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91. 发明申请

US20030060883A1 Surgically implantable knee prosthesis having attachment apertures 有权
标题翻译：具有附接孔的手术植入式膝假体
公开(公告)号：US20030060883A1
公开(公告)日：2003-03-27
申请号：US10226779
申请日：2002-08-23
发明人： Barry M. Fell , Richard H. Hallock
IPC分类号： A61F002/08
CPC分类号： A61F2/3872 , A61B17/06166 , A61B17/68 , A61F2/30756 , A61F2/30767 , A61F2/30942 , A61F2/30965 , A61F2/38 , A61F2/3868 , A61F2/4684 , A61F2002/30026 , A61F2002/30065 , A61F2002/30133 , A61F2002/30324 , A61F2002/30677 , A61F2002/30708 , A61F2002/30762 , A61F2002/30782 , A61F2002/30787 , A61F2002/3895 , A61F2002/4635 , A61F2210/0071 , A61F2230/0015 , A61F2250/0036 , A61F2250/0084 , A61F2310/00017 , A61F2310/00179 , A61F2310/0097
摘要： An implantable knee prosthesis for unicompartmental implantation into a knee joint includes a body having a substantially elliptical shape in plan and a pair of opposed faces. A peripheral face extends between the opposed faces and has first and second opposed sides and first and second opposed ends. At least one aperture extends through the body and extends from a first one of the faces to a second one of the faces.
摘要翻译：用于单室植入膝关节的可植入膝假体包括平面上具有基本上椭圆形的主体和一对相对的面。外围面在相对的面之间延伸，并且具有第一和第二相对侧面以及第一和第二相对端部。至少一个孔延伸穿过主体并且从第一个面延伸到第二个面。

92. 发明申请

US20030033021A1 Cartilage repair and regeneration scaffold and method 审中-公开
标题翻译：软骨修复和再生支架及方法
公开(公告)号：US20030033021A1
公开(公告)日：2003-02-13
申请号：US10195334
申请日：2002-07-15
发明人： Pamela Lynn Plouhar , Herbert Eugene Schwartz , Prasanna Malaviya
IPC分类号： A61F002/28
CPC分类号： A61L27/3852 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0475 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3604 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： A method for the repair of a cartilaginous tissue defect, a cartilage repair device and a method of making a cartilage repair device are disclosed. In the method for the repair of a cartilaginous tissue defect, a device comprising a synthetic polymer is implanted into the defect, and a biological lubricant is administered to the defect. The device comprises a synthetic polymer and a biological lubricant.
摘要翻译：公开了一种修复软骨组织缺损的方法，软骨修复装置和制造软骨修复装置的方法。在修复软骨组织缺损的方法中，将包含合成聚合物的装置植入缺陷中，向缺陷施用生物润滑剂。该装置包括合成聚合物和生物润滑剂。

93. 发明申请

US20020193811A1 Surgical repair kit and its method of use 失效
标题翻译：手术修复包及其使用方法
公开(公告)号：US20020193811A1
公开(公告)日：2002-12-19
申请号：US10119389
申请日：2002-04-09
发明人： Kwan-Ho Chan
IPC分类号： A61B017/04
CPC分类号： A61B17/3403 , A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/062 , A61B17/3401 , A61B17/3421 , A61B2017/00433 , A61B2017/00526 , A61B2017/00946 , A61B2017/06076 , A61F2/3872
摘要： A suture passer comprises a longitudinally extending hollow cannula having a central passage slidingly receivable of a surgical suture; a manually graspable handle connected to the hollow cannula for manipulation thereof, the handle having an upper surface; first guide means, connected to the upper surface of the handle, proximate a proximal end of the handle for releasably, guidingly, holding the surgical suture; second guide means, connected to the upper surface of the handle, distal to the first guide means, for releasably, guidingly, holding the surgical suture. The suture passer can be provided in a kit, for use in the suturing of internal tissue, along with a cannula bender, various hollow surgical needles and surgical suture material. The suture passer finds particular use in the suturing of internal tissues which are at least partially accessible through a body cavity, e.g., arthroscopic surgery.
摘要翻译：缝合路人器包括纵向延伸的中空套管，其具有滑动地可接收外科缝合线的中心通道; 连接到中空套管的手动抓握手柄用于操纵它，手柄具有上表面; 第一引导装置，连接到手柄的上表面，靠近手柄的近端，用于可释放地，引导地保持手术缝合线; 第二引导装置，其连接到手柄的上表面，远离第一引导装置，用于可释放地，引导地保持手术缝合线。缝合路人可以设置在套件中，用于缝合内部组织，以及套管弯曲机，各种中空手术针和外科缝合材料。缝合通道器在缝合内部组织中具有特别的用途，所述内部组织至少部分通过体腔可接近，例如关节镜手术。

94. 发明申请

US20020183850A1 Method and system for mammalian joint resurfacing 审中-公开
公开(公告)号：US20020183850A1
公开(公告)日：2002-12-05
申请号：US10121455
申请日：2002-04-12
发明人： Jeffrey C. Felt , Mark A. Rydell , Paul J. Buscemi , Alexander Arsenyev , Christopher H. Porter
IPC分类号： A61F002/38
CPC分类号： A61B17/562 , A61F2/30721 , A61F2/34 , A61F2/38 , A61F2/3872 , A61F2/3877 , A61F2/389 , A61F2002/30535 , A61F2250/0058 , A61L27/18 , A61L2430/24 , C08G18/10 , C08G18/4854 , C08G18/61 , C08G18/69 , C08L75/04 , C08G18/32
摘要： A method and system for the creation or modification of the wear surface of orthopedic joints, involving the preparation and use of one or more partially or fully preformed and procured components, adapted for insertion and placement into the body and at the joint site. In a preferred embodiment, component(s) can be partially cured and generally formed ex vivo and further and further formed in vivo at the joint site to enhance conformance and improve long term performance. In another embodiment, a preformed balloon or composite material can be inserted into the joint site and filled with a flowable biomaterial in situ to conform to the joint site. In yet another embodiment, the preformed component(s) can be fully cured and formed ex vivo and optionally further fitted and secured at the joint site. Preformed components can be sufficiently pliant to permit insertion through a minimally invasive portal, yet resilient enough to substantially assume, or tend towards, the desired form in vivo with additional forming there as needed.

95. 发明申请

US20020173852A1 Method and system for mammalian joint resurfacing 有权
标题翻译：哺乳动物关节表面置换的方法和系统
公开(公告)号：US20020173852A1
公开(公告)日：2002-11-21
申请号：US10167963
申请日：2002-06-12
发明人： Jeffrey C. Felt , Mark A. Rydell , Paul J. Buscemi , Alexander Arsenyev , Christopher H. Porter
IPC分类号： A61F002/38
CPC分类号： A61B17/562 , A61F2/30721 , A61F2/34 , A61F2/38 , A61F2/3872 , A61F2/3877 , A61F2/389 , A61F2002/30535 , A61F2250/0058 , A61L27/18 , A61L2430/24 , C08G18/10 , C08G18/4854 , C08G18/61 , C08G18/69 , C08L75/04 , C08G18/32
摘要： A method and system for the creation or modification of the wear surface of orthopedic joints, involving the preparation and use of one or more partially or fully preformed and procured components, adapted for insertion and placement into the body and at the joint site. In a preferred embodiment, component(s) can be partially cured and generally formed ex vivo and further and further formed in vivo at the joint site to enhance conformance and improve long term performance. In another embodiment, a preformed balloon or composite material can be inserted into the joint site and filled with a flowable biomaterial in situ to conform to the joint site. In yet another embodiment, the preformed component(s) can be fully cured and formed ex vivo and optionally further fitted and secured at the joint site. Preformed components can be sufficiently pliant to permit insertion through a minimally invasive portal, yet resilient enough to substantially assume, or tend towards, the desired form in vivo with additional forming there as needed.
摘要翻译：一种用于创建或修改整形外科关节磨损表面的方法和系统，涉及准备和使用一种或多种部分或完全预成型和采购的部件，适于插入和放置在身体和关节部位。在一个优选的实施方案中，组分可以部分固化，并且通常在体外形式离体进一步形成并且在接合部位进一步形成，以增强一致性并改善长期性能。在另一个实施方案中，预先形成的球囊或复合材料可以插入到关节部位中并且在原位填充可流动的生物材料以符合关节部位。在另一个实施方案中，预成型组分可以完全固化并离体形成，并任选地进一步装配并固定在接头部位。预成型组件可以足够柔顺以允许通过微创入口插入，但足够弹性足以基本上假设或倾向于体内所需的形式，并根据需要进一步形成。

96. 发明授权

US06387096B1 Magnetic array implant and method of treating adjacent bone portions 失效
标题翻译：磁阵列植入物和处理邻近骨部分的方法
公开(公告)号：US06387096B1
公开(公告)日：2002-05-14
申请号：US09594356
申请日：2000-06-13
申请人： Edward R. Hyde, Jr.
发明人： Edward R. Hyde, Jr.
IPC分类号： A61B1768
CPC分类号： A61N2/06 , A61B17/6425 , A61B17/6491 , A61B17/68 , A61B17/72 , A61F2/3836 , A61F2/3859 , A61F2/3868 , A61F2/3872 , A61F2/389 , A61F2/40 , A61F2/4059 , A61F2/4081 , A61F2002/30079 , A61F2002/30224 , A61F2002/30225 , A61F2002/30604 , A61F2002/30668 , A61F2002/30878 , A61F2002/30892 , A61F2002/4018 , A61F2002/4092 , A61F2210/009 , A61F2230/0069 , A61F2250/0001 , A61N2/008
摘要： The present invention relates to apparatus and methods for stabilizing and or maintaining adjacent bone portions in predetermined desired relationships and for constraining one, two or three-dimensional motion and/or rotation of the adjacent bone portions. More particularly, the present invention relates to a magnetic apparatus with at least two magnetic arrays, each of which may include any number of magnets arranged in a predetermined manner and each magnetic array generating a magnetic field therearound. Once implanted and secured to the adjacent bone portions, the apparatus provides interacting magnetic fields in the area of the bone portions and transduces magnetic energy into mechanical energy and mechanical energy into potential magnetic energy, thereby reproducing functionally anatomic and/or anatomically advantageous arrangement of the bone portions.
摘要翻译：本发明涉及用于在预定的期望关系中稳定和/或维持相邻骨部分并限制相邻骨部分的一维，二维或三维运动和/或旋转的装置和方法。更具体地，本发明涉及具有至少两个磁性阵列的磁性装置，每个磁性阵列可以包括以预定方式布置的任何数量的磁体，并且每个磁阵列周围产生磁场。一旦植入和固定到相邻的骨部分，该装置在骨部分的区域中提供相互作用的磁场，并将磁能转换成机械能并将机械能转换成潜在的磁能，从而再现功能上解剖和/或解剖学上有利的布置骨部分。

97. 发明申请

US20010023373A1 Tissue graft construct for replacement of cartilaginous structures 有权
标题翻译：用于替代软骨结构的组织移植物构建体
公开(公告)号：US20010023373A1
公开(公告)日：2001-09-20
申请号：US09767346
申请日：2001-01-23
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61F002/02
CPC分类号： A61F2/3872 , A61B17/0482 , A61B17/282 , A61B2017/00969 , A61B2017/320052 , A61F2/30756 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.
摘要翻译：描述了具有压缩并固定在一起并成形为提供具有待重建的软骨元件的解剖形状的重建结构的肠粘膜下层组织的多个重叠层的软骨元件的重建结构。形成重建结构的方法包括叠加肠粘膜下层组织的平面层，固定层以形成多层结构，并将所得到的多层结构切割成所需形状。

98. 发明授权

US06231608B1 Aldehyde and glycosidase-treated soft and bone tissue xenografts 有权
标题翻译：醛和糖苷酶处理的软骨和骨组织异种移植物
公开(公告)号：US06231608B1
公开(公告)日：2001-05-15
申请号：US09248476
申请日：1999-02-11
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F228
CPC分类号： A61L2/10 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/38 , A61F2/3872 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L2/0035 , A61L27/3604 , A61L27/3608 , A61L27/3625 , A61L27/3645 , A61L27/365 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： The invention provides articles of manufacture comprising substantially non-immunogenic soft and bone tissue xenografts for implantation into humans. The invention further provides methods for preparing soft and bone tissue xenografts by removing at least a portion of a soft or bone tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; exposing the xenograft to an aldehyde in an amount ranging from about 0.01% to about 0.10%; and digesting the xenograft with a glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft or bone tissue xenograft for implantation into a human including a portion of a soft or bone tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. The extracellular components also have an aldehyde in an amount ranging from about 0.01% to about 0.10% crosslinking the proteins of the extracellular components. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft or bone tissue.
摘要翻译：本发明提供包含用于植入人体的基本上非免疫原性的软骨和骨组织异种移植物的制品。本发明还提供了通过从非人动物中去除至少一部分软组织或骨组织以提供异种移植来制备软骨组织异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 将异种移植物暴露于约0.01％至约0.10％范围内的醛; 并用糖苷酶消化异种移植物，并任选地进行封端处理。本发明还提供了通过本发明的上述方法制造的制品。本发明进一步提供用于植入人的软组织或骨组织异种移植物，其包括来自非人动物的软组织或骨组织的一部分，其中所述部分具有细胞外组分并且基本上仅死细胞。细胞外组分基本上没有对糖苷酶消化敏感的表面碳水化合物部分。细胞外组分还具有约0.01％至约0.10％量的醛交联细胞外组分的蛋白质。本发明的每种异种移植物基本上是非免疫原性的并且具有与相应的天然软骨或骨组织基本相同的机械性质。

99. 发明授权

US06206927B1 Surgically implantable knee prothesis 有权
标题翻译：手术植入式膝盖假体
公开(公告)号：US06206927B1
公开(公告)日：2001-03-27
申请号：US09297943
申请日：1999-05-10
申请人： Barry M. Fell , Richard H. Hallock
发明人： Barry M. Fell , Richard H. Hallock
IPC分类号： A61F238
CPC分类号： A61F2/3872 , A61F2/30767 , A61F2/30965 , A61F2/3868 , A61F2002/30065 , A61F2002/30133 , A61F2002/30324 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/3895 , A61F2002/4635 , A61F2210/0071 , A61F2230/0015 , A61F2250/0036 , A61F2310/00017 , A61F2310/00179 , A61F2310/0097 , B33Y80/00
摘要： A self-centering meniscal prosthesis device suitable for minimally invasive, surgical implantation into the cavity between a femoral condyle and the corresponding tibial plateau is composed of a hard, high modulus material shaped such that the contour of the device and the natural articulation of the knee exerts a restoring force on the free-floating device.
摘要翻译：适合于在股骨髁和相应的胫骨平台之间进行微创手术植入腔内的自定心半月板假体装置由硬的高模量材料构成，使得装置的轮廓和膝盖的自然关节在自由浮动装置上施加恢复力。

100. 发明授权

US06176880B1 Tissue graft construct for replacement of cartilaginous structures 失效
公开(公告)号：US06176880B1
公开(公告)日：2001-01-23
申请号：US08913771
申请日：1997-12-17
申请人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
发明人： Pamela L. Plouhar , Michael D. Dunn , Jerry L. Lower , Thomas C. May
IPC分类号： A61F208
CPC分类号： A61F2/3872 , A61B17/0482 , A61B17/282 , A61B2017/00969 , A61B2017/320052 , A61F2/30756 , A61F2/3094 , A61F2/40 , A61F2/4261 , A61F2/442 , A61F2002/30461 , A61F2002/30563 , A61F2002/30971 , A61F2220/0075 , A61F2240/001 , Y10S623/908
摘要： A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.

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