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91. 发明授权

US06585635B1 Method and system for pericardial modification 失效
标题翻译：用于心包修复的方法和系统
公开(公告)号：US06585635B1
公开(公告)日：2003-07-01
申请号：US09715866
申请日：2000-11-16
申请人： William N. Aldrich
发明人： William N. Aldrich
IPC分类号： A61N1362
CPC分类号： A61B18/148 , A61B17/320708 , A61B2017/00044 , A61B2017/00084 , A61B2017/00243 , A61B2018/00351 , A61B2018/00791 , A61B2018/046 , A61M1/106 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/127 , A61M2205/33 , A61M2205/3303 , A61M2210/122
摘要： The invention adapts the pericardium for use as a pump bladder having a pump cavity formed by at least a portion of the pericardial space between the parietal pericardium and the visceral pericardium. The pump bladder is inflated to provide a compressive pressure on the heart and deflated to relieve the pressure. The pericardium is modified under conditions to improve the pumping characteristics of the pericardium as a pump bladder. A portion of the parietal pericardium may be attached to a portion of the visceral pericardium to isolate a portion of the pericardial space to form the pump cavity. The pericardium may be treated by stiffening, strengthening, tightening, shrinking, reshaping, or reducing the compliance or elasticity of the pericardium, or any combination thereof. The treatment may be carried out by heating the pericardium, applying a chemical to the pericardium, plicating the pericardium, or any combination thereof.
摘要翻译：本发明使心包适用于具有由顶壁心包膜和内脏心包膜之间的至少一部分心包空间形成的泵腔的泵囊。泵囊膨胀以在心脏上提供压缩压力并放气以减轻压力。在改善作为泵囊的心包的泵送特性的条件下改变心包。顶叶心包的一部分可以附着到内脏心包的一部分，以隔离一部分心包空间以形成泵腔。心包可以通过加强，加强，收紧，收缩，整形或降低心包的顺应性或弹性或其任何组合来治疗。治疗可以通过加热心包膜，将化学药物施加到心包膜，使心包化合物或其任何组合来进行。

92. 发明授权

US06553262B1 Arrangement for patient monitoring 有权
标题翻译：患者监护安排
公开(公告)号：US06553262B1
公开(公告)日：2003-04-22
申请号：US09399295
申请日：1999-09-17
申请人： Bernhard Lang , Johannes Neudecker , Armin Bolz
发明人： Bernhard Lang , Johannes Neudecker , Armin Bolz
IPC分类号： A61N1362
CPC分类号： A61B5/1112 , A61B5/0031 , G06F19/00 , Y10S128/903 , Y10S128/904
摘要： An arrangement for patient monitoring. The arrangement includes at least one body sensor to detect a physiological parameter as body signal data and at least one of a body signal processing unit connected to the body sensor for processing body signal data, and a therapy device designed to act on the patient. In addition, the arrangement includes a monitoring center having a signal field strength evaluation means, a mobile phone terminal designed to transmit the data from at least one of the body signal processing unit and the therapy device to the monitoring center and from the monitoring center to the therapy device, and a cellular mobile phone network. The mobile phone terminal is operable in the cellular mobile phone network. The arrangement further includes a base station coordinate storage unit for storage of coordinate data and a mobile phone exchange linked to the base station coordinate storage unit for the reception of position data of the mobile phone terminal. The signal field strength evaluation means is utilized for evaluating signal field strength data reflecting the distance of the mobile phone terminal from at least one base station together with coordinate data of at least one active base station of the mobile phone network in order to determine the whereabouts of the patient.
摘要翻译：病人监护安排。该装置包括至少一个身体传感器，用于检测作为身体信号数据的生理参数，以及连接到身体传感器以用于处理身体信号数据的身体信号处理单元中的至少一个，以及设计成作用于患者的治疗装置。另外，该装置包括具有信号场强评估装置的监视中心，被设计为将数据从身体信号处理单元和治疗装置中的至少一个发送到监视中心的移动电话终端，并且从监视中心到监视中心治疗装置和蜂窝移动电话网络。移动电话终端可在蜂窝移动电话网络中操作。该装置还包括用于存储坐标数据的基站坐标存储单元和链接到基站坐标存储单元的用于接收移动电话终端的位置数据的移动电话交换机。信号场强评估装置用于评估反映移动电话终端距离至少一个基站的距离的信号场强数据以及移动电话网络的至少一个活动基站的坐标数据，以便确定下落的病人。

93. 发明授权

US06530876B1 Supplemental heart pump methods and systems for supplementing blood through the heart 失效
标题翻译：补充心脏泵的方法和系统，用于补充血液通过心脏
公开(公告)号：US06530876B1
公开(公告)日：2003-03-11
申请号：US09557562
申请日：2000-04-25
申请人： Paul A. Spence
发明人： Paul A. Spence
IPC分类号： A61N1362
CPC分类号： A61M1/1063 , A61M1/1008 , A61M1/101 , A61M1/122 , A61M1/127
摘要： Systems and methods of supplementing blood flow from the heart of a patient involving superficial, non-invasive procedures. In one general method, a first conduit is directed into the left side of the heart, a second conduit is directed into a superficial vessel and a pump is connected between the first and second conduits. The pump is implanted superficially in the patient and a power supply is connected to the pump. Blood is then suctioned from the left side of the patient's heart through the first conduit into the pump and expelled from the pump into the second conduit and the superficial vessel. A transcutaneous power supply is disclosed in one aspect and includes an external portion with a connection and alignment feature to assure reliable transmission of power.
摘要翻译：补充来自患者心脏的血液流动的系统和方法，涉及表面，非侵入性程序。在一种一般方法中，第一导管被引导到心脏的左侧，第二导管被引导到浅表血管中，并且泵连接在第一和第二导管之间。泵表面植入患者体内，并将电源连接到泵。然后将血液从患者心脏的左侧通过第一导管吸入泵中并从泵排出到第二导管和浅表血管中。在一个方面公开了一种经皮电源，并且包括具有连接和对准特征的外部部分，以确保功率的可靠传输。

94. 发明授权

US06527698B1 Active left-right flow control in a two chamber cardiac prosthesis 有权
标题翻译：主动左右流控制在两腔心脏假体
公开(公告)号：US06527698B1
公开(公告)日：2003-03-04
申请号：US09687040
申请日：2000-10-12
申请人： Robert T. V. Kung , Robert W. Fasciano
发明人： Robert T. V. Kung , Robert W. Fasciano
IPC分类号： A61N1362
CPC分类号： A61M1/1044 , A61M1/1037 , A61M1/106 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/3334
摘要： A biventricular cardiac prosthesis has a flow balance control system to balance blood flow through the left and right sides of the prosthesis to maintain a patient's left atrial pressure within physiologic bounds. The prosthesis can be configured to have flow characteristics so that a signal representative of the difference in hydraulic pumping pressures on the left and right sides of the prosthesis is representative of the difference between left and right atrial pressures of a patient having the prosthesis implanted. This signal can be used as a control signal to drive the prosthesis so that left atrial pressure is approximately equal to right atrial pressure, and within physiologic bounds. A specific prosthesis includes left and right pumping sections, each having a blood pumping chamber and a hydraulic fluid chamber, with a reciprocating hydraulic pump driving systole alternately on the right and left sides. A hydraulic balance chamber is hydraulically coupled to the right hydraulic fluid chamber and an adjustable occluder varies flow resistance through the hydraulic coupling. The occluder can be adjusted based on the control signal to adjustably derate right side blood flow to achieve the desired pressure balance, or the occluder can be adjusted based on fluid communication with sources of pressure in the prosthesis that are representative of right and left atrial pressures.
摘要翻译：双心室心脏假体具有流量平衡控制系统，以平衡穿过假体左侧和右侧的血流，以将患者的左心房压力维持在生理范围内。假体可被构造成具有流动特性，使得表示假体左侧和右侧的液压泵送压力的差异的信号代表植入假体的患者的左心房和右心房压力之间的差异。该信号可用作驱动假体的控制信号，使得左心房压力近似等于右心房压力，并且在生理范围内。具体的假体包括左右泵送部分，每个部分具有血液泵腔和液压腔，其中往复式液压泵在右侧和左侧交替地驱动收缩器。液压平衡室液压耦合到右液压流体室，可调节的封闭器通过液压联轴器改变流动阻力。可以基于控制信号来调节闭塞器，以可调节地降低右侧血流量以实现所需的压力平衡，或者可以基于与代表右心房和左心房压力的假体中的压力源的流体连通来调节闭塞器。

95. 发明授权

US06511412B1 Cardivascular support control system 有权
标题翻译：血管支持控制系统
公开(公告)号：US06511412B1
公开(公告)日：2003-01-28
申请号：US09690029
申请日：2000-10-16
申请人： Paul S. Freed , Michael Psakhis
发明人： Paul S. Freed , Michael Psakhis
IPC分类号： A61N1362
CPC分类号： A61M39/0247 , A61M1/1037 , A61M1/106 , A61M1/107 , A61M1/1072 , A61M1/1086 , A61M1/122 , A61M1/125 , A61M1/127 , A61M2039/0282 , A61M2205/33 , A61M2205/3303 , A61M2205/8206
摘要： An apparatus for assisting cardiac function of a patient includes an inflatable chamber operably positionable with respect to an aorta of the patient, a percutaneous access device implantable with respect to a hypogastric region of the patient and connectible in fluid communication with the inflatable chamber, and a drive unit connectible through the percutaneous access device for selectively inflating and deflating the inflatable chamber in accordance with a control program stored in memory. The control program controls the drive unit in response to a periodically scheduled patient monitoring routine for measuring values of the physiology of the patient. The control program uses measured values as modified in accordance with the control program and physician programmable parameters for assisting cardiac function of the patient. The program includes the steps of automatically controlling the drive unit in response to a periodically scheduled patient monitoring routine for measuring values of physiology of the patient, and using measured values as modified in accordance with physician programmable parameters for assisting cardiac function of the patient. A software program is connectible in electronic communication with the control program for adjusting settings of the drive unit. The software program is capable of one or more of the following functions: retrieving current values of physician programmable parameters, selectively retrieving a history of the drive unit operation including error detection records, displaying a continuous ECG, and/or displaying a single-beat sample of aortic pressure waveform obtained in real time from the patient.
摘要翻译：一种用于辅助患者的心脏功能的装置包括可相对于患者的主动脉可定位的可充气腔室，相对于患者的下腹部区域可植入并且可与可充气室流体连通的经皮通路装置，以及驱动单元可通过经皮进入装置连接，用于根据存储在存储器中的控制程序选择性地使充气室膨胀和放气。控制程序响应于周期性地调度的患者监视程序来控制驱动单元，用于测量患者的生理学值。控制程序使用根据控制程序修改的测量值和用于辅助患者的心脏功能的医师可编程参数。该程序包括响应于周期性调度的患者监测程序来自动控制驱动单元的步骤，用于测量患者的生理学值，并且使用根据医师可编程参数修改以用于辅助患者的心脏功能的测量值。软件程序可与用于调整驱动单元的设置的控制程序进行电子通信。该软件程序能够具有以下功能中的一个或多个：检索医师可编程参数的当前值，选择性地检索包括错误检测记录，显示连续ECG的驱动单元操作的历史和/或显示单拍样本的主动脉压力波形从患者实时获得。

96. 发明授权

US06506146B1 Apparatus for supporting heart performance 有权
标题翻译：用于支持心脏功能的装置
公开(公告)号：US06506146B1
公开(公告)日：2003-01-14
申请号：US09509077
申请日：2000-05-12
申请人： Werner Mohl
发明人： Werner Mohl
IPC分类号： A61N1362
CPC分类号： A61M1/10 , A61M1/1005 , A61M1/1086 , A61M2025/0002
摘要： In a means for support of the performance of a heart (1) in which fluid is taken from blood vessels via an external pump (7) and is returned to the blood vessels, the amount of fluid being controlled as a function of the measured values, a catheter in the ventricle is equipped with sensors (4) for measuring the volume of fluid per unit of time. The sensors (4) are connected to an evaluation circuit in which the ratio of the diastolic volume to the systolic volume per heartbeat or unit of time, especially the output rate and/or the deviation of the volume which has been delivered by the heart per unit of time from a defined setpoint, for example the setpoint which has been computed from body-specific data for the cardiac output (HZV), is evaluated and a signal is generated. The pump (7) via which fluid is withdrawn from the ventricle is controlled depending on the generated signal.
摘要翻译：在用于支持心脏（1）的手段中，其中流体经由外部泵（7）从血管中取出并返回到血管，作为测量值的函数控制的流体的量，心室中的导管配备有用于每单位时间测量流体体积的传感器（4）。传感器（4）连接到评估电路，其中舒张容积与心跳或单位时间的收缩容积的比率，特别是心脏递送的体积的输出速率和/或偏差从定义的设定点开始的时间单位，例如从心输出量（HZV）的身体特定数据计算出的设定值，并产生信号。根据产生的信号控制流体从心室中取出的泵（7）。

97. 发明授权

US06484058B1 Methods for sensing arrhythmias in a pacemaker/defibrillator and a pacemaker/defibrillator programmed to implement the same 有权
标题翻译：用于检测起搏器/去纤颤器中的心律失常的方法和被编程以实现相同的起搏器/除颤器
公开(公告)号：US06484058B1
公开(公告)日：2002-11-19
申请号：US09972214
申请日：2001-10-04
申请人： Michael O. Williams , Timothy Olson
发明人： Michael O. Williams , Timothy Olson
IPC分类号： A61N1362
CPC分类号： A61N1/3622 , A61N1/3962
摘要： A method for detecting an arrhythmia hidden by rapid pacing in a rate adaptive pacemaker/defibrillator. Unmasking a potential arrhythmia is accomplished by lengthening the pace cycle length by a small amount for a number of cycles followed by a shortening of the pace cycle length for the same number of cycles giving an average pacing rate equivalent to the desired rate. This can occur at all times or only when conditions make arrhythmia masking possible. Changing the pace cycle by a small amount over a number of cycles will move the arrhythmia and paced rhythm out of synchronization. Forcing the pacer to continue sensing the arrhythmia is accomplished by insuring that the pacer's sense refractory is less than one half of the pacing cycle length. This is done by constraining the programming of that value to one half the minimum pacing cycle length or using an adaptive sense refractory period. In another embodiment, a hidden arrhythmia is detected by periodically checking a relative refractory portion of the pace refractory period to see if a signal indicative of arrhythmia can be detected. This relative refractory period is produced by shortening the established refractory period by a calculated adaptive relative refractory period.
摘要翻译：一种用于在速率自适应起搏器/除颤器中检测由快速起搏隐藏的心律失常的方法。解除潜在的心律失常是通过将步伐周期长度延长少量进行多个循环，然后在相同数量的循环中缩短起搏周期长度来实现的，其平均起搏速率等于期望速率。这可以在任何时候发生，或者只有当条件使得心律失常屏蔽成为可能时。在多个周期内将脚步周期改变少量将会导致心律失常和节奏不一致。通过确保起搏器的感觉耐火材料不到起搏周期长度的一半，强制起搏器继续感测心律失常。这通过将该值的编程限制为最小起搏周期长度的一半或使用自适应感应不良期来完成。在另一个实施方案中，通过周期性地检查步骤不良期的相对难治部分来检测是否可以检测到指示心律失常的信号来检测隐藏的心律失常。该相对不应期是通过计算的适应性相对不应期缩短建立的不应期而产生的。

98. 发明授权

US06473646B2 Method and apparatus for assessing cardiac functional status 有权
标题翻译：评估心脏功能状态的方法和装置
公开(公告)号：US06473646B2
公开(公告)日：2002-10-29
申请号：US09551310
申请日：2000-04-18
申请人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
发明人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.
摘要翻译：一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。

99. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

100. 发明授权

US06450172B1 Broadcast audible sound communication from an implantable medical device 失效
标题翻译：从可植入医疗设备广播可听见的声音通信
公开(公告)号：US06450172B1
公开(公告)日：2002-09-17
申请号：US09491398
申请日：2000-01-25
申请人： Jerome T. Hartlaub , David L. Thompson , Daniel R. Greeninger
发明人： Jerome T. Hartlaub , David L. Thompson , Daniel R. Greeninger
IPC分类号： A61N1362
CPC分类号： A61N1/3727 , A61N1/37217 , A61N1/37223 , A61N1/37247 , A61N1/37264
摘要： Methods and apparatus for communication of implantable medical device (IMD) information, including interrogation of programmed parameter values, operating modes and conditions of operation, confirmation of programmed changes thereof, interrogation of data stored in the IMD, and patient warnings or other messages by RF transmission of audible sounds generated by the IMD are disclosed. The IMD includes an RF transmitter that broadcasts or transmits audible sounds including voiced statements or musical tones stored in analog memory correlated to a programming or interrogation operating algorithm or to a warning trigger event. The broadcast radio signal is received, and the audible sounds are demodulated and reproduced by a radio receiver as voiced statements or musical tones that convey human understandable messages comprising IMD information generated during programming and interrogation sessions and warnings or status messages to the patient at other times.
摘要翻译：用于通信植入式医疗装置（IMD）信息的方法和装置，包括询问编程的参数值，操作模式和操作条件，确定其编程的变化，询问存储在IMD中的数据，以及通过RF的患者警告或其他消息公开了由IMD产生的可听见的声音的传输。 IMD包括RF发射器，其广播或发送与编程或询问操作算法相关的模拟存储器中存储的有声语音或音调的声音或发音，或警告触发事件。广播无线电信号被接收，并且可听见的声音由无线电接收机解调和再现，作为语音或乐音，其传达包括在编程期间产生的IMD信息和询问会话以及警告或状态消息的人可理解的消息到患者的其他时间。

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