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101. 发明授权

US4900840A 3-halosuccinimides 失效
标题翻译： 3-卤代琥珀酰亚胺
公开(公告)号：US4900840A
公开(公告)日：1990-02-13
申请号：US240763
申请日：1988-06-15
申请人： Norman Haberle , Anneliese Reutter
发明人： Norman Haberle , Anneliese Reutter
IPC分类号： C07D207/40 , C07D207/416
CPC分类号： C07D207/416
摘要： The invention concerns fungicidal compounds of the formula ##STR1## wherein R signifies a chlorine, bromine or iodine atom, n 0, 1, 2 or 3 and X, X', Y and Z have the meanings given in the description.
摘要翻译： PCT No.PCT / EP87 / 00563 Sec。 371日期1988年6月15日第 102（e）日期1988年6月15日PCT提交1987年10月1日PCT公布。出版物WO88 / 02747 日期：1988年4月21日。本发明涉及式（I）的杀真菌化合物，其中R表示氯，溴或碘原子，n 0,1,2或3，X，X'，Y和Z具有说明中给出的含义。

102. 发明授权

US4891430A Process for synthesizing active esters of carboxylic acids, new alpha-halogenated carbonates which are useful for this synthesis and the method of producing them 失效
标题翻译：用于合成羧酸活性酯的方法，可用于该合成的新型α-卤代碳酸酯及其制备方法
公开(公告)号：US4891430A
公开(公告)日：1990-01-02
申请号：US243885
申请日：1988-09-13
申请人： Gerard Barcelo , Bertrand Castro , Mahmoud Jaouadi , Jean Martinez , Jean-Pierre Senet , Gerard Sennyey
发明人： Gerard Barcelo , Bertrand Castro , Mahmoud Jaouadi , Jean Martinez , Jean-Pierre Senet , Gerard Sennyey
IPC分类号： C07B41/10 , C07B41/00 , C07B51/00 , C07C67/00 , C07C68/02 , C07C68/06 , C07C69/96 , C07C205/43 , C07C239/00 , C07C239/22 , C07C271/22 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D249/18 , C07D295/10 , C07D295/22 , C07D409/12 , C07K1/10 , C07K5/078 , C07K5/097
CPC分类号： C07D409/12 , C07C201/12 , C07C271/22 , C07C68/02 , C07D207/404 , C07D207/46 , C07D249/18 , C07K1/10 , C07K5/0823 , C07C2101/08
摘要： The invention relates to a new process for preparing active esters or carboyxlic acids, which consists in reacting a carboxylic acid, in the presence of an agent for binding hydrohalic acid, with a carbonate of formula: ##STR1## in which R.sup.1 denotes either a radical of formula ##STR2## in which R.sup.3 and R.sup.4, which may be identical or different, are not hydrogen atoms and denote organic radicals which may be substituted or unsubstituted and saturated or unsaturated, and may or may not be bound to a polymer, and which can be joined together to form a hetero-cyclic system with the nitrogen, atom,or a substituted or unsubstituted aryl radical which may or may not be bound to a polymer,R.sup.2 denotes a hydrogen atom, an aliphatic or cycloaliphatic radical which may be substituted or unsubstituted and saturated or unsaturated, or a substituted or unsubstituted aromatic radical,and X denotes a halogen atom.This process is especially useful for the synthesis of active esters of N-protected amino acids. The invention also relates to the new carbonates described above and the method of producing them, which consists in reacting an alpha-halogenated chloroformate of formula:R.sup.2 --CHX--O--COClwith an alcohol of formula R.sup.1 OH in an inert solvent medium in the presence of an organic or inorganic base.

103. 发明授权

US4889870A 2-(2,2-Difluorocyclopropyl)alkyl esters, processes for their preparation and their use as insecticides and acaricides 失效
标题翻译： 2-（2,2-二氟环丙基）烷基酯，其制备方法及其作为杀虫剂和杀螨剂的用途
公开(公告)号：US4889870A
公开(公告)日：1989-12-26
申请号：US149732
申请日：1988-01-29
申请人： Peter Wegner , Hans-Rudolf Kruger , Dietrich Baumert , Hartmut Joppien
发明人： Peter Wegner , Hans-Rudolf Kruger , Dietrich Baumert , Hartmut Joppien
IPC分类号： A01N37/00 , A01N37/10 , A01N37/34 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/48 , A01N37/52 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/36 , A01N43/38 , A01N43/60 , A01P7/02 , A61K31/215 , C07C67/00 , C07C67/08 , C07C69/02 , C07C69/52 , C07C69/612 , C07C69/614 , C07C69/734 , C07C69/76 , C07C69/78 , C07C69/92 , C07C201/00 , C07C205/56 , C07C205/57 , C07C205/58 , C07C229/42 , C07C229/52 , C07C253/00 , C07C255/16 , C07C301/00 , C07C303/30 , C07C309/65 , C07C309/73 , C07C313/00 , C07C323/62 , C07D207/337 , C07D207/34 , C07D207/40 , C07D207/416 , C07D209/42 , C07D213/79 , C07D213/80 , C07D241/24 , C07D307/68 , C07D307/71 , C07D317/68 , C07D333/38 , C07D333/62 , C07D333/70
CPC分类号： C07D207/416 , A01N37/10 , A01N37/34 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/48 , A01N37/52 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/36 , A01N43/38 , A01N43/60 , C07C205/57 , C07C205/58 , C07C309/00 , C07C323/00 , C07D209/42 , C07D213/79 , C07D213/80 , C07D241/24 , C07D307/68 , C07D307/71 , C07D333/38 , C07D333/62
摘要： There are provided new 2-(2,2-difluorocyclopropyl)alkyl esters of general formula I ##STR1## in which Y, R.sub.1-7 and n have the meanings given in the description and processes for their preparation. The new compounds can be used to combat insects and mites.

104. 发明授权

US4868203A Bacterial substance and pharmaceutical composition thereof 失效
标题翻译：细菌物质及其药物组合物
公开(公告)号：US4868203A
公开(公告)日：1989-09-19
申请号：US53021
申请日：1987-05-22
申请人： Ryuzo Ueno , Ryuji Ueno , Hiroshi Kita , Ichie Kato , Akihiko Tabata , Takashi Hironaka
发明人： Ryuzo Ueno , Ryuji Ueno , Hiroshi Kita , Ichie Kato , Akihiko Tabata , Takashi Hironaka
IPC分类号： C07D207/40
CPC分类号： C07D207/40
摘要： A bacterial substance UFC-N11 of the formula: ##STR1##
摘要翻译：具有以下公式的细菌物质UFC-N11： + TR

105. 发明授权

US4831161A N-(amidoalkyl)hydantoins 失效
标题翻译： N-（酰氨基烷基）乙内酰脲
公开(公告)号：US4831161A
公开(公告)日：1989-05-16
申请号：US65740
申请日：1987-06-24
申请人： Pen-Chung Wang , Steven P. Crain
发明人： Pen-Chung Wang , Steven P. Crain
IPC分类号： C07D207/40 , C07D207/404 , C07D209/48 , C07D233/72
CPC分类号： C07D207/404 , C07D209/48 , C07D233/72
摘要： Prepare N-(amidoalkyl)imides by contacting an imide with a 2-oxazoline under reaction conditions, optionally in the presence of a solvent.
摘要翻译：任选在溶剂存在下，在反应条件下使酰亚胺与2-恶唑啉接触，制备N-（酰氨基烷基）酰亚胺。

106. 发明授权

US4824986A Metal chelate protein conjugate 失效
标题翻译：金属螯合蛋白结合物
公开(公告)号：US4824986A
公开(公告)日：1989-04-25
申请号：US727919
申请日：1985-04-26
申请人： Otto Gansow
发明人： Otto Gansow
IPC分类号： G01N33/536 , A61K47/48 , A61K49/00 , A61K49/08 , A61K51/00 , A61K51/04 , A61K51/10 , C07C67/00 , C07C227/00 , C07C325/00 , C07K1/107 , C07K1/113 , C07K14/00 , C07K16/00 , C09K3/00 , G01N33/553 , C07C161/04 , C07C79/40 , C07D207/40
CPC分类号： A61K51/1093 , A61K47/48238 , A61K49/0004 , A61K49/085 , A61K49/16 , A61K51/0478 , A61K2121/00 , A61K2123/00
摘要： A method of forming a novel metal chelate protein conjugate is described. Also described are metal chelates and precursor compounds to the metal chelates. The novel metal chelate protein conjugates are particularly useful in the diagnostic imaging of tumors and in tumor therapy.

107. 发明授权

US4772597A 2-azacycloalkylthiopenem derivatives 失效
标题翻译： 2-氮杂环烷基硫代青霉烯衍生物
公开(公告)号：US4772597A
公开(公告)日：1988-09-20
申请号：US649516
申请日：1984-09-13
申请人： Ernest S. Hamanaka
发明人： Ernest S. Hamanaka
IPC分类号： C07D207/12 , C07D207/26 , C07D207/273 , C07D207/277 , C07D207/40 , C07D207/416 , C07D211/54 , C07D211/76 , C07D263/20 , C07D265/06 , C07D265/10 , C07D277/14 , C07D499/88 , C07F7/18 , C07D499/00 , A61K31/425
CPC分类号： C07D207/273 , C07D207/12 , C07D207/277 , C07D207/416 , C07D211/54 , C07D211/76 , C07D263/20 , C07D265/06 , C07D265/10 , C07D277/14 , C07D499/88 , C07F7/186
摘要： Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R is ##STR2## A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen, S(O).sub.m, or N--R.sub.3 ;B is carbonyl, thiocarbonyl, methylene or imine;R.sub.1 is hydrogen or forms an ester group which is hydroyzed in vivo;R.sub.2 is hydrogen, formyl, alkylcarbonyl, N-alkylaminocarbonyl, N-alkylaminosulfonyl, aminosulfonyl, aminocarbonyl, alkoxycarbonyl having 2-5 carbon atoms, alkylsulfonyl, alkyl, or alkyl substituted by aminocarbonyl, alkyl--S(O).sub.m --, hydroxyl, amino, alkylcarbonylamino, formamido or alkylsulfonylamino, wherein each alkyl has 1-4 carbon atoms;R.sub.3 is hydrogen, methyl, formyl, methylcarbonyl or methylsulfonyl;alk is alkylene having 1-4 carbon atoms;n is zero or one; andm is zero, 1 or 2.
摘要翻译：某些2-氮杂环烷基硫代-2-青霉烯-3-羧酸化合物可用作治疗哺乳动物的抗细菌剂，并且具有式I或其药学上可接受的盐，其中：R为A为2-4的亚烷基碳原子，具有2-4个碳原子的亚烷基，其中碳原子具有氧取代基或具有2-4个碳原子的亚烷基，其中亚甲基被氧，S（O）m或N-R 3取代; B是羰基，硫代羰基，亚甲基或亚胺; R1是氢或形成在体内水解的酯基; R2是氢，甲酰基，烷基羰基，N-烷基氨基羰基，N-烷基氨基磺酰基，氨基磺酰基，氨基羰基，具有2-5个碳原子的烷氧基羰基，烷基磺酰基，烷基或被氨基羰基取代的烷基，烷基-S（O）m - ，羟基，氨基烷基羰基氨基，甲酰氨基或烷基磺酰基氨基，其中每个烷基具有1-4个碳原子; R3是氢，甲基，甲酰基，甲基羰基或甲基磺酰基; 烷基是具有1-4个碳原子的亚烷基; n为零或一; m为零，1或2。

108. 发明授权

US4710201A Modified succinimides (IX) 失效
标题翻译：改性琥珀酰亚胺（IX）
公开(公告)号：US4710201A
公开(公告)日：1987-12-01
申请号：US28351
申请日：1987-03-20
申请人： Thomas F. Buckley
发明人： Thomas F. Buckley
IPC分类号： C07D207/40 , C07D207/412 , C08F8/00 , C10L1/224 , C10L1/2383 , C10M133/16 , C10M133/56 , C10L1/18 , C10L1/22
CPC分类号： C07D207/412 , C08F8/10 , C08F8/32 , C10L1/224 , C10L1/2383 , C10M133/16 , C10M133/56 , C08F2810/20 , C08F2810/40 , C10M2215/04 , C10M2215/086 , C10M2215/26 , C10M2215/28 , C10M2217/046 , C10M2217/06 , C10N2240/06 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： Disclosed are additives which are useful as dispersants in marine crankcase oils, hydraulic oils, and lubricating oils. In particular, disclosed are polyamino alkenyl or alkyl succinimides modified by reaction with a compound of the formula: ##STR1## wherein R.sub.4 is selected from the group consisting of a divalent hydrocarbyl group of from 2 to 30 carbon atoms with the proviso that the hydrocarbyl carbon atom bound to one ##STR2## group is not also bound to the other ##STR3## group and --R.sub.5 --OR.sub.5 --.sub.p wherein R.sub.5 is alkylene of from 2 to 5 carbon atoms and p is an integer of from 1 to 100; X is selected from the group consisting of bromo, chloro and --OR.sub.6 wherein R.sub.6 is selected from the group consisting of alkyl of from 1 to 6 carbon atoms, phenyl and phenyl substituted with 1 to 2 substituents selected from the group consisting of chloro, bromo, nitro, alkyl of from 1 to 6 carbon atoms and trifluoromethyl; and m is independently an integer of from 0 to 1.
摘要翻译：公开了可用作海洋曲轴箱油，液压油和润滑油中的分散剂的添加剂。特别地，公开了通过与下式化合物反应而修饰的聚氨基烯基或烷基琥珀酰亚胺：其中R 4选自2至30个碳原子的二价烃基，条件是烃基碳键合到一个基团的原子不与另一个基团和-R5-OR5-p结合，其中R 5是2至5个碳原子的亚烷基，p是1至100的整数; X选自溴，氯和-OR 6，其中R 6选自1至6个碳原子的烷基，苯基和被1至2个选自氯，溴硝基，1至6个碳原子的烷基和三氟甲基; m独立地为0〜1的整数。

109. 发明授权

US4695391A Modified succinimides (IX) 失效
公开(公告)号：US4695391A
公开(公告)日：1987-09-22
申请号：US904086
申请日：1986-09-04
申请人： Thomas F. Buckley
发明人： Thomas F. Buckley
IPC分类号： C07D207/40 , C07D207/404 , C07D207/412 , C08F8/00 , C10L1/22 , C10L1/224 , C10L1/2383 , C10L10/08 , C10L10/18 , C10M133/16 , C10M133/56 , C10M149/22 , C10M159/12 , C10N30/04 , C10N40/00 , C10N40/25 , C10N40/30 , C10M133/44
CPC分类号： C07D207/412 , C08F8/10 , C08F8/32 , C10L1/224 , C10L1/2383 , C10M133/16 , C10M133/56 , C08F2810/20 , C08F2810/40 , C10M2215/04 , C10M2215/086 , C10M2215/26 , C10M2215/28 , C10M2217/046 , C10M2217/06 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： Disclosed are additives which are useful as dispersants in marine crankcase oils, hydraulic oils, and lubricating oils. In particular, disclosed are polyamino alkenyl or alkyl succinimides modified by reaction with a compound of the formula: ##STR1## wherein R.sub.4 is selected from the group consisting of a divalent hydrocarbyl group of from 2 to 30 carbon atoms with the proviso that the hydrocarbyl carbon atom bound to one ##STR2## group is not also bound to the other ##STR3## group and --R.sub.5 --OR.sub.5 --.sub.p wherein R.sub.5 is alkylene of from 2 to 5 carbon atoms and p is an integer of from 1 to 100; X is selected from the group consisting of bromo, chloro and --OR.sub.6 wherein R.sub.6 is selected from the group consisting of alkyl of from 1 to 6 carbon atoms, phenyl and phenyl substituted with 1 to 2 substituents selected from the group consisting of chloro, bromo, nitro, alkyl of from 1 to 6 carbon atoms and trifluoromethyl; and m is independently an integer of from 0 to 1.

110. 发明授权

US4680414A Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones 失效
标题翻译：取代的3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮
公开(公告)号：US4680414A
公开(公告)日：1987-07-14
申请号：US832488
申请日：1986-02-20
申请人： Edward J. Cragoe, Jr. , Otto W. Woltersdorf, Jr.
发明人： Edward J. Cragoe, Jr. , Otto W. Woltersdorf, Jr.
IPC分类号： C07D207/44 , C07D207/456 , C07D409/10 , C07D207/40 , A61K31/40
CPC分类号： C07D207/456 , C07D409/10
摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.
摘要翻译：本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

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