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101. 发明申请

US20100255574A1 Human Secreted Proteins 有权
标题翻译：人类分泌蛋白
公开(公告)号：US20100255574A1
公开(公告)日：2010-10-07
申请号：US12753401
申请日：2010-04-02
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： C12N5/10 , C07H21/04 , C07K16/00 , C07K14/00 , C12N15/63
CPC分类号： C07K14/47 , C07K14/4702 , C07K16/18
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions (such as immune, cardiovascular, cancer, and other proliferative diseases, disorders, and/or conditions) related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其用于诊断和治疗疾病，病症和/或病症（例如免疫，心血管，癌症和其它增殖性疾病，病症和/或条件）与所述人分泌蛋白质相关。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

102. 发明申请

US20090253626A1 50 Human Secreted Proteins 审中-公开
公开(公告)号：US20090253626A1
公开(公告)日：2009-10-08
申请号：US12325800
申请日：2008-12-01
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N5/00 , G01N33/53 , C07K14/435 , C07K16/00 , C12P21/06
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

103. 发明授权

US07592010B2 Albumin fusion proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US07592010B2
公开(公告)日：2009-09-22
申请号：US11429276
申请日：2006-05-08
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K39/00 , A61K38/00 , A61K38/21 , C07H21/04 , C07H14/00
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

104. 发明申请

US20090226429A1 Antibodies That Immunospecifically Bind to TRAIL Receptors 审中-公开
标题翻译：免疫特异性结合TRAIL受体的抗体
公开(公告)号：US20090226429A1
公开(公告)日：2009-09-10
申请号：US12016372
申请日：2008-01-18
申请人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
发明人： Theodora W. Salcedo , Steven M. Ruben , Craig A. Rosen , Vivian R. Albert , Claire Dobson , Tristan Vaughan
IPC分类号： A61K39/395 , C12N5/06
CPC分类号： C07K16/2878 , A61K39/39558 , A61K2039/505 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译：本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

105. 发明申请

US20090148900A1 HEMCM42 NUCLEIC ACIDS 有权
标题翻译： HEMCM42核酸
公开(公告)号：US20090148900A1
公开(公告)日：2009-06-11
申请号：US12324825
申请日：2008-11-26
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07H21/00 , C12N15/64 , C12N5/10 , C12N15/09 , C12P21/00
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

106. 发明申请

US20090117043A1 Antibodies That Specifically Bind to Neurokinin B 审中-公开
标题翻译：具体绑定到神经激肽B的抗体
公开(公告)号：US20090117043A1
公开(公告)日：2009-05-07
申请号：US12191875
申请日：2008-08-14
申请人： Craig A. Rosen , Steven M. Ruben
发明人： Craig A. Rosen , Steven M. Ruben
IPC分类号： A61K49/00 , C07K16/18 , C12N9/96 , C12N5/06 , C12N15/00 , C12N15/11 , A61K39/395 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/622 , Y10S424/80 , Y10S424/804 , Y10S424/806 , Y10S424/809 , Y10S435/975
摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.
摘要翻译：本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘，胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。

107. 发明申请

US20090099073A1 Albumin Fusion Proteins 审中-公开
公开(公告)号：US20090099073A1
公开(公告)日：2009-04-16
申请号：US11929946
申请日：2007-10-30
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/38 , C07K14/76 , C07H21/04 , C12N15/00 , C12N5/00 , C12N1/00 , C12P21/06
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

108. 发明申请

US20090093402A1 Albumin Fusion Proteins 审中-公开
公开(公告)号：US20090093402A1
公开(公告)日：2009-04-09
申请号：US11929702
申请日：2007-10-30
申请人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
发明人： Craig A. Rosen , William A. Haseltine , David J. Ballance , Andrew J. Turner , Steven M. Ruben
IPC分类号： A61K38/00 , C07K14/00 , C07H21/00 , A61P43/00
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

109. 发明授权

US07504105B2 Treatment using antibodies to cytokine receptor common gamma chain like 有权
标题翻译：治疗使用细胞因子受体常见γ链的抗体
公开(公告)号：US07504105B2
公开(公告)日：2009-03-17
申请号：US10899107
申请日：2004-07-27
申请人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
发明人： Steven M. Ruben , Craig A. Rosen , Paul A. Moore
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/715 , C07K14/7155
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the Cytokine Receptor family. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named Cytokine Receptor Common Gamma Chain Like, or “CRCGCL.” This invention also relates to CRCGCL polypeptides, as well as vectors, host cells, antibodies directed to CRCGCL polypeptides, and the recombinant methods for producing the same. Also provided are diagnostic methods for detecting disorders related to the immune system, and therapeutic methods for treating diagnosing, detecting, and/or preventing such disorders. The invention further relates to screening methods for identifying agonists and antagonists of CRCGCL activity.
摘要翻译：本发明涉及编码作为细胞因子受体家族成员的多肽的新型人基因。更具体地，本发明涉及一种编码新型人多肽的多核苷酸，命名为“细胞因子受体共同伽马链样”或“CRCGCL”。本发明还涉及CRCGCL多肽，以及载体，宿主细胞，针对CRCGCL多肽的抗体及其制备方法。还提供了用于检测与免疫系统相关的疾病的诊断方法，以及用于治疗诊断，检测和/或预防这种疾病的治疗方法。本发明还涉及用于鉴定CRCGCL活性的激动剂和拮抗剂的筛选方法。

110. 发明授权

US07482442B2 HEMCM42 nucleic acids 有权
标题翻译： HEMCM42核酸
公开(公告)号：US07482442B2
公开(公告)日：2009-01-27
申请号：US11226657
申请日：2005-09-15
申请人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
发明人： Steven M. Ruben , Craig A. Rosen , Gregory A. Endress
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

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