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91. 发明申请

US20050238690A1 Controlling resorption of bioresorbable medical implant material 有权
公开(公告)号：US20050238690A1
公开(公告)日：2005-10-27
申请号：US11158154
申请日：2005-06-21
申请人： Jianmin Li , Samuel Baldwin , Tim Harrah
发明人： Jianmin Li , Samuel Baldwin , Tim Harrah
IPC分类号： A61L27/00 , A61F2/02 , A61L27/40 , A61L27/58 , A61L31/12 , A61L31/14 , A61F2/28
CPC分类号： A61L31/148 , A61B17/12113 , A61F2/0004 , A61F2/02 , A61F2/04 , A61F2210/0004 , A61F2210/009 , A61L27/40 , A61L27/58 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/10 , A61L31/12 , A61L31/16 , A61L2300/00
摘要： The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.

92. 发明申请

US20050165468A1 Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same 有权
标题翻译：自支撑层压膜，结构材料和由其制造的医疗装置及其制造方法
公开(公告)号：US20050165468A1
公开(公告)日：2005-07-28
申请号：US11047024
申请日：2005-01-31
申请人： Denes Marton
发明人： Denes Marton
IPC分类号： A61L27/04 , A61L27/06 , A61L27/40 , A61L31/12 , A61F2/06
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/075 , A61F2210/0014 , A61F2210/0076 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61L27/047 , A61L27/06 , A61L27/40 , A61L31/022 , A61L31/12
摘要： Metal foils, wires, and seamless tubes with increased mechanical strength are provided. As opposed to wrought materials that are made of a single metal or alloy, these materials are made of two or more layers forming a laminate structure. Laminate structures are known to increase mechanical strength of sheet materials such as wood and paper products and are used in the area of thin films to increase film hardness, as well as toughness. Laminate metal foils have not been used or developed because the standard metal forming technologies, such as rolling and extrusion, for example, do not lend themselves to the production of laminate structures. Vacuum deposition technologies can be developed to yield laminate metal structures with improved mechanical properties. In addition, laminate structures can be designed to provide special qualities by including layers that have special properties such as superelasticity, shape memory, radio-opacity, corrosion resistance etc. Examples of articles which may be made by the inventive laminate structures include implantable medical devices that are fabricated from the laminated deposited films and which present a blood or body fluid and tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a laminated film material deposited and etched into regions of structural members and web regions subtending interstitial regions between the structural members. An endoluminal graft is also provided which is made of a biocompatible metal or metal-like material. The endoluminal stent-graft is characterized by having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods.
摘要翻译：提供了具有增加的机械强度的金属箔，电线和无缝管。与由单一金属或合金制成的锻造材料相反，这些材料由形成层压结构的两层或更多层制成。已知层压结构可提高木材和纸制品等片材的机械强度，并且用于薄膜区域以提高膜硬度以及韧性。层压金属箔没有被使用或开发，因为例如轧制和挤出的标准金属成形技术不适用于层压结构的生产。可以开发真空沉积技术以产生具有改进的机械性能的层压金属结构。此外，层压结构可以被设计成通过包括具有特殊性质如超弹性，形状记忆，无线电不透明度，耐腐蚀性等的层来提供特殊质量。可以由本发明的层压结构制成的制品的实例包括可植入医疗装置其由层压的沉积膜制成并且呈现具有受控的材料结构异质性的血液或体液和组织接触表面。由层压膜材料制成的腔内支架移植物和网状支架，沉积并蚀刻到结构构件的区域和对着结构构件之间的间隙区域的网区域。还提供了由生物相容性金属或类金属材料制成的腔内移植物。腔内支架移植物的特征在于沿着支架血流表面的支架材料具有受控的异质性，以及使用真空沉积方法制造支架的方法。

93. 发明申请

US20050147585A1 Internal clamp for surgical procedures 有权
标题翻译：用于外科手术的内部夹具
公开(公告)号：US20050147585A1
公开(公告)日：2005-07-07
申请号：US10983164
申请日：2004-11-05
申请人： Alexander Schwarz
发明人： Alexander Schwarz
IPC分类号： A61B20060101 , A61K31/765
CPC分类号： A61L31/06 , A61B17/00491 , A61B17/0057 , A61B17/11 , A61B17/12022 , A61B17/1204 , A61B17/12045 , A61B17/12109 , A61B17/12186 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2017/1139 , A61B2017/12004 , A61K9/0024 , A61K31/00 , A61K31/74 , A61K31/765 , A61K31/77 , A61K31/785 , A61K51/1213 , A61L31/12
摘要： One aspect of the present invention relates to a method of occluding a vascular site in a mammal, comprising the step of introducing into the vasculature of a mammal at or proximal to a surgical site, a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, thereby temporarily occluding a vascular site of said mammal, wherein said temporarily occluded vasculature site is kept in a substantially cylindrical shape.
摘要翻译：本发明的一个方面涉及一种闭塞哺乳动物血管部位的方法，其包括将包含至少一种任选纯化的反相热敏性聚合物的组合物引入外科手术部位或近侧的哺乳动物的脉管系统的步骤，其中所述反相热敏聚合物凝胶在所述脉管系统中，从而暂时封闭所述哺乳动物的血管部位，其中所述暂时闭塞的脉管系统部位保持基本上为圆柱形。

94. 发明申请

US20050119723A1 Medical device with porous surface containing bioerodable bioactive composites and related methods 审中-公开
标题翻译：具有多孔表面的医疗器械，包含生物可蚀塑性生物活性复合材料及相关方法
公开(公告)号：US20050119723A1
公开(公告)日：2005-06-02
申请号：US10724453
申请日：2003-11-28
申请人： James Peacock
发明人： James Peacock
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/90 , A61L31/12 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2250/0068 , A61L31/12 , A61L31/146 , A61L31/148 , A61L2300/41 , A61L2300/416 , A61L2300/45 , A61L2300/604
摘要： An implantable medical device includes a porous surface with a composite material located within the pores that includes a bioerodable material in combination with a bioactive agent. The composite material is adapted to erode upon exposure to the body of a patient, thus releasing the bioactive agent into the patient, whereas the porous surface remains on the device. In one embodiment, the composite material includes micro- or nano-particles that are deposited within the pores. In a further embodiment, the porous surface is an electrolessly electrochemically deposited material. Certain tie layer and other surface modification aspects are described to enhance various aspects of the bioactive composite surface. The bioactive composite surface is of particular benefit when provided on an endolumenal stent assembly in a manner adapted to elute anti-restenosis or anti-thrombosis agents or combinations thereof.
摘要翻译：可植入医疗装置包括具有位于孔内的复合材料的多孔表面，其包括与生物活性剂组合的可生物侵蚀材料。复合材料适于在暴露于患者身体时被侵蚀，从而将生物活性剂释放到患者体内，而多孔表面保留在装置上。在一个实施方案中，复合材料包括沉积在孔内的微米或纳米颗粒。在另一个实施方案中，多孔表面是无电解电化学淀积的材料。描述某些粘结层和其它表面改性方面以增强生物活性复合材料表面的各个方面。以适于洗脱抗再狭窄或抗血栓形成剂或其组合的方式提供在腔内支架组件上时，生物活性复合物表面特别有益。

95. 发明授权

US06849085B2 Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same 有权
公开(公告)号：US06849085B2
公开(公告)日：2005-02-01
申请号：US09853985
申请日：2001-05-11
申请人： Denes Marton
发明人： Denes Marton
IPC分类号： A61F2/06 , A61F2/90 , A61L27/04 , A61L27/06 , A61L27/40 , A61L31/12
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2210/0076 , A61L27/047 , A61L27/06 , A61L27/40 , A61L31/12
摘要： Metal foils, wires, and seamless tubes with increased mechanical strength are provided. As opposed to wrought materials that are made of a single metal or alloy, these materials are made of two or more layers forming a laminate structure. Laminate structures are known to increase mechanical strength of sheet materials such as wood and paper products and are used in the area of thin films to increase film hardness, as well as toughness. Laminate metal foils have not been used or developed because the standard metal forming technologies, such as rolling and extrusion, for example, do not lend themselves to the production of laminate structures. Vacuum deposition technologies can be developed to yield laminate metal structures with improved mechanical properties. In addition, laminate structures can be designed to provide special qualities by including layers that have special properties such as superelasticity, shape memory, radio-opacity, corrosion resistance etc. Examples of articles which may be made by the inventive laminate structures include implantable medical devices that are fabricated from the laminated deposited films and which present a blood or body fluid and tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of a laminated film material deposited and etched into regions of structural members and web regions subtending interstitial regions between the structural members. An endoluminal graft is also provided which is made of a biocompatible metal or metal-like material. The endoluminal stent-graft is characterized by having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods.

96. 发明授权

US06648874B2 Guide catheter with lubricious inner liner 有权
标题翻译：导管带润滑内衬
公开(公告)号：US06648874B2
公开(公告)日：2003-11-18
申请号：US09514721
申请日：2000-02-28
申请人： Mary Parisi , Martin Willard , Yiqun Wang , Robert John Bianchi , Timothy L. Rubesch
发明人： Mary Parisi , Martin Willard , Yiqun Wang , Robert John Bianchi , Timothy L. Rubesch
IPC分类号： A61M2500
CPC分类号： A61L31/12 , A61L29/085 , A61L29/12 , A61L31/10 , A61M25/005 , A61M25/0053 , A61M2025/0047
摘要： A catheter shaft is disclosed utilizing perfluoroalkoxy polytetrafluoroethylene (PFA) as a lubricious inner lumen for which to aid the advancement of additional medical devices. PFA possesses adequate lubricity while requiring no special fabricating techniques. Thus, PFA may be processed by conventional melt-extrusion techniques, as well as by injection, compression, rotational transfer, and blow molding processes; optimizing the manufacturability of the lubricious inner lumen. Additionally, the catheter shaft includes portions of the outer tubular member modified through an ablation process. The ablation process selectively removes extruded polymeric material around and between the contours of a braided support layer. In one illustrative embodiment, a portion of the outer layer of the catheter is removed by laser ablation and then refilled by polymeric inserts having various flexibility characteristics.
摘要翻译：公开了一种使用全氟烷氧基聚四氟乙烯（PFA）作为润滑内腔的导管轴，以帮助推进额外的医疗装置。 PFA具有足够的润滑性，同时不需要特殊的制造技术。因此，PFA可以通过常规的熔融挤出技术以及通过注射，压缩，旋转转移和吹塑成型工艺进行加工; 优化润滑内腔的可制造性。另外，导管轴包括通过消融过程修改的外管状部件的部分。消融过程选择性地去除编织支撑层周围的和在轮廓之间的挤压聚合材料。在一个说明性实施例中，通过激光烧蚀去除导管的外层的一部分，然后通过具有各种柔性特性的聚合物插入物重新填充。

97. 发明申请

US20030134099A1 Bioabsorbable fibers and reinforced composites produced therefrom 审中-公开
标题翻译：生物可吸收纤维和由其生产的增强复合材料
公开(公告)号：US20030134099A1
公开(公告)日：2003-07-17
申请号：US10351881
申请日：2003-01-27
申请人： BioAmide, Inc.
发明人： Thomas H. Barrows
IPC分类号： B32B027/04 , D02G003/00
CPC分类号： D01F8/14 , A61B17/72 , A61B2017/00004 , A61F2/30965 , A61F2/4455 , A61F2/82 , A61F2002/30062 , A61F2210/0004 , A61L27/48 , A61L31/06 , A61L31/12 , A61L31/128 , A61L31/148 , C08L67/04 , D01F6/00 , Y10T428/249924 , Y10T428/24994 , Y10T428/2907 , Y10T428/2929 , Y10T428/2931 , Y10T428/2933
摘要： This invention relates to bioabsorbable fibers, comprising a semicrystalline fiber-forming core polymer and a amorphous sheath polymer, wherein the core polymer and sheath polymer are separately melt extruded and connected to one another through an adhesive bond. The present invention also relates to reinforced composites of the bioabsorbable fibers, and to devices comprising the reinforced composites. The devices are suitable for in vivo implantation. Some embodiments of the present devices can also support high loads, making them useful for fracture fixation and spinal fusion. The invention also relates to methods of making the various materials of the invention.
摘要翻译：本发明涉及生物可吸收纤维，其包含半结晶纤维形成芯聚合物和无定形鞘聚合物，其中芯聚合物和鞘聚合物分别熔融挤出并通过粘合剂粘合彼此连接。本发明还涉及生物可吸收纤维的增强复合材料以及包含增强复合材料的装置。该装置适用于体内植入。本装置的一些实施例还可以支持高负载，使其可用于骨折固定和脊柱融合。本发明还涉及制备本发明的各种材料的方法。

98. 发明授权

US06511748B1 Bioabsorbable fibers and reinforced composites produced therefrom 失效
标题翻译：生物可吸收纤维和由其生产的增强复合材料
公开(公告)号：US06511748B1
公开(公告)日：2003-01-28
申请号：US09582833
申请日：2000-06-30
申请人： Thomas H. Barrows
发明人： Thomas H. Barrows
IPC分类号： D02G300
CPC分类号： D01F8/14 , A61B17/72 , A61B2017/00004 , A61F2/30965 , A61F2/4455 , A61F2/82 , A61F2002/30062 , A61F2210/0004 , A61L27/48 , A61L31/06 , A61L31/12 , A61L31/128 , A61L31/148 , C08L67/04 , D01F6/00 , Y10T428/249924 , Y10T428/24994 , Y10T428/2907 , Y10T428/2929 , Y10T428/2931 , Y10T428/2933
摘要： This invention relates to bioabsorbable fibers, comprising a semicrystalline fiber-forming core polymer and an amorphous sheath polymer, wherein the core polymer and sheath polymer are separately melt extruded and connected to one another through an adhesive bond. The present invention also relates to reinforced composites of the bioabsorbable fibers, and to devices comprising the reinforced composites. The devices are suitable for in vivo implantation. Some embodiments of the present devices can also support high loads, making then useful for fracture fixation and spinal fusion. The invention also relates to methods of making the various materials of the invention.
摘要翻译：本发明涉及生物可吸收纤维，其包含半结晶纤维形成芯聚合物和无定形鞘聚合物，其中芯聚合物和鞘聚合物分别熔融挤出并通过粘合剂粘合彼此连接。本发明还涉及生物可吸收纤维的增强复合材料以及包含增强复合材料的装置。该装置适用于体内植入。本装置的一些实施例还可以支撑高负荷，从而使其用于骨折固定和脊柱融合。本发明还涉及制备本发明的各种材料的方法。

99. 发明申请

US20020138154A1 Controlling resorption of bioresorbable medical implant material 有权
标题翻译：控制生物可吸收的医用植入材料的吸收
公开(公告)号：US20020138154A1
公开(公告)日：2002-09-26
申请号：US09813780
申请日：2001-03-21
发明人： Jianmin Li , Samuel Baldwin , Tim Harrah
IPC分类号： A61F002/54
CPC分类号： A61L31/148 , A61B17/12113 , A61F2/0004 , A61F2/02 , A61F2/04 , A61F2210/0004 , A61F2210/009 , A61L27/40 , A61L27/58 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/10 , A61L31/12 , A61L31/16 , A61L2300/00
摘要： The resorption of a medical implant can be controlled with the use of particles embedded in a resorbable bulk material forming the implant or portion thereof. The implant can be removed from a body of a mammal by natural biological mechanisms after use. The resorption of the implant can involve swelling and/or hydrolyzing of the particles within the implant upon contact with a body fluid such that porosity and flow of fluid within the bulk material of the implant is increased. Resorption of the implant may also involve the use of particles with magnetic properties embedded within the implant such that an applied magnetic field causes the particles to vibrate within the bulk material thereby increasing the porosity and thus the flow of fluid, hence facilitating resorption of the implant. The resorption rate of the implant can be controlled by modulating swelling, hydrolysis, or movement of the embedded particles.
摘要翻译：可以通过使用嵌入到形成植入物或其部分的可再吸收散装材料中的颗粒来控制医用植入物的吸收。植入物可以在使用后通过天然生物学机制从哺乳动物的身体中去除。植入物的吸收可以包括在与体液接触时使植入物内的颗粒溶胀和/或水解，使得植入物的体积材料内的流体的孔隙率和流量增加。植入物的再吸收还可以涉及使用具有嵌入在植入物内的磁特性的颗粒，使得所施加的磁场使得颗粒在体材料内振动，从而增加孔隙率，从而增加流体的流动，从而促进植入物的再吸收。植入物的吸收速率可通过调节嵌入颗粒的溶胀，水解或运动来控制。

100. 发明授权

US11890145B2 Adhesion-preventing composition 有权
公开(公告)号：US11890145B2
公开(公告)日：2024-02-06
申请号：US17896474
申请日：2022-08-26
申请人： Mochida Pharmaceutical Co., Ltd. , The University of Tokyo
发明人： Taichi Ito , Seiichi Ohta , Norihiro Kokudo , Mitsuko Isaji , Satoshi Shimizu
IPC分类号： A61B90/00 , A61L31/14 , A61L31/12 , A61L31/04
CPC分类号： A61B90/08 , A61L31/04 , A61L31/12 , A61L31/128 , A61L31/14 , A61L31/146 , A61B2090/0816 , A61L2420/08
摘要： An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

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