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91. 发明申请

US20150259754A1 DROPLET-BASED MICROFLUIDIC DEVICE HAVING A PLURALITY OF REACTION SITES 审中-公开
标题翻译：具有多个反应场地的基于滴液的微流体装置
公开(公告)号：US20150259754A1
公开(公告)日：2015-09-17
申请号：US14657362
申请日：2015-03-13
申请人： Karan Kaler , Ravi Prakash
发明人： Karan Kaler , Ravi Prakash
IPC分类号： C12Q1/70 , B01L3/00
CPC分类号： C12Q1/701 , B01L3/502707 , B01L3/502715 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/148 , B01L2300/0883 , B01L2300/166 , B01L2300/1827 , B01L2400/0424 , B01L2400/0427
摘要： The present invention provides a droplet-based microfluidic device comprising a passivating top surface and methods for producing and using the same. In particular, the passivating surface comprises of a nano-textured superhydrophobic material.
摘要翻译：本发明提供一种包含钝化顶表面的液滴微流体装置及其制造和使用方法。特别地，钝化表面由纳米纹理超疏水材料组成。

92. 发明授权

US09132426B2 Simplified gating method for sealing and flow control in micro and nano devices 有权
标题翻译：微型和纳米器件密封和流量控制的简化门控方法
公开(公告)号：US09132426B2
公开(公告)日：2015-09-15
申请号：US14303084
申请日：2014-06-12
申请人： NanoMDx, Inc.
发明人： Ranjit A. Prakash
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , B01L3/00 , C12Q1/68
CPC分类号： B01L3/567 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , C12Q1/6837
摘要： A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of DNA fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material. The biochip also includes a plurality of separation and detection chambers that physically separate different DNA fragments that have been marked with labels that emit similar colors, thereby enabling the independent detection of the different DNA fragments.
摘要翻译：公开了用于多重遗传鉴定的生物芯片。用于分离和检测多个DNA片段的生物芯片包括一组输入和室，用于接收进行遗传物质的聚合酶链反应扩增所需的遗传物质和试剂的样品基质。生物芯片还包括多个分离和检测室，其物理分离已经用发出相似颜色的标记标记的不同DNA片段，从而能够独立检测不同的DNA片段。

93. 发明申请

US20150212105A1 ANALYSIS SYSTEM AND ANALYSIS METHOD 审中-公开
标题翻译：分析系统与分析方法
公开(公告)号：US20150212105A1
公开(公告)日：2015-07-30
申请号：US14418979
申请日：2013-07-08
申请人： Hitachi High-Technologies Corporation
发明人： Takayuki Obara
IPC分类号： G01N35/08
CPC分类号： G01N35/08 , B01L3/502715 , B01L3/502784 , B01L2300/0816 , B01L2300/0874 , B01L2300/0883 , G01N2035/00237 , G01N2035/1034 , H01J49/0404
摘要： Disclosed is an analysis system, in which droplets in a microfluidic device are transported to an analysis apparatus outside the microfluidic device, and are analayzed while being distinguished from each other. A flow channel of the microfluidic device and a pipeline are connected to each other using a connection portion that allows the droplets to flow in an orderly row. That is, the analysis system of the present invention includes the microfluidic device having micro flow channels, and the analysis apparatus, in which the microfluidic device has a first inlet and a second inlet, the flow channels from the inlets are confluent with each other therein, and a fluid injected via each of the inlets is discharged to the analysis apparatus. Accordingly, it is possible to transport the droplets to the analysis apparatus in an orderly row via the pipeline, and it is possible to analyze the droplets.
摘要翻译：公开了一种分析系统，其中将微流体装置中的液滴输送到微流体装置外部的分析装置，并在彼此区分的同时进行分析。微流体装置和管道的流动通道使用允许液滴以有序排列的连接部分相互连接。也就是说，本发明的分析系统包括具有微流通道的微流体装置和分析装置，其中微流体装置具有第一入口和第二入口，来自入口的流动通道彼此汇合并且经由每个入口喷射的流体被排出到分析装置。因此，可以通过管道将液滴以有序的方式输送到分析装置，并且可以分析液滴。

94. 发明申请

US20150209781A1 APPARATUS AND SYSTEM FOR MEASURING ASPHALTENE CONTENT OF CRUDE OIL 审中-公开
标题翻译：测定原油油含量的装置和系统
公开(公告)号：US20150209781A1
公开(公告)日：2015-07-30
申请号：US14679377
申请日：2015-04-06
申请人： Schlumberger Technology Corporation
发明人： Farshid Mostowfi , Abdel M. Kharrat , Philip James Homewood , Joseph Samuel Baddeley , Marc Schneider
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502753 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/12 , G01N21/05 , G01N21/59 , G01N21/82 , G01N33/2823
摘要： A system for measuring asphaltene content of crude oil, includes a microfluidic chip, the microfluidic chip having a crude oil sample inlet port, a solvent port, a mixer and reactor section in fluid communication with the crude oil sample inlet port and the solvent port, and a filter in fluid communication with the mixer and reactor section, the filter having an inlet side and an outlet side, a waste port in fluid communication with the inlet side of the filter, and a product port in fluid communication with the outlet side of the filter. The system further includes an optical cell in fluid communication with the product port.
摘要翻译：用于测量原油沥青质含量的系统包括微流体芯片，所述微流体芯片具有与原油样品入口和溶剂端口流体连通的原油样品入口端口，溶剂端口，混合器和反应器部分，以及与所述混合器和反应器部分流体连通的过滤器，所述过滤器具有入口侧和出口侧，与所述过滤器的入口侧流体连通的废气口和与所述过滤器的出口侧流体连通的产品端口过滤器。该系统还包括与产品端口流体连通的光学单元。

95. 发明申请

US20150152206A1 POLYMER MONOLITHS FOR SOLVENT EXCHANGE IN CONTINUOUS FLOW MICROFLUIDIC DEVICE 有权
标题翻译：连续流动微流体装置溶剂交换聚合物单体
公开(公告)号：US20150152206A1
公开(公告)日：2015-06-04
申请号：US14406202
申请日：2013-06-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Pei Yuin Keng , Rehana Ismail , Ariella Machness , Kyoung-Joo Jenny Park
IPC分类号： C08F212/14 , B01J19/00 , C08F236/20 , C07H13/04 , C07B59/00
CPC分类号： C08F212/14 , A61B5/1405 , A61B5/1411 , A61B5/150022 , A61B5/150099 , A61B5/150229 , A61B5/15113 , A61B5/15117 , A61B5/1514 , B01D15/363 , B01J19/0093 , B01J20/3204 , B01J20/327 , B01J20/328 , B01J2219/00831 , B01J2219/00844 , B01J2219/00846 , B01J2219/00905 , B01J2219/00918 , B01J2219/00936 , B01J2219/00943 , B01J2220/82 , B01L3/502753 , B01L2300/0681 , B01L2300/0816 , B01L2300/0883 , C07B59/005 , C07H13/04 , C08F236/20
摘要： The present disclosure relates to the novel multistep procedure for preparation of polymer monoliths for use in solvent exchange, such as methods to exchange and activate fluoride ions on a flow through microfluidic chip for subsequent chemical synthesis. Methods according to the present disclosure include the application of such microfluidic platforms for rapid F18 radiosynthesis on a flow through microfluidic chip with high efficiency, followed by a subsequent nucleophilic fluorination reaction. Various other methods of exchanging and activating fluoride ions on a flow through microfluidic chip are also disclosed. Methods incorporating features of the present invention can be applicable to any flow through microfluidic device in any field, such as radiosyntheses, chemical syntheses, concentration of ions for environmental analyses and sample preparation such as concentrating minute amounts of analyte to improve the downstream detection.
摘要翻译：本公开涉及用于制备用于溶剂交换的聚合物整料的新型多步骤方法，例如在通过微流体芯片的流动上交换和活化氟离子以用于随后的化学合成的方法。根据本公开的方法包括将这种微流体平台用于快速F18放射合成在高效率流过微流控芯片的流体上，随后进行亲核氟化反应。还公开了在流过微流体芯片的流动上交换和激活氟离子的各种其它方法。结合本发明的特征的方法可以适用于任何领域中的任何流过微流体装置的流体，例如放射合成，化学合成，用于环境分析的离子浓度和样品制备，例如浓缩微量分析物以改善下游检测。

96. 发明申请

US20150118110A1 MICROFLUIDIC DEVICE UNIT 有权
标题翻译：微流量器件单元
公开(公告)号：US20150118110A1
公开(公告)日：2015-04-30
申请号：US14517481
申请日：2014-10-17
申请人： Buerkert Werke GmbH
发明人： Thomas HAHN
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0883 , B01L2300/123 , B01L2300/1805 , G01N35/0098 , G01N35/1016 , G01N2035/00237 , G01N2035/00346 , G01N2035/1034
摘要： A microfluidic device unit has a control device which includes at least one actuating unit and with a carrier for a microfluidic chip. The carrier is designed as module separate from the control device, but is connected with the same by at least one connecting line such that the actuating unit can actuate at least one function at the carrier. The carrier is provided with a receptacle for the microfluidic chip.
摘要翻译：微流体装置单元具有包括至少一个致动单元和用于微流体芯片的载体的控制装置。载体被设计为与控制装置分离的模块，但是通过至少一个连接线与其相连，使得致动单元可以致动载体上的至少一个功能。载体设置有用于微流体芯片的容器。

97. 发明申请

US20150087079A1 MICROFLUIDIC DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：微流体装置，系统和方法
公开(公告)号：US20150087079A1
公开(公告)日：2015-03-26
申请号：US14391643
申请日：2013-04-05
申请人： ALERE SAN DIEGO, INC.
发明人： William Patrick Coffey , Paul Michael Crivelli , Austin Matthew Derfus , Tuan Hoang Do , Remus Anders Brix Haupt , Emily Parker , Gregory Reneff , Armando Raul Tovar
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , B01L2200/0621 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0883 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , G01N33/54366
摘要： A combination of capillary forces and gas pressure is used to control the movement of liquid samples within a microfluidic device. A liquid sample introduced to a proximal portion of a capillary channel of a microfluidic device moves by capillary action partway along the capillary channel. As the liquid sample moves, a pressure of a gas acting upon a distal gas-liquid interface of the liquid sample increases by an amount sufficient to stop further movement of the liquid sample. To initiate further movement of the liquid sample, a pump connected to a distal portion of the capillary channel decreases the pressure of the gas acting upon the distal gas-liquid interface of the liquid sample by an amount sufficient to permit the liquid sample to move by capillary action further along the capillary channel of the microfluidic device.
摘要翻译：使用毛细管力和气体压力的组合来控制液体样品在微流体装置内的运动。引入微流体装置的毛细通道的近端部分的液体样品通过毛细管作用沿着毛细管通道移动。当液体样品移动时，作用在液体样品的远端气液界面的气体的压力增加足以停止液体样品进一步运动的量。为了启动液体样品的进一步移动，连接到毛细通道的远端部分的泵降低了作用在液体样品的远端气液界面上的气体的压力，其量足以允许液体样品移动毛细作用沿微流体装置的毛细管通道进一步。

98. 发明授权

US08969976B2 Double-sided diaphragm micro gas-preconcentrator 有权
标题翻译：双面隔膜微气预收敛器
公开(公告)号：US08969976B2
公开(公告)日：2015-03-03
申请号：US13570249
申请日：2012-08-09
申请人： Xiaosong Du , Ze Wu , Yi Li , Yadong Jiang , Dong Qiu
发明人： Xiaosong Du , Ze Wu , Yi Li , Yadong Jiang , Dong Qiu
IPC分类号： H01L27/02
CPC分类号： G01N30/93 , B01L3/5027 , B01L3/502707 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N1/4005 , G01N1/405 , G01N30/08 , G01N2030/085
摘要： A double-sided diaphragm micro gas-preconcentrator has a micro-gas chamber which is formed by bonding an upper silicon substrate with a lower silicon substrate. One or more suspended membranes are provided on every silicon substrate. The silicon where the suspended membrane is provided is completely removed for forming a cavity. A thin-film heater is deposited on every suspended membrane. A sorptive film is coated on an inner wall of every suspended membrane. Thus, the upper and lower sides of the preconcentrator in the present invention are suspended membranes, which improve the area of the sorptive film on the diaphragm. As a result, the preconcentrating factor is improved while keeping the small heat capacity, fast heating rate, and low power consumption features of the planar diaphragm preconcentrator.
摘要翻译：双面隔膜微气体预浓缩器具有通过将上硅基板与下硅基板接合而形成的微气室。在每个硅衬底上提供一个或多个悬浮膜。提供悬浮膜的硅完全除去以形成空腔。薄膜加热器沉积在每个悬浮膜上。吸附膜涂覆在每个悬浮膜的内壁上。因此，本发明的预浓缩器的上侧和下侧是悬浮膜，其改善了隔膜上吸附膜的面积。结果，在保持平面膜片预浓缩器的小热容量，快速加热速率和低功耗特征的同时，提高了预浓缩因子。

99. 发明授权

US08951417B2 Method of transporting magnetic particles 有权
标题翻译：运输磁性颗粒的方法
公开(公告)号：US08951417B2
公开(公告)日：2015-02-10
申请号：US13852367
申请日：2013-03-28
申请人： Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.
发明人： Oliver Strohmeier , Felix Von Stetten , Daniel Mark
IPC分类号： B03C1/00 , B03C1/02 , B81B1/00 , G01N35/00 , B01L3/00
CPC分类号： B03C1/02 , B01L3/502761 , B01L2200/0668 , B01L2300/087 , B01L2300/0883 , B01L2400/0409 , B01L2400/043 , B81B1/00 , G01N35/00069 , Y10T436/111666 , Y10T436/25375
摘要： A method of transporting magnetic particles enables magnetic particles to be transported between a plurality of microfluidic chambers which are connected to one another via a fluidic connection on a radially inner side, and are fluidically separated from one another on a radially outer side. Magnetic forces and centrifugal forces are exploited to transport magnetic particles from one chamber to another across phase boundaries.
摘要翻译：传输磁性颗粒的方法使得磁性颗粒能够在多个微流体室之间传输，多个微流体室通过径向内侧上的流体连接彼此连接，并且在径向外侧上彼此流体分离。利用磁力和离心力将磁性颗粒从一个室传送到另一个室，跨过相位边界。

100. 发明授权

US08945913B2 Kits, compositions and methods for detecting a biological condition 有权
公开(公告)号：US08945913B2
公开(公告)日：2015-02-03
申请号：US14296317
申请日：2014-06-04
申请人： Leukodx Ltd.
发明人： Harvey Lee Kasdan , Julien Meissonnier , Yoav Zuta , Bruce Davis , Micha Rosen , Yael Himmel , Yehoshua Broder
IPC分类号： C12M1/34 , C12M3/00 , G01N33/569 , B01L3/00
CPC分类号： G01N33/5302 , B01L3/502 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/10 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/123 , B01L2300/18 , B01L2400/0406 , B01L2400/0481 , G01N33/5091 , G01N33/54386 , G01N33/569 , G01N33/56972 , G01N33/582 , G01N33/68 , G01N33/6872 , G01N2333/70535 , G01N2333/70596 , G01N2800/26
摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.

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