Gerald W. Fischer , Luke T. Daum
发明人： Gerald W. Fischer , Luke T. Daum
IPC分类号： A61K31/66 , A61K31/19 , C12Q1/68 , C12M3/08 , C09K15/16
CPC分类号： C12Q1/70 , C12Q1/6806 , C12Q2527/125
摘要： Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formulations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing or assay. The disclosed compositions safely facilitate rapid sample collection, and provide extended storage and transport of the samples at ambient or elevated temperature without contamination of the sample or degradation of the nucleic acids contained therein. This process particularly facilitates the collection of specimens from remote locations, and under conditions previously considered hostile for preserving the integrity of nucleic acids released from lysed biological samples without the need of refrigeration or freezing prior to molecular analysis.
摘要翻译：公开了用于从生物，法医和环境样品中分离核酸群体的组合物。还公开了将这些组合物用作用于杀死病原体，灭活核酸酶以及从样品中的其他细胞组分释放多核苷酸的一步制剂，以及在进一步加工或测定之前使核酸稳定的方法。所公开的组合物安全地促进快速样品收集，并且在环境温度或升高的温度下提供样品的延长的储存和运输，而不会污染样品或其中所含的核酸的降解。该方法特别有助于从远程位置收集标本，并且在先前被认为是敌对的条件下收集样品，以保持从裂解的生物样品中释放的核酸的完整性，而不需要在分子分析之前进行冷冻或冷冻。

115. 发明授权

US08071309B2 Methods for rapid identification of pathogens in humans and animals 有权
标题翻译：快速鉴别人和动物病原体的方法
公开(公告)号：US08071309B2
公开(公告)日：2011-12-06
申请号：US11930002
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Ray Ranken , Thomas A. Hall
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Ray Ranken , Thomas A. Hall
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G06F19/20
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
摘要翻译：本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢来自环境，临床或其他样品。

116. 发明申请

US20110237501A1 Detection of Mutations in a Gene Associated with Resistance to Viral Infection, OAS1 审中-公开
标题翻译：检测与病毒感染抵抗相关的基因突变，OAS1
公开(公告)号：US20110237501A1
公开(公告)日：2011-09-29
申请号：US13082119
申请日：2011-04-07
申请人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
发明人： Shawn P. Iadonato , Charles L. Magness , Gary Rosenberg , Christina A. Scherer , Thierry Guillaudeux
IPC分类号： A61K38/17 , A61P31/18 , A61P31/22 , A61P31/12
CPC分类号： C12Q1/707 , A61K38/45 , C07K16/40 , C12N9/1241 , C12N15/1137 , C12Q1/6876 , C12Q1/6883 , C12Q1/6888 , C12Q1/70 , C12Q2600/156 , C12Q2600/172 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465 , Y02A50/53
摘要： A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
摘要翻译：用于检测与编码OAS1的基因有关的突变的方法。这个和其他公开的突变与人类对包括丙型肝炎的病毒感染的抗性相关。还提供了由突变基因编码的蛋白质或多肽或编码该蛋白质或多肽的多核苷酸组成的治疗剂。还提供人OAS1的抑制剂，包括反义寡核苷酸，方法和人类OAS1特异性的组合物。

117. 发明授权

US07973154B2 Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine 有权
标题翻译：通过分析尿液中的病毒性肾上腺核酸来诊断和监测病毒感染的试剂盒
公开(公告)号：US07973154B2
公开(公告)日：2011-07-05
申请号：US11137935
申请日：2005-05-25
申请人： Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
发明人： Hovsep Melkonyan , Angela Cannas , Louis David Tomei , Samuil R. Umansky
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68 , A61K9/14
CPC分类号： C12Q1/706 , C12Q1/70 , C12Q1/703 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The analysis of the nucleic acids is performed through hybridization of the nucleic acids with specific probes, or through a chain amplification reaction with specific primers. The methods are applicable to all viral pathogenic agents, including RNA, DNA, episomal, or integrated viruses.
摘要翻译：本发明涉及用于通过检测在尿样中是否存在来自尿液样本的病毒来源的经肾上腺病毒核酸或核酸的存在来诊断或监测病毒感染的方法，其中或不分离来自尿液样品的核酸。核酸的分析通过核酸与特异性探针的杂交，或通过与特异性引物的链扩增反应来进行。所述方法适用于所有病毒致病剂，包括RNA，DNA，附加型或综合病毒。

118. 发明申请

US20110104660A1 MAL, A MOLECULAR DIAGNOSTIC MARKER FOR HPV-INDUCED INVASIVE CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS 有权
标题翻译： MAL，A型分子诊断标记用于HPV感染的入侵癌及其高等级前列腺炎
公开(公告)号：US20110104660A1
公开(公告)日：2011-05-05
申请号：US12937981
申请日：2009-04-14
申请人： Christophorus Joannes Lambertus Maria Meijer , Petrus Josephus Ferdinandus Snijders , Renske Daniëla Maria Steenbergen
发明人： Christophorus Joannes Lambertus Maria Meijer , Petrus Josephus Ferdinandus Snijders , Renske Daniëla Maria Steenbergen
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/70 , C12Q2523/125 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The inventors now have developed a (molecular) diagnostic marker based on MAL alterations, in particular reduced MAL mRNA and protein expression as well as MAL promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, and high-risk human papillomavirus (HPV)-induced precursor lesions of non-cervical invasive cancers within, cell material obtained via scraping, lavage or by other means and/or tissue. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the gene products thereof as marker for HPV-induced high-grade premalignant lesions, allowing early detection and better treatment option for the individual patient.
摘要翻译：发明人现在已经开发了基于MAL改变的（分子）诊断标记，特别是降低的MAL mRNA和蛋白质表达以及MAL启动子高甲基化，以鉴定人乳头状瘤病毒（HPV）诱导的高级癌前病变，例如癌前宫颈病变侵袭性宫颈癌和高危人乳头状瘤病毒（HPV）诱导的非宫颈浸润性癌症的前体病变，通过刮擦，灌洗或通过其他方式和/或组织获得的细胞材料。特别地，本发明涉及MAL基因（包括其启动子）及其基因产物作为HPV诱导的高级恶变前病变的标记物的使用，能够为个体患者提供早期检测和更好的治疗选择。

119. 发明申请

US20110082180A1 ANTIMICROBIAL COMPOUNDS 有权
标题翻译：抗微生物化合物
公开(公告)号：US20110082180A1
公开(公告)日：2011-04-07
申请号：US12898806
申请日：2010-10-06
申请人： Kevin Rock McClay , Robert Jon Steffan
发明人： Kevin Rock McClay , Robert Jon Steffan
IPC分类号： A61K31/423 , C07D413/08 , C12Q1/26 , A61P33/02 , A61P31/12 , A61P31/10 , A61P31/04 , A61P31/06 , A61P31/00
CPC分类号： A61K31/423 , C07D413/04 , C12Q1/26 , C12Q1/70 , Y02A50/402 , Y02A50/471 , Y02A50/478
摘要： The compounds disclosed herein are isoxazole derivatives that are useful as antimicrobial compounds, particularly as anti-bacterial compounds. The disclosed methods comprise incubating at least two different substrates in the presence of at least one oxygenase to provide the disclosed compounds, or to prepare and identify compounds that have antimicrobial activity.
摘要翻译：本文公开的化合物是异恶唑衍生物，其可用作抗微生物化合物，特别是作为抗菌化合物。所公开的方法包括在存在至少一种加氧酶的情况下孵育至少两种不同的底物以提供所公开的化合物，或制备和鉴定具有抗微生物活性的化合物。

120. 发明申请

US20110076288A1 Compositions for and Methods of Identifying Antigens 有权
标题翻译：组合物和识别抗原的方法
公开(公告)号：US20110076288A1
公开(公告)日：2011-03-31
申请号：US12224074
申请日：2007-02-21
申请人： Darren E. Higgins , Michael N. Starnbach , Todd Gierahn , Nadia R. Roan
发明人： Darren E. Higgins , Michael N. Starnbach , Todd Gierahn , Nadia R. Roan
IPC分类号： A61K39/02 , C40B40/02 , C40B40/06 , C40B30/06 , A61K38/00 , C07K14/00 , C07K14/295
CPC分类号： C12N15/1037 , A61K38/00 , A61K39/00 , A61K39/0011 , C07K14/295 , C07K2319/00 , C12N15/1034 , C12N15/1072 , C12Q1/68 , C12Q1/70 , G01N33/5047
摘要： Replicable libraries having discrete members in defined locations for screening for antigens to a pathogenic organism are provided. Also provided are methods for using such libraries as well as a specific antigen, CT788, which induces T-cell activation during a Chlamydia infection.
摘要翻译：提供了在定义位置具有离散成员的可复制文库，用于将抗原筛选到致病生物体。还提供了使用这种文库以及在衣原体感染期间诱导T细胞活化的特异性抗原CT788的方法。

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