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101. 发明申请

US20090171349A1 ADJUSTABLE LENGTH FLEXIBLE POLYMER ELECTRODE CATHETER AND METHOD FOR ABLATION 有权
标题翻译：可调节长度柔性聚合物电极导体和方法
公开(公告)号：US20090171349A1
公开(公告)日：2009-07-02
申请号：US12347097
申请日：2008-12-31
申请人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
发明人： Israel A. Byrd , Saurav Paul , Claire T. Edlebeck , Riki C. Thao
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1815
摘要： An ablation catheter includes a flexible elongated shaft having a flexible electrode at its distal end. The flexible electrode includes an inner, flexible, electrically-conductive element and an outer, flexible, electrically-conductive polymer layer in electrical contact with the inner, flexible, electrically-conductive element. The catheter further includes an electrically insulative sheath surrounding at least a portion of the flexible electrode and a linear displacement mechanism capable of adjusting at least one of the electrically insulative sheath and the flexible electrode to vary a length of the flexible electrode exposed at the distal end of the shaft. Also disclosed is an adjustable length ablation electrode and methods of ablating tissue.
摘要翻译：消融导管包括在其远端具有柔性电极的柔性细长轴。柔性电极包括内部柔性导电元件和与内部柔性导电元件电接触的外部柔性导电聚合物层。所述导管还包括围绕所述柔性电极的至少一部分的电绝缘护套和能够调节所述电绝缘护套和所述柔性电极中的至少一个的线性位移机构，以改变在所述远端暴露的所述柔性电极的长度的轴。还公开了可调节长度的消融电极和消融组织的方法。

102. 发明申请

US20080275428A1 OPTIC-BASED CONTACT SENSING ASSEMBLY AND SYSTEM 有权
标题翻译：基于光学的接触感应组件和系统
公开(公告)号：US20080275428A1
公开(公告)日：2008-11-06
申请号：US11941073
申请日：2007-11-15
申请人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
发明人： Troy T. Tegg , Saurav Paul , Richard E. Stehr , Reed R. Heimbecher
IPC分类号： A61M25/18
CPC分类号： A61B5/6885 , A61B5/0084 , A61B5/6852 , A61B5/6886 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M2025/0002
摘要： The invention relates to an optic-based sensing assembly and a system incorporating the assembly and related use of the assembly. In particular, the invention relates to an optic-based catheter assembly and related system used to determine contact between a catheter and surrounding proximate environment, such as tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
摘要翻译：本发明涉及一种基于光学的感测组件以及结合该组件的组件和该组件的相关使用的系统。特别地，本发明涉及一种基于光学的导管组件和相关系统，其用于确定导管和周围的近处环境（例如组织）之间的接触。这种系统的实施例可以例如用于组织和/或周围区域的可视化，映射，消融或其它诊断和治疗方法。

103. 发明授权

US09220417B2 Anatomical thermal sensing device and method 有权
标题翻译：解剖热感测装置及方法
公开(公告)号：US09220417B2
公开(公告)日：2015-12-29
申请号：US13777556
申请日：2013-02-26
申请人： Saurav Paul , Todd R. Stangenes , Riki Thao
发明人： Saurav Paul , Todd R. Stangenes , Riki Thao
IPC分类号： A61B5/00 , A61B5/01 , A61B5/053
CPC分类号： A61B18/1402 , A61B5/01 , A61B5/015 , A61B5/053 , A61B5/6852 , A61B5/6885 , A61B2562/0271
摘要： A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
摘要翻译：利用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件，至少一个电极，热传感器和温度响应评估系统或部件。至少一个电极可以连接到细长管状构件的远端部分，并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。热传感器可以被配置为测量解剖体或结构部分（例如组织或血液池）的热响应。温度响应评估系统或组件可以耦合到热传感器。在实施例中，该装置可以包括可容纳诸如针的工具的内腔和端口开口。还公开了使用温度感测来识别解剖体或结构的方法。

104. 发明授权

US09204927B2 System and method for presenting information representative of lesion formation in tissue during an ablation procedure 有权
标题翻译：用于在消融过程中呈现代表组织中病变形成的信息的系统和方法
公开(公告)号：US09204927B2
公开(公告)日：2015-12-08
申请号：US12964910
申请日：2010-12-10
申请人： Valtino X. Afonso , Lubomir V. Dragnev , Yitzhak I. Shai , Saurav Paul
发明人： Valtino X. Afonso , Lubomir V. Dragnev , Sarah E. Cumming , Yitzhak I. Shai , Saurav Paul
IPC分类号： A61B18/10 , A61B18/14 , A61B5/0402 , A61B5/042 , A61B18/12 , A61B18/24 , A61B19/00 , A61B17/00 , A61B18/00 , A61B18/02 , A61N7/02 , A61B5/00
CPC分类号： A61B18/1492 , A61B5/0402 , A61B5/042 , A61B5/7203 , A61B18/1233 , A61B18/14 , A61B18/24 , A61B34/25 , A61B2017/00128 , A61B2017/00199 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00648 , A61B2018/00702 , A61B2018/00714 , A61B2018/00738 , A61B2018/00779 , A61B2018/00875 , A61B2018/00892 , A61B2018/0212 , A61B2018/0262 , A61B2034/104 , A61B2034/2046 , A61B2034/2051 , A61B2034/2072 , A61B2034/301 , A61B2090/065 , A61B2218/002 , A61N7/022
摘要： A method and system for presenting information representative of lesion formation is provided. The system comprises an electronic control unit (ECU). The ECU is configured to acquire a value for an ablation description parameter and/or a position signal metric, wherein the value corresponds to a location in the tissue. The ECU is further configured to evaluate the value, assign it a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generate a marker comprising the visual indicator such that the marker is indicative of the acquired value. The method comprises acquiring a value for the parameter/metric, and evaluating the value. The method further includes assigning a visual indicator of a visualization scheme associated with the parameter/metric corresponding to the value, and generating a marker comprising the visual indicator.
摘要翻译：提供了表示病变形成信息的方法和系统。该系统包括电子控制单元（ECU）。 ECU被配置为获取消融描述参数和/或位置信号度量的值，其中该值对应于组织中的位置。 ECU还被配置为评估该值，为其分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，并且生成包括视觉指示符的标记，使得该标记指示所获取的值。该方法包括获取参数/度量的值并评估该值。该方法还包括分配与该值对应的参数/度量相关联的可视化方案的视觉指示符，以及生成包括视觉指示符的标记。

105. 发明申请

US20140060546A1 CARE UNIT 有权
标题翻译：护理单位
公开(公告)号：US20140060546A1
公开(公告)日：2014-03-06
申请号：US13946038
申请日：2013-07-19
申请人： Felicity Pino , Saurav Paul , James Krocak , John E. Ferguson , Nicole Eugenia Pardo Lamos , David Amor , Ashish Singal , Greg Ruth , Blaine Schneider , Kari Roberts
发明人： Felicity Pino , Saurav Paul , James Krocak , John E. Ferguson , Nicole Eugenia Pardo Lamos , David Amor , Ashish Singal , Greg Ruth , Blaine Schneider , Kari Roberts
IPC分类号： A61F5/37 , A61M21/02 , A61F7/08 , A61M16/00 , A61G7/05 , A61N5/06
CPC分类号： A61F5/37 , A61B5/4836 , A61B5/683 , A61B5/6887 , A61B5/6892 , A61B2503/045 , A61B2560/0412 , A61B2562/06 , A61F7/08 , A61F2007/006 , A61G7/0526 , A61G7/057 , A61G11/00 , A61G2200/14 , A61G2200/322 , A61G2200/325 , A61G2200/327 , A61G2203/34 , A61G2203/46 , A61G2210/70 , A61G2210/90 , A61M16/0057 , A61M21/02 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0061 , A61M2021/0066 , A61M2240/00 , A61N5/06 , A61N5/0621
摘要： Care units and related methods providing a comfortable environment for a patient are disclosed. A care unit can include a base member and a plurality of petal members. Each petal member can extend from a first end, engaged with the base member, to a second end, spaced from the base member. Inward-facing surfaces of at least two petal members and the base member can collectively define a cavity for receiving at least a portion of the patient. The care unit can further include one or both of a therapy component, configured to provide a treatment to the patient, or a sensor component, configured to monitor a condition of the patient. The therapy component can be coupled to, or integrated with, one or both of the base member or a petal member and can include an optical light source, a thermal energy source, an oxygen or air source, a sound wave source, a sound wave-cancelling source, or a pulsating source, for example.
摘要翻译：公开了为患者提供舒适环境的护理单元和相关方法。护理单元可以包括基部构件和多个花瓣构件。每个花瓣构件可以从与基部构件接合的第一端延伸到与基部构件间隔开的第二端。至少两个花瓣构件和基部构件的面向内的表面可以共同限定用于接收患者的至少一部分的空腔。护理单元还可以包括被配置为向患者提供治疗的治疗部件或被配置为监视患者状况的传感器部件中的一个或两个。治疗组件可以与基底构件或花瓣构件中的一个或两者结合或整合，并且可以包括光学光源，热能源，氧气或空气源，声波源，声波例如，取消源或脉动源。

106. 发明申请

US20130338467A1 Electrode catheter device with indifferent electrode for direct current tissue therapies 有权
标题翻译：用于直流组织治疗的具有无关电极的电极导管装置
公开(公告)号：US20130338467A1
公开(公告)日：2013-12-19
申请号：US13885776
申请日：2011-11-18
申请人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
发明人： Martin M. Grasse , Richard E. Stehr , Israel A. Byrd , Lynn E. Clark , D. Curtis Deno , Troy T. Tegg , James V. Kauphusman , Saurav Paul , Jeffrey A. Schweitzer
IPC分类号： A61B18/16
CPC分类号： A61B18/16 , A61B5/042 , A61B18/1492 , A61B2018/00357 , A61B2018/00613 , A61B2018/00791 , A61B2018/1435 , A61B2018/162 , A61M25/0147 , A61M2025/0681
摘要： An electrode catheter device with indifferent electrode for direct current tissue therapies is disclosed. An example of the catheter device has a flexible tubing with at least one ablation electrode. The catheter device also may also be used with a sheath for introducing the flexible tubing inside a patient's body. An indifferent electrode on the sheath can provide a ground for a direct current (DC) pulse to deliver electrical energy and create an electrical field adjacent a tissue. Various other embodiments are also disclosed.
摘要翻译：公开了一种具有用于直流组织治疗的无电极的电极导管装置。导管装置的示例具有带有至少一个消融电极的柔性管。导管装置还可以与护套一起使用以将柔性管引入患者体内。护套上的无电极可以为直流（DC）脉冲提供接地，以传递电能并在组织附近产生电场。还公开了各种其它实施例。

107. 发明授权

US08532743B2 Movable magnet for magnetically guided catheter 有权
标题翻译：磁导管用可动磁铁
公开(公告)号：US08532743B2
公开(公告)日：2013-09-10
申请号：US12851407
申请日：2010-08-05
申请人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
发明人： Todd R. Stangenes , Saurav Paul , James V. Kauphusman , Troy T. Tegg , Jeffrey A. Schweitzer
IPC分类号： A61B5/05 , A61M25/00 , A61M31/00
CPC分类号： A61M25/0127 , A61B5/0422 , A61B5/055 , A61B5/062 , A61B5/6857 , A61B6/12 , A61B6/487 , A61B18/1492 , A61B34/32 , A61B34/73 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2034/301 , A61B2034/303 , A61B2034/731 , A61B2034/732 , A61B2562/0271 , A61M25/0158
摘要： A catheter is disclosed having a flexible tubing with a proximal end and a distal end. The catheter comprising at least one movable magnet provided within the distal end of the flexible tubing. A control mechanism is operable to selectively activate the at least one movable magnet from the proximal end of the flexible tubing. The at least one movable magnet is responsive to an external magnetic field to position and guide the distal end of the flexible tubing within a body of a patient.
摘要翻译：公开了一种具有近端和远端的柔性管的导管。导管包括设置在柔性管的远端内的至少一个可动磁体。控制机构可操作以从柔性管的近端选择性地启动至少一个可动磁体。所述至少一个可移动磁体响应外部磁场来定位和引导患者体内的柔性管的远端。

108. 发明授权

US08515521B2 Coupler assembly for catheters 有权
公开(公告)号：US08515521B2
公开(公告)日：2013-08-20
申请号：US12650461
申请日：2009-12-30
申请人： Arthur G. Erdman , Saurav Paul , Troy T. Tegg
发明人： Arthur G. Erdman , Saurav Paul , Troy T. Tegg
IPC分类号： A61M25/00
CPC分类号： A61M39/10 , A61B5/0084 , A61B5/065 , A61B5/1076 , A61B5/6852 , A61B5/6885 , A61B18/1492 , A61B18/24 , A61B2017/00057 , A61B2017/00084 , A61B2090/065 , A61M25/0043 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/01 , A61M25/0138 , A61M25/0141 , A61M2025/0002
摘要： Coupler assemblies and methods are disclosed as the coupler assemblies may be used with a catheter. An exemplary coupler assembly includes a spherical linkage coupler for a catheter. The coupler comprises a first cylinder portion for connecting to a structure, and a second cylinder portion for connecting to a distal end of a body of the catheter. The coupler also comprises a spherical linkage including at least two link arms. Each of the two link arms are connected on one end to the first cylinder portion and on the other end to the second cylinder portion. The two link arms connect a portion of the structure to the distal end of the catheter and enable the structure to move relative to the distal end of the catheter in response to an external force exerted on the structure.

109. 发明申请

US20130085388A1 TISSUE PUNCTURE ASSEMBLIES AND METHODS FOR PUNCTURING TISSUE 审中-公开
标题翻译：组织支架组件和组织的组织方法
公开(公告)号：US20130085388A1
公开(公告)日：2013-04-04
申请号：US13685250
申请日：2012-11-26
申请人： Todd R. Stangenes , Saurav Paul
发明人： Todd R. Stangenes , Saurav Paul
IPC分类号： A61B17/32 , A61B8/12
CPC分类号： A61B17/320016 , A61B8/12 , A61B17/00234 , A61B17/3415 , A61B18/1492 , A61B2017/00084 , A61B2017/00247 , A61B2018/00392 , A61B2090/3782
摘要： A tissue puncture assembly includes an elongate tubular member having a lumen, a distal portion having a side wall, a side port opening extending through the side wall and, and a guiding surface having a distal end that extends adjacent to a distal edge of the side port opening. The tissue puncture assembly further includes a flexible puncture member insertable through the lumen of the elongate tubular member. The flexible puncture member deflects upon contacting the guiding surface to exit the elongate tubular member through the side port in a lateral direction relative to a longitudinal direction of the elongate tubular member. The tissue puncture member is capable of puncturing tissue at an oblique angle. The tissue puncture member may further adopt a pre-formed shape at its distal end to prevent inadvertent puncture of tissue and to maintain access to the puncture site. The transseptal puncture assembly may include various sensors to identify tissue structures and precisely locate the desired puncture site.
摘要翻译：组织穿刺组件包括具有内腔的细长管状构件，具有侧壁的远侧部分，延伸穿过侧壁的侧面开口，以及具有与侧面的远侧边缘相邻延伸的远端的引导表面港口开放。组织穿刺组件还包括可插入通过细长管状构件的内腔的柔性穿刺构件。柔性穿刺构件在接触引导表面时偏转，以相对于细长管状构件的纵向在横向方向上通过侧端口离开细长管状构件。组织穿刺构件能够以倾斜的角度刺穿组织。组织穿刺构件还可以在其远端处采用预成形的形状，以防止组织的无意的穿刺并且保持对穿刺部位的通路。经腔穿刺组件可以包括用于识别组织结构并精确定位所需穿刺部位的各种传感器。

110. 发明申请

US20120059255A1 CATHETER SYSTEMS 有权
标题翻译：导管系统
公开(公告)号：US20120059255A1
公开(公告)日：2012-03-08
申请号：US12874788
申请日：2010-09-02
申请人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
发明人： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec , John M. Berns
IPC分类号： A61N1/30 , A61B18/14 , A61B6/00
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/0016
摘要： Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
摘要翻译：导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件，电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗，包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。光纤温度感测电极导管包括具有腔体的尖端电极，其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。光纤/检测器装置监测热致变色或热致变色材料，获取光信号并产生指示光信号光谱的输出信号。分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。

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