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91. 发明授权

US6080452A Electro-optical liquid-crystal display 失效
标题翻译：电光液晶显示
公开(公告)号：US6080452A
公开(公告)日：2000-06-27
申请号：US318576
申请日：1999-05-27
申请人： Kazuaki Tarumi , Andreas Beyer , Eike Poetsch
发明人： Kazuaki Tarumi , Andreas Beyer , Eike Poetsch
IPC分类号： G02F1/13 , C07C69/753 , C07C255/50 , C07C255/54 , C09K19/30 , C09K19/34 , C09K19/42 , C09K19/44 , C09K19/46 , C09K19/56 , C09K19/52 , G02F1/1337
CPC分类号： C09K19/3402 , C07C255/50 , C07C255/54 , C07C69/753 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C09K19/3068 , C09K19/3098 , C09K19/42 , C09K19/46 , C09K2019/0444 , C09K2019/3422 , Y10T428/10
摘要： The invention relates to an electro-optical liquid-crystal display having a realignment layer for realigning the liquid crystals whose field has a significant component parallel to the liquid-crystal layer and which contains a liquid-crystalline medium of positive dielectric anisotropy, where the medium comprises at least one mesogenic compound of the formula II ##STR1## in which R.sup.1 is H, an alkyl or alkenyl radical having 1 to 15 carbon atoms which is unsubstituted or monosubstituted or polysubstituted by halogen and in which one or more CH.sub.2 groups may each, independently of one another, be replaced by --O--, --S--, --CO--, --COO--, --OCO-- or --OCO--O-- in such a way that O atoms are not linked directly to one another.
摘要翻译：本发明涉及一种电光液晶显示器，其具有重新排列液晶的重新对准层，该液晶具有平行于液晶层的显着分量，并且含有正介电各向异性的液晶介质，其中介质包括式II的至少一种介晶化合物，其中R 1是H，具有1至15个碳原子的烷基或烯基，其是未被取代的或被卤素单取代或多取代的，并且其中一个或多个CH 2基团各自独立地为一个另一个被-O - ， - S - ， - CO-，-COO-，-OCO-或-OCO-O-取代，使得O原子彼此不直接连接。

92. 发明授权

US6025354A Arylalkyl-thiadiazinones 失效
标题翻译：芳基烷基 - 噻二嗪酮
公开(公告)号：US6025354A
公开(公告)日：2000-02-15
申请号：US8812
申请日：1998-01-20
申请人： Rochus Jonas , Michael Wolf , Michael Klockow
发明人： Rochus Jonas , Michael Wolf , Michael Klockow
IPC分类号： A61K31/54 , A61K31/549 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D285/16 , C07D417/04
CPC分类号： C07D285/16
摘要： Arylalkyl-thiadiazinone derivatives of the formula I ##STR1## and physiologically unobjectionable salts thereof in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and Q have the meanings given in claim 1, exhibit phosphodiesterase IV inhibition and can be used for the therapy of asthmatic disorders.
摘要翻译： R 1，R 2，R 3，R 4，R 5和Q具有权利要求1中给出的含义的式I的芳基烷基 - 噻二嗪酮衍生物及其生理上无反应的盐表现出磷酸二酯酶IV抑制，并且可用于治疗哮喘性疾病。

93. 发明授权

US6001961A Cyclic adhesion inhibitors 失效
标题翻译：环状粘连抑制剂
公开(公告)号：US6001961A
公开(公告)日：1999-12-14
申请号：US694387
申请日：1996-09-16
申请人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
发明人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
IPC分类号： A61K38/00 , A61K38/04 , A61K38/12 , A61P9/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P39/00 , A61P43/00 , C07K1/113 , C07K7/64 , C07K7/00
CPC分类号： C07K7/64 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula Icyclo-(nArg-nGly-nAsp-nD-nE) I,in whichD and E in each case independently of one another are Gly, Ala, .beta.-Ala, Asn, Asp, Asp(OR), Arg, Cha, Cys, Gln, Glu, His, Ile, Leu, Lys, Lys(Ac), Lys(AcNH.sub.2), Lys(AcSH), Met, Nal, Nle, Orn, Phe, 4-Hal-Phe, homo-Phe, Phg, Pro, Pya, Ser, Thr, Tia, Tic, Trp, Tyr or Val, which amino acid residues can also be derivatized,R is alkyl having 1-18 carbon atoms,Hal is F, Cl, Br, I,Ac is alkanoyl having 1-10 carbon atoms, aroyl having 7-11 carbon atoms or aralkanoyl having 8-12 carbon atoms,n denotes no substituent or an alkyl radical R, benzyl or an aralkyl radical having 7-18 carbon atoms on the alpha-amino function of the relevant amino acid residue,with the proviso that at least one amino acid residue has a substituent n and that, where residues of optically active amino acids and amino acid derivatives are involved, both the D and the L forms are included, and also their physiologically acceptable salts.These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, angiogenic disorders, microbial infections and in tumor therapy.
摘要翻译：本发明涉及式I环 - （nArg-nGly-nAsp-nD-nE）I的新型环肽，其中D和E各自独立地为Gly，Ala，β-Ala，Asn，Asp，Asp （OR），Arg，Cha，Cys，Gln，Glu，His，Ile，Leu，Lys，Lys（Ac），Lys（AcNH 2），Lys（AcSH），Met，Nal，Nle，Orn， -Phe，Phe-Phe，Phg，Pro，Pya，Ser，Thr，Tia，Tic，Trp，Tyr或Val，该氨基酸残基也可被衍生化，R是具有1-18个碳原子的烷基，Hal是F， Cl，Br，I，Ac是具有1-10个碳原子的烷酰基，具有7-11个碳原子的芳酰基或具有8-12个碳原子的芳烷酰基，n表示没有取代基或烷基R，苄基或具有7- 相关氨基酸残基的α-氨基官能团上的18个碳原子，条件是至少一个氨基酸残基具有取代基n，并且当涉及光学活性氨基酸和氨基酸衍生物的残基时，D 并且包括L形式，也包括它们的生理学可接受的盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍，血管生成障碍，微生物感染和肿瘤治疗。

94. 发明授权

US5989461A Circular UV polarizer 失效
标题翻译：圆形紫外线偏振片
公开(公告)号：US5989461A
公开(公告)日：1999-11-23
申请号：US888363
申请日：1997-07-03
申请人： David Coates , Emma Jolliffe , Patrick Nolan
发明人： David Coates , Emma Jolliffe , Patrick Nolan
IPC分类号： G02B5/30 , F21V9/14 , C09K19/20 , C09K19/52 , G02F1/1335
CPC分类号： G02B5/3075 , G02B5/3016
摘要： The invention relates to a circular UV polarizer based on a polymerized mesogen being obtainable by curing by actinic radiation or by heat of a polymerizable composition which comprises the following components:a) a liquid mesogenic component A composed of one or more achiral mesogenic compounds having at least one polymerizable end group optionally linked via a spacer group to the mesogenic core,b) a component B composed of one or more chiral compounds in such an amount that the maximum wavelength of reflection (.lambda..sub.max) of the composition is between 320 and 440 nm, inclusive, andc) a photoinitiator or thermal initiator component C.
摘要翻译：本发明涉及一种基于聚合介晶的环形紫外线偏振器，其可通过光化辐射或热可聚合组合物固化而获得，该可聚合组合物包含以下组分：a）由一种或多种非手性介晶化合物组成的液体介晶组分A，其具有至少一个可聚合端基任选地通过间隔基团连接到介晶核，b）由一种或多种手性化合物组成的组分B，其量使组合物的最大反射波长（λmax）在320和440之间 nm，c）光引发剂或热引发剂组分C.

95. 发明授权

US5977161A Kappa-opiate agonists effective in the treatment of postoperative ileus 失效
标题翻译：卡帕阿片激动剂有效治疗术后肠梗阻
公开(公告)号：US5977161A
公开(公告)日：1999-11-02
申请号：US27228
申请日：1998-02-20
申请人： Andrew Barber , Christoph Seyfried , Gerd Bartoszyk , Rudolf Gottschlich
发明人： Andrew Barber , Christoph Seyfried , Gerd Bartoszyk , Rudolf Gottschlich
IPC分类号： C07D207/08 , A61K31/135 , A61K31/165 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61P1/00 , A61P1/04 , A61P29/00 , A61P43/00 , C07D207/12
CPC分类号： A61K31/4025
摘要： Disclosed herein are pharmaceutical preparations which are suitable for the treatment of postoperative ileus and contain at least one compound of the formula I ##STR1## in which R.sup.1 is Ar, cycloalkyl having 3-7 C atoms or cycloalkylalkyl having 4-8 C atoms,R.sup.2 is Ar, orR.sub.1 and R.sup.2 together are ##STR2## R.sup.3 is H, OH, OA or A, R.sup.4 is A or phenyl which can optionally be mono- or disubstituted by Hal, OH, OA, CF.sub.3, NO.sub.2, NH.sub.2, NHA, NHCOA, NHSO.sub.2 A and/or NA.sub.2,R.sup.5 is OH, CH.sub.2 OH,R.sup.6 and R.sup.7 in each case independently of one another are H, Hal, OH, OA, CF.sub.3, NH.sub.2, NHA, NA.sub.2, NHCOA, NHCONH.sub.2, NO.sub.2 or methylenedioxy, with the oxy groups bonded to adjacent carbons on the ring,A is alkyl having 1-7 C atoms,Ar is a mono- or bicyclic aromatic radical which can optionally contain an N, O or S atom in the ring and can be mono-, di- or trisubstituted by A, Hal, OH, OA, CF.sub.3, NH.sub.2, NHA, NA.sub.2, NHCOA and/or NHCONH.sub.2,D is CH.sub.2, O, S, NH, NA, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 NH--, --CH.sub.2 --NA-- or a bondandHal is F, Cl, Br or I.
摘要翻译：本文公开了适用于治疗术后肠梗阻并含有至少一种其中R 1为Ar的式I化合物或具有3-7个C原子的环烷基或具有4-8个C原子的环烷基烷基，R2为Ar，或R 1和R 2一起为R 3为H，OH，OA或A，R 4为A或可任选被Hal，OH，OA，CF 3，NO 2，NH 2，NHA，NHCOA，NHSO 2 A单取代或二取代的苯基和/或 NA2，R5分别为H，Hal，OH，OA，CF3，NH2，NHA，NA2，NHCOA，NHCONH2，NO2或亚甲二氧基的OH，CH2OH，R6和R7彼此独立地键合， A是具有1-7个C原子的烷基，Ar是可以在环中任选含有N，O或S原子的单环或双环芳族基团，并且可以被A，，Hal，OH，OA，CF 3，NH 2，NHA，NA 2，NHCOA和/或NHCONH 2，D是CH 2，O，S，NH，NA，-CH 2 -CH 2 - ， - CH = CH-， - CH 2 NH-， CH2-NA-或键，Hal为F，Cl，Br或I.

96. 发明授权

US5919396A Electro-optical liquid-crystal display 失效
公开(公告)号：US5919396A
公开(公告)日：1999-07-06
申请号：US986334
申请日：1997-12-05
申请人： Kazuaki Tarumi , Andreas Beyer , Eike Poetsch
发明人： Kazuaki Tarumi , Andreas Beyer , Eike Poetsch
IPC分类号： G02F1/13 , C07C69/753 , C07C255/50 , C07C255/54 , C09K19/30 , C09K19/34 , C09K19/42 , C09K19/44 , C09K19/46 , C09K19/56 , C09K19/52 , G02F1/1337
CPC分类号： C09K19/3402 , C07C255/50 , C07C255/54 , C07C69/753 , C09K19/3001 , C09K19/3003 , C09K19/3028 , C09K19/3068 , C09K19/3098 , C09K19/42 , C09K19/46 , C09K2019/0444 , C09K2019/3422 , Y10T428/10
摘要： The invention relates to an electro-optical liquid-crystal display having a realignment layer for realigning the liquid crystals whose field has a significant component parallel to the liquid-crystal layer and which contains a liquid-crystalline medium of positive dielectric anisotropy, where the medium comprises at least one mesogenic compound of the formula II ##STR1## in which R.sup.1 is H, an alkyl or alkenyl radical having 1 to 15 carbon atoms which is unsubstituted or monosubstituted or polysubstituted by halogen and in which one or more CH.sub.2 groups may each, independently of one another, be replaced by --O--, --S--, --CO--, --COO--, --OCO-- or --OCO--O-- in such a way that O atoms are not linked directly to one another.

97. 发明授权

US5904424A Device for mixing small quantities of liquids 失效
标题翻译：用于混合少量液体的装置
公开(公告)号：US5904424A
公开(公告)日：1999-05-18
申请号：US930362
申请日：1997-09-30
申请人： Norbert Schwesinger , Thomas Frank
发明人： Norbert Schwesinger , Thomas Frank
IPC分类号： B01F5/06 , B01F13/00 , B01J19/00 , B01F5/00
CPC分类号： B01F5/0604 , B01F13/0059 , B01F5/0641 , B01J19/0093 , B01J2219/00783 , B01J2219/00828 , B01J2219/00831 , B01J2219/00889 , Y10S366/03
摘要： A device for mixing very small quantities of liquids comprises at least one mixing element with at least one inlet channel and at least one outlet channel; at least two microchannels issue from the inlet channel, all such issuing channels lying in a single branching plane. The microchannels are led to a confluence element in a plane which is rotated 90 degrees in relation to the branching plane. The mixer element is arranged in the planar surface of a substrate, the planar surface being hermetically sealed by a covering. The invention concerns a device for mixing liquids in which mixing is effected by the flow of the liquids to be mixed through narrow channels.
摘要翻译： PCT No.PCT / EP96 / 01359 Sec。 371日期：1997年9月30日 102（e）1997年9月30日PCT PCT 1996年3月28日PCT公布。 WO96 / 30113 PCT出版物日期1996年10月3日用于混合非常少量液体的装置包括至少一个具有至少一个入口通道和至少一个出口通道的混合元件; 从入口通道发出至少两个微通道，所有这些发出通道位于单个分支平面中。微通道被引导到相对于分支平面旋转90度的平面中的汇合元件。混合器元件布置在基板的平面表面中，平面由盖子气密地密封。本发明涉及用于混合液体的装置，其中通过窄通道混合的液体流进行混合。

98. 发明授权

US5885960A Method of treatment comprising administering a combination comprising FGF and polyelectrolytes 失效
标题翻译：治疗方法包括施用包含FGF和聚电解质的组合
公开(公告)号：US5885960A
公开(公告)日：1999-03-23
申请号：US330619
申请日：1994-10-28
申请人： Berthold Nies
发明人： Berthold Nies
IPC分类号： A61K38/00 , A61K9/00 , A61K31/722 , A61K38/18 , A61K38/22 , A61K47/18 , A61K47/36 , A61L15/22 , A61L15/32 , A61L26/00 , A61P17/02
CPC分类号： A61K9/0014 , A61K38/1825 , A61K47/36 , A61K9/0019 , A61L15/225 , A61L15/32 , A61L26/0023 , A61L26/0028 , A61L26/0047 , A61L26/0052 , Y10S424/13 , Y10S514/866 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/928 , Y10S514/944
摘要： The invention relates to active substance combinations which consist of at least one polypeptide with the biological action of fibroblast growth factors and of at least one cationic polyelectrolyte. These combinations permit improved dosage of the FGF activity. The invention also relates to a method of treating wounds, burns, skin ulcers, diabetic gangrene, mucosal ulcers and lesions, skin donation and transplantation sites, or surgical wounds by administering a peptide having FGF activity with an amount of cationic polyelectrolyte which is effective to decrease non-specific binding of the peptide having FGF activity.
摘要翻译：本发明涉及由至少一种具有成纤维细胞生长因子和至少一种阳离子聚电解质的生物作用的多肽组成的活性物质组合。这些组合允许FGF活性的改善剂量。本发明还涉及一种治疗伤口，烧伤，皮肤溃疡，糖尿病性坏疽，粘膜溃疡和损伤，皮肤捐献和移植部位或外科伤口的方法，其通过给予具有FGF活性的肽与一定量的阳离子聚电解质，其有效降低具有FGF活性的肽的非特异性结合。

99. 发明授权

US5859008A Arylalkyl diazinones 失效
标题翻译：芳烷基二嗪酮
公开(公告)号：US5859008A
公开(公告)日：1999-01-12
申请号：US714796
申请日：1996-09-13
申请人： Rochus Jonas , Michael Wolf , Norbert Beier
发明人： Rochus Jonas , Michael Wolf , Norbert Beier
IPC分类号： C07D237/04 , A61K31/42 , A61K31/4965 , A61K31/50 , A61K31/535 , A61K31/54 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D237/24 , C07D273/04 , C07D285/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D273/00
CPC分类号： C07D401/12 , C07D237/24 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Arylalkyl diazinone derivatives of the formula I ##STR1## and their physiologically acceptable salts, in whichR.sup.1, R.sup.2, R.sup.3, R.sup.4, B, Q and X have the meanings indicated in claim 1, exhibit phosphodiesterase IV inhibition and can be employed for the treatment of inflammatory processes and also of allergies, asthma and autoimmune disorders.
摘要翻译：式I的芳烷基二嗪酮衍生物及其生理学上可接受的盐，其中R 1，R 2，R 3，R 4，B，Q和X具有权利要求1所示的含义，表示磷酸二酯酶IV抑制，可用于治疗炎症过程以及过敏，哮喘和自身免疫性疾病。

100. 发明授权

US5853669A Sensor membrane for indicating the PH of a sample, the fabrication and use thereof 失效
标题翻译：用于指示样品的PH的传感器膜，其制造和使用
公开(公告)号：US5853669A
公开(公告)日：1998-12-29
申请号：US588767
申请日：1996-01-19
申请人： Otto S. Wolfbeis
发明人： Otto S. Wolfbeis
IPC分类号： G01N31/22 , G01N21/29 , G01N21/00 , G01N21/75 , G01N33/48
CPC分类号： G01N31/221 , Y10S436/805 , Y10S436/807
摘要： For the purpose of reversible optical indication of the pH of a sample, a hydrophilic accommodating layer is disposed on a hydrophobic mechanically stable support element, which layer contains the indicator dye proper in an immobilized form. This provides a sensor membrane which can be fabricated in a simple manner and is cost-effective, which has a rapid response time and can also be fabricated as a mass product to be used only once.
摘要翻译：为了对样品的pH的可逆光学指示的目的，将亲水性容纳层设置在疏水性机械稳定的支撑元件上，该层包含固定形式的指示剂染料。这提供了一种传感器膜，其可以以简单的方式制造并且成本有效，其具有快速的响应时间，并且还可以制造成仅使用一次的质量产品。

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