专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明申请

US20090074828A1 POLY(AMINO ACID) TARGETING MOIETIES 审中-公开
标题翻译：聚氨酯（AMINO ACID）瞄准动物
公开(公告)号：US20090074828A1
公开(公告)日：2009-03-19
申请号：US12098354
申请日：2008-04-04
申请人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
发明人： Frank Alexis , Liangfang Zhang , Aleksandar F. Radovic-Moreno , Frank X. Gu , Pamela Basto , Etgar Levy-Nissenbaum , Juliana Chan , Robert S. Langer , Omid C. Farokhzad
IPC分类号： A61K9/14 , A61K47/42 , A61K31/135 , A61K31/337 , A61K38/16 , A61K31/4353 , A61K31/56 , A61K9/00 , C07K5/10 , A61P9/00
CPC分类号： A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K47/62 , A61K47/6935 , A61K47/6937 , B82Y5/00
摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
摘要翻译：本发明一般涉及聚合物和大分子，特别是涉及可用于颗粒如纳米颗粒的聚合物。本发明的一个方面涉及一种开发具有所需性质的纳米颗粒的方法。在一组实施方案中，该方法包括制备具有高度控制性质的纳米颗粒的文库，其可通过将两种或多种不同比例的大分子混合在一起形成。一个或多个大分子可以是部分与生物相容性聚合物的聚合物缀合物。在一些情况下，纳米颗粒可以含有药物。本发明的其它方面涉及使用纳米颗粒文库的方法。

102. 发明申请

US20090047256A1 Biodegradable Elastomers 有权
标题翻译：可生物降解弹性体
公开(公告)号：US20090047256A1
公开(公告)日：2009-02-19
申请号：US11623041
申请日：2007-01-12
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： A61K35/12 , C08G63/00 , C08G63/06 , C08G63/66 , C08G73/02 , A61K47/34 , A61N1/30 , A61K31/7088 , A61K31/715 , A61K38/02 , A61K35/00
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译：本发明在各方面提供弹性可生物降解的聚合物。在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化的共聚物共聚。

103. 发明申请

US20080248017A1 METHODS AND DEVICES FOR THE SUSTAINED RELEASE OF MULTIPLE DRUGS 有权
公开(公告)号：US20080248017A1
公开(公告)日：2008-10-09
申请号：US12125571
申请日：2008-05-22
申请人： Eyal S. Ron , Robert S. Langer , William F. Crowley
发明人： Eyal S. Ron , Robert S. Langer , William F. Crowley
IPC分类号： A61K38/43 , A61K47/30 , A61K47/32 , A61K38/45 , A61K31/715 , A61K39/00 , A61K38/18 , A61K39/395 , A61K38/46 , A61K38/44 , A61K31/56
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.

104. 发明申请

US20080221557A1 METHOD OF OPENING RESERVOIR OF CONTAINMENT DEVICE 有权
标题翻译：打开储存装置储存的方法
公开(公告)号：US20080221557A1
公开(公告)日：2008-09-11
申请号：US11925466
申请日：2007-10-26
申请人： John T. Santini , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard
发明人： John T. Santini , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard
IPC分类号： B23K26/36 , A61K9/22
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to said reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.
摘要翻译：提供了一种用于选择性地打开容纳储存器的方法。该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到所述储存器盖以使储存器盖分解或变得可渗透。该装置可以是可植入医疗装置。储存器可以含有用于控制释放的药物或生物传感器。

105. 发明申请

US20080182240A1 Uses And methods of making Microarrays of Polymeric biomaterials 审中-公开
标题翻译：使用和制备聚合物生物材料微阵列的方法
公开(公告)号：US20080182240A1
公开(公告)日：2008-07-31
申请号：US11676729
申请日：2007-02-20
申请人： Daniel G. Anderson , Robert S. Langer , David A. Putnam
发明人： Daniel G. Anderson , Robert S. Langer , David A. Putnam
IPC分类号： C12Q1/02 , C12Q1/68
CPC分类号： B01J19/0046
摘要： A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably said polymeric biomaterials comprise a synthetic polymer. Said polymeric biomaterials may also comprise other compounds covalently or non-covalently attached to said synthetic polymer. Methods of preparing the microarray of polymeric biomaterials of the present invention and uses of the microarray of polymeric biomaterials of the present invention are also provided.
摘要翻译：提供了聚合物生物材料的微阵列。具体地，提供了包含具有细胞疏松表面的基底的聚合物生物材料的微阵列和与细胞积极表面结合的多个离散的聚合物生物材料。优选地，所述聚合物生物材料包含合成聚合物。所述聚合物生物材料还可以包含与所述合成聚合物共价或非共价连接的其它化合物。还提供了制备本发明的聚合物生物材料的微阵列的方法和本发明的聚合物生物材料的微阵列的用途。

106. 发明授权

US07226442B2 Microchip reservoir devices using wireless transmission of power and data 有权
标题翻译： Microchip库设备使用无线传输电源和数据
公开(公告)号：US07226442B2
公开(公告)日：2007-06-05
申请号：US09975672
申请日：2001-10-10
申请人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61K9/22
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042 , G06F19/00
摘要： Devices, systems, and methods are provided for wirelessly powering and/or communicating with microchip devices used for the controlled exposure and release of reservoir contents, such as drugs, reagents, and sensors. In one embodiment, the system includes (1) a microchip device comprising a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate said release or exposure of the reservoir contents. In another embodiment, the system comprises (1) a microchip device comprising a substrate a plurality of reservoirs containing reservoir contents for release or exposure; and (2) a telemetry system for the wireless transfer of data between the microchip device and a remote controller.
摘要翻译：提供了设备，系统和方法，用于与用于受控地暴露和释放储存器内容物（例如药物，试剂和传感器）的微芯片装置的无线供电和/或通信。在一个实施例中，系统包括（1）微芯片装置，其包括具有多个储存器的基板，所述储存器包含用于释放或曝光的储存器内容物; 和（2）可充电或点播电源，其包括本地组件，其可以从远程发射器无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。在另一个实施例中，系统包括（1）微芯片装置，其包括基板，多个储存器包含用于释放或曝光的储存器内容物; 和（2）用于在微芯片设备和遥控器之间无线传输数据的遥测系统。

107. 发明授权

US07070592B2 Medical device with array of electrode-containing reservoirs 有权
标题翻译：带有电极储存器阵列的医疗器械
公开(公告)号：US07070592B2
公开(公告)日：2006-07-04
申请号：US10886405
申请日：2004-07-07
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer
IPC分类号： A61K9/22 , A61N1/30
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： Devices are provided for medical diagnostics comprising a substrate; an array of reservoirs; one or more electrodes located at least partially inside the reservoirs; a plurality of discrete reservoir caps covering openings in the plurality reservoirs; control circuitry for selectively disintegrating or permeabilizing the reservoir cap over a reservoir opening; and, optionally, a diagnostic reagent in the reservoirs. Devices also are provided for the controlled delivery of molecules comprising a substrate; an array of reservoirs; a release system in the reservoirs comprising molecules for release; one or more electrodes attached to the substrate inside the reservoirs or to a surface outside of the reservoirs, wherein the electrodes are not reservoir caps; and means for applying an electric current or potential across the electrodes effective to activate release of the molecules from the reservoirs. The devices can be adapted for implantation for in vivo diagnostics or drug delivery.
摘要翻译：提供用于医疗诊断的装置，包括基底; 一系列水库; 一个或多个电极至少部分地位于储存器内部; 多个分立储存器盖，覆盖多个储存器中的开口; 用于选择性地将储存器盖分解或渗透在储存器开口上的控制电路; 和任选地，在储存器中的诊断试剂。还提供了用于受控输送包含基底的分子的装置; 一系列水库; 储存器中的释放系统包括用于释放的分子; 一个或多个电极附着到储存器内的基底或储存器外部的表面，其中电极不是储存器盖; 以及用于施加跨过电极的电流或电位的装置，有效地激活分子从储存器的释放。该装置可适于植入用于体内诊断或药物递送。

108. 发明授权

US06998115B2 Biodegradable poly(β-amino esters) and uses thereof 有权
公开(公告)号：US06998115B2
公开(公告)日：2006-02-14
申请号：US09969431
申请日：2001-10-02
申请人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
发明人： Robert S. Langer , David M. Lynn , David Putnam , Mansoor M. Amiji , Daniel G. Anderson
IPC分类号： A61K31/765 , C08G69/44 , C08G63/44 , C07C327/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/711 , A61K31/713 , A61K47/59 , A61K47/593 , A61K47/6929 , B82Y5/00 , C08G63/685 , C08G73/02 , C08G73/0273 , C08G73/06 , C08G73/0611 , C08G73/0616 , C12N15/88
摘要： Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

109. 发明授权

US06855329B1 Surface coating spatially controlled patterns 失效
标题翻译：表面涂层空间控制图案
公开(公告)号：US06855329B1
公开(公告)日：2005-02-15
申请号：US09600502
申请日：1999-01-20
申请人： Kevin Shakesheff , Nikin Patel , Scott M. Cannizzaro , Robert S. Langer
发明人： Kevin Shakesheff , Nikin Patel , Scott M. Cannizzaro , Robert S. Langer
IPC分类号： A61K47/48 , A61L27/00 , A61L27/34 , A61L27/58 , A61L31/00 , A61L31/10 , A61L31/14 , A01N25/08 , A01N43/04 , A61F2/00 , C12Q1/68 , A01N61/90
CPC分类号： A61L31/148 , A61L27/34 , A61L27/58 , A61L31/10 , C08L89/00
摘要： The invention provides a biodegradable and biocompatible polymer article having a surface wherein a biologically active ligand is provided on said surface in a spatially controlled pattern. The pattern may be formed using a poly(dimethyl siloxane) mold. The biologically active ligand may be attached to the polymer article by a biotin-avidin-biotin linkage.
摘要翻译：本发明提供了具有表面的可生物降解和生物相容的聚合物制品，其中在空间控制图案中在所述表面上提供生物活性配体。图案可以使用聚（二甲基硅氧烷）模具形成。生物活性配体可以通过生物素 - 抗生物素蛋白 - 生物素键连接到聚合物制品上。

110. 发明授权

US06840962B1 Tissue engineered tendons and ligaments 失效
标题翻译：组织工程肌腱和韧带
公开(公告)号：US06840962B1
公开(公告)日：2005-01-11
申请号：US09670051
申请日：2000-09-25
申请人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
发明人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
IPC分类号： A61F2/08 , A61L27/18 , A61L27/38 , A61L27/58 , A61F2/02
CPC分类号： A61L27/3804 , A61F2/08 , A61L27/18 , A61L27/3604 , A61L27/3662 , A61L27/3817 , A61L27/3843 , A61L27/386 , A61L27/58 , A61L2430/10 , C08L67/04
摘要： Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.
摘要翻译：结缔组织，包括新肌腱和韧带，已经使用可生物降解的合成支架被种植有腱鞘细胞。支架优选由聚合物如聚乙醇酸 - 聚乳酸共聚物形成的可生物降解的纤维形成，并通过酶切消化或直接接种到外植体的组织培养皿中，从自体肌腱或韧带分离的细胞接种。然后手术移植细胞聚合物构建体以代替功能性肌腱或韧带的缺失部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式