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101. 发明申请

US20120197545A1 DETERMINATION OF FRACTIONAL COMPOSITIONS USING NONLINEAR SPECTROPHONOMETRY 审中-公开
标题翻译：使用非线性光谱测定法确定部分成分
公开(公告)号：US20120197545A1
公开(公告)日：2012-08-02
申请号：US13322489
申请日：2010-05-28
申请人： David Burns , Jonathan Dion
发明人： David Burns , Jonathan Dion
IPC分类号： G06F19/00 , G01N31/00
CPC分类号： G01N29/036 , G01N29/46 , G01N2291/011 , G01N2291/0224
摘要： Applicants have discovered new methods and apparatuses for determining the fractional composition of a component in a multi-component mixture using multivariate statistical analysis of the ultrasonic frequency profile. Applicants show the use of ultrasonic spectrophonometry to determine the fractional composition of a component in a 3-component solvent mixture comprising water, ethanol and methanol as well as determination of the fractional composition of certain contaminants in water. Applicants provide a method of determining a fractional composition of a component in a multi-component mixture comprising pulsing a mixture with a source of ultrasounds, detecting “non-linear” ultrasonic spectral data propagating through the mixture and computing the fractional composition of the component.
摘要翻译：申请人已经发现了使用超声波频率分布的多变量统计分析来确定多组分混合物中组分的分数组成的新方法和装置。申请人显示使用超声波分光光度法来测定包含水，乙醇和甲醇的3组分溶剂混合物中组分的分数组成，以及测定水中某些污染物的分数组成。申请人提供了一种确定多组分混合物中组分的分数组成的方法，包括将脉冲与超声波源混合，检测通过混合物传播的“非线性”超声频谱数据并计算组分的分数组成。

102. 发明申请

US20120196384A1 BIOSENSOR UTILIZING A RESONATOR HAVING A FUNCTIONALIZED SURFACE 审中-公开
标题翻译：生物传感器利用具有功能化表面的共振器
公开(公告)号：US20120196384A1
公开(公告)日：2012-08-02
申请号：US13444045
申请日：2012-04-11
申请人： Yuegang Zhang , Andrew A. Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
发明人： Yuegang Zhang , Andrew A. Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
IPC分类号： G01N33/53
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
摘要翻译：使用包含具有功能化表面以与靶生物分子反应的共振器的生物传感器来检测样品中存在生物分子的系统和方法。在一个实施例中，器件包括压电谐振器，其具有被配置为与靶分子反应的官能化表面，从而改变谐振器的质量和/或电荷，从而改变谐振器的频率响应。将曝光后的谐振器频率响应与参考值进行比较，例如在暴露于采样之前的频率响应，存储的基准频率响应或控制谐振器的频率响应。

103. 发明申请

US20120184051A1 DEVICE AND METHOD FOR DETECTING AT LEAST ONE SUBSTANCE 有权
标题翻译：用于检测至少一种物质的装置和方法
公开(公告)号：US20120184051A1
公开(公告)日：2012-07-19
申请号：US13499074
申请日：2010-08-10
申请人： Martin Nirschl
发明人： Martin Nirschl
IPC分类号： G01N33/53
CPC分类号： G01N29/022 , G01N29/036 , G01N2291/0256 , G01N2291/0426 , G01N2291/0427 , H03H9/175
摘要： A device for detecting at least one substance may include a resonator which, on its surface facing away from the carrier, is provided with a chemically sensitive layer for selectively binding a substance that is to be detected. An acoustic mirror is arranged between the carrier and the resonator. The acoustic mirror constitutes a band elimination filter having two closely adjacent notch frequencies, as a result of which the device is capable of oscillating in two resonant frequencies. The mass binding of the substance and the temperature can be determined computationally from the measured resonant frequencies.
摘要翻译：用于检测至少一种物质的装置可以包括谐振器，其在其表面背离载体的表面上设置有用于选择性地结合待检测物质的化学敏感层。声镜被布置在载体和谐振器之间。声镜构成具有两个紧密相邻陷波频率的带除滤波器，其结果是器件能够以两个谐振频率振荡。可以从测量的谐振频率计算地确定物质的质量结合和温度。

104. 发明申请

US20120174360A1 Method for Manufacturing Piezoelectric Vibration Device 有权
标题翻译：制造压电振动装置的方法
公开(公告)号：US20120174360A1
公开(公告)日：2012-07-12
申请号：US13418669
申请日：2012-03-13
申请人： Takeo Sato , Yuichiro Nagamine
发明人： Takeo Sato , Yuichiro Nagamine
IPC分类号： H01L41/22
CPC分类号： H03H3/04 , C04B35/46 , C04B35/48 , G01H3/00 , G01N29/022 , G01N29/036 , G01N2291/0256 , G01N2291/0426 , H01L41/22 , H01L41/25 , H03H3/02 , H03H9/10 , H03H9/1021 , H03H9/105 , H03H9/1092 , H03H2003/022 , H03H2003/0485 , Y10T29/42 , Y10T29/49005
摘要： A method for manufacturing a piezoelectric vibration device wherein a substrate is prepared, and a piezoelectric resonator element is mounted on the substrate. Before or after a packaging member is joined to the substrate, the piezoelectric resonator element is exposed to an environment at a higher temperature than ambient temperature and a higher humidity than ambient humidity, and then an electrical property is measured to detect attachment of dust and/or foreign matter according to a variation of the electrical property.
摘要翻译：一种制造压电振动装置的方法，其中制备了基底，并且压电谐振元件安装在基底上。在将包装部件接合到基板之前或之后，将压电谐振元件暴露在比环境温度高的环境温度和比环境湿度更高的湿度的环境中，然后测量电性能以检测灰尘和/ 或异物根据电性能的变化而变化。

105. 发明授权

US08215170B2 Chemical and biological sensing using tuning forks 有权
标题翻译：化学和生物传感使用调音叉
公开(公告)号：US08215170B2
公开(公告)日：2012-07-10
申请号：US11568209
申请日：2006-10-23
申请人： Nongjian Tao , Salah Boussaad
发明人： Nongjian Tao , Salah Boussaad
IPC分类号： G01N29/12
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/014 , G01N2291/0257 , Y10T29/49117 , Y10T29/49574
摘要： A device for sensing a chemical analyte is disclosed. The device is comprised of a vibrating structure having first and second surfaces and having an associated resonant frequency and a wire coupled between the first and second surfaces of the vibrating structure, wherein the analyte interacts with the wire and causes a change in the resonant frequency of the vibrating structure. The vibrating structure can include a tuning fork. The vibrating structure can be comprised of quartz. The wire can be comprised of polymer. A plurality of vibrating structures are arranged in an array to increase confidence by promoting a redundancy of measurement or to detect a plurality of chemical analytes. A method of making a device for sensing a chemical analyte is also disclosed.
摘要翻译：公开了用于感测化学分析物的装置。该装置包括具有第一和第二表面并且具有相关联的谐振频率的振动结构和耦合在振动结构的第一和第二表面之间的导线，其中分析物与导线相互作用并导致谐振频率的变化振动结构。振动结构可以包括音叉。振动结构可以由石英组成。电线可以由聚合物组成。多个振动结构被布置成阵列以通过促进测量的冗余或检测多个化学分析物来增加置信度。还公开了一种制造用于感测化学分析物的装置的方法。

106. 发明申请

US20120164753A1 MONOLITHIC FBAR-CMOS STRUCTURE SUCH AS FOR MASS SENSING 有权
标题翻译：单声道FBAR-CMOS结构如大众传感
公开(公告)号：US20120164753A1
公开(公告)日：2012-06-28
申请号：US13283670
申请日：2011-10-28
申请人： Matthew Johnston , Kenneth Shepard , Ioannis Kymissis
发明人： Matthew Johnston , Kenneth Shepard , Ioannis Kymissis
IPC分类号： G01N27/00 , H03B5/36 , H01L41/22 , H01L41/04
CPC分类号： G01N29/245 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , G01N2291/045 , H03B5/364 , H03H9/175 , H03H9/545 , Y10T29/42
摘要： An apparatus comprises a thin-film bulk acoustic resonator such as including an acoustic mirror, a piezoelectric region acoustically coupled to the acoustic mirror, and first and second conductors electrically coupled to the piezoelectric region. In an example, an integrated circuit substrate can include an interface circuit connected to the first and second conductors of the resonator, the integrated circuit substrate configured to mechanically support the resonator. An example can include an array of such resonators co-integrated with the interface circuit and configured to detect a mass change associated with one or more of a specified protein binding, a specified antibody-antigen coupling, a specified hybridization of a DNA oligomer, or an adsorption of specified gas molecules.
摘要翻译：一种装置包括薄膜体声波谐振器，例如包括声反射镜，声耦合到声镜的压电区域，以及电耦合到压电区域的第一和第二导体。在一个示例中，集成电路衬底可以包括连接到谐振器的第一和第二导体的接口电路，该集成电路衬底被配置为机械地支撑谐振器。一个示例可以包括与接口电路共同整合的这种谐振器的阵列，并且被配置为检测与指定的蛋白质结合，指定抗体 - 抗原偶联，DNA低聚物的指定杂交中的一个或多个相关联的质量变化，或特定气体分子的吸附。

107. 发明申请

US20120148448A1 MICROFLUIDIC-CHANNEL EMBEDDABLE, LATERALLY OSCILLATING GRAVIMETRIC SENSOR DEVICE FABRICATED WITH MICRO-ELECTRO-MECHANICAL SYSTEMS (MEMS) TECHNOLOGY 有权
标题翻译：微电子通道可嵌入式，具有微电子机械系统（MEMS）技术的横向振荡电磁传感器器件
公开(公告)号：US20120148448A1
公开(公告)日：2012-06-14
申请号：US13391349
申请日：2009-08-20
申请人： Haluk Kulah , Ata Tuna Ciftlik
发明人： Haluk Kulah , Ata Tuna Ciftlik
IPC分类号： G01N30/00
CPC分类号： G01G3/16 , G01N29/022 , G01N29/036 , G01N29/222 , G01N2291/0256 , G01N2291/0427 , Y10T436/11
摘要： Laterally oscillating gravimetric sensing device embeddable under micro-fluidic channels and fabricated with micro-electro mechanical systems (MEMS) technology, which detects biological cells and analytes by measuring the change of mass attached on its surface is composed of four main groups, namely a resonator that can be placed onto the basis of the channel, components of the resonator bio-activation, a micro fluidic channel, and the microfabrication techniques, and its main components are the proof mass (1), comb fingers fixed to proof mass (2), folded spring beams (3), channel floor and mechanical soil (4), stationary electrodes (5), comb fingers attached to the stationary electrodes (6), golden film deposited onto the mass (7), immobilized biologic recognition molecules (8), and micro fluidic channel placed on resonator structure (9).
摘要翻译：在微流体通道下嵌入的横向振动重力传感装置，通过微电子机械系统（MEMS）技术制造，通过测量附着在其表面上的质量变化来检测生物细胞和分析物，由四个主要组成，即谐振器可以放置在通道的基础上，谐振器的生物活性成分，微流体通道和微细加工技术，其主要组成部分为固定质量块（2）的检测质量（1），折叠弹簧梁（3），通道地板和机械土壤（4），固定电极（5），固定电极（6）上的梳齿，沉积在质量块（7）上的金膜，固定的生物识别分子）和放置在谐振器结构（9）上的微流体通道。

108. 发明申请

US20120142135A1 METHOD OF FABRICATING SENSORS HAVING FUNCTIONALIZED RESONATING BEAMS 有权
标题翻译：具有功能化共振物质传感器的方法
公开(公告)号：US20120142135A1
公开(公告)日：2012-06-07
申请号：US13308878
申请日：2011-12-01
申请人： Cornel P. COBIANU
发明人： Cornel P. COBIANU
IPC分类号： H01L21/02
CPC分类号： G01N29/022 , B01L3/502707 , B81B2201/0214 , B81B2203/0118 , B81B2207/015 , B81C1/00214 , B81C2201/0185 , B81C2203/0118 , B81C2203/0714 , B81C2203/0735 , B82Y40/00 , G01N29/036 , G01N29/222 , G01N2291/021 , G01N2291/0255 , G01N2291/0256 , G01N2291/0427
摘要： Some embodiments relate to method of fabricating a sensor. The method includes providing a substrate wafer that includes a suspended beam; adding an adhesive layer to the substrate wafer such that the adhesive layer covers portions of the substrate without covering the suspended beam; positioning a cover wafer onto the adhesive layer such that the suspend beam is exposed to ambient air through openings in the cover wafer; and functionalizing the suspended beam by contacting the suspended beam with materials through the opening in the cover wafer.
摘要翻译：一些实施例涉及制造传感器的方法。该方法包括提供包括悬挂梁的衬底晶片; 向所述基板晶片添加粘合剂层，使得所述粘合剂层覆盖所述基板的部分而不覆盖所述悬挂梁; 将覆盖晶片定位在粘合剂层上，使得悬挂梁通过盖晶片中的开口暴露于环境空气; 并且通过使悬挂的梁与材料通过覆盖晶片中的开口接触使悬臂的功能化。

109. 发明授权

US08176783B2 Non-contact fluid characterization in containers using ultrasonic waves 有权
标题翻译：使用超声波在容器中的非接触流体表征
公开(公告)号：US08176783B2
公开(公告)日：2012-05-15
申请号：US11861208
申请日：2007-09-25
申请人： Dipen N. Sinha
发明人： Dipen N. Sinha
IPC分类号： G01N29/02 , G01N29/22
CPC分类号： G01N29/036 , G01N29/348 , G01N29/4463 , G01N29/46 , G01N2291/2634
摘要： Apparatus and method for non-contact (stand-off) ultrasonic determination of certain characteristics of fluids in containers or pipes are described. A combination of swept frequency acoustic interferometry (SFAI), wide-bandwidth, air-coupled acoustic transducers, narrowband frequency data acquisition, and data conversion from the frequency domain to the time domain, if required, permits meaningful information to be extracted from such fluids.
摘要翻译：描述了用于非接触（对立）超声波测定容器或管道中的流体的某些特性的装置和方法。如果需要，扫频频声干涉测量（SFAI），宽带宽，空气耦合声换能器，窄带频率数据采集和从频域到时域的数据转换的组合允许从这种流体中提取有意义的信息。

110. 发明申请

US20120105174A1 SINGLE-INPUT MULTI-OUTPUT SURFACE ACOUSTIC WAVE DEVICE 有权
标题翻译：单输入多输出表面声波设备
公开(公告)号：US20120105174A1
公开(公告)日：2012-05-03
申请号：US13172431
申请日：2011-06-29
申请人： Yeol ho LEE , Soo Suk LEE , Kee Keun LEE
发明人： Yeol ho LEE , Soo Suk LEE , Kee Keun LEE
IPC分类号： H03H9/00 , H01L41/22 , H02N2/00
CPC分类号： G01N29/022 , G01N29/036 , G01N29/32 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , H03H9/6453
摘要： A single-input multi-output surface acoustic wave (“SAW”) device contains two or more output inter-digital transducers (“IDTs”) arranged in a longitudinal direction of a single input IDT. The detection sensitivity and reliability of the SAW device may be improved by eliminating the deviation and signal interference between multiple input IDTs.
摘要翻译：单输入多输出表面声波（“SAW”）装置包含沿单个输入IDT的纵向布置的两个或更多个输出数字间换能器（“IDT”）。通过消除多个输入IDT之间的偏差和信号干扰，可以提高SAW器件的检测灵敏度和可靠性。

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