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111. 发明授权

US08992936B2 Altered OspA of Borrelia burgdorferi 有权
标题翻译：改变了Borrelia burgdorferi的OspA
公开(公告)号：US08992936B2
公开(公告)日：2015-03-31
申请号：US13944078
申请日：2013-07-17
申请人： Brookhaven Sciences Associates, LLC , University of Rochester , Research Foundation of the State University of New York
发明人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
IPC分类号： C07K14/20 , A61K39/02 , A61K38/00
CPC分类号： C07K14/20 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
摘要翻译：本文提供了具有某些改变的来自莱姆病引起的疏螺旋体的OspA多肽。在一个实施方案中，所述改变增加含有所述改变的OspA多肽的构象稳定性，同时保持相应未改变的OspA多肽的至少一些抗原性。在另一个实施方案中，与相应的未改变的OspA多肽相比，改变的OspA多肽具有降低的与hLFA-1的交叉反应性。

112. 发明申请

US20130204613A1 LARGE-SCALE SENTIMENT ANALYSIS 审中-公开
标题翻译：大规模分析
公开(公告)号：US20130204613A1
公开(公告)日：2013-08-08
申请号：US13832584
申请日：2013-03-15
申请人： The Research Foundation of the State University of New York
发明人： Namrata GODBOLE , Steven Skiena , Manjunath Srinivasaiah
IPC分类号： G06F17/21
CPC分类号： G06F17/21 , G06F17/279
摘要： A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.
摘要翻译：用于确定与实体相关联的情绪的方法包括输入与该实体相关联的多个文本，将多个文本中的种子字标注为正或负，基于标签确定多个单词的分数估计，列举所述多个单词的路径并确定情绪交替的数量，使用只有多个交替数在阈值内的路径来确定所述多个单词的最终得分，将所述最终分数转换为所述多个单词中的每一个的相应z分数的字，并输出与该实体相关联的情绪。

113. 发明申请

US20120046938A1 LARGE-SCALE SENTIMENT ANALYSIS 有权
标题翻译：大规模分析
公开(公告)号：US20120046938A1
公开(公告)日：2012-02-23
申请号：US13163636
申请日：2011-06-17
申请人： Namrata Godbole , Steven Skiena , Manjunath Srinivasaiah
发明人： Namrata Godbole , Steven Skiena , Manjunath Srinivasaiah
IPC分类号： G06F17/27
CPC分类号： G06F17/21 , G06F17/279
摘要： A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.
摘要翻译：用于确定与实体相关联的情绪的方法包括输入与该实体相关联的多个文本，将多个文本中的种子字标注为正或负，基于标签确定多个单词的分数估计，列举所述多个单词的路径并确定情绪交替的数量，使用只有多个交替数在阈值内的路径来确定所述多个单词的最终得分，将所述最终分数转换为所述多个单词中的每一个的相应z分数的字，并输出与该实体相关联的情绪。

114. 发明授权

US08088768B2 Protein kinase and phosphatase inhibitors 有权
标题翻译：蛋白激酶和磷酸酶抑制剂
公开(公告)号：US08088768B2
公开(公告)日：2012-01-03
申请号：US12854094
申请日：2010-08-10
申请人： David G. Hangauer, Jr. , Moustafa E. El-Araby , Karen L. Milkiewicz
发明人： David G. Hangauer, Jr. , Moustafa E. El-Araby , Karen L. Milkiewicz
IPC分类号： A61K31/5377 , A61K31/404 , A61K31/454 , A61K31/496 , C07D403/06 , C07D413/14 , A61P3/10 , A61P9/10
CPC分类号： C07D209/42 , A61K31/404 , A61K31/47
摘要： The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.
摘要翻译：本发明提供了鉴定蛋白激酶和/或蛋白磷酸酶抑制剂的方法。还提供了用于抑制蛋白激酶和/或蛋白磷酸酶活性的方法。提供特异性非肽蛋白酪氨酸激酶和/或蛋白磷酸酶抑制剂。本发明的蛋白激酶或蛋白磷酸酶抑制剂可用于治疗患者的许多病症，包括癌症，牛皮癣，关节动脉硬化，免疫系统活性，II型糖尿病和肥胖症。

115. 发明授权

US07996210B2 Large-scale sentiment analysis 有权
标题翻译：大规模情绪分析
公开(公告)号：US07996210B2
公开(公告)日：2011-08-09
申请号：US11739187
申请日：2007-04-24
申请人： Namrata Godbole , Steven Skiena , Manjunath Srinivasaiah
发明人： Namrata Godbole , Steven Skiena , Manjunath Srinivasaiah
IPC分类号： G06F17/27
CPC分类号： G06F17/21 , G06F17/279
摘要： A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.
摘要翻译：用于确定与实体相关联的情绪的方法包括输入与该实体相关联的多个文本，将多个文本中的种子字标注为正或负，基于标签确定多个单词的分数估计，列举所述多个单词的路径并确定情绪交替的数量，使用只有多个交替数在阈值内的路径来确定所述多个单词的最终得分，将所述最终分数转换为所述多个单词中的每一个的相应z分数的字，并输出与该实体相关联的情绪。

116. 发明申请

US20100129286A1 Methods of controlling the morphology of perovskite submicron-sized particles 审中-公开
标题翻译：控制钙钛矿亚微米尺寸颗粒形态的方法
公开(公告)号：US20100129286A1
公开(公告)日：2010-05-27
申请号：US12587491
申请日：2009-10-06
申请人： Stanislaus S. Wong , Hongjun Zhou
发明人： Stanislaus S. Wong , Hongjun Zhou
IPC分类号： C01G25/02
CPC分类号： C01G25/00 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2004/32 , C01P2004/38 , C01P2004/61 , C01P2004/62
摘要： The present invention includes a method of making a plurality of nanoparticles comprising single crystalline spherical BaZrO3 particles, cubic BaZrO3 particles or a mixture of both. The method comprises: providing a mixture of a barium precursor, a zirconium precursor and a hydroxide salt or hydroxide salts; heating the mixture to an isothermic annealing temperature, wherein the annealing temperature is in a range of from about 470° C. to about 800° C.; annealing the mixture at the isothermic annealing temperature for an annealing time of in a range of about 15 minutes to about 280 minutes; and cooling the mixture at a fixed cooling rate to form the plurality of nanoparticles, wherein the cooling rate is in a range of from about 2° C./minute to about 200° C./minute. The ratio of spherical particles to cubic particles in the plurality is greater if the isothermic annealing temperature is at the higher end of the range; the ratio of spherical particles to cubic particles in the plurality is greater if the annealing time is at the higher end of the range; and the ratio of spherical particles to cubic particles in the plurality is greater if the cooling rate is at the lower end of the range.
摘要翻译：本发明包括制造包含单晶球形BaZrO 3颗粒，立方BaZrO 3颗粒或两者的混合物的多种纳米颗粒的方法。该方法包括：提供钡前体，锆前体和氢氧化物盐或氢氧化物盐的混合物; 将混合物加热到等温退火温度，其中退火温度在约470℃至约800℃的范围内; 在等温退火温度下退火混合物，退火时间为约15分钟至约280分钟; 并以固定的冷却速度冷却混合物以形成多个纳米颗粒，其中冷却速率在约2℃/分钟至约200℃/分钟的范围内。如果等温退火温度在该范围的较高端，多颗粒中的球形颗粒与立方颗粒的比率更大; 如果退火时间在该范围的较高端，则多个球形颗粒与立方体颗粒的比例更大; 如果冷却速率在该范围的较低端，则多个球形颗粒与立方体颗粒的比例更大。

117. 发明申请

US20100080843A1 Natural and synthetic sulfur and selenium analogs and polymer conjugated forms thereof for the modulation of angiogenesis 审中-公开
标题翻译：用于血管发生调节的天然和合成的硫和硒类似物及其聚合物缀合形式
公开(公告)号：US20100080843A1
公开(公告)日：2010-04-01
申请号：US11428194
申请日：2006-06-30
申请人： Shaker Mousa , Eric Block
发明人： Shaker Mousa , Eric Block
IPC分类号： A61K31/38 , A61K31/381 , A61K31/10 , A61K31/095 , A61K9/127 , A61P35/00
CPC分类号： A61K31/095 , A61K31/10 , A61K47/60
摘要： The present invention relates to inhibiting angiogenesis with sulfur- or selenium-containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfur- or selenium-containing compounds, and polymeric forms thereof, can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfur- or selenium-containing compounds, and polymeric forms thereof, with other anti-angiogenesis agents, with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.
摘要翻译：本发明涉及在包括动物和人的哺乳动物中，用含硫或硒的化合物及其聚合物形式抑制血管生成。含硫或硒的化合物及其聚合物形式可以单独使用或与标准治疗组合使用以抑制血管发生介导的病症。本发明还涉及将含硫或硒的化合物及其聚合形式与其它抗血管生成剂与各种抗炎和细胞毒剂以及癌症中的放射治疗剂的组合使用，以及用激光，光动力学治疗眼部相关疾病如糖尿病性视网膜病变或年龄相关性黄斑变性。

118. 发明授权

US07645512B1 Nano-structure enhancements for anisotropic conductive adhesive and thermal interposers 失效
标题翻译：各向异性导电粘合剂和热插入件的纳米结构增强
公开(公告)号：US07645512B1
公开(公告)日：2010-01-12
申请号：US10402293
申请日：2003-03-31
申请人： Bahgat Sammakia , Wayne E. Jones, Jr. , Ganesh Subbarayan
发明人： Bahgat Sammakia , Wayne E. Jones, Jr. , Ganesh Subbarayan
IPC分类号： H01B1/20 , H01R4/04 , H01R11/01
CPC分类号： H01B1/22 , H01B1/24 , H01R4/04 , H05K3/323 , H05K2201/0373 , Y10T29/49126 , Y10T29/4913 , Y10T428/29 , Y10T428/2913 , Y10T428/2944 , Y10T428/2991 , Y10T428/2998
摘要： The present invention features additions of nano-structures to interconnect conductor fine particles (spheres) to: (1) reduce thermal interface resistance by using thermal interposers that have high thermal conductivity nano-structures at their surfaces; (2) improve the anisotropic conductive adhesive interconnection conductivity with microcircuit contact pads; and (3) allow lower compression forces to be applied during the microcircuit fabrication processes which then results in reduced deflection or circuit damage. When pressure is applied during fabrication to spread and compress anisotropic conductive adhesive and the matrix of interconnect particles and circuit conductors, the nano-structures mesh and compress into a more uniform connection than current technology provides, thereby eliminating voids, moisture and other contaminants, increasing the contact surfaces for better electrical and thermal conduction.
摘要翻译：本发明的特征在于添加了纳米结构以将导体细颗粒（球体）互相连接，以：（1）通过使用在其表面具有高导热性纳米结构的热插入件来降低热界面电阻; （2）通过微电路接触焊盘改善各向异性导电胶的互连电导率; 和（3）允许在微电路制造过程期间施加较低的压缩力，其然后导致偏转或电路损坏的减小。当在制造期间施加压力以扩展和压缩各向异性导电粘合剂和互连颗粒和电路导体的基体时，纳米结构网格并且压缩成比当前技术提供的更均匀的连接，从而消除空隙，水分和其它污染物，增加接触表面更好的电和热传导。

119. 发明申请

US20090278798A1 Active Fingertip-Mounted Object Digitizer 审中-公开
标题翻译：主动指尖安装对象数字化仪
公开(公告)号：US20090278798A1
公开(公告)日：2009-11-12
申请号：US11828463
申请日：2007-07-26
申请人： Young-Seok Kim , Thenkurussi Kesavadas
发明人： Young-Seok Kim , Thenkurussi Kesavadas
IPC分类号： G06F3/033
CPC分类号： G06F3/0346 , G06F3/011 , G06F3/014 , G06F3/016 , G06F3/017 , G06F2203/0331
摘要： A finger-mounted implement including a kinesthetic sensor, at least one tactile sensor, and means for securing the kinesthetic sensor and the at least one tactile sensor to a fingertip. The tactile sensor may be a thin-film force transducer, a piezoelectric accelerometer, or a combination thereof. An artificial fingernail may be connected to the accelerometer. The kinesthetic sensor may include a magnetic transducer and may sense an X-Y-Z position and an angular orientation of a fingertip to which the kinesthetic sensor is secured. The securing means may include at least one means selected from the group consisting of adhesive tape, an elastically deformable cover, and detachable adhesive. The implement can be further connected to a computer processing system for, amongst other things, the virtual representation of sensed objects. The implement can also be used as part of a method of haptic sensing of objects.
摘要翻译：一种手指式工具，其包括运动感应传感器，至少一个触觉传感器，以及用于将感觉传感器和至少一个触觉传感器固定到指尖的装置。触觉传感器可以是薄膜力传感器，压电加速度计或其组合。人造指甲可以连接到加速度计。动觉传感器可以包括磁换能器，并且可以感测X-Y-Z位置和固定感觉传感器的指尖的角度定向。固定装置可以包括从粘合带，可弹性变形的盖和可拆卸粘合剂组成的组中选择的至少一种装置。该装置可以进一步连接到计算机处理系统，用于除其他之外，感测对象的虚拟表示。该工具还可以用作触觉感测物体的方法的一部分。

120. 发明授权

US07582304B2 Groups of Borrelia burgdorferi and Borrelia afzelii that cause Lyme Disease in humans 失效
标题翻译：在人类中引起莱姆病的博氏疏螺旋体和疏螺旋体的组
公开(公告)号：US07582304B2
公开(公告)日：2009-09-01
申请号：US11371564
申请日：2006-03-09
申请人： Raymond J. Dattwyler , Gerald Seinost , Daniel Dykhuizen , Benjamin J. Luft , Maria J. C. Gomes-Solecki
发明人： Raymond J. Dattwyler , Gerald Seinost , Daniel Dykhuizen , Benjamin J. Luft , Maria J. C. Gomes-Solecki
IPC分类号： A61K39/02 , A61K39/00 , C12N15/00 , C07K17/00 , C07K1/00
CPC分类号： A61K39/0225 , A61K39/00 , C07K14/20 , C07K2319/00 , G01N33/56911 , Y02A50/401 , Y02A50/57
摘要： The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia burgdorferi OspC families A, B, I and K. In another embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia afzelii OspC families A and B.
摘要翻译：本发明涉及包含来自莱姆病引起的疏螺旋体的OspC多肽的免疫原性组合物。在一个实施方案中，本发明的免疫原性组合物包含来自勃氏疏螺旋体OspC家族A，B，I和K中的每一种的至少一种OspC多肽或其免疫原性片段。在另一个实施方案中，本发明的免疫原性组合物至少包含来自Borrelia afzelii OspC家族A和B的每一个的一个OspC多肽或其免疫原性片段。

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