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101. 发明申请

US20020106685A1 Method for specifically detecting tumor cells and their precursors in uterine cervical smears by simultaneously measuring at least 2 different molecular markers 审中-公开
标题翻译：通过同时测量至少2种不同的分子标记物，在子宫颈涂片中特异性检测肿瘤细胞及其前体的方法
公开(公告)号：US20020106685A1
公开(公告)日：2002-08-08
申请号：US10022618
申请日：2001-12-17
发明人： Guido Henning , Ralph Wirtz , Margit Doth , Kerstin Bohmann , Sylvia Unger
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： C12Q1/708 , C12Q1/6886 , C12Q2600/158 , G01N33/57411
摘要： The present invention relates to an automatable method for obtaining an improved diagnosis of cancer, and its precancerous stages in uterine cervical smears by simultaneously staining and detecting at least two different molecular markers, which exhibit a disease-associated change in gene expression, in a cell by means of using antibodies or nucleic acid probes.
摘要翻译：本发明涉及通过同时染色和检测在细胞中表现出与基因表达有关的疾病相关变化的至少两种不同分子标记物来获得癌症的改善诊断及其癌前期的子宫颈涂片的可自动化方法通过使用抗体或核酸探针。

102. 发明申请

US20020051968A1 Immunogenic compositions of human papillomavirus and sera produced therefrom 失效
标题翻译：人乳头瘤病毒及其产生的血清的免疫原性组成
公开(公告)号：US20020051968A1
公开(公告)日：2002-05-02
申请号：US09987557
申请日：2001-11-15
申请人： Institut Pasteur
发明人： Gerard Orth , Sylvie Beaudenon , Michel Favre , Dina Kremsdorf , Odile Croissant , Gerard Pehau-Arnaudet
IPC分类号： C12Q001/70 , C12Q001/68 , C07H021/04
CPC分类号： C07K14/005 , C12N2710/20022 , C12Q1/708 , Y10S435/948
摘要： A purified human papillomavirus gene selected from the group consisting of E1, E6-E7, L1, and L2, wherein said human papillomavirus is selected from the group consisting of HPV-2d, HPV-10b, HPV-14a, HPV-14b, HPV-15, HPV-17a, HPV-17b, HPV-19, HPV-20, HPV-21, HPV-22, HPV-23, HPV-24, HPV-28, HPV-29, HPV-31, HPV-32, HPV-IP2 and HPV-IP4. Polypeptides encoded by these genes. The polypeptides can be used in immunogenic compositions.
摘要翻译：一种选自E1，E6-E7，L1和L2的纯化人乳头瘤病毒基因，其中所述人乳头瘤病毒选自HPV-2d，HPV-10b，HPV-14a，HPV-14b，HPV -15，HPV-17a，HPV-17b，HPV-19，HPV-20，HPV-21，HPV-22，HPV-23，HPV-24，HPV-28，HPV-29，，HPV-IP2和HPV-IP4。由这些基因编码的多肽。多肽可用于免疫原性组合物。

103. 发明授权

US06355424B1 Assessment of human papillomavirus-related disease 有权
标题翻译：人乳头状瘤病毒相关疾病的评估
公开(公告)号：US06355424B1
公开(公告)日：2002-03-12
申请号：US09210168
申请日：1998-12-11
申请人： Attila T. Lorincz , James G. Lazar
发明人： Attila T. Lorincz , James G. Lazar
IPC分类号： C12Q168
CPC分类号： C12Q1/708 , A01N1/021 , C12Q1/6806 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2543/10 , C12Q2523/101 , C12Q2545/114
摘要： This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention.
摘要翻译：本发明提供了用于评估HPV感染的新方法。基因表达水平用于评估HPV感染从良性到恶性生长的进展。还提供了用于实施本发明的方法的试剂盒。

104. 发明授权

US06218104B1 Method of detection of carcinogenic human papillomavirus 失效
标题翻译：检测致癌人乳头状瘤病毒的方法
公开(公告)号：US06218104B1
公开(公告)日：2001-04-17
申请号：US09000634
申请日：1997-12-30
申请人： Brian James Morris , Brian Nightingale
发明人： Brian James Morris , Brian Nightingale
IPC分类号： C12Q170
CPC分类号： C12Q1/686 , C12Q1/708
摘要： High risk carcinogenic human types 16, 18 and 33 are distinguished from low risk human papillomavirus types 6 and 11 in a sample of human cervical tissue. A selected characteristic portion of the E6 region of the virus defined by specific oligonucleotide primers is amplified using a polymerase chain reaction. The presence or absence of the characteristic portion of the E6 region is detected by gel electrophoresis or using a labeled oligonucleotide probe.
摘要翻译：高风险致癌人类16,18和33与人类宫颈组织样本中6型和11型的低危人乳头瘤病毒不同。使用聚合酶链反应扩增由特异性寡核苷酸引物定义的病毒的E6区域的选定特征部分。通过凝胶电泳或使用标记的寡核苷酸探针检测E6区的特征部分的存在或不存在。

105. 发明授权

US6027891A Method of early detection of HPV-associated carcinomas and extreme dysplasias caused by HPV 失效
标题翻译： HPV相关癌的早期检测方法和HPV导致的极度异常发育不良
公开(公告)号：US6027891A
公开(公告)日：2000-02-22
申请号：US913547
申请日：1998-01-28
申请人： Magnus Von Knebel-Doberitz , Stefan Worner , Florian Emmerich
发明人： Magnus Von Knebel-Doberitz , Stefan Worner , Florian Emmerich
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/686 , C12Q1/708
摘要： This invention relates to a method of detection of an mRNA having HPV and cellular sequences in a body sample, comprising the following steps:(a) obtaining a body sample;(b) isolating mRNA from the body sample of (a);(c) translating the mRNA of (b) into cDNA using a primer common for reverse transcription;(d) amplifying the cDNA of (c) by a PCR reaction with a 5' HPV primer and a 3' primer having sequences of the primer of (c);(e) cleaving the amplified cDNA of (d) with an endonuclease cleaving on the 5' side of the HPV polyadenylation sequence;(f) amplifying the non-cleaved cDNA of (e) with the primers of (d) or with "nested" primers; and(g) detecting the amplified cDNA of (f).Furthermore, this invention concerns the use of such a method of early detection of HPV-associated carcinomas and extreme dysplasias caused by HPV, respectively.
摘要翻译： PCT No.PCT / DE96 / 00306 Sec。 371日期1998年1月28日 102（e）日期1998年1月28日PCT提交1996年2月23日PCT公布。 WO96 / 26293 PCT出版物日期：1996年8月29日本发明涉及检测身体样品中具有HPV和细胞序列的mRNA的方法，包括以下步骤：（a）获得身体样品; （b）从（a）的身体样品中分离mRNA; （c）使用通用于逆转录的引物将（b）的mRNA翻译成cDNA; （d）用5'HPV引物和具有（c）引物序列的3'引物通过PCR反应扩增（c）的cDNA; （e）用HPV聚腺苷酸化序列的5'侧切割内切酶切割（d）扩增的cDNA; （f）用（d）或“嵌套”引物的引物扩增（e）的未裂解的cDNA; 和（g）检测（f）的扩增cDNA。此外，本发明涉及分别由HPV引起的早期检测HPV相关癌和极度发育不良的方法的使用。

106. 发明授权

US6010704A Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them 失效
标题翻译：多肽和乳头瘤病毒特征的抗体，以及利用它们的诊断程序和疫苗
公开(公告)号：US6010704A
公开(公告)日：2000-01-04
申请号：US467281
申请日：1995-06-06
申请人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
发明人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/42 , A61P17/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K1/22 , C07K14/005 , C07K14/025 , C07K14/195 , C07K16/00 , C07K16/08 , C07K19/00 , C12N15/00 , C12N15/09 , C12N15/37 , C12P21/00 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , C12R1/92 , G01N33/569 , C12P21/06
CPC分类号： C07K14/005 , C12Q1/708 , G01N33/56983 , A61K38/00 , A61K39/00 , C12N2710/20022 , G01N2333/025 , Y10S435/975 , Y10S436/811 , Y10S436/813
摘要： The present invention provides papillomavirus DNA, and more particularly DNA probes derived from papillomavirus. The present invention also provides procedures for the use of DNA derived from papillomavirus in the in vitro diagnosis of papillomavirus infections.
摘要翻译：本发明提供乳头瘤病毒DNA，更特别地，提供衍生自乳头瘤病毒的DNA探针。本发明还提供了在乳头瘤病毒感染的体外诊断中使用来自乳头瘤病毒的DNA的方法。

107. 发明授权

US5955260A Polypeptides and antibodies characteristics of papillomavirus, and diagnostic procedures and vaccines making use of them 失效
标题翻译：乳头瘤病毒的多肽和抗体特征，以及利用它们的诊断程序和疫苗
公开(公告)号：US5955260A
公开(公告)日：1999-09-21
申请号：US426648
申请日：1995-04-21
申请人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
发明人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/42 , A61P17/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K1/22 , C07K14/005 , C07K14/025 , C07K14/195 , C07K16/00 , C07K16/08 , C07K19/00 , C12N15/00 , C12N15/09 , C12N15/37 , C12P21/00 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , C12R1/92 , G01N33/569
CPC分类号： C07K14/005 , C12Q1/708 , G01N33/56983 , A61K38/00 , A61K39/00 , C12N2710/20022 , G01N2333/025 , Y10S435/975 , Y10S436/811 , Y10S436/813
摘要： The invention relates to the DNAs of papillomaviruses, and more particularly to the probes derived from these papillomaviruses, as well as procedures for their implementation in the in vitro diagnosis of papillomavirus infections.
摘要翻译：本发明涉及乳头瘤病毒的DNA，更具体地涉及从这些乳头瘤病毒衍生的探针，以及其在乳头瘤病毒感染的体外诊断中的实施方法。

108. 发明授权

US5919615A Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them 失效
标题翻译：多肽和乳头瘤病毒特征的抗体，以及利用它们的诊断程序和疫苗
公开(公告)号：US5919615A
公开(公告)日：1999-07-06
申请号：US470471
申请日：1995-06-06
申请人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
发明人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/42 , A61P17/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K1/22 , C07K14/005 , C07K14/025 , C07K14/195 , C07K16/00 , C07K16/08 , C07K19/00 , C12N15/00 , C12N15/09 , C12N15/37 , C12P21/00 , C12P21/08 , C12Q1/68 , C12Q1/70 , C12R1/19 , C12R1/92 , G01N33/569
CPC分类号： C07K14/005 , C12Q1/708 , G01N33/56983 , A61K38/00 , A61K39/00 , C12N2710/20022 , G01N2333/025 , Y10S435/975 , Y10S436/811 , Y10S436/813
摘要： The present invention provides papillomavirus polypeptides and antibodies against said polypeptides. The peptides and antibodies of the present invention are particularly useful for in the prevention, diagnosis, and treatment of infections caused by distinct papillomaviruses. These papillomaviruses are linked to distinct infectious states. The polypeptides of the present invention are derived from L2 genes of different papillomaviruses (or from a portion of said genes). The present invention further provides kits containing one or more antibodies according to the present invention, and a method for the detection and identification of papillomaviruses in biological samples by immunological reaction with said antibodies. The diagnostic kits of the present invention are suitable for diagnosis of the specific infection affecting the donor subject of the biological sample, or infections to which the subject risks being exposed.
摘要翻译：本发明提供了乳头瘤病毒多肽和针对所述多肽的抗体。本发明的肽和抗体特别可用于预防，诊断和治疗由不同乳头状瘤病毒引起的感染。这些乳头状瘤病毒与不同的感染状态有关。本发明的多肽衍生自不同乳头瘤病毒（或所述基因的一部分）的L2基因。本发明还提供了含有根据本发明的一种或多种抗体的试剂盒，以及通过与所述抗体的免疫反应来检测和鉴定生物样品中乳头状瘤病毒的方法。本发明的诊断试剂盒适合于诊断影响生物样品的供体受试者的特异性感染，或受试者有暴露风险的感染。

109. 发明授权

US5885770A Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them 失效
标题翻译：多肽和乳头瘤病毒特征的抗体，以及利用它们的诊断程序和疫苗
公开(公告)号：US5885770A
公开(公告)日：1999-03-23
申请号：US466693
申请日：1995-06-06
申请人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
发明人： Carol Ann Komly , Odile Croissant , Francoise Breitburd
IPC分类号： C12Q1/70 , G01N33/569
CPC分类号： G01N33/56983 , C12Q1/708
摘要： The invention relates to the DNAs of papillomaviruses, and more particularly to the probes derived from these papillomaviruses, as well as procedures for their implementation in the in vitro diagnosis of papillomavirus infection.
摘要翻译：本发明涉及乳头瘤病毒的DNA，更具体地涉及从这些乳头瘤病毒衍生的探针，以及其在体外诊断乳头瘤病毒感染中的实施方法。

110. 发明授权

US5824796A Cross-linking oligonucleotides 失效
标题翻译：交联寡核苷酸
公开(公告)号：US5824796A
公开(公告)日：1998-10-20
申请号：US334490
申请日：1994-11-04
申请人： Charles R. Petrie , Rich B. Meyer , John C. Tabone , Gerald D. Hurst
发明人： Charles R. Petrie , Rich B. Meyer , John C. Tabone , Gerald D. Hurst
IPC分类号： C07D487/04 , C07H19/06 , C07H19/10 , C07H21/00 , C12Q1/68 , C12Q1/70 , C07H19/04 , C07H21/02 , C07H21/04
CPC分类号： C07D487/04 , C07H19/06 , C07H19/10 , C07H21/00 , C12Q1/6813 , C12Q1/6816 , C12Q1/708
摘要： This invention is directed to novel substituted nucleotide bases with a crosslinking arm which accomplish crosslinking between specific sites on adjoining strands of oligonucleotides or oligodeoxynucleotides. The invention is also directed to oligonucleotides comprising at least one of these crosslinking agents and to the use of the resulting novel oligonucleotides for diagnostic and therapeutic purposes. The crosslinking agents of the invention are of the following formula (I'): R.sub.1 --B--(CH.sub.2).sub.q --(Y).sub.r --(CH.sub.2).sub.m --A'(I') wherein, R.sub.1 is hydrogen, or a sugar moiety or analog thereof optionally substituted at its 3' or its 5' position with a phosphorus derivative attached to the sugar moiety by an oxygen and including groups Q.sub.1 Q.sub.2 and Q.sub.3 or with a reactive precursor thereof suitable for nucleotide bond formation; Q.sub.1 is hydroxy, phosphate or diphosphate; Q.sub.2 is .dbd.O or .dbd.S; Q.sub.3 is CH.sub.2 --R', S--R', O--R', or N--R'R"; each of R' and R" is independently hydrogen or C.sub.1-6 alkyl; B is a nucleic acid base or analog thereof that is a component of an oligonucleotide; Y is a functional linking group; each of m and q is independently 0 to 8, inclusive; r is 0 or 1; and A' is a leaving group. This invention is also directed to novel 3,4-disubstituted and 3,4,-trisubstituted pyrazolo�3,4-d!-pyrimidines and to the use of these nucleic acid bases in the preparation of oligonucleotides. The invention includes nucleosides and mono- and oligonucleotides comprising at least one of these pyrazolopyrimidines, and to the use of the resulting novel oligonucleotides for diagnostic purposes.
摘要翻译：本发明涉及具有交联臂的新型取代的核苷酸碱基，其在寡核苷酸或寡脱氧核苷酸的相邻链上的特定位点之间实现交联。本发明还涉及包含这些交联剂中的至少一种的寡核苷酸以及用于诊断和治疗目的的所得新的寡核苷酸的用途。本发明的交联剂具有下式（I'）：R1-B-（CH2）q-（Y）r-（CH2）m-A'（Ⅰ'）其中R1是氢或糖其部分或类似物任选在其3'或5'位被取代，其中磷衍生物通过氧连接到糖部分，并且包括具有适合于核苷酸键形成的反应性前体的基团Q1 Q2和Q3or; Q1是羟基，磷酸酯或二磷酸酯; Q2 = O或= S; Q3是CH2-R'，S-R'，O-R'或N-R'R“; R'和R“各自独立地为氢或C 1-6烷基; B是寡核苷酸成分的核酸碱基或其类似物; Y是功能连接基团; m和q各自独立地为0〜8，包括0和8; r为0或1; 而A'是离职团体。本发明还涉及新的3,4-二取代和3,4-取代的吡唑并[3,4 + E，未d + EE] - 嘧啶，以及这些核酸碱基用于制备寡核苷酸的用途。本发明包括核苷和包含这些吡唑并嘧啶中的至少一种的单核苷酸和寡核苷酸，以及所得到的新型寡核苷酸用于诊断目的。

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