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1. 发明授权

US08567561B2 Personal escape device and methods for using same 有权
标题翻译：个人逃生装置及其使用方法
公开(公告)号：US08567561B2
公开(公告)日：2013-10-29
申请号：US12218922
申请日：2008-07-18
申请人： Michael Strasser , Thomas King , Kevin R. Stone
发明人： Michael Strasser , Thomas King , Kevin R. Stone
IPC分类号： A62B1/10
CPC分类号： A62B1/10
摘要： The invention presents devices for controlled descent from buildings. Such a device includes a housing having a primary spool about which a cord is wound, a payload coupler for attaching a harness assembly to the housing, and an unwind control assembly for controlling the rate of exit of the cord from the housing. An inventive device kit may include a convertible storage unit used to protectively store a device and which, upon deployment, may be used as a protective helmet. In using an inventive device, a user attaches the device to a fixture in a building, dons a harness and the converted helmet, attaches the device to the harness, and exits the building from a window or roof.
摘要翻译：本发明提出了用于从建筑物控制下降的装置。这样的装置包括具有初级线轴的外壳，绕线缠绕在该主壳体上，用于将线束组件附接到壳体的有效负载耦合器，以及用于控制电线从壳体的退出速率的退绕控制组件。本发明的设备套件可以包括用于保护性地存储设备的可转换存储单元，并且在部署时可以将其用作防护头盔。在使用本发明的设备时，使用者将设备附接到建筑物中的固定装置，无用的线束和转换的头盔，将装置附接到线束，并从窗户或屋顶离开建筑物。

2. 发明授权

US07722672B2 Bone xenografts 有权
标题翻译：骨异种移植物
公开(公告)号：US07722672B2
公开(公告)日：2010-05-25
申请号：US10290661
申请日：2002-11-08
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/28
CPC分类号： A61L27/3687 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L27/3608 , A61L27/365 , A61L27/3683
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.
摘要翻译：本发明提供了一种包含用于植入人体的基本上非免疫原性骨异种移植物的制品。本发明进一步提供了通过从非人动物中去除至少一部分骨以提供异种移植物（X）来制备骨异种移植物的方法。用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 并用糖苷酶处理异种移植物以除去表面碳水化合物部分。本发明还提供了通过上述确定的发明方法生产的制品。本发明进一步提供用于植入人的骨异种移植物，其包括来自非人动物的骨的一部分（10），其中所述部分基本上没有对糖苷酶消化敏感的表面碳水化合物部分。本发明的每个异种移植物具有与相应的天然骨基本上相同的机械性质。

3. 发明授权

US07594934B2 Galactosidase-treated prosthetic devices 有权
标题翻译：半乳糖苷酶处理的假体装置
公开(公告)号：US07594934B2
公开(公告)日：2009-09-29
申请号：US10517863
申请日：2003-06-04
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/36 , A61F2/38
CPC分类号： A61L27/56 , A61F2/30756 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/30062 , A61F2002/30131 , A61F2002/3023 , A61F2002/30535 , A61F2002/30736 , A61F2002/30766 , A61F2002/30957 , A61F2210/0004 , A61F2230/0013 , A61F2230/0069 , A61F2250/0058 , A61F2310/00293 , A61F2310/00365 , A61L27/24 , A61L27/26 , A61L27/3604 , A61L27/3645 , A61L27/3687 , A61L27/46 , A61L27/48 , A61L27/58 , Y10T442/2525 , C08L89/06 , C08L5/08
摘要： Matrix material for a substantially immunologically-compatible meniscal augmentation device of biocompatible and partially bioresorbable fibers is prepared by treatment with oc-galactosidase to eliminate oc-Gal epitopes. Upon implantation into a segmental defect of a meniscus, the composite of the meniscal augmentation device and the meniscus establishes a scaffold adapted for ingrowth of meniscal fibrochondrocytes.
摘要翻译：通过用α-半乳糖苷酶处理以消除oc-Gal表位制备用于生物相容性和部分生物可再吸收纤维的基本上免疫相容的半月板增加装置的基质材料。当植入半月板的节段性缺损时，半月板增大装置和弯液面的复合体建立了适应于半月板纤维软骨细胞向内生长的支架。

4. 发明申请

US20090030517A1 BONE XENOGRAFTS 审中-公开
标题翻译：骨骼XENOGRAFTS
公开(公告)号：US20090030517A1
公开(公告)日：2009-01-29
申请号：US12049809
申请日：2008-03-17
申请人： Kevin R. Stone , Uri Galili
发明人： Kevin R. Stone , Uri Galili
IPC分类号： A61F2/28 , A61B19/00 , A61F2/02
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/3687 , A61L27/3847
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft (X) for implantation into a defect (D) located in a bone portion (10) of a human. The invention further provides methods for preparing a bone xenograft (X) by removing at least a portion of bone from a non-human animal to provide a xenograft (X); washing the xenograft (X) in saline and alcohol; and subjecting the xenograft (X) to at least one of the treatments including exposure to ultraviolet radiation, immersion in alcohol, ozonic, and freeze/thaw cycling. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment, and digestion of the carbohydrate moieties of the xenograft (X) with a glycosidase followed by treatment for sialylation.
摘要翻译：本发明提供了一种制品，其包括用于植入位于人的骨部分（10）中的缺陷（D）的基本上非免疫原性骨异种移植物（X）。本发明还提供了通过从非人动物中去除至少一部分骨以提供异种移植物（X）来制备骨异种移植物（X）的方法; 用盐水和酒精清洗异种移植物（X）; 并将异种移植物（X）进行至少一种处理，包括暴露于紫外线辐射，浸入酒精，臭氧和冷冻/融化循环中。除了上述处理之外或代替上述处理，所述方法包括细胞破碎处理和用糖苷酶消化异种移植物（X）的碳水化合物部分，接着进行唾液酸化处理。

5. 发明授权

US07064187B2 Substantially non-immunogenic injectable collagen 有权
公开(公告)号：US07064187B2
公开(公告)日：2006-06-20
申请号：US10722869
申请日：2003-11-26
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： C07K1/14 , A61K38/17
CPC分类号： A61L27/24 , A61K38/39 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/50
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic injectable collagen for implantation into humans. The invention further provides methods for preparing injectable collagen material by removing collagen-containing material from a non-human animal; washing in saline and alcohol; subjecting material to cellular disruption treatment; and digesting the material with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the method. The injectable collagen material of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.

6. 发明授权

US06972041B1 Bone xenografts 失效
标题翻译：骨异种移植物
公开(公告)号：US06972041B1
公开(公告)日：2005-12-06
申请号：US09646376
申请日：1999-03-15
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/28 , A61F2/30 , A61L27/36 , A61F2/02
CPC分类号： A61L27/3687 , A61F2/28 , A61F2/3094 , A61F2002/2835 , A61L27/3608 , A61L27/365 , A61L27/3683
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic bone xenograft for implantation into humans. The invention further provides a method for preparing a bone xenograft by removing at least a portion of a bone from a non-human animal to provide a xenograft (X); washing the xenograft in saline and alcohol; subjecting the xenograft to a cellular disruption treatment; and treating the xenograft with a glycosidase to remove surface carbohydrate moieties. The invention also provides an article of manufacture produced by the above identified method of invention. The invention further provides a bone xenograft for implantation into a human including a portion (10) of a bone from a nonhuman animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. Each xenograft of the invention has substantially the same mechanical properties as a corresponding native bone.
摘要翻译：本发明提供了一种包含用于植入人体的基本上非免疫原性骨异种移植物的制品。本发明进一步提供了通过从非人动物中去除至少一部分骨以提供异种移植物（X）来制备骨异种移植物的方法。用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 并用糖苷酶处理异种移植物以除去表面碳水化合物部分。本发明还提供了通过上述确定的发明方法生产的制品。本发明进一步提供用于植入人的骨异种移植物，其包括来自非人动物的骨的一部分（10），其中所述部分基本上没有对糖苷酶消化敏感的表面碳水化合物部分。本发明的每个异种移植物具有与相应的天然骨基本上相同的机械性质。

7. 发明授权

US06267786B1 Proteoglycan-reduced soft tissue xenografts 有权
标题翻译：蛋白多糖减少的软组织异种移植物
公开(公告)号：US06267786B1
公开(公告)日：2001-07-31
申请号：US09248336
申请日：1999-02-11
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F228
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3687 , A61L2430/40 , Y10S623/915
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.
摘要翻译：本发明提供了一种包含用于植入人体的基本上非免疫原性软组织异种移植物的制品。本发明还提供了通过从非人动物中去除至少一部分软组织以提供异种移植物来制备软组织异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 并用蛋白聚糖消耗因子和/或糖苷酶消化异种移植物，并任选地进行封端处理。本发明还提供了通过本发明的上述方法制造的制品。本发明还提供了用于植入人的软组织异种移植物，其包括来自非人动物的软组织的一部分，其中所述部分具有细胞外组分并且基本上仅仅是死细胞。细胞外成分降低蛋白聚糖分子。本发明的每种异种移植物基本上是非免疫原性的并且具有与相应的天然软组织基本相同的机械性质。

8. 发明授权

US06231608B1 Aldehyde and glycosidase-treated soft and bone tissue xenografts 有权
标题翻译：醛和糖苷酶处理的软骨和骨组织异种移植物
公开(公告)号：US06231608B1
公开(公告)日：2001-05-15
申请号：US09248476
申请日：1999-02-11
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F228
CPC分类号： A61L2/10 , A61F2/08 , A61F2/28 , A61F2/30756 , A61F2/3094 , A61F2/38 , A61F2/3872 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L2/0035 , A61L27/3604 , A61L27/3608 , A61L27/3625 , A61L27/3645 , A61L27/365 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： The invention provides articles of manufacture comprising substantially non-immunogenic soft and bone tissue xenografts for implantation into humans. The invention further provides methods for preparing soft and bone tissue xenografts by removing at least a portion of a soft or bone tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; exposing the xenograft to an aldehyde in an amount ranging from about 0.01% to about 0.10%; and digesting the xenograft with a glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft or bone tissue xenograft for implantation into a human including a portion of a soft or bone tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion. The extracellular components also have an aldehyde in an amount ranging from about 0.01% to about 0.10% crosslinking the proteins of the extracellular components. Each of the xenografts of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft or bone tissue.
摘要翻译：本发明提供包含用于植入人体的基本上非免疫原性的软骨和骨组织异种移植物的制品。本发明还提供了通过从非人动物中去除至少一部分软组织或骨组织以提供异种移植来制备软骨组织异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行细胞破坏处理; 将异种移植物暴露于约0.01％至约0.10％范围内的醛; 并用糖苷酶消化异种移植物，并任选地进行封端处理。本发明还提供了通过本发明的上述方法制造的制品。本发明进一步提供用于植入人的软组织或骨组织异种移植物，其包括来自非人动物的软组织或骨组织的一部分，其中所述部分具有细胞外组分并且基本上仅死细胞。细胞外组分基本上没有对糖苷酶消化敏感的表面碳水化合物部分。细胞外组分还具有约0.01％至约0.10％量的醛交联细胞外组分的蛋白质。本发明的每种异种移植物基本上是非免疫原性的并且具有与相应的天然软骨或骨组织基本相同的机械性质。

9. 发明授权

US6063120A Anterior cruciate ligament heterograft 失效
标题翻译：前十字韧带异种移植
公开(公告)号：US6063120A
公开(公告)日：2000-05-16
申请号：US22658
申请日：1998-02-12
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/08 , A61L27/36
CPC分类号： A61L27/3691 , A61L27/3604 , A61L27/3608 , A61L27/3654 , A61L27/3662 , A61L27/3683 , A61L27/3687 , A61F2/08 , A61L2430/10
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic ligament or tendon heterografts for implantation into humans. The invention further provides a method for preparing an ligament heterograft by removing at least a portion of an ligament from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic ligament.
摘要翻译：本发明提供了一种包括用于植入人体的基本上非免疫原性的韧带或腱异种移植物的制品。本发明还提供了一种通过从非人动物中去除至少一部分韧带以提供异种移植来制备韧带异种移植物的方法; 用盐水和酒精清洗异种移植物; 对异种移植物进行选自紫外线辐射，浸入酒精，臭氧化，冷冻/融化循环以及任选地进行化学交联的至少一种处理。根据本发明，异种移植物具有与天然异种韧带基本上相同的机械性质。

10. 发明授权

US5944755A Articular cartilage xenografts 失效
标题翻译：关节软骨异种移植物
公开(公告)号：US5944755A
公开(公告)日：1999-08-31
申请号：US36070
申请日：1998-03-06
申请人： Kevin R. Stone
发明人： Kevin R. Stone
IPC分类号： A61F2/30 , A61F2/38 , A61L27/36 , A61F2/28
CPC分类号： A61F2/30756 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61F2/3094 , A61F2/3859 , A61F2/389
摘要： The invention provides an article of manufacture comprising a substantially non-immunogenic articular cartilage xenograft for implantation into humans. The invention further provides a method for preparing an articular cartilage xenograft by removing at least a portion of an articular cartilage from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In addition to or in lieu of the above treatments, the methods include a cellular disruption treatment and glycosidase digestion of carbohydrate moieties of the xenograft followed by treatment of carbohydrate moieties of the xenograft with capping molecules. The invention also provides articles of manufacture produced by one or more of the above-identified methods of the invention. The invention further provides an articular cartilage xenograft for implantation into a human including a portion of an articular cartilage from a non-human animal, wherein the portion includes extracellular matrix and substantially only dead cells. The matrix and dead cells have substantially no surface .alpha.-galactosyl moieties and have capping molecules linked to at least a portion of surface carbohydrate moieties. Each of the xenografts of the invention is substantially non-immunogenic and has substantially the same mechanical properties as the respective native articular cartilage.
摘要翻译：本发明提供了一种包括用于植入人体的基本上非免疫原性的关节软骨异种移植物的制品。本发明还提供了通过从非人动物中移除至少一部分关节软骨以提供异种移植物来制备关节软骨异种移植物的方法; 用盐水和酒精清洗异种移植物; 使异种移植物进行至少一种治疗，所述治疗选自紫外线照射，浸入酒精，臭氧化，冷冻/解冻循环，以及任选地进行化学交联。除了或代替上述处理之外，所述方法包括异种移植物的碳水化合物部分的细胞破碎处理和糖苷酶消化，随后用封端分子处理异种移植物的碳水化合物部分。本发明还提供了通过本发明的一种或多种上述方法生产的制品。本发明还提供了一种用于植入人的关节软骨异种移植物，其包括来自非人动物的关节软骨的一部分，其中所述部分包括细胞外基质和基本上只有死细胞。基质和死细胞基本上没有表面α-半乳糖基部分，并且具有连接至表面碳水化合物部分的至少一部分的封端分子。本发明的每种异种移植物基本上是非免疫原性的并且具有与各自的天然关节软骨基本相同的机械性质。

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