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91. 发明授权

US08519086B2 Degradable thiol-ene polymers 有权
公开(公告)号：US08519086B2
公开(公告)日：2013-08-27
申请号：US12556640
申请日：2009-09-10
申请人： Christopher Bowman , Kristi Anseth , Blige Hacioglu , Charlie Nuttelman
发明人： Christopher Bowman , Kristi Anseth , Blige Hacioglu , Charlie Nuttelman
IPC分类号： C08G75/04 , C08G81/00
CPC分类号： C08L89/00 , A01N25/04 , A61K47/34 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/52 , A61L27/54 , A61L2300/62 , C05G3/0029 , C05G3/0076 , C08G75/045 , C08G81/00 , C08G81/027 , C08G2261/126 , C08J3/075 , C08J2329/04 , C08J2367/04 , C08J2371/02 , C08L71/02 , C08L81/02 , C08L2205/05 , Y10S524/916 , Y10S525/936 , C08L83/00 , C08L2666/22
摘要： A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.

92. 发明授权

US08481651B2 Biodegradable multi-block co-polymers 有权
标题翻译：可生物降解的多嵌段共聚物
公开(公告)号：US08481651B2
公开(公告)日：2013-07-09
申请号：US10586226
申请日：2005-01-14
申请人： Catharina Everdina Hissink , Rob Steendam , Ronald Meyboom , Theodorus Adrianus Cornelius Flipsen
发明人： Catharina Everdina Hissink , Rob Steendam , Ronald Meyboom , Theodorus Adrianus Cornelius Flipsen
IPC分类号： C08G63/91
CPC分类号： A61K47/34 , A61K9/1635 , A61K9/1647 , A61K9/7007 , C08G63/66 , C08G63/664 , C08G63/91 , C08G63/912 , C08G81/00 , C08G2261/126 , C08L2203/02 , Y10T428/139
摘要： The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.
摘要翻译：本发明涉及一种可生物降解的多嵌段共聚物，其包含至少两种衍生自预聚物A和B的可水解链段，该链段通过多官能扩链剂连接并选自预聚物A和B，和三嵌段共聚物ABA和BAB，其中多嵌段共聚物在生理（体）条件下是无定形的。本发明还涉及一种制备所述共聚物及其用作医用植入物，用于医疗装置或药物递送载体的涂层的方法。

93. 发明申请

US20130126804A1 MODIFIED POLYAMINE 有权
标题翻译：改性聚氨酯
公开(公告)号：US20130126804A1
公开(公告)日：2013-05-23
申请号：US13741667
申请日：2013-01-15
申请人： AJINOMOTO CO., INC.
发明人： Yuji KOSHIMA
IPC分类号： C08G79/04 , C09D11/00 , C09D185/02
CPC分类号： C08G79/04 , C08G81/00 , C09B67/0002 , C09B67/0023 , C09B67/009 , C09D7/40 , C09D11/037 , C09D11/102 , C09D11/30 , C09D11/326 , C09D185/02 , C09D187/00
摘要： A pigment dispersant which includes a modified polyamine obtained by the reaction of a polyamine having two or more primary and/or secondary amino groups per molecule and containing 2 to 1800 nitrogen atoms per molecule, a polyester, and a phosphorus-containing compound. The modified polyamine exhibits excellent pigment dispersion performance, shows little change in color tone upon heating, and has excellent heat resistance.
摘要翻译：一种颜料分散剂，其包括通过每分子具有两个或更多个伯和/或仲氨基，每分子含有2至1800个氮原子的聚胺，聚酯和含磷化合物反应获得的改性多胺。改性聚胺表现出优异的颜料分散性能，加热后的色调几乎没有变化，并且具有优异的耐热性。

94. 发明申请

US20130122103A1 ELECTROSTATICALLY BONDED VESICLE 有权
标题翻译：静电粘合的VESICLE
公开(公告)号：US20130122103A1
公开(公告)日：2013-05-16
申请号：US13812383
申请日：2011-07-27
申请人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
发明人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
IPC分类号： C08G81/00 , A61K9/16
CPC分类号： C08G81/00 , A61K9/1273 , A61K9/1641 , C08G69/10 , C08G73/0233 , C08L77/04 , C08L2205/02 , Y10T428/2989
摘要： The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.
摘要翻译：本发明的目的是提供一种带有二硫键或硫醇基的静电粘结囊泡。本发明涉及具有由（a）或（b）的第一聚合物和（c）或（d）的第二聚合物形成的膜的囊泡（条件是（b）和（d）除外），其中聚合物的阳离子链段和阴离子链段部分交联。第一聚合物：（a）具有不带电荷的亲水链段和阳离子链段的嵌段共聚物（I），（b）具有阳离子链段的氨基酸聚合物（I）。第二聚合物：（c）具有不带电荷的亲水链段和阴离子链段的嵌段共聚物（II），（d）具有阴离子链段的氨基酸聚合物（II）。

95. 发明授权

US08436103B2 Star polymer and method of producing the same 有权
标题翻译：星形聚合物及其制造方法
公开(公告)号：US08436103B2
公开(公告)日：2013-05-07
申请号：US11991595
申请日：2006-09-07
申请人： Takeshi Niitani
发明人： Takeshi Niitani
IPC分类号： C08F293/00 , C08F257/02 , C08G81/02
CPC分类号： C08F289/00 , C08F4/00 , C08F265/04 , C08F285/00 , C08F291/00 , C08F293/00 , C08F293/005 , C08F297/00 , C08F297/02 , C08G81/00 , C08G83/003 , C08L53/00 , C08L2666/02
摘要： The present invention provides a novel narrow distribution dendrimer-like star polymer having a controlled molecular structure, and a method capable of easily producing the star polymer. Disclosed is a polymer comprising a core portion and an arm portion, wherein the arm portion includes a first generation composed of a polymer chain and a second generation composed of a polymer chain formed at the outer shell of the first generation, the number of arms of the second generation is larger than the number of arms of the first generation, the first generation composed of the polymer chain is a polymer chain derived from a monomer having a polymerizable double bond, and the ratio of the weight average molecular weight (Mw) to the number average molecular weight (Mn), (Mw/Mn), of the star polymer is within a range from 1.001 to 2.50. A compound containing a functional group capable of reacting with an anion, which serves as a core portion, is reacted with a polymer chain containing two or more functional groups and an anion end which serves as an arm portion.
摘要翻译：本发明提供了具有受控分子结构的新型窄分布树枝状大分子星形聚合物和能够容易地制备星形聚合物的方法。公开了一种包含芯部分和臂部分的聚合物，其中臂部分包括由聚合物链组成的第一代和由在第一代的外壳形成的聚合物链构成的第二代，第二代大于第一代的臂数，由聚合物链构成的第一代是衍生自具有可聚合双键的单体的聚合物链，并且重均分子量（Mw）与星形聚合物的数均分子量（Mn）（Mw / Mn）在1.001〜2.50的范围内。使含有能够与作为核心部分的阴离子反应的官能团的化合物与含有两个以上官能团的聚合物链和作为臂部分的阴离子末端反应。

96. 发明授权

US08431545B2 Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof 有权
标题翻译：包括不带电荷的亲水嵌段和在一部分侧链具有疏水基团的阳离子聚氨基酸嵌段的共聚物及其用途
公开(公告)号：US08431545B2
公开(公告)日：2013-04-30
申请号：US12922116
申请日：2009-03-06
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
IPC分类号： A61K48/00 , A61K38/00 , A61K47/00 , A61K9/127 , A61K9/14 , A61P35/00 , A01N25/00
CPC分类号： C08G69/10 , C08G81/00 , Y10T428/2982
摘要： The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.
摘要翻译：本发明涉及含有不带电荷的亲水性聚合物链段和阳离子聚氨基酸链嵌段的嵌段共聚物，其中亲水性聚合物链嵌段共价键合到聚氨基酸链嵌段的主链的一端，疏水基与聚氨基酸链嵌段中氨基酸重复单元的侧链共价结合不少于10％且不大于70％。该嵌段共聚物在生理条件下与siRNA（小分子核酸）形成稳定的聚集体。

97. 发明申请

US20130052155A1 Compositions and Methods for Treating a Disorder or Defect in Soft Tissue 审中-公开
标题翻译：治疗软组织障碍或缺陷的组合和方法
公开(公告)号：US20130052155A1
公开(公告)日：2013-02-28
申请号：US13508466
申请日：2010-11-09
申请人： Michele Marcolongo , Edward Vresilovic , Benjamin Jackson , Sumona Sarkar , Caroline Schauer
发明人： Michele Marcolongo , Edward Vresilovic , Benjamin Jackson , Sumona Sarkar , Caroline Schauer
IPC分类号： C07K17/08 , A61K31/78 , A61K38/39 , A61P19/00 , C08G63/91 , A61P9/00 , A61P19/04 , A61P27/02 , A61P25/00 , A61P19/02 , A61K31/765 , A61P17/00
CPC分类号： C08L5/08 , C08B37/003 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08G81/00 , C08L5/00 , C08L5/10
摘要： The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.
摘要翻译：本发明包括用于产生仿生蛋白多糖的方法和组合物。本发明包括使用生物模拟蛋白多糖治疗软组织的疾病，病症或病症的方法。

98. 发明授权

US08338545B2 Multi-arm block copolymers as drug delivery vehicles 有权
标题翻译：多臂嵌段共聚物作为药物输送载体
公开(公告)号：US08338545B2
公开(公告)日：2012-12-25
申请号：US13287852
申请日：2011-11-02
申请人： Xuan Zhao
发明人： Xuan Zhao
IPC分类号： C08F283/00 , C08G63/91
CPC分类号： C08G63/914 , A61K31/724 , A61K31/74 , A61K31/77 , A61K47/593 , A61K47/60 , A61K47/6949 , B82Y5/00 , C08G65/2609 , C08G81/00 , C08G2650/24 , C08L71/02 , C08L2205/05 , C08L2666/18
摘要： The invention provides methods for making copolymers and multi-arm block copolymers useful as drug delivery vehicles. The multi-arm block copolymers comprise a central core molecule, such as a residue of a polyol, and at least three copolymer arms covalently attached to the central core molecule, each copolymer arm comprising an inner hydrophobic polymer segment covalently attached to the central core molecule and an outer hydrophilic polymer segment covalently attached to the hydrophobic polymer segment, wherein the central core molecule and the hydrophobic polymer segment define a hydrophobic core region. The solubility of hydrophobic biologically active agents can be improved by entrapment within the hydrophobic core region of the block copolymer. The invention further includes pharmaceutical compositions including such block copolymers, pharmaceutical compositions, and methods of using the block copolymers as drug delivery vehicles.
摘要翻译：本发明提供了制备用作药物递送载体的共聚物和多臂嵌段共聚物的方法。多臂嵌段共聚物包括中心核心分子，例如多元醇的残基，以及共价连接到中心核心分子上的至少三个共聚物臂，每个共聚物臂包含共价连接到中心核心分子上的内部疏水性聚合物链段和共价连接到疏水性聚合物链段上的外部亲水性聚合物链段，其中中心核心分子和疏水聚合物链段限定疏水核心区域。疏水性生物活性剂的溶解度可以通过在嵌段共聚物的疏水核心区域内捕获来改善。本发明还包括药物组合物，包括这种嵌段共聚物，药物组合物和使用嵌段共聚物作为药物递送载体的方法。

99. 发明申请

US20120231043A1 IMMOBILISED BIOLOGICAL ENTITIES 有权
标题翻译：固定生物实体
公开(公告)号：US20120231043A1
公开(公告)日：2012-09-13
申请号：US13416880
申请日：2012-03-09
申请人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
发明人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
IPC分类号： A61K31/785 , C09D161/32 , A61L33/06 , A61P7/02 , B32B9/00 , A61K9/00 , C09D177/00
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译：尤其描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的芯部分（ii）总分子量（iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体到此。

100. 发明申请

US20120225926A1 AMPHIPHILIC MACROMOLECULES FOR NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于核酸递送的大分子大分子
公开(公告)号：US20120225926A1
公开(公告)日：2012-09-06
申请号：US13402793
申请日：2012-02-22
申请人： Kathryn E. Uhrich , Sarah M. Sparks , Li Gu , Alex Harmon , Charles M. Roth , Carolyn Waite
发明人： Kathryn E. Uhrich , Sarah M. Sparks , Li Gu , Alex Harmon , Charles M. Roth , Carolyn Waite
IPC分类号： A61K31/711 , C12N5/02 , A61K31/713 , A61K31/7105 , C08G69/40 , C08G69/48
CPC分类号： C08G81/00 , C08G73/024
摘要： The invention provides amphiphilic macromolecules that are useful for delivering nucleic acids to cells and that are useful as delivery agents for gene therapy.
摘要翻译：本发明提供了可用于将核酸递送至细胞并且可用作基因治疗递送剂的两亲大分子。

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