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    • 103. 发明授权
    • Circuit connecting device of steering module for vehicle
    • 车辆转向模块电路连接装置
    • US5993228A
    • 1999-11-30
    • US812397
    • 1997-03-05
    • Minoru Kubota
    • Minoru Kubota
    • B60R16/027B60R16/02B62D1/04H01R35/02H01R35/04H01R3/00
    • B60R16/027H01R2201/26H01R35/025
    • A circuit connecting device has a circuit connecting body constructed by a fixed body connected to a connector for a wire harness and a rotating body rotatable with respect to this fixed body and fixed onto a steering wheel side. An inner cylindrical portion inserting a steering shaft thereinto is formed in an inner circumference of this rotating body. A collar is mounted to this inner cylindrical portion and is slidable in an axial direction and a rotating movement of the collar is restricted. A relative rotation of the rotating body and the fixed body is restricted by engaging this collar and the fixed body with each other. This engagement is released by pushing-in the collar at an inserting time of the steering shaft. Accordingly, a vehicle assembly working property of a steering module can be improved.
    • 电路连接装置具有电路连接体,该电路连接体由连接于线束用连接器的固定体和能够相对于该固定体旋转并固定在方向盘侧的旋转体构成。 在该旋转体的内周形成有将转向轴插入其中的内圆筒部。 套环安装在该内圆柱形部分上,并且可沿轴向方向滑动,并且套环的旋转运动受到限制。 旋转体和固定体的相对旋转通过使该轴环和固定体彼此接合而受到限制。 通过在转向轴的插入时间推入轴环来释放该接合。 因此,能够提高转向模块的车辆组装工作性。
    • 104. 发明授权
    • Meter module and structure for assembling the same
    • 仪表模块和组装结构
    • US5883777A
    • 1999-03-16
    • US779954
    • 1996-12-23
    • Keizo NishitaniMinoru Kubota
    • Keizo NishitaniMinoru Kubota
    • B60K37/02B60K37/06B60R16/02B60R16/023H02B1/10
    • B60R16/0231B60K37/02B60K37/06B60K2350/302B60K2350/305B60K2350/946
    • The present invention relates to a meter module to be installed in an instrument panel of a car and a structure for assembling the meter module and to provide a meter module wherein the designs of the meters and switches can easily be modified and the functions thereof can be changed in accordance with a model and grade of the motor vehicle for installing them in the instrument panel in an easier and preferable manner. The meter module consists of an independent meter display unit and cluster unit having a guide protrusion respectively, both guide protrusions can be inserted into the same introducing guides of a module accommodation portion. The meter display unit includes meters and electric circuits thereof and cluster unit includes control switches and control circuits for the meters and the like and the electrical connection between the meter module and the wire harness installed in the motor vehicle can be performed simultaneously with the insertion of the meter module into the module accommodation portion of the instrument panel of the motor vehicle.
    • 本发明涉及一种要安装在汽车仪表板中的仪表模块和用于组装仪表模块的结构,并提供一种仪表模块,其中可以容易地修改仪表和开关的设计,其功能可以是 根据机动车辆的型号和等级,以更容易和更优选的方式将其安装在仪表板中。 仪表模块由分别具有引导突起的独立的仪表显示单元和集群单元组成,两个引导突起可以插入模块容纳部分的相同导入引导件中。 仪表显示单元包括仪表及其电路,并且集群单元包括用于仪表等的控制开关和控制电路以及仪表模块和安装在机动车辆中的线束之间的电连接可以与插入 仪表模块进入机动车辆仪表板的模块收纳部分。
    • 105. 发明授权
    • Meter module, connecting device thereof, wiring harness protector, and
connecting device of instrument wiring harness
    • 仪表模块,其连接装置,线束保护器和仪表线束的连接装置
    • US5711675A
    • 1998-01-27
    • US816886
    • 1997-03-13
    • Keizo NishitaniYoshiaki NakayamaMinoru KubotaKeiichi Ozaki
    • Keizo NishitaniYoshiaki NakayamaMinoru KubotaKeiichi Ozaki
    • B60R16/02B60R16/023H01R13/621H01R33/00
    • B60R16/0239B60R16/0215H01R13/6215
    • A meter module includes a meter panel in which meters and indication lamps are mounted, a centralized control circuit board in which control circuits for a vehicle's electrical devices (including meters and indication lamps) are installed, an electric junction box for distribution of power, input and output signals and for integration of earth lines, and a module case. The electric junction box is formed by setting a bus-bar circuit board and an insulator cover in the module case. The electric junction box is formed by setting a bus-bar circuit board and an insulator cover in the module case. The centralized control circuit board and the meter panel are fixed over the electric junction box, whereby the meter panel, the centralized control circuit board and the electric junction box are intensively incorporated. Thus, the electric wiring in the instrument panel portion of the vehicle is simplified and this facilitates setting and assembling of the electric devices such as the meter panel. Furthermore, a wiring harness protector includes a protector main body for protecting a wiring harness therein and a cover. A plurality of through holes are concentrated in the cover, and a plurality of connectors in the wiring harness set in the protector main body are set through the corresponding through holes in a direction perpendicular to the wiring harness extending direction. The connectors are fixed through a connector stopper to form a multipolar connector. The wiring harness protector simplifies the wiring harness, especially the wiring arrangement of instrument panel wiring harness, and facilitates setting and assembling of the wiring harness.
    • 仪表模块包括安装仪表和指示灯的仪表板,安装车辆电气设备(包括仪​​表和指示灯)的控制电路的集中控制电路板,用于分配电力的电接线盒,输入 并输出信号并集成地线,以及模块外壳。 电接线盒通过在组合箱中设置母线电路板和绝缘体盖而形成。 电接线盒通过在组合箱中设置母线电路板和绝缘体盖而形成。 集中控制电路板和仪表板固定在电接线盒上,集中控制仪表板,集中控制电路板和电接线盒。 因此,车辆的仪表板部分中的电线被简化,这便于诸如仪表板的电气装置的设置和组装。 此外,线束保护器包括用于保护线束的保护器主体和盖。 多个通孔集中在盖中,并且设置在保护器主体中的线束中的多个连接器沿垂直于线束延伸方向的相应通孔设置。 连接器通过连接器止动器固定以形成多极连接器。 线束保护器简化了线束,特别是仪表板线束的布线布置,便于线束的设置和组装。
    • 107. 发明授权
    • Effective antagonists of the luteinizing hormone releasing hormone which
release negligible histamine
    • 促黄体生成激素释放激素的有效拮抗剂释放出可忽略的组胺
    • US4935491A
    • 1990-06-19
    • US88431
    • 1987-08-24
    • Karl FolkersAnders LjungqvistDong-Mei FengCyril Y. BowersPui-Fun L. TangMinoru Kubota
    • Karl FolkersAnders LjungqvistDong-Mei FengCyril Y. BowersPui-Fun L. TangMinoru Kubota
    • A61K38/04A61K38/00A61P15/00C07K7/06C07K7/23
    • C07K7/23A61K38/00Y10S930/13
    • The objective of the research was the achievement of antagonists of the luteinizing hormone releasing hormone (LHRH) which would have adequate antagonistic activity to prevent ovulation, and yet would not have a pronounced structural feature to release a histamine, in vivo. Some existing antagonists of LHRH produced edema of the face and extremities in rats. This recent recognition of the edematogenic and anaphylactoid activities of an antagonist of LHRH necessitated new structural changes if such antagonists were to be considered for potential use as contraceptive agents in the human. Consequently, 57 peptides have been designed, synthesized and bioassayed toward achieving a potent antagonist which releases negligible histamine. Since there was no predictable structural sequence which offered assurance of such achievement, it was necessary to design, synthesize and bioassay a very large number of peptides having diverse structural changes toward ultimately discovering an antagonist with the necessary potency of antiovulatory activity and the necessary negligible release of histamine. Ultimately, this objective was achieved, and this application describes the diverse and unpredictable many positive steps which finally led to the objectives.
    • 研究的目标是实现促黄体激素释放激素(LHRH)的拮抗剂,其具有足够的拮抗活性以防止排卵,并且在体内不具有释放组胺的显着结构特征。 一些现有的LHRH拮抗剂在大鼠中产生了四肢的水肿。 最近对LHRH拮抗剂引起的血液发生和过敏性活性的认识需要新的结构改变,如果这样的拮抗剂被认为可能用作人类的避孕药。 因此,已经设计,合成和生物测定了57种肽,以实现释放可忽略的组胺的有效拮抗剂。 由于没有可预测的结构序列来提供这种成就的保证,所以有必要设计,合成和生物测定大量具有不同结构变化的肽,以最终发现拮抗剂具有必需的抗疟药活性和必需的可忽略的释放 的组胺。 最终,这个目标已经实现,这个应用程序描述了最终导致目标的多样化和不可预测的许多积极步骤。
    • 108. 发明授权
    • Effective peptides related to the luteinizing hormone releasing hormone
from L-amino acids
    • US4721775A
    • 1988-01-26
    • US771546
    • 1985-08-26
    • Karl FolkersCyril Y. BowersPui-Fun L. TangMinoru Kubota
    • Karl FolkersCyril Y. BowersPui-Fun L. TangMinoru Kubota
    • A61K38/00C07K7/23C07K7/20
    • C07K7/23A61K38/00Y10S930/13
    • The chemical structure of the luteinizing hormone releasing hormone (LHRH) was elucidatd in 1971. Since then, a very large number of international investigators synthesized more than 100 monosubstituted and about 14 disubstituted analogs of LHRH. All of these analogs were synthesized from natural amino acids having the L-configuration. Not one of these approximately 114 analogs showed agonist activity equivalent to that of LHRH. Two of the 114 were about 60% as active, and neither one has had any utility. We have investigated the six individual L-amino acids which occur in positions 5, 7, and 8 of the four naturally occurring LHRH's which exist in porcine/ovine, salmon, and chicken tissue. There are a total of 16 peptides with these structural features, and we have discovered that not only one but five of these peptides are not only equivalent in certain assays in activity to LHRH, but that two of the five are surprisingly superior to LHRH in activity, and that two of the five have a unique and unpredictable dissociation of activity for the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). These five peptides are:A. p-Glu His Trp Ser His Gly Leu Arg Pro Gly-NH.sub.2,B. p-Glu His Trp Ser His Gly Trp Arg Pro Gly-NH.sub.2,C. p-Glu His Trp Ser His Gly Trp Gln Pro Gly-NH.sub.2,D. p-Glu His Trp Ser His Gly Trp Leu Pro Gly-NH.sub.2,E. p-Glu His Trp Ser Tyr Gly Trp Arg Pro Gly-NH.sub.2,Peptide C might be the naturally occurring as FSHRH, because of its dissociated release of LH and FSH. The discovery for the first time of decapeptides with L-amino acids equal to or more potent than LHRH was based on about 14 years of background. Our new peptides are particularly useful in medical fields for pituitary stimulation and inhibition, for enhancement or inhibition of fertility in humans and animals, for the therapy of hormone-dependent tumors, for special effects on sexual behavior in humans and animals, and for design of new categories of superagonists and antagonists. Extrapituitary effects by these new peptides may be observed on the central nervous system or reproductive organs of humans and animals that are different from those of LHRH. The latter will be especially true if some of these new peptides are found to be native peptides such as FSH-RH or the LHRH-like peptides that have been detected in the gonads that are yet to be identified. The reason for believing this projection is possible is that some of these peptides have high or unique LH and FSH releasing activity in the LHRH radioreceptor assay, as exemplified by the biological activities of peptide C.