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101. 发明授权

US09095361B2 Methods and apparatuses for fluoro-less or near fluoro-less percutaneous surgery access 有权
标题翻译：无氟或接近无氟经皮手术的方法和装置
公开(公告)号：US09095361B2
公开(公告)日：2015-08-04
申请号：US14295148
申请日：2014-06-03
申请人： FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE
发明人： Dalton Duane Baldwin
IPC分类号： A61B19/00 , A61B5/06 , A61B1/00 , A61B1/307 , A61B8/08
CPC分类号： A61B17/3415 , A61B1/00147 , A61B1/00154 , A61B1/018 , A61B1/063 , A61B1/0676 , A61B1/307 , A61B5/061 , A61B5/065 , A61B6/12 , A61B6/485 , A61B6/487 , A61B8/0841 , A61B17/00234 , A61B17/3403 , A61B17/3423 , A61B34/20 , A61B90/13 , A61B2017/0034 , A61B2017/00707 , A61B2017/00853 , A61B2017/00907 , A61B2017/3413 , A61B2034/2055 , A61B2090/0807 , A61B2090/3762 , A61B2090/3966 , A61M25/0074 , A61M25/0097 , A61M25/10
摘要： A needle access assembly and method for obtaining percutaneous needle access with little or no fluoroscopy. The method can include selecting a target for percutaneous access, directing a laser guide at a desired needle-insertion angle and in line with the selected target, aligning the needle access assembly with the laser, and inserting the needle into the target.
摘要翻译：一种用于获取经皮针入口的针头组件和方法，其中几乎不进行荧光透视。该方法可以包括选择用于经皮进入的靶，将激光引导件引导到期望的针插入角度并与所选择的目标一致，使针访问组件与激光对准，并将针插入靶中。

102. 发明授权

US09084887B2 Proton scattering analysis system 有权
标题翻译：质子散射分析系统
公开(公告)号：US09084887B2
公开(公告)日：2015-07-21
申请号：US14159259
申请日：2014-01-20
申请人： Loma Linda University Medical Center
发明人： Reinhard W. Schulte , Vladimir A. Bashkirov
IPC分类号： A61N5/10 , A61B6/00 , G01N23/02
CPC分类号： A61N5/1071 , A61B6/54 , A61N5/103 , A61N5/1048 , A61N2005/1087 , G01N23/02
摘要： Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy.
摘要翻译：公开了用于表征组织中的相互作用或质子束的系统和方法。在某些实施方案中，可以以较大的角度检测在质子通过期间发射的带电粒子，例如用于治疗和/或成像目的的那些。在光束强度相对较低的情况下，例如在某些成像应用中，具有带电粒子的质子束的表征可以提供足够的统计量来有意义的结果，同时避免光束本身。在光束强度相对较高的情况下，例如在某些治疗应用中，具有散射的一级质子和二级质子的质子束的表征可以提供信息，例如当光束穿过组织时所遇到的密度差异以及沿着光束路径。在某些情况下，这种光束表征可以促进更准确地规划和监测基于质子的治疗。

103. 发明授权

US09084886B2 Device and method for immobilizing patients for breast radiation therapy 有权
标题翻译：用于固定患者进行乳房放射治疗的装置和方法
公开(公告)号：US09084886B2
公开(公告)日：2015-07-21
申请号：US14015002
申请日：2013-08-30
申请人： Loma Linda University Medical Center
发明人： David A. Bush
IPC分类号： A41C3/00 , A61N5/10 , A61B6/04
CPC分类号： A61N5/10 , A41C3/00 , A61B6/0435 , A61N5/1049 , A61N2005/1097
摘要： According to the improved systems and methods described herein, a patient may be immobilized so that one or both breasts are returned to a known position. Additionally, the improved systems and methods reduce respiratory movement of the breasts. Thus, the immobilization devices and techniques described herein provide accurate and reproducible breast positioning while simultaneously reducing respiratory motion.
摘要翻译：根据本文描述的改进的系统和方法，可以固定患者，使得一个或两个乳房返回到已知位置。此外，改进的系统和方法减少了乳房的呼吸运动。因此，本文所述的固定装置和技术提供精确和可再现的乳房定位，同时减少呼吸运动。

104. 发明申请

US20150032233A1 PATH PLANNING AND COLLISION AVOIDANCE FOR MOVEMENT OF INSTRUMENTS IN A RADIATION THERAPY ENVIRONMENT 有权
标题翻译：放射治疗环境中仪器运动的路径规划和冲突避免
公开(公告)号：US20150032233A1
公开(公告)日：2015-01-29
申请号：US14298082
申请日：2014-06-06
申请人： Loma Linda University Medical Center
发明人： Chieh C. Cheng , David A. Lesyna , Michael F. Moyers
IPC分类号： G05B15/02 , A61N5/10
CPC分类号： A61N5/107 , A61B6/0442 , A61B6/4092 , A61B6/547 , A61B2090/3937 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/1069 , A61N5/1078 , A61N2005/105 , A61N2005/1059 , A61N2005/1061 , A61N2005/1062 , A61N2005/1087 , A61N2005/1097 , B25J9/1666 , G05B15/02 , G05B2219/45117
摘要： Apparatus and methods for therapy delivery are disclosed. In one embodiment, a therapy delivery system includes a plurality of movable components including a radiation therapy nozzle and a patient pod for holding a patient, a patient registration module for determining a desired position of at least one of the plurality of movable components, and a motion control module for coordinating the movement of the least one of the plurality of movable components from a current position to the desired position. The motion control module includes a path planning module for simulating at least one projected trajectory of movement of the least one of the plurality of moveable components from the current position to the desired position
摘要翻译：公开了用于治疗递送的装置和方法。在一个实施例中，治疗递送系统包括多个可移动部件，包括放射治疗喷嘴和用于保持患者的患者托架，用于确定多个可移动部件中的至少一个的期望位置的患者登记模块，以及运动控制模块，用于协调多个可移动部件中的至少一个从当前位置到期望位置的移动。运动控制模块包括路径规划模块，用于将多个可移动组件中的至少一个可移动组件的至少一个运动轨迹从当前位置模拟到期望位置

105. 发明申请

US20140342005A1 METHODS FOR THE PRODUCTION, MODIFICATION AND USE OF METALLIC NANONPARTICLES 有权
标题翻译：金属纳米颗粒的生产，改性和使用方法
公开(公告)号：US20140342005A1
公开(公告)日：2014-11-20
申请号：US14364274
申请日：2013-02-28
申请人： LOMA LINDA UNIVERSITY
发明人： Ralph S. Kurti, JR. , Christopher C. Perry , Theodore Sabir
IPC分类号： A61K9/14 , A61K33/30 , A61K33/34 , A61K33/26 , A61K33/24 , A61K33/38
CPC分类号： A61K9/513 , A61K9/14 , A61K9/5192 , A61K33/24 , A61K33/245 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/38 , A61K47/60 , A61K47/6923 , A61K47/6929 , B01J13/22 , B82Y5/00
摘要： A method for producing triblock copolymer-coated metallic nanoparticle seeds which increases the size and shape homogeneity of the triblock copolymer-coated metallic nanoparticle seeds. A quantity of triblock copolymer-coated metallic nanoparticle seeds. A method for producing triblock copolymer-coated metallic nanoparticles which increases the size and shape homo-geneity of the triblock copolymer-coated metallic nanoparticles. A quantity of triblock copolymer-coated metallic nanoparticles. A method for producing modified metallic nanoparticles which increases the size and shape homogeneity of the modified metallic nanoparticles. A quantity of modified metallic nanoparticles.
摘要翻译：制备三嵌段共聚物涂覆的金属纳米颗粒种子的方法，其增加了三嵌段共聚物涂覆的金属纳米颗粒种子的尺寸和形状均匀性。一定量的三嵌段共聚物涂覆的金属纳米颗粒种子。一种制备三嵌段共聚物涂覆的金属纳米颗粒的方法，其增加了三嵌段共聚物涂覆的金属纳米颗粒的尺寸和形状的均匀性。一定量的三嵌段共聚物涂覆的金属纳米粒子。一种制备改性金属纳米粒子的方法，其增加改性金属纳米粒子的尺寸和形状均匀性。一定量的改性金属纳米粒子。

106. 发明申请

US20140288164A1 TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译：治疗自身免疫性疾病
公开(公告)号：US20140288164A1
公开(公告)日：2014-09-25
申请号：US14217070
申请日：2014-03-17
申请人： Loma Linda University
发明人： Alan P. ESCHER
IPC分类号： C12N15/85
摘要： Compositions can be used to stimulate growth of a hair shaft from a hair follicle. These compositions can include methylated polynucleotides useful in treatment of autoimmune diseases or conditions, including those, such as alopecia areata, that result in hair loss.
摘要翻译：组合物可用于刺激毛囊从毛囊生长。这些组合物可以包括可用于治疗自身免疫性疾病或病症的甲基化多核苷酸，包括导致脱发的斑秃等。

107. 发明申请

US20140141005A1 AGENTS AND METHOD FOR TREATING INFLAMMATION-RELATED CONDITIONS AND DISEASES 失效
公开(公告)号：US20140141005A1
公开(公告)日：2014-05-22
申请号：US14163933
申请日：2014-01-24
申请人： LOMA LINDA UNIVERSITY
发明人： David J. Baylink , Kin-Hing William Lau , Xuezhong Qin
IPC分类号： A61K48/00 , A61K45/06 , C12N15/85
CPC分类号： C12N15/85 , A61K35/15 , A61K38/18 , A61K38/1841 , A61K38/30 , A61K38/44 , A61K39/00 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/0058 , C12N2740/15043 , C12N2840/20 , C12Y114/13013
摘要： Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages.

108. 发明申请

US20140065157A1 AGENTS AND METHOD FOR TREATING INFLAMMATION-RELATED CONDITIONS AND DISEASES 失效
标题翻译：用于治疗与炎症有关的病症和疾病的药剂和方法
公开(公告)号：US20140065157A1
公开(公告)日：2014-03-06
申请号：US14076055
申请日：2013-11-08
申请人： LOMA LINDA UNIVERSITY
发明人： David J. Baylink , Kin-Hing William Lau , Xuezhong Qin
IPC分类号： A61K35/14
CPC分类号： C12N15/85 , A61K35/15 , A61K38/18 , A61K38/1841 , A61K38/30 , A61K38/44 , A61K39/00 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/0058 , C12N2740/15043 , C12N2840/20 , C12Y114/13013
摘要： Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages.
摘要翻译：包含1-α-羟化酶基因的基因修饰的炎症特异性单核细胞，其中当单核细胞转分化成基因修饰的炎症特异性巨噬细胞时，1-α-羟化酶基因被表达以产生功能性1-α-羟化酶。包含1-α-羟化酶基因的基因修饰的炎症特异性巨噬细胞。一种用于治疗一种或多于一种炎症相关病症或疾病的方法，所述方法包括施用基因修饰的，包含1-α-羟化酶基因的炎症特异性单核细胞，其中所述1-α-羟化酶基因被表达以产生当单核细胞转分化为基因修饰的炎症特异性巨噬细胞时，功能性1-α-羟化酶。

109. 发明申请

US20140058443A1 VASCULAR WOUND CLOSURE DEVICE AND METHOD 有权
标题翻译：血管闭合装置及方法
公开(公告)号：US20140058443A1
公开(公告)日：2014-02-27
申请号：US14069118
申请日：2013-10-31
申请人： Loma Linda University Medical Center
发明人： Yong Hua Zhu , Wolff M. Kirsch
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0206 , A61B17/3439 , A61B2017/00243 , A61B2017/00292 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00862 , A61B2017/00884 , A61B2017/00942 , A61B2090/037 , A61M25/0668 , A61M2025/0681
摘要： A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
摘要翻译：用于闭合血管伤口的方法和装置包括可以在导线上或与伤口相邻的位置上穿过导线的装置。该装置包括在其中封闭止血材料的腔室。当根据需要将装置定位在伤口附近时，止血材料从腔室展开。止血材料远端的阻塞构件用作防止止血材料进入伤口的屏障。血液接触止血材料，血液凝固优选由材料内的止血剂促进。因此，血管穿刺伤口被血块形成密封。

110. 外观设计

USD989321S1 Adjustable aerosol evacuation dam frame 有权
公开(公告)号：USD989321S1
公开(公告)日：2023-06-13
申请号：US29749863
申请日：2020-09-09
申请人： Loma Linda University
设计人： Abraham Montalvo , Jessica Kim , Joseph Caruso , Seth Myhre , Roberto Savignano
摘要： FIG. 1 is a front and left side perspective view of a first embodiment of an adjustable aerosol evacuation dam frame, showing our new design in use;
FIG. 2 is another front and left side perspective view thereof;
FIG. 3 is a front and right side isometric view thereof;
FIG. 4 is a front elevational thereof;
FIG. 5 is a rear elevational view thereof;
FIG. 6 is a right side elevational view thereof;
FIG. 7 is a left side elevational view thereof;
FIG. 8 is a top plan view thereof;
FIG. 9 is a bottom plan view thereof;
FIG. 10 is a right side elevational view of a second embodiment of an adjustable aerosol evacuation dam frame, showing our new design; and,
FIG. 11 is a left side elevational view thereof.
The second embodiment of the adjustable aerosol evacuation dam frame is identical to the first embodiment of an adjustable aerosol evacuation dam frame shown in FIGS. 1-9, excepting the removal of symbolic break lines on the bottom protruding frame portion and the inclusion of two downward-pointing protrusions on the bottom of the article which correspond to the structures shown in broken lines in the first embodiment in FIGS. 1-7 and 9.
The broken lines showing a head in FIGS. 1 and 3 represent environmental structure that forms no part of the claimed design. The remaining broken lines shown in the figures depict portions of the adjustable aerosol evacuation dam frame that form no part of the claimed design. The adjustable aerosol evacuation dam frame is shown with a symbolic break in its length. Any portions not shown between the break lines form no part of the claimed design.

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