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101. 发明授权

US08614340B2 Bicyclic compound and use thereof for medical purposes 有权
公开(公告)号：US08614340B2
公开(公告)日：2013-12-24
申请号：US13384383
申请日：2010-07-27
申请人： Tohru Kambe , Toru Maruyama , Shinsaku Yamane , Satoshi Nakayama , Kousuke Tani
发明人： Tohru Kambe , Toru Maruyama , Shinsaku Yamane , Satoshi Nakayama , Kousuke Tani
IPC分类号： C07D313/00
CPC分类号： A61K31/335 , A61K9/0048 , A61K31/4427 , A61K31/558 , C07D313/06 , C07D401/06 , C07D405/06 , C07D407/12 , C07D417/04
摘要： Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

102. 发明申请

US20130299099A1 TARGET SUBSTANCE TRANSFER METHOD, CRYSTAL PRODUCTION METHOD, COMPOSITION PRODUCTION METHOD, AND TARGET SUBSTANCE TRANSFER DEVICE 有权
标题翻译：目标物质转移方法，晶体生产方法，组合物生产方法和目标物质转移装置
公开(公告)号：US20130299099A1
公开(公告)日：2013-11-14
申请号：US13980212
申请日：2012-01-18
申请人： Yusuke Mori , Tsuyoshi Inoue , Kazufumi Takano , Hiroyoshi Matsumura , Hiroaki Adachi , Shigeru Sugiyama , Ryota Murai , Masateru Kurata , Hiroshi Yoshikawa , Mihoko Hirao , Satoshi Nakayama , Yoshinori Takahashi , Satoshi Murakami
发明人： Yusuke Mori , Tsuyoshi Inoue , Kazufumi Takano , Hiroyoshi Matsumura , Hiroaki Adachi , Shigeru Sugiyama , Ryota Murai , Masateru Kurata , Hiroshi Yoshikawa , Mihoko Hirao , Satoshi Nakayama , Yoshinori Takahashi , Satoshi Murakami
IPC分类号： B01J19/00
CPC分类号： B01J19/008 , B01D9/0081 , B01J19/10 , B01J19/121 , C30B5/00 , C30B29/58
摘要： The present invention provides a target substance transfer method, a crystal production method, a composition production method, and a target substance transfer device, which allow the concentration of a target substance to be increased easily and effectively. The target substance transfer method is a method for transferring a target substance 103 from a first phase 101 that is a liquid or solid phase containing the target substance 103 to a second phase 102 including: a phase approximation step of bringing the first phase 101 and the second phase 102 into close proximity; and a bubble collapse step of forming bubbles in the vicinity of a boundary between the first phase 101 and the second phase 102 and then causing the bubbles to collapse.
摘要翻译：本发明提供了能够容易且有效地增加目标物质浓度的目标物质转移方法，结晶生产方法，组合物制备方法和目标物质转移装置。目标物质转移方法是从包含目标物质103的液相或固相的第一相101向第二相102输送目标物质103的方法，包括：使第一相101和第二阶段102接近; 以及在第一相101和第二相102之间的边界附近形成气泡，然后使气泡塌陷的气泡塌陷步骤。

103. 发明授权

US08558908B2 Image sensing apparatus and method of controlling the image sensing apparatus 有权
标题翻译：图像感测装置及其控制方法
公开(公告)号：US08558908B2
公开(公告)日：2013-10-15
申请号：US13084443
申请日：2011-04-11
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： H04N5/225
CPC分类号： H04N5/2353 , H04N5/202 , H04N5/232 , H04N5/23245
摘要： An image sensing apparatus including an image sensing unit that converts light into an electric signal corresponding to a quantity of incident light, and periodically outputs an image signal obtained by the conversion at intervals of a predetermined period, a mode switch that switches among a plurality of image sensing modes including at least a special image sensing mode and a normal image sensing mode, a delay unit that delays an image signal by the predetermined period, an adder that adds the image signal output from the image sensing unit and the image signal output from the delay unit in set proportions, and outputs an image signal obtained by the addition, and a setting unit that sets the proportions used by the adder, according to the image sensing mode selected by the mode switch.
摘要翻译：一种图像感测装置，包括将光转换成与入射光量相对应的电信号的图像感测单元，并且周期性地输出以预定周期的间隔通过转换获得的图像信号;模式切换，其在多个包括至少特定图像感测模式和正常图像感测模式的图像感测模式，将图像信号延迟预定周期的延迟单元，将从图像感测单元输出的图像信号和从图像信号输出的图像信号相加的加法器延迟单元以设定的比例输出，并输出通过相加获得的图像信号，以及设置单元，其根据由模式切换选择的图像感测模式来设置由加法器使用的比例。

104. 发明授权

US08077225B2 Image pickup apparatus 有权
标题翻译：摄像设备
公开(公告)号：US08077225B2
公开(公告)日：2011-12-13
申请号：US12337710
申请日：2008-12-18
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： H04N5/262
CPC分类号： H04N5/2628 , H04N5/232 , H04N5/23296
摘要： An image pickup apparatus includes optical and electronic zooming units, and a controller configured to control an operation of the electronic zooming unit. When the first aspect ratio is selected, the controller operates the electronic zooming unit along with an operation of the optical zooming unit between a first zoom state and a second zoom state that is closer to a telephoto end than the first zoom state. When the second aspect ratio is selected, the controller does not operate the electronic zooming unit between the first zoom state and a third zoom state that is located between the first zoom state and the second zoom state, and operates the electronic zooming unit along with the operation of the optical zooming unit between the second zoom state and the third zoom state.
摘要翻译：图像拾取装置包括光学和电子变焦单元，以及控制器，被配置为控制电子变焦单元的操作。当选择第一高宽比时，控制器与第一缩放状态和第二缩放状态之间的光学变焦单元的操作一起操作电子变焦单元，该第一缩放状态和第二缩放状态比第一缩放状态更靠近长焦端。当选择第二宽高比时，控制器不在第一变焦状态和位于第一变焦状态和第二变焦状态之间的第三变焦状态之间操作电子变焦单元，并且与电子变焦单元一起操作在第二缩放状态和第三缩放状态之间操作光学变焦单元。

105. 发明申请

US20110246413A1 METHOD FOR JUDGING RISK OF CANCER RECURRENCE, COMPUTER PROGRAM, AND COMPUTER SYSTEM 有权
标题翻译：判断癌症复发风险的方法，计算机程序和计算机系统
公开(公告)号：US20110246413A1
公开(公告)日：2011-10-06
申请号：US13074745
申请日：2011-03-29
申请人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
发明人： Masaki SHIBAYAMA , Hideki Ishihara , Keigo Gohda , Satoshi Nakayama , Tadashi Kiniwa
IPC分类号： G06N5/04 , C12Q1/48
CPC分类号： G06F19/18 , G01N33/57496 , G01N2800/54
摘要： A method for judging a risk of cancer recurrence comprising: acquiring an activity value and expression level of a first cyclin dependent kinase (CDK) of a cell contained in tissues extracted from cancer patients, an activity value and expression level of a second CDK, and a number of Ki67-expressing cells or an expression level of Ki67; and judging a risk of cancer recurrence based on the acquired activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and a percentage of Ki67-expressing cells or the expression level of Ki67. A computer program product and a computer system are also disclosed.
摘要翻译：一种判断癌症复发风险的方法，包括：获得癌症患者提取的组织中含有的细胞的第一细胞周期蛋白依赖性激酶（CDK）的活性值和表达水平，第二CDK的活性值和表达水平，以及多个Ki67表达细胞或Ki67表达水平; 根据获得的第一CDK的活性值和表达水平，第二CDK的活性值和表达量以及Ki67表达细胞的百分比或Ki67的表达水平来判断癌症复发的风险。还公开了一种计算机程序产品和计算机系统。

106. 发明申请

US20110157425A1 VIDEO PROCESSING APPARATUS AND VIDEO PROCESSING METHOD 失效
标题翻译：视频处理设备和视频处理方法
公开(公告)号：US20110157425A1
公开(公告)日：2011-06-30
申请号：US12969746
申请日：2010-12-16
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： H04N9/68
CPC分类号： G06K9/4647 , H04N5/23245 , H04N5/235 , H04N5/2351
摘要： An imaging apparatus includes a histogram shape determination unit that acquires a histogram of luminance values from video captured by an image capturing unit and determines whether or not the captured video is a night scene from the shape of the histogram. The imaging apparatus also includes a point light source determination unit that acquires the maximum value of contrast for each horizontal line in the video as a line evaluation value and determines whether the captured video is a night scene based on whether or not the line evaluation value has a characteristic of an object as a point light source. If the histogram shape determination unit and the point light source determination unit determine that the captured video is a night scene, the imaging apparatus determines that the scene captured by the image capturing unit is a night scene.
摘要翻译：成像装置包括直方图形状确定单元，其从图像捕获单元捕获的视频中获取亮度值的直方图，并根据直方图的形状确定捕获的视频是否为夜景。成像装置还包括点光源确定单元，其获取视频中的每个水平线的最大对比度作为线评估值，并且基于线评估值是否具有夜间场景来确定捕获的视频是否是夜景作为点光源的物体的特征。如果直方图形状确定单元和点光源确定单元确定所捕获的视频是夜景，则成像设备确定由图像捕获单元捕获的场景是夜景。

107. 发明授权

US07903146B2 Image capturing apparatus with image signal and object luminance detection for exposure control 有权
标题翻译：用于曝光控制的具有图像信号和物体亮度检测的图像捕获装置
公开(公告)号：US07903146B2
公开(公告)日：2011-03-08
申请号：US11943174
申请日：2007-11-20
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： H04N5/235
CPC分类号： H04N5/2352 , H04N5/2351 , H04N5/2353 , H04N5/238
摘要： This invention improves the response characteristic of exposure control while keeping the exposure control precision high in an image capturing apparatus. An image capturing apparatus includes an image sensor which photo-electrically converts an object image to output an image signal, an output interval control unit which controls the output interval of the image signal from the image sensor, a first detection unit which detects object luminance information from the image signal, a second detection unit which detects the object luminance information by directly receiving light from an object, and a control unit which controls the exposure of the image sensor by selectively using a detection signal from the first detection unit and a detection signal from the second detection unit based on the output interval of the image signal controlled by the output interval control unit.
摘要翻译：本发明在摄像装置中保持曝光控制精度高的同时，提高曝光控制的响应特性。一种图像拍摄装置，包括：光电转换对象图像以输出图像信号的图像传感器;控制来自图像传感器的图像信号的输出间隔的输出间隔控制单元;检测对象亮度信息的第一检测单元从图像信号中，通过直接接收来自物体的光检测对象亮度信息的第二检测单元和通过选择性地使用来自第一检测单元的检测信号来控制图像传感器的曝光的控制单元，基于由输出间隔控制单元控制的图像信号的输出间隔从第二检测单元输出。

108. 发明授权

US07808545B2 Image-pickup device, color chart, image adjusting method, and image adjusting system 有权
标题翻译：图像拾取装置，色彩图，图像调整方法和图像调整系统
公开(公告)号：US07808545B2
公开(公告)日：2010-10-05
申请号：US11035241
申请日：2005-01-13
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： G03B7/00 , H04N5/235 , H04N9/73 , H04N17/02
CPC分类号： H04N5/23245 , H04N5/2351 , H04N9/735
摘要： When switching a mode between an imaging mode imaging an object and an adjustment mode adjusting an image produced by the imaging, in accordance with the switched mode, one photometric region is selected from at least two photometric regions to an image signal obtained from incident light, and exposure of the incident light is controlled on the selected photometric region based on photometric information, thereby achieving accuracy in adjusting the image produced by imaging an object by preventing effect on exposure due to dispersion in field angle.
摘要翻译：当在成像对象的成像模式和调整由成像产生的图像的调整模式之间切换模式时，根据切换模式，从至少两个测光区域选择一个测光区域到从入射光获得的图像信号，并且基于光度信息将入射光的曝光控制在所选择的测光区域上，从而通过防止由于场角的分散引起的对曝光的影响来实现通过对物体成像而产生的图像的调整的精度。

109. 发明授权

US07754442B2 Reagent kit for determining characteristic of tissue 失效
标题翻译：用于确定组织特征的试剂盒
公开(公告)号：US07754442B2
公开(公告)日：2010-07-13
申请号：US11529998
申请日：2006-09-29
申请人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
发明人： Hideki Ishihara , Satoshi Nakayama , Yuko Kawasaki , Aya Katayama
IPC分类号： G01N33/53
CPC分类号： C12Q1/485 , G01N2333/912 , Y10S435/81 , Y10S436/808
摘要： A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents and second reagents, and the activity measurement reagents comprise third reagents and fourth reagents. In the reagent kit, a first reagent set of the first and third reagents is stored under a first storage condition relating to temperature, and a second reagent set of the second and fourth reagents is stored under a second storage condition relating to temperature.
摘要翻译：描述了用于确定从患者获得的组织特征的试剂盒。该试剂盒包含用于测量细胞周期蛋白依赖性激酶（CDK）的表达水平的表达测量试剂和用于测量CDK的活性值的活性测量试剂。表达测量试剂包含第一试剂和第二试剂，活性测量试剂包括第三试剂和第四试剂。在试剂盒中，第一和第三试剂的第一试剂组在与温度有关的第一储存条件下储存，第二和第四试剂的第二试剂组在与温度有关的第二储存条件下储存。

110. 发明授权

US07362358B2 Correction of level difference between signals output from split read-out type image sensing apparatus 有权
标题翻译：从分离式读出型图像感测装置输出的信号之间的电平差的校正
公开(公告)号：US07362358B2
公开(公告)日：2008-04-22
申请号：US10913852
申请日：2004-08-06
申请人： Satoshi Nakayama
发明人： Satoshi Nakayama
IPC分类号： H04N5/225 , H04N5/235 , H04N5/217
CPC分类号： H04N5/3653
摘要： Disclosed is an sensing apparatus using an image sensing device having at least first and second output terminals, comprising first and second amplifiers that independently amplify signals output from the first and second output terminals, respectively; a first gain controller that controls gain applied to the first amplifier; memory that stores data, which relates to gain to be applied to the second amplifier, that corresponds to respective ones of a plurality of different gains to be applied to the first amplifier; and a second gain controller that controls gain applied to the second amplifier in accordance with the data relating to gain to be applied to the second amplifier, obtained from the memory, corresponding to the gain applied to the first amplifier.
摘要翻译：公开了一种使用具有至少第一和第二输出端的图像感测装置的感测装置，包括分别独立地放大从第一和第二输出端子输出的信号的第一和第二放大器; 第一增益控制器，其控制施加到第一放大器的增益; 存储器，其存储与要施加到第二放大器的增益相关的数据，其对应于要施加到第一放大器的多个不同增益中的相应的增益; 以及第二增益控制器，其根据与应用于第一放大器的增益对应的从存储器获得的与施加到第二放大器的增益有关的数据来控制施加到第二放大器的增益。

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