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    • 112. 发明申请
    • Honeycomb structured body
    • 蜂窝结构体
    • US20060194018A1
    • 2006-08-31
    • US11341507
    • 2006-01-30
    • Kazushige OhnoAtsushi Kudo
    • Kazushige OhnoAtsushi Kudo
    • B32B3/12
    • B01D46/2474B01D46/0063B01D46/2451B01D46/2455B01D46/2459B01D46/2466B01D46/247B01D53/94B01D2046/2481B01D2046/2485B01D2046/2496B01J35/04C04B38/0012C04B2111/0081F01N3/0222F01N2240/20F01N2260/06F01N2330/06F01N2330/34F01N2330/48Y02T10/20Y10T428/24149Y10T428/24157Y10T428/24165C04B35/00
    • The honeycomb structured body of the present invention is a pillar-shaped honeycomb structured body comprising a large number of through holes that are longitudinally placed in parallel with one another with a partition wall therebetween, wherein the large number of through holes include a group of large-capacity through holes being sealed at one side of an end portion of the honeycomb structured body, so that the sum of areas on a cross section perpendicular to the longitudinal direction is made relatively larger, and a group of small-capacity through holes being sealed at the other side of the end portion of the honeycomb structured body, so that the sum of areas on the cross section is made relatively smaller, and when an aperture rate which is a ratio at which the area of the group of large-capacity through holes accounts for the total area of the end face on the inlet-side of the honeycomb structured body is represented by α (%), and a difference in thickness on the cross section between: the portion of the partition wall that separates adjacently located through holes constituting the group of large-capacity through holes from each other; and the portion of the partition wall that separates adjacently located through holes, one of which constituting the group of large-capacity through holes and the other of which constituting the group of small-capacity through holes, is represented by β (mm), relationships indicated by the following inequalities (1) and (2) are satisfied: 0.0022α+0.0329≦β≦0.0071α+0.2553  (1), and about 35≦α≦about 60  (2).
    • 本发明的蜂窝结构体是一种柱状蜂窝结构体,其包括多个通孔,所述通孔纵向彼此平行放置,并具有间隔壁,其中大量通孔包括一组大的通孔 能够通过孔密封在蜂窝结构体的端部的一侧,使得与纵向方向垂直的横截面上的面积之和相对较大,并且一组小容量通孔被密封 在蜂窝结构体的端部的另一侧,使得横截面上的面积的总和相对较小,并且当作为大容量通过的组的面积的比率的开口率 占蜂窝结构体入口侧端面总面积的孔由α(%)表示,横截面上的厚度差 分隔开的分隔壁的相邻部分分隔相邻的通孔构成大容量通孔组; 分隔相邻的贯通孔的分隔壁的一部分,其中一个构成大容量通孔组,另一个构成小容量通孔组,由β(mm)表示,关系 由以下不等式(1)和(2)表示:<?in-line-formula description =“In-line Formulas”end =“lead”?> 0.0022alpha + 0.0329 <= beta <= 0.0071alpha + 0.2553 (1)和<?in-line-formula description =“In-line Formulas”end =“tail”?> <?in-line-formula description =“In-line Formulas”end =“lead”?> about 35 <=α<=约60(2)。 <?in-line-formula description =“In-line Formulas”end =“tail”?>
    • 119. 发明授权
    • Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative
    • 红藻氨酸神经毒性抑制剂和吡啶并噻嗪衍生物
    • US6133258A
    • 2000-10-17
    • US68534
    • 1998-05-13
    • Jun-ichi ShishikuraHiroshi InamiTomoyuki YasunagaMasaaki HiranoShuichi SakamotoKazushige OhnoMasamichi OkadaShin-ichi Tsukamoto
    • Jun-ichi ShishikuraHiroshi InamiTomoyuki YasunagaMasaaki HiranoShuichi SakamotoKazushige OhnoMasamichi OkadaShin-ichi Tsukamoto
    • A61K31/5415A61K31/542C07D513/04
    • A61K31/5415
    • Neuroprotective agents based on inhibition of kainic acid neurotoxicity and compounds useful as neuroprotective agents based on inhibition of kainic acid neurotoxicity. An inhibitors of kainic acid neurotoxicity, comprising as an active ingredient a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, and a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR2## R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or a lower alkyl, cycloalkyl, alkenyl, aryl, carboxyl or lower alkoxycarbonyl group which may have substituent(s), or are not present, with the proviso that R.sup.2 and R.sup.3 may together form a nitrogen-containing heterocyclic group which may have nitrogen atoms as another hetero atom, may be fused with a benzene ring and may have a lower alkyl group as a substituent.
    • PCT No.PCT / JP96 / 03339 Sec。 371日期1998年5月13日 102(e)日期1998年5月13日PCT 1996年11月14日PCT PCT。 出版物WO97 / 17970 日期1997年5月22日基于抑制红藻氨酸神经毒性的神经保护剂和基于抑制红藻氨酸神经毒性作用的神经保护剂的化合物。 作为活性成分的红藻氨酸神经毒性抑制剂,含有下述通式(I)所示的吡哆噻嗪衍生物或其药学上可接受的盐,以及下述通式(I)表示的吡哒嗪衍生物或其药学上可接受的盐 其中式中的符号具有以下各自的含义:环A:吡啶环; R 1,R 2,R 3,R 4和R 5可以相同或不同,各自表示氢原子或可以具有取代基或不存在的低级烷基,环烷基,烯基,芳基,羧基或低级烷氧基羰基, 条件是R2和R3可以一起形成可以具有氮原子作为另一个杂原子的含氮杂环基,可以与苯环稠合并且可以具有低级烷基作为取代基。