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1. 发明授权

US08021308B2 Breath end-tidal gas monitor 有权
标题翻译：呼吸终端气体监测仪
公开(公告)号：US08021308B2
公开(公告)日：2011-09-20
申请号：US10561561
申请日：2003-06-19
申请人： Lee R. Carlson , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
发明人： Lee R. Carlson , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
IPC分类号： A61B5/08
CPC分类号： A61B5/097 , A61B5/08 , A61B5/082 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/087
摘要： An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.
摘要翻译：一种用于捕获和分析呼气末端部分的改进的装置和方法。监测吸入系统（10）的空气的二氧化碳含量，以区分吸入和呼气。当检测到吸入系统（10）中的空气中的CO 2水平的降低时，指示呼气和吸气之间的转变，一对流量选择阀（26,28）被操作以捕获吸入的空气的潮气量在检测到CO 2水平的降低之前立即进入系统（10）。进入的空气被转移到捕获的空气体积周围，并且持续监测CO 2水平，以确保所捕获的空气体积对应于呼气的末端潮汐部分。一旦被捕获的空气量被确定为呼气的末端潮气部分，则捕获的体积被通过气体分析器（44），用于分析一个或多个预定气体水平。

2. 发明申请

US20120150055A1 BREATH END-TIDAL GAS MONITOR 有权
标题翻译： BREATH END-TIDAL气体监测仪
公开(公告)号：US20120150055A1
公开(公告)日：2012-06-14
申请号：US13153169
申请日：2011-06-03
申请人： Lee R. CARLSON , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
发明人： Lee R. CARLSON , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
IPC分类号： A61B5/097
CPC分类号： A61B5/097 , A61B5/08 , A61B5/082 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/087
摘要： An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.
摘要翻译：一种用于捕获和分析呼气末端部分的改进的装置和方法。监测吸入系统（10）的空气的二氧化碳含量，以区分吸入和呼气。当检测到吸入系统（10）的空气中的CO 2水平的降低时，指示呼气和吸入之间的过渡，一对流量选择阀（26,28）被操作以捕获抽出的空气的潮气量在检测到CO 2水平的降低之前立即进入系统（10）。进入的空气被转移到捕获的空气体积周围，并且持续监测CO 2水平，以确保所捕获的空气体积对应于呼气的末端潮汐部分。一旦被捕获的空气量被确定为呼气的末端潮气部分，则捕获的体积被通过气体分析器（44），用于分析一个或多个预定气体水平。

3. 发明授权

US09095276B2 Breath end-tidal gas monitor 有权
标题翻译：呼吸终端气体监测仪
公开(公告)号：US09095276B2
公开(公告)日：2015-08-04
申请号：US13153169
申请日：2011-06-03
申请人： Lee R. Carlson , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
发明人： Lee R. Carlson , Edward A. McClatchie , Joe Martinosky , Ralph Walden , Elvir Causevic
IPC分类号： A61B5/08 , A61B5/083 , A61B5/087
CPC分类号： A61B5/097 , A61B5/08 , A61B5/082 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/087
摘要： An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.
摘要翻译：一种用于捕获和分析呼气末端部分的改进的装置和方法。监测吸入系统（10）的空气的二氧化碳含量，以区分吸入和呼气。当检测到吸入系统（10）中的空气中的CO 2水平的降低时，指示呼气和吸气之间的转变，一对流量选择阀（26,28）被操作以捕获吸入的空气的潮气量在检测到CO 2水平的降低之前立即进入系统（10）。进入的空气被转移到捕获的空气体积周围，并且持续监测CO 2水平，以确保所捕获的空气体积对应于呼气的末端潮汐部分。一旦被捕获的空气量被确定为呼气的末端潮气部分，则捕获的体积被通过气体分析器（44），用于分析一个或多个预定气体水平。

4. 发明申请

US20070167694A1 Integrated Portable Anesthesia and Sedation Monitoring Apparatus 审中-公开
标题翻译：综合便携式麻醉和镇静监测仪
公开(公告)号：US20070167694A1
公开(公告)日：2007-07-19
申请号：US11614582
申请日：2006-12-21
申请人： Elvir Causevic , Robert Hedges , Randall Krohn , Christian Christiansen , Ralph Walden
发明人： Elvir Causevic , Robert Hedges , Randall Krohn , Christian Christiansen , Ralph Walden
IPC分类号： A61B5/00 , A61B5/04 , A61B5/08
CPC分类号： A61B5/4064 , A61B5/024 , A61B5/0402 , A61B5/0404 , A61B5/0476 , A61B5/04845 , A61B5/08 , A61B5/082 , A61B5/14542 , A61B5/1455 , A61B5/411 , A61B5/4821 , A61B5/7203 , A61B5/726 , A61B2562/08
摘要： A system and method for performing monitoring of anesthesia and sedation in a patient includes a patient sensor integrating EEG, pulse oximetry, ECG, and AEP signal inputs, integrated analog hardware, digital hardware, and a digital signal processing system that executes a selected algorithm to process received signals representative of a patient's condition, and which generates an index value associated with said patient condition.
摘要翻译：用于执行患者麻醉和镇静监测的系统和方法包括将EEG，脉搏血氧饱和度测量，ECG和AEP信号输入集成的综合模拟硬件，数字硬件和执行所选算法的数字信号处理系统的患者传感器处理接收到的代表患者状况的信号，并产生与所述患者状况相关联的指标值。

5. 发明申请

US20180165605A1 MACHINE LEARNING-BASED PATENT QUALITY METRIC 审中-公开
公开(公告)号：US20180165605A1
公开(公告)日：2018-06-14
申请号：US15837652
申请日：2017-12-11
申请人： Matthew Beers , Elvir Causevic
发明人： Matthew Beers , Elvir Causevic
IPC分类号： G06N99/00 , G06K9/62 , G06K9/00 , G06N5/04
CPC分类号： G06N20/00 , G06K9/00442 , G06K9/6227 , G06K9/626 , G06K9/6262 , G06K9/6277 , G06N3/0454 , G06N3/086 , G06N5/043
摘要： A machine-learning based artificial intelligence device for finding an estimate of patent quality, such as patent lifetime or term is disclosed. Such a device may receive a first set of patent data and generate a list of binary classifiers. A candidate set of binary classifiers may be selected and using a heuristic search, for example an artificial neural network (ANN), a genetic algorithm, a final set of binary classifiers is found by maximizing iteratively a yield according to a cost function, such an area under a curve (AUC) of a receiver operating characteristic (ROC). The device may then receive patent information for a target patent and report an estimate of patent quality according to the final set of binary classifiers.

6. 发明授权

US07333619B2 Fast wavelet estimation of weak bio-signals using novel algorithms for generating multiple additional data frames 有权
标题翻译：使用用于生成多个附加数据帧的新算法对弱生物信号进行快速小波估计
公开(公告)号：US07333619B2
公开(公告)日：2008-02-19
申请号：US11420862
申请日：2006-05-30
申请人： Elvir Causevic , Eldar Causevic , Mladen Victor Wickerhauser
发明人： Elvir Causevic , Eldar Causevic , Mladen Victor Wickerhauser
IPC分类号： H04B15/00 , G10L21/02 , G10L19/14
CPC分类号： G06K9/00516 , A61B5/04845 , A61B5/121 , A61B5/7203 , A61B5/726 , G10L21/0208 , G10L25/27 , H03G3/007
摘要： A method and apparatus for de-noising weak bio-signals having a relatively low signal to noise ratio utilizes an iterative process of wavelet de-noising a data set comprised of a new set of frames of wavelet coefficients partially generated through a cyclic shift algorithm. The method preferably operates on a data set having 2N frames, and the iteration is performed N−1 times. The resultant wavelet coefficients are then linearly averaged and an inverse discrete wavelet transform is performed to arrive at the de-noised original signal. The method is preferably carried out in a digital processor.
摘要翻译：用于消除具有相对低的信噪比的弱生物信号的方法和装置利用小波去噪的迭代过程，该数据集包括通过循环移位算法部分产生的新的一组小波系数。该方法优选地对具有2个N帧的数据集进行操作，并且迭代被执行N-1次。然后对所得到的小波系数进行线性平均，并执行逆离散小波变换以得到去噪的原始信号。该方法优选在数字处理器中进行。

7. 发明申请

US20070167857A1 Method and apparatus for signal encoding evoked responses 有权
标题翻译：用于信号编码诱发响应的方法和装置
公开(公告)号：US20070167857A1
公开(公告)日：2007-07-19
申请号：US10587461
申请日：2005-01-28
申请人： Elvir Causevic
发明人： Elvir Causevic
IPC分类号： A61B5/04 , A61B13/00 , A61B5/00
CPC分类号： A61B5/125 , A61B5/0048 , A61B5/04842 , A61B5/04845 , A61B5/742
摘要： A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.
摘要翻译：一种用于利用编码信号传输和接收的益处来增强适于唤起和测量例如听觉诱发电位（AEP）和听觉脑干响应（ABR）的生物反应信号的医学测试装置（100）的性能的方法和装置，信号特别。诸如点击的听觉刺激以预定编码序列呈现给人类患者的耳朵，导致在人类患者中产生听觉反应和生物电响应信号。获取并观察来自患者的这些响应信号，并且根据将听觉刺激呈现给患者耳朵的预定编码序列进行处理，以便提取期望的听觉诱发电位信号或ABR信号。

8. 发明申请

US20070167691A1 Multifunction infant monitoring system 审中-公开
标题翻译：多功能婴儿监护系统
公开(公告)号：US20070167691A1
公开(公告)日：2007-07-19
申请号：US10587476
申请日：2005-01-28
申请人： Elvir Causevic
发明人： Elvir Causevic
IPC分类号： A61B5/00 , A61B5/04 , A61B5/08
CPC分类号： A61B5/14546 , A61B5/0002 , A61B5/04 , A61B5/04845 , A61B5/0836 , A61B5/7275 , A61B5/7445
摘要： A medical screening device (100) configured to measure and monitor combinations of blood chemistry, breath gasses, and bioelectrical signals such as evoked auditory signals and EEG signals associated with human auditory testing to facilitate detection of abnormal medical conditions or disorders in human patients by providing a cumulative index representative of at least one detected medical disorder in the human patient.
摘要翻译：一种医疗筛选装置（100），其被配置为测量和监测血液化学，呼吸气体和生物电信号的组合，例如与人类听觉测试相关的诱发听觉信号和脑电信号，以便于通过提供人类病人的异常医学状况或障碍来检测代表人类患者中至少一种检测到的医学病症的累积指数。

9. 发明授权

US08734361B2 Method and apparatus for signal encoding evoked responses 有权
标题翻译：用于信号编码诱发响应的方法和装置
公开(公告)号：US08734361B2
公开(公告)日：2014-05-27
申请号：US13180339
申请日：2011-07-11
申请人： Elvir Causevic
发明人： Elvir Causevic
IPC分类号： A61B13/00 , A61B5/00
CPC分类号： A61B5/125 , A61B5/0048 , A61B5/04842 , A61B5/04845 , A61B5/742
摘要： A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.
摘要翻译：一种用于利用编码信号传输和接收的益处来增强适于唤起和测量例如听觉诱发电位（AEP）和听觉脑干响应（ABR）的生物反应信号的医学测试装置（100）的性能的方法和装置，信号特别。诸如点击的听觉刺激以预定编码序列呈现给人类患者的耳朵，导致在人类患者中产生听觉反应和生物电响应信号。获取并观察来自患者的这些响应信号，并且根据将听觉刺激呈现给患者耳朵的预定编码序列进行处理，以便提取期望的听觉诱发电位信号或ABR信号。

10. 发明授权

US08364254B2 Method and device for probabilistic objective assessment of brain function 有权
标题翻译：脑功能概率客观评估的方法和装置
公开(公告)号：US08364254B2
公开(公告)日：2013-01-29
申请号：US12361174
申请日：2009-01-28
申请人： Arnaud Jacquin , Elvir Causevic
发明人： Arnaud Jacquin , Elvir Causevic
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/16 , A61B5/4076 , A61B5/7203 , A61B5/7207 , A61B5/726 , A61B5/7264 , G06F19/00
摘要： A method and apparatus for providing objective assessment of the brain state of a subject using a field portable device. The method includes placing an electrode set coupled to a handheld base unit on the subject's head, acquiring electrical brain signals from the subject through the electrode set, processing the acquired electrical brain signals using a feature extraction algorithm, classifying the extracted features into brain states, computing brain abnormality indices reflecting the probability of correct classification of brain state, and graphically displaying the classification result and the abnormality indices on the handheld base unit.
摘要翻译：一种使用现场便携式设备提供对象的脑状态的客观评估的方法和装置。该方法包括将耦合到手持基座单元的电极组放置在对象的头部上，通过电极组获取来自对象的电脑信号，使用特征提取算法处理所获取的电脑信号，将所提取的特征分类为脑状态，计算反映大脑状态正确分类概率的脑异常指标，并在手持式基站上图形显示分类结果和异常指数。

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