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91. 发明授权

US3207666A Method of producing dry free flowing preparations which are stable in air and contain an oxidizable organic substance 失效
标题翻译：制备在空气中稳定并含有可氧化有机物质的干燥自由流动制剂的方法
公开(公告)号：US3207666A
公开(公告)日：1965-09-21
申请号：US2112860
申请日：1960-04-11
申请人： PHILIPS CORP
发明人： HENK HOUTGRAAF , TEN HAM EVERT JAN
IPC分类号： A61K9/14 , A61K9/50 , B01D1/18 , B01J2/00 , B01J2/04 , B01J2/06 , B01J13/04
CPC分类号： A61K9/14 , A61K9/50 , B01D1/18 , B01J2/00 , B01J2/04 , B01J2/06 , B01J13/04 , Y10S436/829

92. 发明申请

US20120171758A1 Device for extracting nucleic acid from a sample 有权
标题翻译：从样品中提取核酸的装置
公开(公告)号：US20120171758A1
公开(公告)日：2012-07-05
申请号：US11977615
申请日：2007-10-24
申请人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译：本发明提供一种用于分析流体样品的盒。盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。

93. 发明申请

US20120009667A1 APPARATUS AND METHOD FOR ANALYZING FLUID SAMPLE 审中-公开
标题翻译：用于分析流体样品的装置和方法
公开(公告)号：US20120009667A1
公开(公告)日：2012-01-12
申请号：US13081060
申请日：2011-04-06
申请人： KURT E. PETERSON , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： KURT E. PETERSON , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： C12M1/34 , C12M1/12 , C12M1/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译：本发明提供一种用于分析流体样品的盒。盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。

94. 发明授权

US07939170B2 Water soluble metal and semiconductor nanoparticle complexes 有权
标题翻译：水溶性金属和半导体纳米颗粒复合物
公开(公告)号：US07939170B2
公开(公告)日：2011-05-10
申请号：US10219440
申请日：2002-08-15
申请人： Benoit Dubertret , Vincent Noireaux , Albert Libchaber
发明人： Benoit Dubertret , Vincent Noireaux , Albert Libchaber
IPC分类号： A61K9/50
CPC分类号： B82Y30/00 , A61K49/0067 , B82Y5/00 , B82Y25/00 , H01F1/0054 , H01F1/0063 , H01F1/36 , H01F1/37 , Y10S436/829 , Y10T428/2989 , Y10T428/2991
摘要： The invention provides a water soluble complex comprising an inner core of a metal or semi-conductor nanoparticle. The nanoparticle is coated with a hydrophobic ligand, which is encapsulated in a micelle. In an aqueous medium, the micelle comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell comprising a plurality of hydrophilic moieties, the hydrophobic core comprising a plurality of hydrophobic moieties, each hydrophobic moiety comprising at least one chain, each chain comprising a minimum of 8 atoms; wherein the total number of atoms in all chains for each moiety comprises at least 24 atoms. The micelle has a minimum average diameter of approximately 5 nm and a maximum average diameter of approximately 45 nm.
摘要翻译：本发明提供一种包含金属或半导体纳米颗粒的内芯的水溶性络合物。纳米颗粒涂覆有疏水性配体，其被包封在胶束中。在水性介质中，胶束包括亲水壳和疏水性芯，所述亲水壳包含多个亲水部分，所述疏水性芯包含多个疏水部分，每个疏水部分包含至少一个链，每条链包含最小的8个原子; 其中每个部分的所有链中的原子总数包含至少24个原子。胶束具有约5nm的最小平均直径和约45nm的最大平均直径。

95. 发明授权

US07419796B2 Method of making a test device 失效
标题翻译：制作测试装置的方法
公开(公告)号：US07419796B2
公开(公告)日：2008-09-02
申请号：US10264159
申请日：2002-10-02
申请人： Richard A. Durst , Daniel Martorell-Pena , Sui Ti Atienza Siebert
发明人： Richard A. Durst , Daniel Martorell-Pena , Sui Ti Atienza Siebert
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/586 , Y10S436/829
摘要： The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixture on the membrane under vacuum pressure at a temperature of from about 4° C. to about 80° C., wherein said mixture further includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration. The present invention also relates to a test device and method for detecting or quantifying an analyte in a sample. The test device includes a membrane which includes an immobilized liposome zone, wherein the immobilized liposome zone has bound thereto dehydrated, derivatized, marker-loaded liposomes dehydrated under vacuum pressure at a temperature of from about 4° C. to about 80° C. from a mixture which includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration.
摘要翻译：本发明涉及一种用于制造用于检测或定量样品中的分析物的测试装置的方法。该方法包括使膜与包含衍生的标记负载的脂质体的混合物接触，并且在真空压力下在约4℃至约80℃的温度下使膜上的混合物基本上脱水，其中所述混合物还包括一种或多种足以在脱水和再水合过程中促进脂质体的稳定性的糖。本发明还涉及用于检测或定量样品中的分析物的测试装置和方法。该测试装置包括一个包含固定的脂质体区的膜，其中固定的脂质体区结合有脱水，衍生化的标志物负载的脂质体，其在真空压力下在约4℃至约80℃的温度下脱水一种混合物，其包含足以在脱水和再水化过程中促进脂质体稳定性的一种或多种糖。

96. 发明授权

US06939721B2 Fluorescence immunoassays using organo-metallic complexes for energy transfer 有权
标题翻译：荧光免疫法使用有机金属配合物进行能量转移
公开(公告)号：US06939721B2
公开(公告)日：2005-09-06
申请号：US09740660
申请日：2000-12-18
申请人： Ganapati R. Mauze , Dan-Hui Yang
发明人： Ganapati R. Mauze , Dan-Hui Yang
IPC分类号： G01N33/542 , G01N33/58 , G01N33/545 , G01N33/533 , G01N33/552
CPC分类号： G01N33/582 , G01N33/542 , G01N2458/40 , Y10S436/80 , Y10S436/805 , Y10S436/829
摘要： The invention includes a composition of matter and method that utilizes energy transfer between one or more donor and acceptor molecules. The composition of matter includes an encapsulation vesicle having a matrix, a surface coating of an organo-metallic complex and a transparent protection layer. The transparent protection layer is capable of modification by addition of biomolecules to the surface in order to bind other molecules. The proximity of the bound biomolecules to the protective layer allows for energy transfer from a donor molecule internal to the protection layer to an acceptor molecule outside the protection layer. The protection layer acts to diminish the effects of collisional quenching on the donor molecules caused by ubiquitous small molecules such as molecular oxygen. The application also teaches a method of making and applying the complexes to immunoassays.
摘要翻译：本发明包括利用一个或多个供体和受体分子之间的能量转移的物质和方法的组合物。物质的组成包括具有基质的包封囊泡，有机金属络合物的表面涂层和透明保护层。透明保护层能够通过向表面添加生物分子来进行修饰，以便结合其他分子。结合的生物分子与保护层的接近允许从保护层内部的施主分子到保护层外部的受体分子的能量转移。保护层起到减少由普遍存在的小分子（如分子氧）引起的激发猝灭对供体分子的影响。本申请还教导了制备和应用复合物免疫测定法的方法。

97. 发明申请

US20050186265A1 Novel cochleate formulations 审中-公开
标题翻译：新型耳蜗配方
公开(公告)号：US20050186265A1
公开(公告)日：2005-08-25
申请号：US11040615
申请日：2005-01-18
申请人： Leila Zarif , Tuo Jin , Ignacio Segarra , Raphael Mannino
发明人： Leila Zarif , Tuo Jin , Ignacio Segarra , Raphael Mannino
IPC分类号： C07D233/60 , A61K9/00 , A61K9/127 , A61K31/05 , A61K31/192 , A61K31/198 , A61K31/216 , A61K31/337 , A61K31/405 , A61K31/4174 , A61K31/436 , A61K31/4422 , A61K31/48 , A61K31/522 , A61K31/568 , A61K31/704 , A61K31/7042 , A61K31/7048 , A61K45/00 , A61K47/02 , A61K47/24 , A61K47/30 , A61K47/34 , A61K47/36 , A61K47/42 , A61K47/44 , A61P9/10 , A61P23/00 , A61P25/20 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/06 , C07D209/26 , C07D211/90 , C07D305/00 , C07D473/18 , C07D519/00 , C07J1/00 , C12N15/88
CPC分类号： A61K9/1274 , A61K31/07 , A61K31/11 , A61K31/20 , A61K31/472 , A61K31/496 , A61K31/704 , A61K31/7048 , A61K31/713 , A61K36/54 , A61K38/13 , Y10S436/829 , Y10S514/966 , Y10S514/967 , Y10T428/2984
摘要： A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
摘要翻译：一种生产小型脂质类耳蜗的方法。耳蜗源自脂质体，其悬浮在水性两相聚合物溶液中，使得能够通过相分离差异分配极性分子基结构。用带正电荷的分子如Ca 2+或Zn 2+ 2+处理的含脂质体的两相聚合物溶液形成粒径小于1的耳蜗沉淀物微米。该方法可用于产生含有生物相关分子的耳蜗细胞。

98. 发明申请

US20050136064A1 Therapeutic liposome composition and method of preparation 审中-公开
标题翻译：治疗脂质体组成及制备方法
公开(公告)号：US20050136064A1
公开(公告)日：2005-06-23
申请号：US11049848
申请日：2005-02-02
申请人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
发明人： Theresa Allen , Paul Uster , Francis Martin , Samuel Zalipsky
IPC分类号： A61K9/127 , A61K51/12 , A61K39/395 , C07K16/46 , C12N9/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
摘要翻译：描述了用于制备对目标细胞敏化的治疗性脂质体组合物的试剂。试剂包括由预先形成的脂质体组成的脂质体组合物，其具有包埋的治疗剂和由脂质，亲水性聚合物和靶向配体组成的多种靶向缀合物。通过将脂质体组合物与所选择的缀合物孵育来形成治疗性靶细胞致敏脂质体组合物。

99. 发明申请

US20030215490A1 Therapeutic liposome composition and method of preparation 审中-公开
标题翻译：治疗脂质体组成及制备方法
公开(公告)号：US20030215490A1
公开(公告)日：2003-11-20
申请号：US10115566
申请日：2002-04-02
申请人： Sequus Pharmaceuticals, Inc.
发明人： Theresa M. Allen , Paul Steven Uster , Francis J. Martin , Samuel Zalipsky
IPC分类号： A61K039/395 , A61K009/127
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1272 , A61K47/544 , A61K47/61 , A61K47/62 , A61K47/6849 , A61K47/6911 , A61K47/6913 , A61K51/1234 , C07K16/2854 , C07K2317/55 , Y10S424/812 , Y10S436/829
摘要： Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
摘要翻译：描述了用于制备对目标细胞敏化的治疗性脂质体组合物的试剂。试剂包括由预先形成的脂质体组成的脂质体组合物，其具有包埋的治疗剂和由脂质，亲水性聚合物和靶向配体组成的多种靶向缀合物。通过将脂质体组合物与所选择的缀合物孵育来形成治疗性靶细胞致敏脂质体组合物。

100. 发明申请

US20020192722A1 Sensor surfaces for detecting analytes 失效
标题翻译：用于检测分析物的传感器表面
公开(公告)号：US20020192722A1
公开(公告)日：2002-12-19
申请号：US10116013
申请日：2002-04-02
申请人： Prolinx Incorporated
发明人： Mark L. Stolowitz , Jean P. Wiley , Guisheng Li , Kevin Lund
IPC分类号： G01N033/53 , G01N033/542 , C12M001/34
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N21/553 , G01N33/54353 , G01N33/553 , G01N2610/00 , Y10S436/806 , Y10S436/829 , Y10T436/143333
摘要： The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.
摘要翻译：本发明提供了一种传感器表面，包括：涂覆有自由电子金属的基底; 以及设置在所述自由电子金属上的基质层，其中所述基质层包含具有硼酸络合部分的有机化合物。基质优选为自组装单层（SAM），混合自组装单层（mSAM）或其组合。

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