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111. 发明授权

US07785271B2 Sensor for blood component analysis 有权
标题翻译：血液成分分析传感器
公开(公告)号：US07785271B2
公开(公告)日：2010-08-31
申请号：US10952702
申请日：2004-09-28
申请人： Masaki Fujiwara , Shin Ikeda
发明人： Masaki Fujiwara , Shin Ikeda
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150442 , A61B5/150572 , A61B5/150969 , A61B2562/0295 , C12Q1/005 , C12Q1/006 , G01N27/3272
摘要： A sensor for blood component analysis, which allows even a trace amount of blood to be led to an analysis portion reliably. The sensor for blood component analysis includes a substrate, a spacer, and a cover. The cover is disposed on the substrate with the spacer intervening between the cover and the substrate, whereby a space that serves as an analysis portion and a channel for leading blood to the analysis portion is formed inside the sensor. Through holes are formed in the substrate and the spacer, respectively, so that a common through hole through which a needle of a lancet can pass is formed when the spacer is disposed on the substrate. The through hole of the spacer communicates with the channel and a top of the through hole of the spacer is covered with the cover, whereby a lancing portion is formed by the common through hole and a portion of the cover covering the top of the through hole of the spacer. In use, the sensor is placed at a position where blood collection is to be performed, the portion of the cover covering the lancing portion is broken through with the needle of the lancet so that the needle is allowed to pass through the common through hole to puncture the position, and blood that has come out is guided by a downwardly protruding burr formed when the cover is broken through so that the blood is led to the channel and flows through the channel to be led to the analysis portion.
摘要翻译：用于血液成分分析的传感器，其甚至允许将微量的血液可靠地引导到分析部分。用于血液成分分析的传感器包括基底，间隔物和盖。盖子设置在基板上，间隔物插入在盖和基板之间，由此在传感器的内部形成用作分析部分的空间和用于使血液引导到分析部分的通道。在衬底和间隔件中分别形成通孔，使得当间隔件设置在基板上时，形成有刺血针的针穿过的公共通孔。间隔件的通孔与通道连通，并且间隔件的通孔的顶部被盖覆盖，由此通过公共通孔形成起毛部分，并且覆盖通孔顶部的盖的一部分的间隔物。在使用中，将传感器置于要进行血液收集的位置，覆盖穿刺部分的盖部分用刺血针的针断开，使得针被允许穿过公共通孔穿刺位置，并且当盖被破坏时形成的向下突出的毛刺引导出来的血液，使得血液被引导到通道并流过通道以被引导到分析部分。

112. 发明申请

US20100121368A1 LANCET SYSTEM 有权
标题翻译： LANCET系统
公开(公告)号：US20100121368A1
公开(公告)日：2010-05-13
申请号：US12452314
申请日：2008-07-21
申请人： Stanley I. Kim
发明人： Stanley I. Kim
IPC分类号： A61B17/34
CPC分类号： A61B5/150969 , A61B5/1411 , A61B5/150022 , A61B5/150152 , A61B5/150198 , A61B5/150396 , A61B5/150412 , A61B5/150427 , A61B5/150519 , A61B5/150549 , A61B5/150587 , A61B5/150603 , A61B5/150618 , A61B5/150717 , A61B5/150916 , A61B5/150938 , A61B5/150977 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B5/1519 , A61B5/15194
摘要： A lancing system comprising a lancet with a handle portion to and a needle bearing portion, the needle bearing portion retaining a thin needle protected by a safety cap. The safety cap includes first and second chambers, where the first chamber acts as a sheath and the second chamber having a surface positioned to compromise the structure of the needle when the needle bearing portion of the lancet body is inserted into the second chamber.
摘要翻译：一种牵引系统，包括具有手柄部分的刺血针和滚针轴承部分，所述滚针轴承部分保持由安全帽保护的细针。安全帽包括第一和第二腔室，其中第一腔室用作护套，并且第二腔室具有定位成当柳叶刀体的针轴承部分插入第二腔室时破坏针的结构的表面。

113. 发明授权

US07420659B1 Flow control system of a cartridge 有权
标题翻译：墨盒的流量控制系统
公开(公告)号：US07420659B1
公开(公告)日：2008-09-02
申请号：US10908014
申请日：2005-04-25
申请人： Cleopatra Cabuz , Eugen Cabuz
发明人： Cleopatra Cabuz , Eugen Cabuz
IPC分类号： G01N33/49 , F04B17/00
CPC分类号： B01L9/527 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150755 , A61B5/150969 , B01L3/5027 , B01L2200/0636 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0633 , B01L2400/0655 , F16K99/0015 , F16K99/0051 , G01F1/7086 , G01N15/1056 , G01N15/1404 , G01N15/1484 , G01N2015/1486
摘要： An apparatus having a disposable cytometer cartridge containing pumps, pressure chambers, reservoirs, flow sensors, flow channels, and microfluidic circuits with fluid operations on the cartridge. The circuits may include mesopumps and mesovalves embedded in the chip, card or cartridge. The apparatus may have multiple detecting, analyzing and identification capabilities of blood or other fluids of interest. The sample to be tested may be entered in the disposable microfluidic cartridge which in turn is insertable in a hand-holdable or portable cytometer instrument. This apparatus may have significant application in biological warfare agent detection, water analyses, environmental checks, hematology, and other clinical and research fields.
摘要翻译：一种装置，其具有一个包含泵，压力室，储存器，流量传感器，流动通道和在墨盒上具有流体操作的微流体电路的一次性血细胞计数器盒。这些电路可以包括嵌入在芯片，卡或盒中的中间泵和中间阀。该装置可以具有对感兴趣的血液或其它流体的多个检测，分析和识别能力。待测试的样品可以进入一次性微流控盒，其又可插入手持式或便携式的血液计仪器中。该装置可能在生物战剂检测，水分析，环境检查，血液学等临床和研究领域具有重要应用。

114. 发明授权

US07384396B2 System and method for continuous analyte monitoring 有权
标题翻译：用于连续分析物监测的系统和方法
公开(公告)号：US07384396B2
公开(公告)日：2008-06-10
申请号：US10435221
申请日：2003-05-08
申请人： Mark A. Samuels , Jonathan A. Eppstein , Michael R. Hatch , Alan Smith , Mark Faupel
发明人： Mark A. Samuels , Jonathan A. Eppstein , Michael R. Hatch , Alan Smith , Mark Faupel
IPC分类号： A61B5/00
CPC分类号： A61B5/14514 , A61B5/00 , A61B5/0002 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15134 , A61B5/155 , A61B5/157 , A61B10/0045 , A61B2010/008
摘要： A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.
摘要翻译：一种用于从生物体提取生物流体并连续监测其特征的系统和方法。该系统包括适于定位在生物体的生物膜的表面上或周围的组织界面装置以及耦合到组织界面装置的监测和控制单元。组织接口装置包括定位在流体的流动路径中的传感器，用于在生物流体从形成在生物膜中的一个或多个人造开口流出时持续感测生物流体的特性。传感器产生代表其的传感器信号。监视器和控制单元以电或光学方式读取传感器，以连续的方式获得生物流体特性的浓度，例如特定分析物的浓度。

115. 发明申请

US20070088377A1 BLOOD SAMPLING DEVICE 有权
标题翻译：血液采样装置
公开(公告)号：US20070088377A1
公开(公告)日：2007-04-19
申请号：US11611998
申请日：2006-12-18
申请人： Richard LeVAUGHN , Gwenn KENNEDY , Christopher RUF , Mitchell SOLIS , Avi ROBBINS , Jason HEATH , Wolfgang OSTERTAG , Armin LOHRENGEL , Herbert STOHR
发明人： Richard LeVAUGHN , Gwenn KENNEDY , Christopher RUF , Mitchell SOLIS , Avi ROBBINS , Jason HEATH , Wolfgang OSTERTAG , Armin LOHRENGEL , Herbert STOHR
IPC分类号： A61B17/32
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/150022 , A61B5/150183 , A61B5/150259 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150564 , A61B5/150572 , A61B5/150618 , A61B5/150702 , A61B5/150725 , A61B5/150969 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15161 , A61B5/15163 , A61B5/15176 , A61B5/157 , A61B5/681 , A61B2562/0295
摘要： A device for sampling and/or analyzing blood or other body fluid of a subject. A housing contains a plurality of lancets and optionally includes test elements to take up a sample of blood, an evaluation system and a display. A complete system that can be handled as a single device, for example in the form of a wristwatch, includes a multiplicity of test elements and lancets, which can be brought successively to a working position to perform multiple measurements. A cassette or carrier includes multiple lancets and/or test elements, for insertion into the device.
摘要翻译：用于对受试者的血液或其他体液进行取样和/或分析的装置。壳体包含多个刺血针并且可选地包括用于吸取血液样本的测试元件，评估系统和显示器。可以作为单个装置处理的完整系统，例如以手表的形式，包括多个测试元件和刺血针，其可连续地连续工作以进行多次测量。盒或载体包括多个刺血针和/或测试元件，用于插入到装置中。

116. 发明申请

US20060290496A1 Diagnostic radio frequency identification sensors and applications thereof 有权
标题翻译：诊断射频识别传感器及其应用
公开(公告)号：US20060290496A1
公开(公告)日：2006-12-28
申请号：US10530901
申请日：2005-01-24
申请人： John Peeters
发明人： John Peeters
IPC分类号： G08B13/14
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0008 , A61B5/02 , A61B5/1112 , A61B5/1411 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1491 , A61B5/150022 , A61B5/150358 , A61B5/150793 , A61B5/150854 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B90/98 , A61B2560/0242 , A61B2560/0285 , A61B2560/0412 , A61B2560/0462 , A61B2562/08 , A62B99/00 , B01L2300/08 , B01L2300/0816 , B01L2300/0819 , B01L2300/0825 , G01D21/00 , G01K13/00 , G01N33/02 , G01N33/146 , G01N33/54373 , G01N33/5438 , G01N33/58 , G01N35/00871 , G01N2035/00881 , G06K19/0717 , G06K19/0723 , G08B31/00 , H04M1/7253 , H04M2250/02 , H04W64/00 , H04W80/00 , H04W84/18 , H04W88/02 , H04W88/06 , Y02A30/50
摘要： An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, MEMS, electrochemical, thermal, resistive, nano or microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and self-diagnostics on smart skin patches, Point of Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones.
摘要翻译：描述了一种集成的无源无线芯片诊断传感器系统，其可以与诸如具有多协议RFID读取器能力的修改的手机（例如新兴的Gen-2标准）或蓝牙等无线设备进行远程询问，提供通用的易于使用，低成本和立即的定量分析，地理位置和传感器网络功能的用户的技术。本发明可以集成到各种诊断平台中，并且适用于诸如薄膜，MEMS，电化学，热，电阻，纳米或微流体传感器技术的低功率传感器。本发明的应用包括智能皮肤贴片上的现场医疗和自我诊断，护理点（POC）分析，食品诊断，病原体检测，疾病特异性无线生物标志物检测，远程结构应力检测和传感器网络工业或国土安全使用低成本无线设备，如修改手机。

117. 发明申请

US20060182738A1 Medical device for analyte monitoring and drug delivery 有权
公开(公告)号：US20060182738A1
公开(公告)日：2006-08-17
申请号：US11202206
申请日：2005-08-12
申请人： Elizabeth Holmes
发明人： Elizabeth Holmes
IPC分类号： A61K39/395 , A61N1/00 , C12Q1/68 , G01N33/53 , C12M1/34
CPC分类号： A61B5/073 , A61B5/0024 , A61B5/0031 , A61B5/1411 , A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/14556 , A61B5/1473 , A61B5/1477 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150282 , A61B5/150343 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417 , A61B5/4238 , A61B5/4839 , A61B5/4848 , A61B5/6833 , A61B5/685 , A61B5/6865 , A61B5/7282 , A61B2560/0412 , A61M5/14276 , A61M37/0015 , A61M2005/14513 , A61M2005/1726 , A61M2037/0023 , A61M2205/0244 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0472 , B01L2400/0487 , G01N2035/00158
摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

118. 发明申请

US20060178599A1 Sytem and method for the extraction and monitoring of a biological fluid 有权
标题翻译：用于提取和监测生物流体的系统和方法
公开(公告)号：US20060178599A1
公开(公告)日：2006-08-10
申请号：US10515039
申请日：2003-05-22
申请人： Mark Faupel , Danny Lincoln
发明人： Mark Faupel , Danny Lincoln
IPC分类号： A61B5/00
CPC分类号： A61B5/155 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150969 , A61B10/0045 , A61B2010/008
摘要： Systems and methods use extraction devices for extracting and monitoring biological fluids of patients. The systems and methods involve creating an opening in the biological tissue of the patient and placing a sampling aperture of the extraction device over the opening. The sampling aperture is defined in a contact surface of the extraction device that is placed into contact with the tissue of the patient. A pump of the extraction device such as a depressible bulb sealed to the body is charged to create a vacuum between the pump through a sampling channel to the sampling aperture, and the vacuum draws the biological fluid from the tissue opening into the sampling channel. An access point is exposed to the sampling channel, and the sample of fluid may be accessed from the access point. The access point may be an extraction opening covered by an access door, and the access door is opened to access the sample. Alternatively, the access point may be electrodes extending into the sampling channel where the electrodes are connectable to a fluid analyzer device.
摘要翻译：系统和方法使用提取装置来提取和监测患者的生物液体。所述系统和方法涉及在患者的生物组织中产生开口并将提取装置的采样孔放置在开口上。取样孔限定在提取装置的与患者组织接触的接触表面中。对诸如密封到身体的可压迫的灯泡的提取装置的泵进行充电以在泵通过采样通道到采样孔之间产生真空，并且真空将生物流体从组织开口吸入采样通道。接入点暴露于采样通道，可以从接入点访问流体样本。接入点可以是由进入门覆盖的提取开口，并且访问门被打开以访问样本。或者，接入点可以是延伸到采样通道中的电极，其中电极可连接到流体分析器装置。

119. 发明授权

US07066884B2 System, method, and device for non-invasive body fluid sampling and analysis 失效
公开(公告)号：US07066884B2
公开(公告)日：2006-06-27
申请号：US09979096
申请日：2001-03-16
申请人： Linda Custer , Tuan A. Elstrom , Scott C. Kellogg , Joseph Kost , Nicholas F. Warner
发明人： Linda Custer , Tuan A. Elstrom , Scott C. Kellogg , Joseph Kost , Nicholas F. Warner
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B8/00 , A61B2010/008 , A61M25/02 , A61M37/0092 , A61M2025/0206
摘要： A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level; (2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte; and (8) providing the results of the step of analyzing the body fluid.

120. 发明授权

US07004928B2 Autonomous, ambulatory analyte monitor or drug delivery device 有权
公开(公告)号：US07004928B2
公开(公告)日：2006-02-28
申请号：US10131268
申请日：2002-04-23
申请人： John Gregory Aceti , Sterling Eduard McBride , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
发明人： John Gregory Aceti , Sterling Eduard McBride , Richard Morgan Moroney, III , Christopher Carter Gregory , Peter John Zanzucchi
IPC分类号： A61M5/00 , A61M5/315 , A61B5/00 , B65D81/00
CPC分类号： A61B5/150984 , A61B5/1411 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/150022 , A61B5/150076 , A61B5/150213 , A61B5/150389 , A61B5/150503 , A61B5/150526 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15109 , A61B5/15119 , A61B5/15123 , A61B5/15146 , A61B5/15153 , A61B5/15163 , A61B5/155 , A61B5/157 , A61B5/681 , A61B5/6833 , A61B2560/0412 , A61B2560/0443 , A61M37/0015 , A61M2037/0023 , A61M2037/0038 , A61M2209/088 , A61M2230/201 , G01N33/491
摘要： The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.

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