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91. 发明申请

US20080009051A1 Method and Device for Isolating Cells 审中-公开
标题翻译：隔离细胞的方法和装置
公开(公告)号：US20080009051A1
公开(公告)日：2008-01-10
申请号：US11660783
申请日：2005-08-24
申请人： Assaf Deutsch , Mordechai Deutsch
发明人： Assaf Deutsch , Mordechai Deutsch
IPC分类号： C12N13/00 , C12M1/36
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00441 , B01J2219/00711 , B01J2219/00716 , B01J2219/00743 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2300/16 , G01N35/00029 , G01N2035/00158
摘要： A method for selecting specific cells from amongst a group of cells and a device for implementing the method, the method including the use of a radiation sensitive medium having a first state that does not immobilize cells and a second state that immobilizes cells wherein the radiation sensitive medium locally transforms from the first state to the second state upon exposure to radiation.
摘要翻译：一种用于从一组细胞中选择特定细胞的方法和用于实施该方法的装置，所述方法包括使用具有不固定细胞的第一状态的辐射敏感介质和固定细胞的第二状态，其中辐射敏感介质在暴露于辐射时从第一状态转换到第二状态。

92. 发明授权

US07300199B2 Retaining microfluidic microcavity and other microfluidic structures 有权
公开(公告)号：US07300199B2
公开(公告)日：2007-11-27
申请号：US11010977
申请日：2004-12-13
申请人： Per Andersson , Gunnar Ekstrand
发明人： Per Andersson , Gunnar Ekstrand
IPC分类号： B01F15/02
CPC分类号： G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

93. 发明申请

US20070151942A1 Apparatus to send biological fluids through a printed wire board 有权
标题翻译：将生物流体通过印刷线板发送的装置
公开(公告)号：US20070151942A1
公开(公告)日：2007-07-05
申请号：US11319419
申请日：2005-12-29
申请人： Terry Dishongh , Bradford Needham , Kevin Rhodes
发明人： Terry Dishongh , Bradford Needham , Kevin Rhodes
IPC分类号： H01B13/00
CPC分类号： H05K1/0272 , B01L3/502707 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/16 , B82Y30/00 , G01N21/05 , G01N21/658 , G01N21/69 , G01N2021/0346 , G01N2021/056 , G01N2021/651 , H05K2201/09981
摘要： A device containing a printed wire board (PWB), wherein the PWB comprises a fluid channel, wherein the fluid channel is a closed channel having a noble metal-containing layer on a surface of the fluid channel is disclosed. A method of making a device containing providing a substrate of a PWB; and fabricating a fluid channel in the PWB, wherein the fluid channel is a closed channel having a noble meal-containing layer on a surface of the fluid channel is disclosed. Also, a method containing providing a printed wire board (PWB), wherein the PWB comprises a fluid channel, wherein the fluid channel is a closed channel having a noble metal-containing layer on a surface of the fluid channel, and flowing fluid the fluid channel is disclosed.
摘要翻译：一种包含印刷线路板（PWB）的装置，其中PWB包括流体通道，其中流体通道是在流体通道的表面上具有含贵金属的层的闭合通道。一种制造包含提供PWB的基板的装置的方法; 并且在所述PWB中制造流体通道，其中所述流体通道是在所述流体通道的表面上具有含贵金属含量层的封闭通道。另外，包括提供印刷线路板（PWB）的方法，其中PWB包括流体通道，其中流体通道是在流体通道的表面上具有含贵金属的层的封闭通道，并且流体流体流体渠道被披露。

94. 发明申请

US20060254916A1 Methods of forming microfluidic devices and uses thereof 审中-公开
标题翻译：微流体装置的形成方法及其用途
公开(公告)号：US20060254916A1
公开(公告)日：2006-11-16
申请号：US11130698
申请日：2005-05-16
申请人： Juan Hernandez , Eric Burch , Gary Larson
发明人： Juan Hernandez , Eric Burch , Gary Larson
IPC分类号： C07K1/26
CPC分类号： B01L3/502707 , B01L2200/16 , B01L2300/16 , G01N27/44756
摘要： One microfluidic device of the present invention includes a substrate having a surface and a depression formed in the surface of the substrate. The microfluidic device further includes a detectable marker in the depression and a coating covering the surface. Methods of producing and using the microfluidic device are further described.
摘要翻译：本发明的一个微流体装置包括具有在基板表面上形成的表面和凹陷的基板。微流体装置还包括凹陷中的可检测标记和覆盖表面的涂层。进一步描述生产和使用微流体装置的方法。

95. 发明申请

US20060228723A1 System and method for electronic sensing of biomolecules 审中-公开
标题翻译：电子感应生物分子的系统和方法
公开(公告)号：US20060228723A1
公开(公告)日：2006-10-12
申请号：US11259414
申请日：2005-10-25
申请人： Keith Bradley , Jean-Christophe Gabriel , George Gruner , Alexander Star , Eugene Tu , Christian Valcke
发明人： Keith Bradley , Jean-Christophe Gabriel , George Gruner , Alexander Star , Eugene Tu , Christian Valcke
IPC分类号： C12Q1/68 , C12N11/16 , H01L29/06
CPC分类号： B82Y30/00 , B01L3/50857 , B01L2300/0636 , B01L2300/0663 , B01L2300/0819 , B01L2300/0851 , B01L2300/0893 , B01L2300/0896 , B01L2300/16 , B82Y10/00 , G01N33/5438 , G01N33/551 , G01N33/566 , G01N33/582
摘要： A nanoelectronic device is combined with a cellular membrane component to provide a sensor for biomolecules or to provide information about the structure of the membrane. The nanoelectronic device may comprise a network of randomly-oriented nanotubes, or other nanostructure, arranged on a substrate with adjacent electrodes so as to operate as a field-effect transistor sensor or as a capacitive sensor. A cellular membrane is disposed over the nanostructure element.
摘要翻译：纳米电子器件与细胞膜组件组合以提供用于生物分子的传感器或提供关于膜结构的信息。纳米电子器件可以包括布置在具有相邻电极的衬底上的随机取向的纳米管或其他纳米结构的网络，以便作为场效应晶体管传感器或电容式传感器工作。细胞膜设置在纳米结构元件上。

96. 发明申请

US20060093836A1 Polymer surface modification 有权
公开(公告)号：US20060093836A1
公开(公告)日：2006-05-04
申请号：US11304316
申请日：2005-12-14
申请人： Jiang Huang , Shoujun Xiao , Marc Unger
发明人： Jiang Huang , Shoujun Xiao , Marc Unger
IPC分类号： B32B9/04 , B32B25/20
CPC分类号： B32B3/26 , B01J20/285 , B01J20/286 , B01J20/327 , B01J20/3272 , B01J2220/54 , B01L3/502707 , B01L2200/12 , B01L2300/16 , B01L2300/163 , C08F257/02 , C08F263/04 , C08F265/04 , C08F279/02 , C08F287/00 , C08F291/00 , C08J5/12 , C08J7/12 , F04B43/043 , Y10T428/139 , Y10T428/1393 , Y10T428/24661 , Y10T428/24744 , Y10T428/249953 , Y10T428/249958 , Y10T428/249978 , Y10T428/31663 , Y10T428/31667
摘要： The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between an intrinsic functional group that is present in the polymer and the functional group of the surface modifying compound. By using a polymer having an intrinsic functional group, a separate surface activation step is avoided.

97. 发明申请

US20050164404A1 Diagnostic testing process 有权
标题翻译：诊断测试过程
公开(公告)号：US20050164404A1
公开(公告)日：2005-07-28
申请号：US10497925
申请日：2002-12-12
申请人： David Marlborugh , Andrew Sloane , Robert Cole , William Hunter
发明人： David Marlborugh , Andrew Sloane , Robert Cole , William Hunter
IPC分类号： G01N33/52 , B01L3/00 , G01N33/48 , G01N33/543 , G01N33/545 , G01N33/553 , G01N33/558
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体）已知结合特定蛋白质可以结合在一起所需的时间段。此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

98. 发明授权

US06919058B2 Retaining microfluidic microcavity and other microfluidic structures 有权
标题翻译：保留微流体微腔和其他微流体结构
公开(公告)号：US06919058B2
公开(公告)日：2005-07-19
申请号：US10229676
申请日：2002-08-28
申请人： Per Andersson , Gunnar Ekstrand
发明人： Per Andersson , Gunnar Ekstrand
IPC分类号： B01F5/06 , B01F13/00 , B01F15/02 , B01J19/00 , B01L3/00 , C40B40/10 , G01N30/46 , G01N30/60 , G01N33/543 , G01N35/00 , H01J49/04
CPC分类号： G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).
摘要翻译：一种微流体装置，其包括几个微通道结构，其中存在入口，出口以及其间包括流体功能的结构单元。可以在单元之间选择结构单元，使得能够保持包含通过在微流体装置（单元A）内混合等分试样而定义的组分的n1等分试样，b）混合等分试样的液体（单元B），c）分隔将较大等分的液体分装成更小等分的液体并分别分配后者并且平行于同一微流体装置（单元C）的不同微通道结构，d）快速渗入分配到入口的液体等分试样的微通道结构微通道结构的端口（单元D），以及e）集成在微通道结构（单元E）内的体积定义。

99. 发明申请

US20050153432A1 Retaining microfluidic microcavity and other microfluidic structures 有权
公开(公告)号：US20050153432A1
公开(公告)日：2005-07-14
申请号：US11010870
申请日：2004-12-13
申请人： Per Andersson , Derand Helen
发明人： Per Andersson , Derand Helen
IPC分类号： B01F5/06 , B01F13/00 , B01F15/02 , B01J19/00 , B01L3/00 , C40B40/10 , G01N30/46 , G01N30/60 , G01N33/543 , G01N35/00 , H01J49/04 , C12M1/34
CPC分类号： G01N35/00069 , B01F5/0646 , B01F5/0647 , B01F5/0655 , B01F13/0059 , B01F15/0201 , B01F15/0233 , B01J19/0093 , B01J2219/00536 , B01J2219/00725 , B01J2219/00738 , B01L3/5025 , B01L3/5027 , B01L3/502738 , B01L2200/027 , B01L2200/06 , B01L2200/0605 , B01L2200/10 , B01L2200/142 , B01L2300/069 , B01L2300/0803 , B01L2300/0806 , B01L2300/0861 , B01L2300/087 , B01L2300/14 , B01L2300/16 , B01L2400/0409 , B01L2400/0418 , B01L2400/0633 , B01L2400/0688 , C40B40/10 , G01N30/466 , G01N30/6095 , G01N33/54366 , G01N2035/00504 , H01J49/04 , Y10S366/04
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and there between a structural unit comprising a fluidic function. The structural unit can be selected amongst units enabling a) retaining of nl-aliquots comprising constituents which has been defined by mixing of aliquots within the microfluidic device (unit A), b) mixing of aliquots of liquids (unit B), c) partition of larger aliquots of liquids into smaller aliquots of liquids and distributing the latter individually and in parallel to different microchannel structure of the same microfluidic device (unit C), d) quick penetration into a microchannel structure of an aliquot of a liquid dispensed to an inlet port of a microchannel structure (unit D), and e) volume definition integrated within a microchannel structure (unit E).

100. 发明申请

US20050124077A1 Diagnostic testing process and apparatus 有权
标题翻译：诊断测试过程和设备
公开(公告)号：US20050124077A1
公开(公告)日：2005-06-09
申请号：US10487052
申请日：2002-08-20
申请人： Robert Cole , Andrew Sloane , William Hunter
发明人： Robert Cole , Andrew Sloane , William Hunter
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为与胶体金或荧光标签结合的抗体）已知结合特定蛋白质的蛋白质可以结合在一起所需的时间段。该预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

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