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    • 113. 发明授权
    • Channel device and sample treatment apparatus including the same
    • 通道装置和包括其的样品处理装置
    • US09114402B2
    • 2015-08-25
    • US13513331
    • 2010-07-26
    • Takatoki Yamamoto
    • Takatoki Yamamoto
    • B03C5/02B01L3/00G01N15/10
    • B03C5/026B01L3/502761B01L2200/0652B01L2300/0645B01L2300/0864B01L2300/0896B01L2400/0415B03C2201/26G01N15/1031G01N15/1056
    • A channel device including a nanosize channel through which single molecule flows, at least one electrode pair arranged near the nanosize channel, and an AC power source that applies an AC voltage to the electrodes. This channel device is useful for identifying molecules one by one. Furthermore, a channel device including a nanosize channel through which single molecule flows, a branching portion, and a plurality of branching channels, wherein (i) an electrode pair is arranged near the nanosize channel so as to sandwich the nanosize channel between the electrodes, or (ii) one electrode of the electrode pair is located near the nanosize channel, whereas the other is arranged near the branching channels. This channel device is useful for separating single molecule. The present channel device achieves identification or separation at an accuracy of 100% in principle. A sample treatment apparatus according to present invention includes a channel device, a measurement section, and an arithmetic processing section. The measurement section applies a voltage (DC or AC) to between electrodes of an electrode pair installed in the nanosize channel, and measures an electric signal when single molecule passes between the electrodes to identify the molecule (see FIG. 1B).
    • 包括单分子流过的纳米尺寸通道,配置在纳米尺寸通道附近的至少一个电极对的通道器件以及向电极施加AC电压的AC电源。 该通道装置可用于逐个识别分子。 此外,包括单分子流过的纳米尺寸通道,分支部分和多个分支通道的通道器件,其中(i)电极对布置在纳米尺寸通道附近,以将纳米尺寸通道夹在电极之间, 或(ii)电极对的一个电极位于纳米尺寸通道附近,而另一个设置在分支通道附近。 该通道装置可用于分离单分子。 本通道装置原则上以100%的精度实现识别或分离。 根据本发明的样品处理装置包括通道装置,测量部和运算处理部。 测量部分在安装在纳米尺寸通道中的电极对的电极之间施加电压(DC或AC),并且当单分子通过电极之间测量电信号以识别分子(参见图1B)。