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101. 发明申请

US20110081302A1 PROCESS FOR THE OBTENTION OF PURIFIED HEPTAFLUOROPROPANE 有权
标题翻译：纯化的HEPTAFLORORROPANE的残留过程
公开(公告)号：US20110081302A1
公开(公告)日：2011-04-07
申请号：US12965177
申请日：2010-12-10
申请人： Thomas Müller , Dominique Balthasart , Bernd Kutzner
发明人： Thomas Müller , Dominique Balthasart , Bernd Kutzner
IPC分类号： A62D1/08 , A61K9/12
CPC分类号： C07C19/08 , C07C17/087 , C07C17/383
摘要： Process for the obtention of HFC-227ea having a reduced content of organic impurities, comprising at least subjecting a crude HPC-227ea to two distillation steps at different pressures.
摘要翻译：获得具有降低的有机杂质含量的HFC-227ea的方法，包括至少使粗制HPC-227ea在不同压力下进行两个蒸馏步骤。

102. 发明授权

US07691838B2 Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics 失效
标题翻译：使用HSP90抑制剂与抗虚型药物组合治疗疾病的方法
公开(公告)号：US07691838B2
公开(公告)日：2010-04-06
申请号：US10856742
申请日：2004-05-27
申请人： Robert Johnson, Jr. , Yiqing Zhou , Thomas Müller
发明人： Robert Johnson, Jr. , Yiqing Zhou , Thomas Müller
IPC分类号： A01N43/00 , A61K31/33 , A01N43/02 , A61K31/335 , A01N43/42 , A61K31/44 , A01N43/78 , A61K31/425
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗有丝分裂剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一个步骤中一种抗有丝分裂剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用受试者的HSP90抑制剂治疗并随后用剂量的抗有丝分裂剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一种抗有丝分裂的剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

103. 发明授权

US07248839B2 Arrangement for operating various terminal devices 失效
标题翻译：各种终端设备的安排
公开(公告)号：US07248839B2
公开(公告)日：2007-07-24
申请号：US10297565
申请日：2001-06-06
申请人： Johann-Friedrich Luy , Thomas Müller , Stephan Mayer , Günter Reichert
发明人： Johann-Friedrich Luy , Thomas Müller , Stephan Mayer , Günter Reichert
IPC分类号： H04B1/46
CPC分类号： H03H11/342 , H01P1/213 , H04B1/38
摘要： In a first embodiment, the invention relates to an arrangement for operating a plurality of terminal devices (6) on a common antenna (4) with a coupling network (2) comprising a first separator (8) associated with the antenna (4) and a second separator (10) associated with the respective terminal (6). In a second embodiment, the invention relates to an arrangement for operating a plurality of terminal devices (6) on a common transmitting antenna (4″) and on a common receiving antenna (4) which is separate from the common transmitting antenna (4″) with a coupling network (2) comprising a separator (10) which is associated with the respective terminal.
摘要翻译：在第一实施例中，本发明涉及一种用于在公共天线（4）上操作多个终端设备（6）的装置，其中耦合网络（2）包括与天线（4）相关联的第一分离器（8）和与相应端子（6）相关联的第二分隔器（10）。在第二实施例中，本发明涉及一种用于在公共发射天线（4“）和公用接收天线（4）上操作多个终端设备（6）以及与公共发射天线（4）分离的装置（2）包括与相应终端相关联的分离器（10）。

104. 发明授权

US06960013B2 High frequency immersion vibrator comprising a cooled electronic frequency converter 失效
标题翻译：包括冷却电子变频器的高频浸没式振动器
公开(公告)号：US06960013B2
公开(公告)日：2005-11-01
申请号：US10250960
申请日：2002-01-11
申请人： Michael Steffen , Christian Glanz , Dirk Sibila , Thomas Müller
发明人： Michael Steffen , Christian Glanz , Dirk Sibila , Thomas Müller
IPC分类号： E04G21/08 , B01F11/00
CPC分类号： E04G21/08
摘要： An electronic frequency converter is used with a high frequency immersion vibrator in order to compact concrete. The frequency converter comprises a cooling circuit containing a cooling medium; a first heat exchanger which is integrated into said cooling circuit and is used to transmit heat generated in the housing of the frequency converter to the cooling medium; and a second heat exchanger which is integrated into the cooling circuit and is used to outwardly transmit heat absorbed by the cooling medium. The second heat exchanger is received in a vibrator housing of the high frequency immersion vibrator. If the vibrator housing is immersed in concrete, the heat produced in the converter housing can be conducted away to the concrete.
摘要翻译：电子变频器与高频浸入式振动器一起使用，以便使混凝土紧凑。变频器包括一个包含冷却介质的冷却回路; 第一热交换器，其集成在所述冷却回路中，用于将在变频器壳体中产生的热量传递到冷却介质; 以及第二热交换器，其集成到冷却回路中并用于向外传递由冷却介质吸收的热量。第二热交换器被接收在高频浸没式振动器的振动器壳体中。如果振动器壳体浸在混凝土中，则转换器壳体产生的热量可以传导到混凝土。

105. 发明授权

US06723718B2 Substituted &agr;, &bgr;-anellated butyrolactones 失效
标题翻译：取代的α，β-蒽醌丁内酯
公开(公告)号：US06723718B2
公开(公告)日：2004-04-20
申请号：US10206166
申请日：2002-07-25
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K315377
CPC分类号： C07D401/10 , C07D307/88 , C07D401/12 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/06 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12
摘要： The present invention relates to novel substituted &agr;,&bgr;-fused butyrolactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的α，β-稠合的丁内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统，特别是脑缺血性脑血管病，颅脑缺血创伤，疼痛状态或CNS介导的痉挛状态。

106. 发明授权

US06625230B1 Multi-frequency superposition receiver method 失效
标题翻译：多频叠加接收机方法
公开(公告)号：US06625230B1
公开(公告)日：2003-09-23
申请号：US09389074
申请日：1999-09-02
申请人： Konrad Böhm , Johann-Friedrich Luy , Thomas Müller
发明人： Konrad Böhm , Johann-Friedrich Luy , Thomas Müller
IPC分类号： H04L2722
CPC分类号： H04L27/2275 , H04L1/04
摘要： A method of receiving data signals having identical contents and different frequencies. The frequency position of the data signals is analyzed by means of an FFT, and the signals are down-converted to the same intermediate frequency. The frequencies are selected such that the partial waves are constructively superpositioned, thereby improving the signal-noise ratio in the sum.
摘要翻译：一种接收具有相同内容和不同频率的数据信号的方法。通过FFT分析数据信号的频率位置，并将信号下变频至相同的中频。频率被选择为使得部分波被建设性地叠加，从而提高了总和中的信噪比。

107. 发明授权

US06433004B1 Substituted &bgr;,&ggr;-anellated lactones 失效
标题翻译：取代的β，γ-安息内酯
公开(公告)号：US06433004B1
公开(公告)日：2002-08-13
申请号：US09600430
申请日：2000-07-14
申请人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
发明人： Andreas Stolle , Horst-Peter Antonicek , Stephen Lensky , Arnd Voerste , Thomas Müller , Jörg Baumgarten , Karsten von dem Bruch , Gerhard Müller , Udo Stropp , Ervin Horváth , Jean-Marie-Viktor de Vry , Rudy Schreiber
IPC分类号： A61K31381
CPC分类号： C07D307/935 , C07D409/06
摘要： The present invention relates to novel substituted &bgr;,&ggr;-fused lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cerebral ischaemias, craniocerebral trauma, states of pain or CNS-mediated spasms.
摘要翻译：本发明涉及新的取代的β，γ-融合的内酯，其制备方法及其用于预防和/或治疗由谷氨酸能系统的过度功能或功能不全引起的疾病，特别是脑缺血性颅脑损伤创伤，疼痛状态或CNS介导的痉挛状态。

108. 发明授权

US06390273B1 Apparatus for deflecting mass flows of rod-shaped articles 失效
标题翻译：用于偏转杆状物品的质量流量的装置
公开(公告)号：US06390273B1
公开(公告)日：2002-05-21
申请号：US09638901
申请日：2000-08-15
申请人： Thomas Müller
发明人： Thomas Müller
IPC分类号： B65G100
CPC分类号： A24C5/35
摘要： A horizontal belt conveyor delivers a mass flow of rod-shaped articles of the tobacco processing industry at a variable rate to a deflecting station where successive increments of the mass flow are caused to descend into an upright duct. The increments at the deflecting station are overlapped exclusively by two arcuate baffles which deflect the oncoming articles into the duct. The baffles are pivotable relative to each other about parallel axes and include intermeshing tongue-like end portions remote from the respective axes. A linkage couples the baffles to each other in such a way that any pivotal movements of one of the baffles entail predetermined movements of the other baffle.
摘要翻译：水平带式输送机将烟草加工业的棒状制品的质量流以可变的速率输送到偏转站，其中使质量流的连续增量下降到直立管道中。偏转台上的增量仅由两个弯曲的折流板重叠，从而将迎面而来的物品偏转到管道中。隔板相对于彼此围绕平行轴线可枢转，并且包括远离相应轴线的相互啮合的舌状端部。连接件将挡板彼此连接，使得挡板之一的任何枢转运动都需要另一挡板的预定运动。

109. 发明授权

US06258933B1 Process for the one-stage resalting and purification of oligopeptides 失效
标题翻译：寡肽一步分离和纯化的方法
公开(公告)号：US06258933B1
公开(公告)日：2001-07-10
申请号：US09276709
申请日：1999-03-26
申请人： Kurt Günther , Franz-Rudolf Kunz , Karlheinz Drauz , Thomas Müller
发明人： Kurt Günther , Franz-Rudolf Kunz , Karlheinz Drauz , Thomas Müller
IPC分类号： C07K116
CPC分类号： C07K7/23 , C07K1/122 , C07K1/36
摘要： The present invention relates to a process for the one-stage resalting and purification of oligopeptides. Oligopeptides are often not formed directly as acetates when synthesised. Acetate salts of oligopeptides are however desirable as bulk-active material for medical and formulation reasons. Processes known from the prior art have hitherto involved two separate steps or pyridine-containing solvents. The resalting and purification can be combined in one step and the use of pyridine as solvent can be avoided, if the oligopeptide in the form of its chloride salt is purified with an acetate-containing solvent by liquid chromatography methods.
摘要翻译：本发明涉及寡肽一步骤分离和纯化的方法。当合成时，寡肽通常不直接形成为乙酸酯。然而，寡肽的乙酸盐作为用于医学和制剂原因的体积活性材料是理想的。已知现有技术的方法迄今涉及两个独立的步骤或含吡啶的溶剂。如果用含有乙酸酯的溶剂通过液相色谱法纯化其氯化物盐形式的寡肽，则可以将脱盐和纯化结合在一个步骤中，并且可以避免使用吡啶作为溶剂。

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