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111. 发明授权

US08388935B2 Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions 有权
公开(公告)号：US08388935B2
公开(公告)日：2013-03-05
申请号：US13315671
申请日：2011-12-09
申请人： Henry C. Lin , Mark Pimentel
发明人： Henry C. Lin , Mark Pimentel
IPC分类号： A61K49/00 , A61K35/00 , A61K45/00
CPC分类号： A61K38/54 , A23L33/40 , A23V2002/00 , A61B5/0836 , A61B5/412 , A61B5/415 , A61B5/418 , A61K9/0053 , A61K9/0087 , A61K31/135 , A61K31/138 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/4045 , A61K31/4164 , A61K31/4184 , A61K31/424 , A61K31/43 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/534 , A61K38/1796 , A61K38/22 , A61K38/225 , A61K38/2271 , A61K45/06 , A61K49/0004 , A61K51/1206 , G01N33/497 , G01N33/6893 , G01N2033/4977 , G01N2333/70571 , G01N2800/06 , Y10S426/80 , Y10S426/801 , Y10T436/145555 , Y10T436/147777 , Y10T436/18 , Y10T436/214 , Y10T436/22 , A61K2300/00
摘要： Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.

112. 发明申请

US20130030272A1 TONOMETRIC DEVICE FOR EXAMINING RESPIRATORY INSUFFICIENCY AND REGIONAL TISSUE PERFUSION FAILURE 审中-公开
标题翻译：用于检查呼吸障碍和区域组织灌注失败的测量装置
公开(公告)号：US20130030272A1
公开(公告)日：2013-01-31
申请号：US13521336
申请日：2010-09-01
申请人： Domokos Boda
发明人： Domokos Boda
IPC分类号： A61B5/145
CPC分类号： A61B5/0836
摘要： A probe comprising a tubular member arranged substantially in a plane within a perimeter fitting into the sublingual or postlabial area of a human patient. The tubular member is made preferably of silicone rubber or a material permeable for gases, particularly for carbon dioxide, and forming a barrier against body fluids. The tubular member has consecutive curved sections communicating with each other and form a continuous flow pass. Ends of the tubular member have connection tubes adapted for delivering the fluid inside the lumen of the tubular member directly or indirectly to a measuring apparatus. The connection tubes are made preferably of a material substantially impermeable for carbon dioxide.
摘要翻译：一种探针，其包括基本上布置在与人类患者的舌下或后阴道区域相配合的周边内的平面中的管状构件。管状构件优选地由硅橡胶或可渗透气体的材料制成，特别是用于二氧化碳，并形成抵抗体液的屏障。管状构件具有彼此连通并形成连续流动通道的连续弯曲部分。管状构件的端部具有适于将管状构件的内腔内的流体直接或间接地传送到测量装置的连接管。连接管优选由二氧化碳基本上不可渗透的材料制成。

113. 发明申请

US20130023741A1 Integrated Portable Medical Diagnostic System 审中-公开
标题翻译：综合便携式医疗诊断系统
公开(公告)号：US20130023741A1
公开(公告)日：2013-01-24
申请号：US13552582
申请日：2012-07-18
申请人： Stephen Teni Ayanruoh
发明人： Stephen Teni Ayanruoh
IPC分类号： A61B6/00 , A61B5/0205 , A61B5/0402 , A61B5/1455 , A61B5/01 , A61B5/087 , A61M16/10 , A61B8/00 , A61B7/04 , A61B5/08 , A61B1/31 , A61B1/307 , A61B1/273 , A61B1/24 , A61B13/00 , A61B1/04 , A61B5/20 , A61B5/145 , A61B1/227 , A61B1/233 , A61B3/12 , A61B5/00
CPC分类号： A61B5/02055 , A61B1/24 , A61B1/267 , A61B1/2736 , A61B1/307 , A61B1/31 , A61B5/0077 , A61B5/01 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0402 , A61B5/08 , A61B5/0836 , A61B5/14532 , A61B5/14542 , A61B5/20 , A61B5/68 , A61B6/4405 , A61B8/4427 , A61B13/00 , Y10T29/49826
摘要： A portable integrated self-contained rechargeable with AC-DC direct current battery system mounted within an instrument case for housing a foldable keyboard, a display and plurality of medical test and treatment modules. It optionally includes a suitable DC to AC inverter to supply AC power. The system includes at least one USB port for adding external test and treatment modules on ad hoc basis. It also includes full duplex data and information input, processing output and communications interface to and from sensors, transducers, networks and other data/information generation or consumption modules, devices and subsystems. It is also known by its three trademark names “Hospital-in-a-Box”, RK Ruskat (Stylized) and SCOMET.
摘要翻译：一种便携式集成式独立充电式，AC-DC直流电池系统安装在仪器箱内，用于容纳可折叠键盘，显示屏和多个医疗测试和治疗模块。它可选地包括一个合适的直流到交流逆变器来提供交流电源。该系统包括至少一个USB端口，用于临时添加外部测试和处理模块。它还包括传感器，传感器，网络和其他数据/信息生成或消耗模块，设备和子系统的全双工数据和信息输入，处理输出和通信接口。它也被称为三个商标名为Hospital-in-a-Box，RK Ruskat（风格化）和SCOMET。

114. 发明授权

US08357099B2 Signal quality determination and signal correction system and methods 有权
标题翻译：信号质量确定和信号校正系统及方法
公开(公告)号：US08357099B2
公开(公告)日：2013-01-22
申请号：US11957995
申请日：2007-12-17
申请人： Paul B. Gunneson , Anthony T. Pierry
发明人： Paul B. Gunneson , Anthony T. Pierry
IPC分类号： A61B5/08
CPC分类号： A61B5/083 , A61B5/0836 , A61M16/021 , A61M16/0816 , A61M16/0833 , A61M16/0858 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2230/432 , A61M2230/435
摘要： A mainstream gas monitoring system and method that includes using a mainstream airway adapter and a gas sensing assembly associated with the airway adapter to measure an analyte of a gas flow through the adapter. A gas sensing portion outputs a signal indicative of the analyte in a gas flow in the mainstream airway adapter. A processing portion receives the signal from the gas sensing portion and determines an amount of the analyte in the gas flow based on the signal from the gas sensing portion. The processing portion determines whether the oxygen measurements are of sufficient quality for their intended use, such as for measuring oxygen consumption or metabolic estimations. Quality measurements may be used to improve accuracy of derived metabolic estimations. Methods are provided by which carbon dioxide measurements can be processed and substituted for direct oxygen measurement for all or part of a respiratory cycle.
摘要翻译：主流气体监测系统和方法，其包括使用主流气道适配器和与气道适配器相关联的气体感测组件来测量通过适配器的气流的分析物。气体传感部分输出指示主流气道适配器中气体流中分析物的信号。处理部分接收来自气体检测部分的信号，并且基于来自气体感测部分的信号确定气流中的分析物的量。处理部分确定氧测量对于其预期用途是否具有足够的质量，例如用于测量氧消耗或代谢估计。可以使用质量测量来提高派生代谢估计的准确性。提供了可以处理二氧化碳测量并代替全部或部分呼吸循环的直接氧气测量的方法。

115. 发明申请

US20130006134A1 METHODS AND SYSTEMS FOR MONITORING VOLUMETRIC CARBON DIOXIDE 审中-公开
标题翻译：监测体积二氧化碳的方法和系统
公开(公告)号：US20130006134A1
公开(公告)日：2013-01-03
申请号：US13174240
申请日：2011-06-30
申请人： Peter R. Doyle , Gardner Kimm , Mehdi M. Jafari
发明人： Peter R. Doyle , Gardner Kimm , Mehdi M. Jafari
IPC分类号： A61B5/08
CPC分类号： A61B5/0836 , A61M16/0063 , A61M16/026 , A61M16/0833 , A61M2016/0027 , A61M2016/0036 , A61M2205/502 , A61M2230/432
摘要： This disclosure describes novel systems and methods for monitoring volumetric CO2 during ventilation of a patient being ventilated by a medical ventilator. The disclosure describes more accurate, more cost effective, and/or less burdensome non-invasive methods and systems for calculating volumetric CO2 than previously utilized methods and systems. The disclosure describes estimating a flow rate in a breathing circuit to calculate a volumetric CO2. Further, the disclosure describes synchronizing the estimated flow rate with a measured CO2 to calculate a volumetric CO2. Additionally, the disclosure describes synchronizing a measured flow rate from within the breathing circuit with a measured CO2 to calculate a volumetric CO2.
摘要翻译：本公开描述了在通过医疗呼吸机通气的患者的通气期间监测体积二氧化碳的新型系统和方法。本公开描述了比以前使用的方法和系统更准确，更具成本效益和/或更少的非侵入性方法和用于计算体积CO 2的系统。本公开内容描述了估计呼吸回路中的流量以计算体积二氧化碳。此外，本公开描述了将估计的流量与测量的CO 2同步以计算体积CO 2。此外，本公开内容描述了将来自呼吸回路内的测量流量与测量的CO 2同步以计算体积CO 2。

116. 发明申请

US20120289838A1 CARBON-DIOXIDE SAMPLING SYSTEM FOR ACCURATELY MONITORING CARBON DIOXIDE IN EXHALED BREATH 有权
标题翻译：二氧化碳采样系统，用于精确监测二氧化碳在呼吸道中的吸入
公开(公告)号：US20120289838A1
公开(公告)日：2012-11-15
申请号：US13105840
申请日：2011-05-11
申请人： Christopher M. Varga , Stephen J. Birch , Brian W. Pierro
发明人： Christopher M. Varga , Stephen J. Birch , Brian W. Pierro
IPC分类号： A61B5/097 , A61B6/00
CPC分类号： A61B5/0836 , A61B5/097 , A61M11/00 , A61M15/00 , A61M16/0093 , A61M16/044 , A61M16/0463 , A61M16/06 , A61M16/0605 , A61M16/0611 , A61M16/0627 , A61M16/0683 , A61M16/0694 , A61M16/08 , A61M16/0825 , A61M16/0833 , A61M16/085 , A61M16/1055 , A61M16/1065 , A61M16/208 , A61M2016/0027 , A61M2016/003 , A61M2205/02 , A61M2205/0205 , A61M2205/0238 , A61M2205/15 , A61M2205/18 , A61M2205/3313 , A61M2205/3331 , A61M2205/584 , A61M2205/6027 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/6081 , A61M2205/75 , A61M2210/1053 , A61M2230/432
摘要： A carbon-dioxide sampling system for accurately monitoring carbon dioxide in exhaled breath. The system includes a ventilator. The ventilator is configured to ventilate a patient with respiratory gases. The ventilator includes a carbon-dioxide sampling control unit and a carbon-dioxide analyzer. The carbon-dioxide sampling control unit is configured to control the timing of sampling of carbon dioxide in the exhaled breath of a patient, and to control the timing of the analysis of exhaled gases by the carbon-dioxide analyzer.
摘要翻译：用于精确监测呼出气中二氧化碳的二氧化碳取样系统。该系统包括呼吸机。呼吸机被配置为使呼吸气体患者通气。呼吸机包括二氧化碳取样控制单元和二氧化碳分析仪。二氧化碳取样控制单元被配置为控制患者的呼出气中二氧化碳取样的时间，并且控制由二氧化碳分析仪分析呼出气体的时间。

117. 发明申请

US20120263790A1 METHODS OF DIAGNOSING AND TREATING SMALL INTESTINAL BACTERIAL OVERGROWTH (SIBO) AND SIBO-RELATED CONDITIONS 有权
标题翻译：诊断和治疗小肠细菌生长（SIBO）和SIBO相关病症的方法
公开(公告)号：US20120263790A1
公开(公告)日：2012-10-18
申请号：US13315671
申请日：2011-12-09
申请人： Henry C. Lin , Mark Pimentel
发明人： Henry C. Lin , Mark Pimentel
IPC分类号： A61K31/4525 , A61P1/00 , A61P25/24 , A61P25/28 , A61P27/16 , A61K31/4465 , A61K9/14 , A61K9/28 , A61K31/4045 , A61K31/496 , A61K31/445 , A61P31/04 , A61P37/06
CPC分类号： A61K38/54 , A23L33/40 , A23V2002/00 , A61B5/0836 , A61B5/412 , A61B5/415 , A61B5/418 , A61K9/0053 , A61K9/0087 , A61K31/135 , A61K31/138 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/4045 , A61K31/4164 , A61K31/4184 , A61K31/424 , A61K31/43 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/534 , A61K38/1796 , A61K38/22 , A61K38/225 , A61K38/2271 , A61K45/06 , A61K49/0004 , A61K51/1206 , G01N33/497 , G01N33/6893 , G01N2033/4977 , G01N2333/70571 , G01N2800/06 , Y10S426/80 , Y10S426/801 , Y10T436/145555 , Y10T436/147777 , Y10T436/18 , Y10T436/214 , Y10T436/22 , A61K2300/00
摘要： Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.
摘要翻译：公开了一种在人类受试者中治疗小肠细菌过度生长（SIBO）或SIBO引起的病症的方法。 SIBO引起的病症包括肠易激综合征，纤维肌痛，慢性盆腔疼痛综合征，慢性疲劳综合征，抑郁症，受损的记忆力，记忆障碍，口臭，耳鸣，糖渴求，自闭症，注意力缺陷/多动障碍，药物敏感性，自身免疫性疾病，和克罗恩病。还公开了筛选人受试者中SIBO异常可能存在的方法以及检测人受试者中SIBO的方法。还公开了确定已经检测到小肠细菌过度生长（SIBO）的人受试者中SIBO或SIBO引起的病症的相对严重性的方法。

118. 发明申请

US20120203128A1 RESPIRATORY RATE DETECTION DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：呼吸速率检测装置，系统和方法
公开(公告)号：US20120203128A1
公开(公告)日：2012-08-09
申请号：US13369160
申请日：2012-02-08
申请人： Jeffrey Alexander Levison , Michael Brian Frieswyk
发明人： Jeffrey Alexander Levison , Michael Brian Frieswyk
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/082 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/0873 , A61B5/0876 , A61B5/0878 , A61B5/6819 , A61B5/682
摘要： A respiration rate measurement device comprising a tubular housing configured to be disposed over a nose and mouth on a face of a subject. The tubular housing comprises a proximal end configured to communicate with the nose and mouth of the subject and receive a transient pressure event from the nose and mouth and a distal end that opens to ambient atmosphere. The tubular housing is configured to guide a flow of air, generated from the transient pressure event, between the proximal end and the distal end. The respiration rate measurement device further comprises a sensor disposed within the housing. The sensor is configured to detect a respiration event by monitoring the flow of air within the tubular housing.
摘要翻译：一种呼吸率测量装置，包括管状壳体，所述管状壳体被配置为设置在受试者的脸部上的鼻子和嘴部之上。管状壳体包括构造成与受试者的鼻子和嘴部连通的近端，并且接收来自鼻子和嘴部的瞬时压力事件以及向大气环境敞开的远端。管状壳体构造成引导从过渡压力事件产生的空气流在近端和远端之间。呼吸率测量装置还包括设置在壳体内的传感器。传感器被配置为通过监测管状壳体内的空气流来检测呼吸事件。

119. 发明申请

US20120150055A1 BREATH END-TIDAL GAS MONITOR 有权
标题翻译： BREATH END-TIDAL气体监测仪
公开(公告)号：US20120150055A1
公开(公告)日：2012-06-14
申请号：US13153169
申请日：2011-06-03
申请人： Lee R. CARLSON , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
发明人： Lee R. CARLSON , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
IPC分类号： A61B5/097
CPC分类号： A61B5/097 , A61B5/08 , A61B5/082 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/087
摘要： An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.
摘要翻译：一种用于捕获和分析呼气末端部分的改进的装置和方法。监测吸入系统（10）的空气的二氧化碳含量，以区分吸入和呼气。当检测到吸入系统（10）的空气中的CO 2水平的降低时，指示呼气和吸入之间的过渡，一对流量选择阀（26,28）被操作以捕获抽出的空气的潮气量在检测到CO 2水平的降低之前立即进入系统（10）。进入的空气被转移到捕获的空气体积周围，并且持续监测CO 2水平，以确保所捕获的空气体积对应于呼气的末端潮汐部分。一旦被捕获的空气量被确定为呼气的末端潮气部分，则捕获的体积被通过气体分析器（44），用于分析一个或多个预定气体水平。

120. 发明申请

US20120083707A1 METHOD AND DEVICE FOR THE AUTOMATIC EVALUATION AND ANALYSIS OF A CAPNOGRAM AND COMPUTER PROGRAM FOR IMPLEMENTING THE METHOD AS WELL AS COMPUTER PROGRAM PRODUCT WITH SUCH A COMPUTER PROGRAM 有权
标题翻译：用于自动评估和分析CAPNOGRAM和计算机程序的方法和设备，用于实现具有这样一个计算机程序的计算机程序产品的方法
公开(公告)号：US20120083707A1
公开(公告)日：2012-04-05
申请号：US13079335
申请日：2011-04-04
申请人： Hans-Joachim KOHL
发明人： Hans-Joachim KOHL
IPC分类号： A61B5/08
CPC分类号： G06F19/345 , A61B5/0836 , A61B5/091 , G06F19/00 , G16H50/20
摘要： A method implemented, e.g., as software and a device operating according to the method for the automatic evaluation and analysis of a capnogram are provided. Measured values for an expired volume—volume measured values—and measured values for a carbon dioxide concentration—concentration measured values—are recorded for the breathing gas of a test subject. An automatic approximation of at least one part of the curve of the concentration measured values over the volume measured values is performed, by using three mutually adjacent straight lines for the approximation. The area is determined using the third straight line according to Fowler for the determination of the serial dead space Vds.
摘要翻译：提供了一种实现的方法，例如，作为软件和根据用于自动评估和分析大呼记录的方法操作的设备。记录测试对象呼吸气体的过期体积体积测量值的测量值和二氧化碳浓度 - 浓度测量值的测量值。通过使用三个相互相邻的直线来进行对体积测量值的浓度测量值的曲线的至少一部分的自动近似。根据Fowler，使用第三条直线确定该区域以确定串联死区Vds。

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