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91. 发明授权

US08568988B2 Use of CFH or ApoH as a biochemical diagnostic marker for complete remission in acute myeloid leukemia 有权
标题翻译：使用CFH或ApoH作为急性骨髓性白血病完全缓解的生化诊断标志物
公开(公告)号：US08568988B2
公开(公告)日：2013-10-29
申请号：US12874612
申请日：2010-09-02
申请人： Seung Won Lee
发明人： Seung Won Lee
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57426 , G01N2800/54 , G01N2800/56
摘要： The present invention relates to a diagnostic method for acute myeloid leukemia, in particular, a method for using CFH or ApoH in patient sera as biochemical diagnostic markers to determine complete remission in acute myeloid leukemia. In accordance with this invention, CFH and ApoH are identified as a novel biochemical marker for understanding the biological mechanism and responsiveness to disease in AML patients after induction chemotherapy, and can be used as a biochemical marker for evaluating the prognosis of disease in patients after induction chemotherapy.
摘要翻译：本发明涉及急性骨髓性白血病的诊断方法，特别是使用患者血清中的CFH或ApoH作为生化诊断标记物来确定急性骨髓性白血病完全缓解的方法。根据本发明，CFH和ApoH被鉴定为诱导化疗后AML患者生物学机制和对疾病反应性的新型生物化学标志物，可用作评估诱导后患者疾病预后的生化标志物化疗。

92. 发明申请

US20130244221A1 METHOD FOR ISOLATING HEPATITIS A VIRUS OR SPRING VIREMIA OF CARP VIRUS 有权
标题翻译：用于分离乙型肝炎病毒的病毒或弹簧病毒的方法
公开(公告)号：US20130244221A1
公开(公告)日：2013-09-19
申请号：US13703626
申请日：2012-10-12
申请人： Du Woon Kim , Hee Min Lee , Se Young Cho , Sang Mu Ko , Kyung Seo Oh , Joseph Kwon , Jong Soon Choi
发明人： Du Woon Kim , Hee Min Lee , Se Young Cho , Sang Mu Ko , Kyung Seo Oh , Joseph Kwon , Jong Soon Choi
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70 , C12Q1/701 , C12Q1/706 , G01N33/5768 , G01N2333/145 , Y02A50/54
摘要： A method for isolating Hepatitis A virus or Spring viremia of Carp virus. A virus probe is prepared by linking a magnetic bead-conjugated Protein G with an anti-HAV (Hepatitis A Virus) antibody or an anti-rhabdovirus antibody. The virus probe is contacted with a sample to be analyzed to form a virus probe-virus complex. The virus probe-virus complex is then isolated. It may specifically isolate Hepatitis A virus or Spring viremia of Carp virus from a sample mixed viruses.
摘要翻译：一种分离甲型肝炎病毒或鲤鱼病毒春季病毒血症的方法。通过将磁珠缀合的蛋白G与抗HAV（甲型肝炎病毒）抗体或抗淋巴细胞病毒抗体连接来制备病毒探针。将病毒探针与要分析的样品接触以形成病毒探针 - 病毒复合物。然后分离病毒探针 - 病毒复合物。它可以从样品混合病毒中特异性分离甲型肝炎病毒或鲤鱼病毒的春季病毒血症。

93. 发明申请

US20130206685A1 METHOD FOR FIXING CARBON DIOXIDE AND COMPOSITION THEREFOR 审中-公开
标题翻译：固定二氧化碳及其组合物的方法
公开(公告)号：US20130206685A1
公开(公告)日：2013-08-15
申请号：US13660587
申请日：2012-10-25
申请人： Industry Foundation of Chonnam National University
发明人： Yul ROH , Sur Ku KANG
IPC分类号： C02F3/32
CPC分类号： C02F3/322 , C02F3/341 , C12N1/00
摘要： Provided is a method for biologically fixing carbon dioxide dissolved in contaminated water using a microorganism derived from rhodolith. The method includes enrichment-incubating a microorganism derived from rhodolith, and treating and reacting the enrichment-incubated microorganism in contaminated water to fix carbon dioxide dissolved in contaminated water as a carbonate mineral. The method for biologically fixing carbon dioxide has a simple fixing process and is environmentally friendly, compared with chemical carbon dioxide fixing technology. In addition, this method enables fast fixation of carbon dioxide even at room temperature, and thus can be easily applied in the industrial field, and is also useful in an aspect of resource recycling since the carbon dioxide is eventually fixed in the form of calcium carbonate.
摘要翻译：本发明提供一种使用来自玫瑰石的微生物将溶解在污染水中的二氧化碳进行生物固定的方法。该方法包括富集培养来自玫瑰石的微生物，并将富集培养的微生物处理和反应在污染的水中以固定溶解在污染的水中的二氧化碳作为碳酸盐矿物。与化学二氧化碳固定技术相比，生物固定二氧化碳的方法具有简单的定影过程并且是环境友好的。此外，该方法即使在室温也能够快速固定二氧化碳，因此可以容易地应用于工业领域，并且在资源循环方面也是有用的，因为二氧化碳最终以碳酸钙的形式固定。

94. 发明申请

US20130177810A1 METHOD FOR SYNTHESIZING NANO SCALE ELECTRODE MATERIALS USING AN ULTRA-FAST COMBUSTION METHOD, AND NANO SCALE ELECTRODE MATERIALS SYNTHESIZED BY THE METHOD 有权
标题翻译：使用超快速燃烧法合成纳米鳞片状电极材料的方法，以及由该方法合成的纳米鳞片状电极材料
公开(公告)号：US20130177810A1
公开(公告)日：2013-07-11
申请号：US13641441
申请日：2011-04-14
申请人： Jae Kook Kim , Eun Joung Kim , In Sun Yoo , Jin Sub Lim
发明人： Jae Kook Kim , Eun Joung Kim , In Sun Yoo , Jin Sub Lim
IPC分类号： H01M4/131 , H01M4/58
CPC分类号： H01M4/131 , B82B3/00 , C01B25/45 , H01L21/28 , H01M4/366 , H01M4/5825 , H01M4/587 , H01M4/625 , H01M10/052
摘要： Provided are embodiments of a method of synthesizing nano scale electrode materials using an ultrafast combustion technique and nano scale electrode materials synthesized using the method. The method does not require a process of annealing reaction products required for synthesis of electrode materials or any other additional processes, such as cleaning, filtering, and drying processes, so that it can take only several seconds to several minutes to obtain a resultant product.
摘要翻译：提供了使用超快速燃烧技术合成纳米级电极材料的方法和使用该方法合成的纳米级电极材料的方法的实施方案。该方法不需要合成电极材料所需的退火反应产物或任何其它附加方法如清洁，过滤和干燥过程的方法，从而仅需几秒至几分钟即可获得所得产物。

95. 发明申请

US20130060130A1 THERAPEUTIC MICROROBOT SYSTEM FOR BRAIN AND SPINAL CORD DISEASES 有权
标题翻译：用于脑和脊髓疾病的治疗微阵列系统
公开(公告)号：US20130060130A1
公开(公告)日：2013-03-07
申请号：US13696720
申请日：2012-04-05
申请人： Suk Ho Park , Jong Oh Park , Kyoung Rae Cha
发明人： Suk Ho Park , Jong Oh Park , Kyoung Rae Cha
IPC分类号： A61B6/00
CPC分类号： A61B6/12 , A61B6/037 , A61B6/466 , A61B6/481 , A61B6/504 , A61B34/10 , A61B34/30 , A61B34/70 , A61B34/72 , A61B34/73 , A61B2090/376
摘要： Disclosed is a microrobot for the therapy of brain/spinal cord diseases. It comprises a microrobot comprising a driving unit having a magnet therein, and a therapeutic means or drug delivery means for treating a disease lesion; a microrobot driving module for performing and controlling various motions of the microrobot by generating an electromagnetic force through an electromagnetic coil system; an imaging module for imaging a thecal sac filled with cerebrospinal fluid, a ventricle, and the microrobot; a diagnosis module for diagnosing the brain/spinal cord disease, based on a pre-operative image produced by the imaging module; and a navigation module for planning a moving path for the microrobot, based on the pre-operative image produced by the imaging module and for monitoring the microrobot through an intraoperative image produced by the imaging module.
摘要翻译：公开了用于治疗脑/脊髓疾病的微型机器人。它包括一个包括其中具有磁体的驱动单元的微型机器人，以及用于治疗疾病病变的治疗装置或药物递送装置; 微型驾驶模块，用于通过电磁线圈系统产生电磁力来执行和控制所述微型机身的各种运动; 用于对填充有脑脊液，心室和微型机器的囊囊成像的成像模块; 基于由所述成像模块产生的术前图像的用于诊断脑/脊髓疾病的诊断模块; 以及导航模块，用于基于由所述成像模块产生的所述手术前图像来规划所述微机器的移动路径，并且用于通过所述成像模块产生的术中图像监视所述微机架。

96. 发明申请

US20130024955A1 METHOD FOR DETERMINING GENOTOXICITY USING NON-FLUORESCENT PROTEINS 有权
标题翻译：使用非荧光蛋白测定细胞毒性的方法
公开(公告)号：US20130024955A1
公开(公告)日：2013-01-24
申请号：US13578183
申请日：2011-03-31
申请人： Hyon El Choy , Seok-Yong Choi
发明人： Hyon El Choy , Seok-Yong Choi
IPC分类号： A61K49/00 , C12N15/12
CPC分类号： G01N33/5014 , A01K67/0275 , A01K2217/052 , A01K2227/40 , A01K2267/0393 , G01N33/5088
摘要： The present invention relates to a method for determining a genotoxicity of a test substance, comprising the steps of: (a) transforming a fish with a nucleotide sequence encoding a non-fluorescent fluorescence protein with a mutation; (b) treating a test substance to the transformed fish; and (c) measuring a fluorescence in the test substance-treated fish, wherein the fluorescence is generated by reversion of the non-fluorescent fluorescence protein to the fluorescence protein due to a back mutation of the nucleotide sequence in the test substance-treated fish. According to the present invention, MutaFish system, Zebrafish (Brachydanio rerio) line, in which the fluorescence protein variant, preferably wild type EGFP variant (EGFPmut) is transformed, provides a much excellent animal system for measuring a genotoxicity of a test substance via production of a fluorescent fry larvae generated through reversion of the fluorescent protein variant caused by treatment of the test substance. Accordingly, the MutaFish system of the present invention may determine a genotoxicity of a test substance in much more simple and high-throughput manner in an eukaryote to which the conventional methods (e.g., Ames test) may be not applied.
摘要翻译：本发明涉及测定物质的基因毒性的方法，其特征在于，包括以下步骤：（a）用编码具有突变的非荧光荧光蛋白的核苷酸序列转化鱼; （b）将经检测的物质处理至经转化的鱼; 和（c）测定被检物质处理过的鱼中的荧光，其中，由于检测物质处理的鱼中的核苷酸序列的反向突变，通过将非荧光荧光蛋白逆转为荧光蛋白而产生荧光。根据本发明，其中荧光蛋白变体，优选野生型EGFP变体（EGFPmut）被转化的MutaFish系统斑马鱼（Brachydanio rerio）系提供了非常优异的用于通过生产测量测试物质的基因毒性的动物系统通过由测试物质的处理引起的荧光蛋白质变体的逆转产生的荧光鱼苗。因此，本发明的MutaFish系统可以以更加简单和高通量的方式在常规方法（例如Ames测试）中不能应用的真核细胞中确定测试物质的基因毒性。

97. 发明授权

US08290277B2 Method and apparatus for setting a lip region for lip reading 有权
标题翻译：用于设置唇部读数的唇部区域的方法和装置
公开(公告)号：US08290277B2
公开(公告)日：2012-10-16
申请号：US12646600
申请日：2009-12-23
申请人： Seong-Taek Hwang , Jin-Young Kim
发明人： Seong-Taek Hwang , Jin-Young Kim
IPC分类号： G06K9/46
CPC分类号： G06K9/00248
摘要： A method for setting a lip region of a face included in an image, including setting a first region and a second region in an image including a face, identifying contrast information of the first region, setting a threshold for binarization using the contrast information, and binarizing the second region based on the threshold. A region in which a pixel having an identical binary value continuously distributed within a predetermined number of ranges in the binarized image is set as an eye candidate object. An eye region is then extracted from the eye candidate object based on geometric characteristic of an eye region in an image, and the lip region is set with reference to the extracted eye region based on geometric information of the eye region and the lip region.
摘要翻译：一种用于设置包括在图像中的脸部的唇部区域的方法，包括在包括脸部的图像中设置第一区域和第二区域，识别第一区域的对比度信息，使用对比度信息设置二值化阈值，以及基于阈值二值化第二区域。将其中在二值化图像中的预定数量范围内连续分布的相同二进制值的像素设置为候选对象的区域。然后基于图像中的眼睛区域的几何特征，从眼睛候选物体中提取眼睛区域，并且基于眼睛区域和唇部区域的几何信息，参照提取的眼睛区域设定唇部区域。

98. 发明授权

US08232106B2 Detection methods of proteins on polyacrylamide gels using gel background staining and organic dye compositions for the same 有权
标题翻译：使用凝胶背景染色和有机染料组合物对聚丙烯酰胺凝胶上蛋白质的检测方法
公开(公告)号：US08232106B2
公开(公告)日：2012-07-31
申请号：US12863367
申请日：2008-10-27
申请人： Jung-kap Choi
发明人： Jung-kap Choi
IPC分类号： G01N33/68 , C09B67/00 , C07K1/26
CPC分类号： G01N33/6803 , Y10T436/25375
摘要： Disclosed are a method for detecting proteins on a polyacrylamide gel by background staining method using an organic dye composition containing eosin Y or phloxine B, and the organic dye composition for use in the method, which enables the rapid and simple detection of the protein on the polyacrylamide gel with a high sensitivity.
摘要翻译：公开了通过背景染色法使用含有曙红Y或者氧化物B的有机染料组合物和用于该方法的有机染料组合物来检测聚丙烯酰胺凝胶上的蛋白质的方法，其能够快速和简单地检测蛋白质在聚丙烯酰胺凝胶具有高灵敏度。

99. 发明申请

US20120191192A1 IMAGE-BASED PATIENT-SPECIFIC MEDICAL SPINAL SURGERY METHOD AND SPINAL PROSTHESIS 有权
标题翻译：基于图像的患者特异性医疗脊柱手术方法和脊柱前凸
公开(公告)号：US20120191192A1
公开(公告)日：2012-07-26
申请号：US13499612
申请日：2009-12-09
申请人： Suk Ho Park , Jong Oh Park
发明人： Suk Ho Park , Jong Oh Park
IPC分类号： A61F2/44
CPC分类号： A61B17/7062 , A61B17/7065 , A61B90/361 , A61B90/37 , A61F2/44
摘要： The present invention relates to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis to the surgery, and particularly, to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis which are intended to solve a problem of damage to a spine caused by installing a spinal prosthesis used in spinal surgery, by introducing an image of a patient to manufacture an insertable spinal prosthesis that is customized for a shape of a spine of an individual patient in a polymer-based material.
摘要翻译：本发明涉及一种基于图像的患者特异性医疗脊柱手术技术和涉及手术的脊柱假体，特别涉及一种基于图像的患者特异性医疗脊柱手术技术和旨在用于脊柱假体的脊柱假体通过引入患者的图像来制造针对个体患者的脊柱形状而定制的可插入的脊椎假体，从而解决由脊柱外科手术中使用的脊椎假体安装引起的对脊柱损伤的问题，基材料。

100. 发明授权

US08198325B2 Unsaturated alkyl esters of 5-aminolevulinic acid, their preparation and their use 有权
标题翻译： 5-氨基乙酰丙酸的不饱和烷基酯，其制备及其应用
公开(公告)号：US08198325B2
公开(公告)日：2012-06-12
申请号：US12227085
申请日：2007-06-28
申请人： Jonghoon Oh , Jee-Bum Lee , Hyoung-Ryun Park
发明人： Jonghoon Oh , Jee-Bum Lee , Hyoung-Ryun Park
IPC分类号： A61K31/22 , C07C229/00
CPC分类号： C07C229/22
摘要： Disclosed are unsaturated alkyl esters of 5-aminovulinic acid of the following chemical formula 1, or pharmaceutically acceptable salts thereof, a method for preparing the same, and uses thereof. [Chemical Formula I] NH2—CH2—CO—CH2—CH2—CO—O—R wherein, R is a group selected from a group consisting of 2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, cis-2-pentenyl, cis-3-hexenyl, cis-4-hexenyl, and trans-2-hexenyl. Also, a pharmaceutical composition comprising the unsaturated alkyl ester of 5-aminovulinic acid or a salt thereof as an active ingredient is provided. This pharmaceutical composition is easily absorbed transdermally and is of low cytotoxicity. Featuring no amino-protecting processes, the method guarantees high production yields.
摘要翻译：公开了以下化学式1的5-氨基丙烯酸的不饱和烷基酯或其药学上可接受的盐，其制备方法及其应用。 [化学式I] NH 2 -CH 2 -CO-CH 2 -CH 2 -CO-O-R其中，R是选自2-丙烯基，3-丁烯基，4-戊烯基，5-己烯基，顺式 - 2-戊烯基，顺式-3-己烯基，顺式-4-己烯基和反式-2-己烯基。此外，提供了包含5-氨基乙酰丙酸的不饱和烷基酯或其盐作为活性成分的药物组合物。该药物组合物容易被透皮吸收并具有低细胞毒性。不具有氨基保护过程，该方法保证了高产量。

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